Manish Kushwaha
@manishmicrobe.bsky.social
Research Director at the Micalis Institute, INRAE-AgroParisTech, University of Paris-Saclay. Research interests: Synthetic Biology, Biological Computing, Bioengineering.
https://cellularcomputing.team/
https://manishkushwaha.net/
https://cellularcomputing.team/
https://manishkushwaha.net/
Reposted by Manish Kushwaha
New in #PhilTransB - a theme issue exploring one of science’s deepest questions: how life can emerge from non-living matter. Edited by @ricardsole.bsky.social and colleagues. Read: buff.ly/7iz4tGu
October 3, 2025 at 8:15 PM
New in #PhilTransB - a theme issue exploring one of science’s deepest questions: how life can emerge from non-living matter. Edited by @ricardsole.bsky.social and colleagues. Read: buff.ly/7iz4tGu
Reposted by Manish Kushwaha
How dit life originate in our planet? How can we create it in the lab?Our @royalsocietypublishing.org Theme Issue "Origins of Life: the possible and the actual", coedited with @sfiscience.bsky.social C Kempes and Susan Stepney is out! royalsocietypublishing.org/toc/rstb/202... @manlius.bsky.social
Philosophical Transactions of the Royal Society B: Biological Sciences: Vol 380, No 1936
royalsocietypublishing.org
October 2, 2025 at 9:04 AM
How dit life originate in our planet? How can we create it in the lab?Our @royalsocietypublishing.org Theme Issue "Origins of Life: the possible and the actual", coedited with @sfiscience.bsky.social C Kempes and Susan Stepney is out! royalsocietypublishing.org/toc/rstb/202... @manlius.bsky.social
Pleased to share that our review on 'Reconstituting alternative life using the test-bed of cell-free systems' is now out in the Phil Trans B special issue on ‘Origins of life: the possible and the actual’. royalsocietypublishing.org/doi/10.1098/...
Reconstituting alternative life using the test-bed of cell-free systems | Philosophical Transactions of the Royal Society B: Biological Sciences
The current form of life on Earth is the outcome of a series of biochemical events that led to the formation of early life with a specific molecular composition encoding its many functions. However, other trajectories of events with widely different ...
royalsocietypublishing.org
October 2, 2025 at 8:02 AM
Pleased to share that our review on 'Reconstituting alternative life using the test-bed of cell-free systems' is now out in the Phil Trans B special issue on ‘Origins of life: the possible and the actual’. royalsocietypublishing.org/doi/10.1098/...
Reposted by Manish Kushwaha
Four leading researchers on bacterial computing in the @femsmicro.org Workshop on the the topic during the Congress—quite amazing talks by @angelgm.bsky.social, Yolanda Schaerli, Manish Kushwaha & Samgram Bagh. Do bacteria compute? Can we make them to compute wth our logic or do they have their own?
July 15, 2025 at 5:01 PM
Four leading researchers on bacterial computing in the @femsmicro.org Workshop on the the topic during the Congress—quite amazing talks by @angelgm.bsky.social, Yolanda Schaerli, Manish Kushwaha & Samgram Bagh. Do bacteria compute? Can we make them to compute wth our logic or do they have their own?
Reposted by Manish Kushwaha
#FEMS2025 kicks off in just 2 days 🚀✨
Now is the perfect time to explore the FEMS MICRO app and start building your personalised onsite agenda 📅✅
Flag your favourite sessions ⭐️, identify must-see speakers 🎤, and plan your day 🗺️ to make the most of every moment ⏳
buff.ly/nN0DaPL
Now is the perfect time to explore the FEMS MICRO app and start building your personalised onsite agenda 📅✅
Flag your favourite sessions ⭐️, identify must-see speakers 🎤, and plan your day 🗺️ to make the most of every moment ⏳
buff.ly/nN0DaPL
July 12, 2025 at 6:01 AM
#FEMS2025 kicks off in just 2 days 🚀✨
Now is the perfect time to explore the FEMS MICRO app and start building your personalised onsite agenda 📅✅
Flag your favourite sessions ⭐️, identify must-see speakers 🎤, and plan your day 🗺️ to make the most of every moment ⏳
buff.ly/nN0DaPL
Now is the perfect time to explore the FEMS MICRO app and start building your personalised onsite agenda 📅✅
Flag your favourite sessions ⭐️, identify must-see speakers 🎤, and plan your day 🗺️ to make the most of every moment ⏳
buff.ly/nN0DaPL
Reposted by Manish Kushwaha
Next in Lab's conference agenda: FEMS @femsmicro.org! @vdlorenzo.bsky.social and myself are running a session on bacterial computation. Talks by @yschaerli.bsky.social, @manishmicrobe.bsky.social, Sangram Bagh & organisers. Very looking forward to it! #biocomputation #synbio
July 9, 2025 at 11:57 AM
Next in Lab's conference agenda: FEMS @femsmicro.org! @vdlorenzo.bsky.social and myself are running a session on bacterial computation. Talks by @yschaerli.bsky.social, @manishmicrobe.bsky.social, Sangram Bagh & organisers. Very looking forward to it! #biocomputation #synbio
Two days of excellent discussions with @ceronifranci.bsky.social and Luca Ciandrini. So great to have them visit.
June 19, 2025 at 1:52 PM
Two days of excellent discussions with @ceronifranci.bsky.social and Luca Ciandrini. So great to have them visit.
We are hiring for a funded PhD in design of cross- and multi-species genetic circuits. #PhD #synbio #crossspecies #multispecies #biocomputing #circuits #pathways @inrae-france.bsky.social @parissaclay.bsky.social
Details here: www.cellularcomputing.team/joinus/
Details here: www.cellularcomputing.team/joinus/
May 10, 2025 at 3:01 PM
We are hiring for a funded PhD in design of cross- and multi-species genetic circuits. #PhD #synbio #crossspecies #multispecies #biocomputing #circuits #pathways @inrae-france.bsky.social @parissaclay.bsky.social
Details here: www.cellularcomputing.team/joinus/
Details here: www.cellularcomputing.team/joinus/
Reposted by Manish Kushwaha
On the way back from Abhinav's thesis defense. It's been great to follow this project from start. Congrats to the new doctor, and to his supervisor @manishmicrobe.bsky.social
The main paper from the thesis (so far...) 👇
The main paper from the thesis (so far...) 👇
Our latest work on Biocomputation in Bacterial Consortia is out in Nucleic Acids Research 😀. In a process we term "intercellular CRISPRi", filamentous phages transmit DNA messages from sender to receiver cells to regulate gene expression by CRISPR interference. doi.org/10.1093/nar/...
Phage-mediated intercellular CRISPRi for biocomputation in bacterial consortia
Abstract. Coordinated actions of cells in microbial communities and multicellular organisms enable them to perform complex tasks otherwise difficult for si
doi.org
April 10, 2025 at 4:33 PM
On the way back from Abhinav's thesis defense. It's been great to follow this project from start. Congrats to the new doctor, and to his supervisor @manishmicrobe.bsky.social
The main paper from the thesis (so far...) 👇
The main paper from the thesis (so far...) 👇
Reposted by Manish Kushwaha
Very happy to share our newly published work! We engineered phages for intercellular communication in multicellular consortia and integrated it with CRISPR-based gene regulation for biocomputing. Congratulations to @astrikusuma.bsky.social @dmf-unil.bsky.social @fbm-unil.bsky.social
rdcu.be/ehORO
rdcu.be/ehORO
Engineering intercellular communication using M13 phagemid and CRISPR-based gene regulation for multicellular computing in Escherichia coli
Nature Communications - Engineering multicellular consortia, where information processing is distributed across specialized cell types, offers a promising strategy for implementing sophisticated...
rdcu.be
April 15, 2025 at 11:21 AM
Very happy to share our newly published work! We engineered phages for intercellular communication in multicellular consortia and integrated it with CRISPR-based gene regulation for biocomputing. Congratulations to @astrikusuma.bsky.social @dmf-unil.bsky.social @fbm-unil.bsky.social
rdcu.be/ehORO
rdcu.be/ehORO
Reposted by Manish Kushwaha
Keep an eye out for the Special Sessions of the European Academy of Microbiology this July at FEMS2025 fems-microbiology.org/eam-sessions... ! Do not miss the one on bacterial computation, featuring top experts @angelgm.bsky.social, Manish Kushwaha, Yolanda Schaerli, and Sangram Bagh!
March 19, 2025 at 2:58 PM
Keep an eye out for the Special Sessions of the European Academy of Microbiology this July at FEMS2025 fems-microbiology.org/eam-sessions... ! Do not miss the one on bacterial computation, featuring top experts @angelgm.bsky.social, Manish Kushwaha, Yolanda Schaerli, and Sangram Bagh!
Reposted by Manish Kushwaha
This is a great review on using nanopores to sequence proteins. Out today.
It covers how nanopores work, why they haven't historically been able to sequence individual proteins, and how researchers are adapting them to solve those problems.
Clear writing throughout.
It covers how nanopores work, why they haven't historically been able to sequence individual proteins, and how researchers are adapting them to solve those problems.
Clear writing throughout.
March 17, 2025 at 7:27 PM
This is a great review on using nanopores to sequence proteins. Out today.
It covers how nanopores work, why they haven't historically been able to sequence individual proteins, and how researchers are adapting them to solve those problems.
Clear writing throughout.
It covers how nanopores work, why they haven't historically been able to sequence individual proteins, and how researchers are adapting them to solve those problems.
Clear writing throughout.
Reposted by Manish Kushwaha
Experimental evolution of evolvability | Science www.science.org/doi/10.1126/...
Experimental evolution of evolvability
Evolvability—the capacity to generate adaptive variation—is a trait that can itself evolve through natural selection. However, the idea that mutation can become biased toward adaptive outcomes remains...
www.science.org
February 20, 2025 at 9:16 PM
Experimental evolution of evolvability | Science www.science.org/doi/10.1126/...
Reposted by Manish Kushwaha
🚀 Join the #EUSynBioS Steering Committee!
🧬 Passionate about #SyntheticBiology? Based in #Europe? Help grow our community!
We are opening new positions, check them out & apply here 👉 linkedin.com/feed/update/...
#SynBio #ScienceCommunication #Policy
🧬 Passionate about #SyntheticBiology? Based in #Europe? Help grow our community!
We are opening new positions, check them out & apply here 👉 linkedin.com/feed/update/...
#SynBio #ScienceCommunication #Policy
European Synthetic Biology Society (EUSynBioS) on LinkedIn: #syntheticbiology #europe #synbio #europe #outreach #communication…
🧬 Are you passionate about #SyntheticBiology, based in #Europe and willing to help our growing community? ⭐️ 𝗝𝗼𝗶𝗻 𝘁𝗵𝗲 𝗘𝗨𝗦𝘆𝗻𝗕𝗶𝗼𝗦…
linkedin.com
February 24, 2025 at 12:33 PM
🚀 Join the #EUSynBioS Steering Committee!
🧬 Passionate about #SyntheticBiology? Based in #Europe? Help grow our community!
We are opening new positions, check them out & apply here 👉 linkedin.com/feed/update/...
#SynBio #ScienceCommunication #Policy
🧬 Passionate about #SyntheticBiology? Based in #Europe? Help grow our community!
We are opening new positions, check them out & apply here 👉 linkedin.com/feed/update/...
#SynBio #ScienceCommunication #Policy
Reposted by Manish Kushwaha
Massive upgrade to our preprint "Reprogramming genetic circuits using space": mathematical modeling, time-based experiments, new functions, more supplementary material... We're thrilled about this work and hope you enjoy it! www.biorxiv.org/content/10.1...
January 15, 2025 at 12:56 PM
Massive upgrade to our preprint "Reprogramming genetic circuits using space": mathematical modeling, time-based experiments, new functions, more supplementary material... We're thrilled about this work and hope you enjoy it! www.biorxiv.org/content/10.1...
Reposted by Manish Kushwaha
1/ Hello BlueSky world -- my first post is about a new study from the lab, just published in @nchembio.bsky.social. We demonstrate how population-level gene regulation can be dynamically controlled and amplified using programmable gene transfer.
Link to paper: doi.org/10.1038/s415...
Link to paper: doi.org/10.1038/s415...
Population-level amplification of gene regulation by programmable gene transfer - Nature Chemical Biology
Gene regulation in engineered microbial populations is often tuned at individual cell levels. Now, a population-wide amplification system has been devised that expands the dynamic range of plasmid tra...
doi.org
January 13, 2025 at 3:40 PM
1/ Hello BlueSky world -- my first post is about a new study from the lab, just published in @nchembio.bsky.social. We demonstrate how population-level gene regulation can be dynamically controlled and amplified using programmable gene transfer.
Link to paper: doi.org/10.1038/s415...
Link to paper: doi.org/10.1038/s415...
Reposted by Manish Kushwaha
How can we model the emergent complexity of microbial ecosystems? How do you do the maths & predict their dynamics, from the gut & the soil to the biosphere? Here's a great review paper in @natureecoevo.bsky.social. @vmaull.bsky.social @saramitri.bsky.social
nature.com/articles/s41...
nature.com/articles/s41...
January 10, 2025 at 6:18 PM
How can we model the emergent complexity of microbial ecosystems? How do you do the maths & predict their dynamics, from the gut & the soil to the biosphere? Here's a great review paper in @natureecoevo.bsky.social. @vmaull.bsky.social @saramitri.bsky.social
nature.com/articles/s41...
nature.com/articles/s41...
Our latest work on Biocomputation in Bacterial Consortia is out in Nucleic Acids Research 😀. In a process we term "intercellular CRISPRi", filamentous phages transmit DNA messages from sender to receiver cells to regulate gene expression by CRISPR interference. doi.org/10.1093/nar/...
Phage-mediated intercellular CRISPRi for biocomputation in bacterial consortia
Abstract. Coordinated actions of cells in microbial communities and multicellular organisms enable them to perform complex tasks otherwise difficult for si
doi.org
December 28, 2024 at 8:29 AM
Our latest work on Biocomputation in Bacterial Consortia is out in Nucleic Acids Research 😀. In a process we term "intercellular CRISPRi", filamentous phages transmit DNA messages from sender to receiver cells to regulate gene expression by CRISPR interference. doi.org/10.1093/nar/...