NNF Center for Basic Metabolic Research
@cbmr.science
Interdisciplinary research into cardiometabolic health and disease at the University of Copenhagen. https://cbmr.ku.dk/
See our Following list for CBMR scientists: https://bsky.app/profile/cbmr.science/follows
See our Following list for CBMR scientists: https://bsky.app/profile/cbmr.science/follows
Reposted by NNF Center for Basic Metabolic Research
🌍 Excited to be part of this global effort! 🦠
Microbial and metabolic diversity was mapped across 51 vivaria & 12 wild colonies, revealing striking functional convergence despite taxonomic divergence.
🔗 www.cell.com/cell-host-mi...
Microbial and metabolic diversity was mapped across 51 vivaria & 12 wild colonies, revealing striking functional convergence despite taxonomic divergence.
🔗 www.cell.com/cell-host-mi...
November 10, 2025 at 1:39 PM
🌍 Excited to be part of this global effort! 🦠
Microbial and metabolic diversity was mapped across 51 vivaria & 12 wild colonies, revealing striking functional convergence despite taxonomic divergence.
🔗 www.cell.com/cell-host-mi...
Microbial and metabolic diversity was mapped across 51 vivaria & 12 wild colonies, revealing striking functional convergence despite taxonomic divergence.
🔗 www.cell.com/cell-host-mi...
"For decades, we’ve been told that weight loss is a matter of willpower: eat less, move more. But modern science has proven this isn’t actually the case."
@clemmensenc.bsky.social and @johansenvbi.bsky.social in @theconversation.com 👇
theconversation.com/the-science-...
#obesity #metabolism
@clemmensenc.bsky.social and @johansenvbi.bsky.social in @theconversation.com 👇
theconversation.com/the-science-...
#obesity #metabolism
The science of weight loss – and why your brain is wired to keep you fat
The evolutionary science of weight regain unpacked.
theconversation.com
November 10, 2025 at 9:03 AM
"For decades, we’ve been told that weight loss is a matter of willpower: eat less, move more. But modern science has proven this isn’t actually the case."
@clemmensenc.bsky.social and @johansenvbi.bsky.social in @theconversation.com 👇
theconversation.com/the-science-...
#obesity #metabolism
@clemmensenc.bsky.social and @johansenvbi.bsky.social in @theconversation.com 👇
theconversation.com/the-science-...
#obesity #metabolism
Reposted by NNF Center for Basic Metabolic Research
A framework from @easoobesity.bsky.social to guide pharmacological treatment of 'fat mass diseases' versus 'sick fat diseases' 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Framework for the pharmacological treatment of obesity and its complications from the European Association for the Study of Obesity (EASO) - Nature Medicine
Obesity and associated complications can be managed by obesity medications, prompting the revision of criteria for the diagnosis and staging of this disease.
www.nature.com
October 7, 2025 at 6:43 AM
A framework from @easoobesity.bsky.social to guide pharmacological treatment of 'fat mass diseases' versus 'sick fat diseases' 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by NNF Center for Basic Metabolic Research
Stoked to receive this award that will help to dissect the relative contribution of aberrant glycogen levels and impaired glycogenesis in influencing skeletal muscle glucose metabolism.
🎉👏 We’re thrilled to congratulate the 2025 #EFSD / Lilly Diabetes International Young Investigators Award recipients.
Award recognises early career scientists/clinicians driving innovation in diabetes research.
Learn more about their projects 👉 www.europeandiabetesfoundation.org/recipients/e...
Award recognises early career scientists/clinicians driving innovation in diabetes research.
Learn more about their projects 👉 www.europeandiabetesfoundation.org/recipients/e...
October 17, 2025 at 10:49 AM
Stoked to receive this award that will help to dissect the relative contribution of aberrant glycogen levels and impaired glycogenesis in influencing skeletal muscle glucose metabolism.
Reposted by NNF Center for Basic Metabolic Research
🚨 Dealing with sparse, noisy single-cell DNA methylation data (scBS-seq)? Check out #scDMV.
It uses a zero-one inflated beta mixture model to tackle the excess of 0s/1s and low coverage, boosting accuracy in identifying differentially methylated regions (DMRs).
It uses a zero-one inflated beta mixture model to tackle the excess of 0s/1s and low coverage, boosting accuracy in identifying differentially methylated regions (DMRs).
scDMV: a zero–one inflated beta mixture model for DNA methylation variability with scBS-seq data
AbstractMotivation. The utilization of single-cell bisulfite sequencing (scBS-seq) methods allows for precise analysis of DNA methylation patterns at the i
academic.oup.com
October 20, 2025 at 11:35 AM
🚨 Dealing with sparse, noisy single-cell DNA methylation data (scBS-seq)? Check out #scDMV.
It uses a zero-one inflated beta mixture model to tackle the excess of 0s/1s and low coverage, boosting accuracy in identifying differentially methylated regions (DMRs).
It uses a zero-one inflated beta mixture model to tackle the excess of 0s/1s and low coverage, boosting accuracy in identifying differentially methylated regions (DMRs).
CBMR's Zach Gerhart-Hines is awarded the first Flemming Quaade Prize for Outstanding Obesity Research for his pioneering discoveries on how fat tissue influences insulin sensitivity, energy expenditure, and appetite control.
Read more: cbmr.ku.dk/news/2025/za...
#obesity #metabolism
Read more: cbmr.ku.dk/news/2025/za...
#obesity #metabolism
October 22, 2025 at 10:14 AM
CBMR's Zach Gerhart-Hines is awarded the first Flemming Quaade Prize for Outstanding Obesity Research for his pioneering discoveries on how fat tissue influences insulin sensitivity, energy expenditure, and appetite control.
Read more: cbmr.ku.dk/news/2025/za...
#obesity #metabolism
Read more: cbmr.ku.dk/news/2025/za...
#obesity #metabolism
Reposted by NNF Center for Basic Metabolic Research
Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle
Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...
www.biorxiv.org
September 30, 2025 at 10:42 AM
Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by NNF Center for Basic Metabolic Research
Great visit to Novo Nordisk Foundation Center for Genomic Mechanisms of Disease in Boston at Broad Institute. Delighted to see great collaborations with Novo Nordisk Foundation Center for Basic Metabolic Research @cbmr.science @novo-nordisk.bsky.social
September 29, 2025 at 9:45 AM
Great visit to Novo Nordisk Foundation Center for Genomic Mechanisms of Disease in Boston at Broad Institute. Delighted to see great collaborations with Novo Nordisk Foundation Center for Basic Metabolic Research @cbmr.science @novo-nordisk.bsky.social
Reposted by NNF Center for Basic Metabolic Research
Remember to sign up for the Gut-Brain Axis @keystonesymposia.bsky.social meeting in March 2026!
Upcoming deadlines:
Scholarship Deadline: November 18, 2025
Short Talk Abstract Deadline: November 18, 2025
Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers
keysym.us/KSGutBrain26
Upcoming deadlines:
Scholarship Deadline: November 18, 2025
Short Talk Abstract Deadline: November 18, 2025
Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers
keysym.us/KSGutBrain26
September 24, 2025 at 8:51 AM
Remember to sign up for the Gut-Brain Axis @keystonesymposia.bsky.social meeting in March 2026!
Upcoming deadlines:
Scholarship Deadline: November 18, 2025
Short Talk Abstract Deadline: November 18, 2025
Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers
keysym.us/KSGutBrain26
Upcoming deadlines:
Scholarship Deadline: November 18, 2025
Short Talk Abstract Deadline: November 18, 2025
Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers
keysym.us/KSGutBrain26
Could the season you were conceived determine your lifelong health?
@camillascheele.bsky.social & Taylah Gaynor ask why cold temperatures during the pre-conception period are associated with higher BAT density and activity and point to a possible epigenetic reprogramming of the father's sperm.
1/2
@camillascheele.bsky.social & Taylah Gaynor ask why cold temperatures during the pre-conception period are associated with higher BAT density and activity and point to a possible epigenetic reprogramming of the father's sperm.
1/2
September 29, 2025 at 8:56 AM
Could the season you were conceived determine your lifelong health?
@camillascheele.bsky.social & Taylah Gaynor ask why cold temperatures during the pre-conception period are associated with higher BAT density and activity and point to a possible epigenetic reprogramming of the father's sperm.
1/2
@camillascheele.bsky.social & Taylah Gaynor ask why cold temperatures during the pre-conception period are associated with higher BAT density and activity and point to a possible epigenetic reprogramming of the father's sperm.
1/2
Reposted by NNF Center for Basic Metabolic Research
💡Meet Assoc. Prof. @adeshmukh.bsky.social ( @cbmr.science), #EFSD/ @novo-nordisk.bsky.social Future Leaders Awardee. His work uncovers exercise-induced peptides & #proteins that improve insulin sensitivity in #T2D.
📅 See him at #EASD2025 (18 Sept, 12:45 CEST, Milan Hall).
📖 doi.org/10.1016/j.ce...
📅 See him at #EASD2025 (18 Sept, 12:45 CEST, Milan Hall).
📖 doi.org/10.1016/j.ce...
September 2, 2025 at 1:07 PM
💡Meet Assoc. Prof. @adeshmukh.bsky.social ( @cbmr.science), #EFSD/ @novo-nordisk.bsky.social Future Leaders Awardee. His work uncovers exercise-induced peptides & #proteins that improve insulin sensitivity in #T2D.
📅 See him at #EASD2025 (18 Sept, 12:45 CEST, Milan Hall).
📖 doi.org/10.1016/j.ce...
📅 See him at #EASD2025 (18 Sept, 12:45 CEST, Milan Hall).
📖 doi.org/10.1016/j.ce...
Reposted by NNF Center for Basic Metabolic Research
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827
The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.
www.science.org
September 9, 2025 at 3:17 PM
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by NNF Center for Basic Metabolic Research
Are you using metabolic tolerance tests in your research? 💉Are you interested in metabolites? Or do you study the effects of exercise? 🏃🏻♂️➡️ 1/4
September 17, 2025 at 1:07 PM
Are you using metabolic tolerance tests in your research? 💉Are you interested in metabolites? Or do you study the effects of exercise? 🏃🏻♂️➡️ 1/4
Reposted by NNF Center for Basic Metabolic Research
Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 7, 2025 at 3:02 PM
Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by NNF Center for Basic Metabolic Research
@jphysiol.bsky.social, and several other journals, has a 'Journal Club' format targeted to early-career researchers. It is a great opportunity for young scientists to get started with scientific writing and cultivating independent thinking. Check it out! 1/3
Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 8, 2025 at 12:15 PM
@jphysiol.bsky.social, and several other journals, has a 'Journal Club' format targeted to early-career researchers. It is a great opportunity for young scientists to get started with scientific writing and cultivating independent thinking. Check it out! 1/3
Reposted by NNF Center for Basic Metabolic Research
A must read!
@cellpress.bsky.social Review 🚨 ‘Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy’
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
August 8, 2025 at 6:31 AM
A must read!
@cellpress.bsky.social Review 🚨 ‘Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy’
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
August 7, 2025 at 3:19 PM
@cellpress.bsky.social Review 🚨 ‘Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy’
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
Reposted by NNF Center for Basic Metabolic Research
Looking for a Postdoc position? (great program with 3-year funding and running costs)
@clemmensenc.bsky.social has a fantastic project in wonderful Copenhagen at the fantastic @cbmr.science research center
Being a program alumni I can can highly recommend the program and the Clemmensen lab :)
@clemmensenc.bsky.social has a fantastic project in wonderful Copenhagen at the fantastic @cbmr.science research center
Being a program alumni I can can highly recommend the program and the Clemmensen lab :)
Kickstart your research career in Copenhagen with a PhD or Postdoctoral fellowship at CBMR!
Four PhD and four Postdoc positions are currently available:
cbmr.ku.dk/join-us/fell...
#phdposition #postdocposition
Four PhD and four Postdoc positions are currently available:
cbmr.ku.dk/join-us/fell...
#phdposition #postdocposition
August 1, 2025 at 8:18 AM
Looking for a Postdoc position? (great program with 3-year funding and running costs)
@clemmensenc.bsky.social has a fantastic project in wonderful Copenhagen at the fantastic @cbmr.science research center
Being a program alumni I can can highly recommend the program and the Clemmensen lab :)
@clemmensenc.bsky.social has a fantastic project in wonderful Copenhagen at the fantastic @cbmr.science research center
Being a program alumni I can can highly recommend the program and the Clemmensen lab :)
Reposted by NNF Center for Basic Metabolic Research
Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 9, 2025 at 8:28 AM
Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by NNF Center for Basic Metabolic Research
After an immensely enriching and rewarding PhD in @caina89.bsky.social lab at @pioneercampus.bsky.social, I am excited to announce that I moved to beautiful Copenhagen for my postdoc in Simon Rasmussen's group @cbmr.science!
July 9, 2025 at 4:26 PM
After an immensely enriching and rewarding PhD in @caina89.bsky.social lab at @pioneercampus.bsky.social, I am excited to announce that I moved to beautiful Copenhagen for my postdoc in Simon Rasmussen's group @cbmr.science!
Kickstart your research career in Copenhagen with a PhD or Postdoctoral fellowship at CBMR!
Four PhD and four Postdoc positions are currently available:
cbmr.ku.dk/join-us/fell...
#phdposition #postdocposition
Four PhD and four Postdoc positions are currently available:
cbmr.ku.dk/join-us/fell...
#phdposition #postdocposition
August 1, 2025 at 8:04 AM
Kickstart your research career in Copenhagen with a PhD or Postdoctoral fellowship at CBMR!
Four PhD and four Postdoc positions are currently available:
cbmr.ku.dk/join-us/fell...
#phdposition #postdocposition
Four PhD and four Postdoc positions are currently available:
cbmr.ku.dk/join-us/fell...
#phdposition #postdocposition
🔎 𝐃𝐞𝐜𝐢𝐩𝐡𝐞𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐆𝐈𝐏 𝐩𝐚𝐫𝐚𝐝𝐨𝐱
Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective?
Prof. Jens Juul Holst outlines the evidence in Diabetes 👇
diabetesjournals.org/diabetes/art...
#GIP #GLP1 #biotech #obesity
Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective?
Prof. Jens Juul Holst outlines the evidence in Diabetes 👇
diabetesjournals.org/diabetes/art...
#GIP #GLP1 #biotech #obesity
June 23, 2025 at 9:12 AM
🔎 𝐃𝐞𝐜𝐢𝐩𝐡𝐞𝐫𝐢𝐧𝐠 𝐭𝐡𝐞 𝐆𝐈𝐏 𝐩𝐚𝐫𝐚𝐝𝐨𝐱
Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective?
Prof. Jens Juul Holst outlines the evidence in Diabetes 👇
diabetesjournals.org/diabetes/art...
#GIP #GLP1 #biotech #obesity
Why does activating the GIP receptor contribute to weight-loss, given the evidence that blocking the receptor ought to be more effective?
Prof. Jens Juul Holst outlines the evidence in Diabetes 👇
diabetesjournals.org/diabetes/art...
#GIP #GLP1 #biotech #obesity
Scientists from @cbmr.science and the @ucph.bsky.social Department of Neuroscience have identified a neural circuit in the mouse’s brain that prioritises safety over other needs. The findings were published in @nature.com Neuroscience.
Read more, below 👇
healthsciences.ku.dk/newsfaculty-...
Read more, below 👇
healthsciences.ku.dk/newsfaculty-...
Safety becomes more important than foraging when a specific neuronal circuit in the brain is activated
Researchers from the University of Copenhagen have identified a neural circuit in the mouse’s brain which ensures that it prioritises safety over other needs, e.g. food seeking, and that this happens ...
healthsciences.ku.dk
June 13, 2025 at 8:34 AM
Scientists from @cbmr.science and the @ucph.bsky.social Department of Neuroscience have identified a neural circuit in the mouse’s brain that prioritises safety over other needs. The findings were published in @nature.com Neuroscience.
Read more, below 👇
healthsciences.ku.dk/newsfaculty-...
Read more, below 👇
healthsciences.ku.dk/newsfaculty-...
Reposted by NNF Center for Basic Metabolic Research
Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
Great collaboration with @adeshmukh.bsky.social @JeppeKjaergaard.bsky.social and team @cbmr.science
www.sciencedirect.com/science/arti...
Great collaboration with @adeshmukh.bsky.social @JeppeKjaergaard.bsky.social and team @cbmr.science
www.sciencedirect.com/science/arti...
Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
Skeletal muscle glucose uptake, essential for metabolic health, is regulated by both insulin and exercise. Using phosphoproteomics, we analyze skeleta…
www.sciencedirect.com
June 7, 2025 at 9:33 PM
Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
Great collaboration with @adeshmukh.bsky.social @JeppeKjaergaard.bsky.social and team @cbmr.science
www.sciencedirect.com/science/arti...
Great collaboration with @adeshmukh.bsky.social @JeppeKjaergaard.bsky.social and team @cbmr.science
www.sciencedirect.com/science/arti...
Reposted by NNF Center for Basic Metabolic Research
New publication!
We mapped the phosphoproteomic landscape of insulin & exercise in human skeletal muscle (same individuals) and discovered REPS1 as a new regulator of muscle glucose uptake.
www.sciencedirect.com/science/arti...
@cbmr.science @jeppekjaergaard.bsky.social
We mapped the phosphoproteomic landscape of insulin & exercise in human skeletal muscle (same individuals) and discovered REPS1 as a new regulator of muscle glucose uptake.
www.sciencedirect.com/science/arti...
@cbmr.science @jeppekjaergaard.bsky.social
Insulin- and exercise-induced phosphoproteomics of human skeletal muscle identify REPS1 as a regulator of muscle glucose uptake
Skeletal muscle glucose uptake, essential for metabolic health, is regulated by both insulin and exercise. Using phosphoproteomics, we analyze skeleta…
www.sciencedirect.com
June 8, 2025 at 8:52 PM
New publication!
We mapped the phosphoproteomic landscape of insulin & exercise in human skeletal muscle (same individuals) and discovered REPS1 as a new regulator of muscle glucose uptake.
www.sciencedirect.com/science/arti...
@cbmr.science @jeppekjaergaard.bsky.social
We mapped the phosphoproteomic landscape of insulin & exercise in human skeletal muscle (same individuals) and discovered REPS1 as a new regulator of muscle glucose uptake.
www.sciencedirect.com/science/arti...
@cbmr.science @jeppekjaergaard.bsky.social