NNF Center for Basic Metabolic Research
@cbmr.science
Interdisciplinary research into cardiometabolic health and disease at the University of Copenhagen. https://cbmr.ku.dk/
See our Following list for CBMR scientists: https://bsky.app/profile/cbmr.science/follows
See our Following list for CBMR scientists: https://bsky.app/profile/cbmr.science/follows
Reposted by NNF Center for Basic Metabolic Research
A big congratulations and thank you for all the marvelous achievements & hardwork to all members of the group. Looking forward for a productive and eventful 2026! Merry Christmas and Happy New Year to everyone from the Sakamoto group @cbmr.science
December 25, 2025 at 12:12 AM
A big congratulations and thank you for all the marvelous achievements & hardwork to all members of the group. Looking forward for a productive and eventful 2026! Merry Christmas and Happy New Year to everyone from the Sakamoto group @cbmr.science
Reposted by NNF Center for Basic Metabolic Research
New findings from @CBMR.science show that insulin-resistance-linked hyperinsulinemia is associated with colorectal cancer risk, but not other diabetogenic processes. Largest study yet on this link – led by postdoc Xuan Zhou and @jmerino.bsky.social link.springer.com/article/10.1...
Diabetogenic processes for insulin resistance-linked hyperinsulinaemia are associated with colorectal cancer - Diabetologia
Aims/hypothesis Type 2 diabetes has been associated with increased risk of colorectal cancer (CRC), but the specific diabetogenic pathways contributing to this risk remain unclear. Methods We analysed...
link.springer.com
December 22, 2025 at 11:04 AM
New findings from @CBMR.science show that insulin-resistance-linked hyperinsulinemia is associated with colorectal cancer risk, but not other diabetogenic processes. Largest study yet on this link – led by postdoc Xuan Zhou and @jmerino.bsky.social link.springer.com/article/10.1...
Register now for Metabolism Day 2026! 🚀
The 7th annual conference about cardiometabolic diseases and energy control takes place on March 10, 2026 at @ucph.bsky.social, Denmark.
Attend in-person or watch the live stream.
Read more and register on our website!
eventsignup.ku.dk/metabolismda...
The 7th annual conference about cardiometabolic diseases and energy control takes place on March 10, 2026 at @ucph.bsky.social, Denmark.
Attend in-person or watch the live stream.
Read more and register on our website!
eventsignup.ku.dk/metabolismda...
December 16, 2025 at 8:20 AM
Register now for Metabolism Day 2026! 🚀
The 7th annual conference about cardiometabolic diseases and energy control takes place on March 10, 2026 at @ucph.bsky.social, Denmark.
Attend in-person or watch the live stream.
Read more and register on our website!
eventsignup.ku.dk/metabolismda...
The 7th annual conference about cardiometabolic diseases and energy control takes place on March 10, 2026 at @ucph.bsky.social, Denmark.
Attend in-person or watch the live stream.
Read more and register on our website!
eventsignup.ku.dk/metabolismda...
Reposted by NNF Center for Basic Metabolic Research
🔔 Excited to teach the PhD course “Bioinformatics Analysis of Gene Expression Data from Bulk RNA-seq” at University of Copenhagen!
📅 26 Jan – 12 Feb 2026
👍 Bring your own data (or use a public one) and learn the full RNA-seq pipeline:
📅 26 Jan – 12 Feb 2026
👍 Bring your own data (or use a public one) and learn the full RNA-seq pipeline:
December 3, 2025 at 8:34 AM
🔔 Excited to teach the PhD course “Bioinformatics Analysis of Gene Expression Data from Bulk RNA-seq” at University of Copenhagen!
📅 26 Jan – 12 Feb 2026
👍 Bring your own data (or use a public one) and learn the full RNA-seq pipeline:
📅 26 Jan – 12 Feb 2026
👍 Bring your own data (or use a public one) and learn the full RNA-seq pipeline:
Reposted by NNF Center for Basic Metabolic Research
"#Throwback 🧪
COMMENT | Shaping the future of cardiometabolic innovation: advances and opportunities
@clemmensenc.bsky.social et al
https://bit.ly/4iIBBvY
COMMENT | Shaping the future of cardiometabolic innovation: advances and opportunities
@clemmensenc.bsky.social et al
https://bit.ly/4iIBBvY
Shaping the future of cardiometabolic innovation: advances and opportunities - Nature Metabolism
Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.
bit.ly
December 6, 2025 at 3:26 PM
"#Throwback 🧪
COMMENT | Shaping the future of cardiometabolic innovation: advances and opportunities
@clemmensenc.bsky.social et al
https://bit.ly/4iIBBvY
COMMENT | Shaping the future of cardiometabolic innovation: advances and opportunities
@clemmensenc.bsky.social et al
https://bit.ly/4iIBBvY
"I think we made a lot of our discoveries because of our tenacity and detective work. We were staying on it and not giving up."
Learn more about CBMR Group Leader Professor Jens Juul Holst and his important role in discovering GLP-1:
cbmr.ku.dk/news/2025/we...
Learn more about CBMR Group Leader Professor Jens Juul Holst and his important role in discovering GLP-1:
cbmr.ku.dk/news/2025/we...
"We were walking in the streets, chanting 'research for the people, not for profit'"
From emergency surgeon to discoverer of GLP-1 and its effects on insulin production and satiety, CBMR Group Leader Professor Jens Juul Holst has spent fifty years pursuing one question: how does metab...
cbmr.ku.dk
November 27, 2025 at 9:11 AM
"I think we made a lot of our discoveries because of our tenacity and detective work. We were staying on it and not giving up."
Learn more about CBMR Group Leader Professor Jens Juul Holst and his important role in discovering GLP-1:
cbmr.ku.dk/news/2025/we...
Learn more about CBMR Group Leader Professor Jens Juul Holst and his important role in discovering GLP-1:
cbmr.ku.dk/news/2025/we...
#Inuit genetic adaptations, evolved over 1000s of years as they adapted to a cold climate and consumed a diet largely consisting of marine mammals, influence circulating protein levels in the blood and may modify their risk of diabetes and cardiovascular disease today.
cbmr.ku.dk/news/2025/an...
cbmr.ku.dk/news/2025/an...
Ancient arctic adaptations may influence modern disease risk
Inuit in Greenland possess a unique genome, which has evolved over thousands of years as they adapted to a cold climate and consumed a diet largely consisting of marine mammals. Now, a team of interna...
cbmr.ku.dk
November 21, 2025 at 9:37 AM
#Inuit genetic adaptations, evolved over 1000s of years as they adapted to a cold climate and consumed a diet largely consisting of marine mammals, influence circulating protein levels in the blood and may modify their risk of diabetes and cardiovascular disease today.
cbmr.ku.dk/news/2025/an...
cbmr.ku.dk/news/2025/an...
Reposted by NNF Center for Basic Metabolic Research
🌍 Excited to be part of this global effort! 🦠
Microbial and metabolic diversity was mapped across 51 vivaria & 12 wild colonies, revealing striking functional convergence despite taxonomic divergence.
🔗 www.cell.com/cell-host-mi...
Microbial and metabolic diversity was mapped across 51 vivaria & 12 wild colonies, revealing striking functional convergence despite taxonomic divergence.
🔗 www.cell.com/cell-host-mi...
November 10, 2025 at 1:39 PM
🌍 Excited to be part of this global effort! 🦠
Microbial and metabolic diversity was mapped across 51 vivaria & 12 wild colonies, revealing striking functional convergence despite taxonomic divergence.
🔗 www.cell.com/cell-host-mi...
Microbial and metabolic diversity was mapped across 51 vivaria & 12 wild colonies, revealing striking functional convergence despite taxonomic divergence.
🔗 www.cell.com/cell-host-mi...
"For decades, we’ve been told that weight loss is a matter of willpower: eat less, move more. But modern science has proven this isn’t actually the case."
@clemmensenc.bsky.social and @johansenvbi.bsky.social in @theconversation.com 👇
theconversation.com/the-science-...
#obesity #metabolism
@clemmensenc.bsky.social and @johansenvbi.bsky.social in @theconversation.com 👇
theconversation.com/the-science-...
#obesity #metabolism
The science of weight loss – and why your brain is wired to keep you fat
The evolutionary science of weight regain unpacked.
theconversation.com
November 10, 2025 at 9:03 AM
"For decades, we’ve been told that weight loss is a matter of willpower: eat less, move more. But modern science has proven this isn’t actually the case."
@clemmensenc.bsky.social and @johansenvbi.bsky.social in @theconversation.com 👇
theconversation.com/the-science-...
#obesity #metabolism
@clemmensenc.bsky.social and @johansenvbi.bsky.social in @theconversation.com 👇
theconversation.com/the-science-...
#obesity #metabolism
Reposted by NNF Center for Basic Metabolic Research
A framework from @easoobesity.bsky.social to guide pharmacological treatment of 'fat mass diseases' versus 'sick fat diseases' 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Framework for the pharmacological treatment of obesity and its complications from the European Association for the Study of Obesity (EASO) - Nature Medicine
Obesity and associated complications can be managed by obesity medications, prompting the revision of criteria for the diagnosis and staging of this disease.
www.nature.com
October 7, 2025 at 6:43 AM
A framework from @easoobesity.bsky.social to guide pharmacological treatment of 'fat mass diseases' versus 'sick fat diseases' 👇
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by NNF Center for Basic Metabolic Research
Stoked to receive this award that will help to dissect the relative contribution of aberrant glycogen levels and impaired glycogenesis in influencing skeletal muscle glucose metabolism.
🎉👏 We’re thrilled to congratulate the 2025 #EFSD / Lilly Diabetes International Young Investigators Award recipients.
Award recognises early career scientists/clinicians driving innovation in diabetes research.
Learn more about their projects 👉 www.europeandiabetesfoundation.org/recipients/e...
Award recognises early career scientists/clinicians driving innovation in diabetes research.
Learn more about their projects 👉 www.europeandiabetesfoundation.org/recipients/e...
October 17, 2025 at 10:49 AM
Stoked to receive this award that will help to dissect the relative contribution of aberrant glycogen levels and impaired glycogenesis in influencing skeletal muscle glucose metabolism.
Reposted by NNF Center for Basic Metabolic Research
🚨 Dealing with sparse, noisy single-cell DNA methylation data (scBS-seq)? Check out #scDMV.
It uses a zero-one inflated beta mixture model to tackle the excess of 0s/1s and low coverage, boosting accuracy in identifying differentially methylated regions (DMRs).
It uses a zero-one inflated beta mixture model to tackle the excess of 0s/1s and low coverage, boosting accuracy in identifying differentially methylated regions (DMRs).
scDMV: a zero–one inflated beta mixture model for DNA methylation variability with scBS-seq data
AbstractMotivation. The utilization of single-cell bisulfite sequencing (scBS-seq) methods allows for precise analysis of DNA methylation patterns at the i
academic.oup.com
October 20, 2025 at 11:35 AM
🚨 Dealing with sparse, noisy single-cell DNA methylation data (scBS-seq)? Check out #scDMV.
It uses a zero-one inflated beta mixture model to tackle the excess of 0s/1s and low coverage, boosting accuracy in identifying differentially methylated regions (DMRs).
It uses a zero-one inflated beta mixture model to tackle the excess of 0s/1s and low coverage, boosting accuracy in identifying differentially methylated regions (DMRs).
CBMR's Zach Gerhart-Hines is awarded the first Flemming Quaade Prize for Outstanding Obesity Research for his pioneering discoveries on how fat tissue influences insulin sensitivity, energy expenditure, and appetite control.
Read more: cbmr.ku.dk/news/2025/za...
#obesity #metabolism
Read more: cbmr.ku.dk/news/2025/za...
#obesity #metabolism
October 22, 2025 at 10:14 AM
CBMR's Zach Gerhart-Hines is awarded the first Flemming Quaade Prize for Outstanding Obesity Research for his pioneering discoveries on how fat tissue influences insulin sensitivity, energy expenditure, and appetite control.
Read more: cbmr.ku.dk/news/2025/za...
#obesity #metabolism
Read more: cbmr.ku.dk/news/2025/za...
#obesity #metabolism
Reposted by NNF Center for Basic Metabolic Research
Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Common and distinct roles of AMPKγ isoforms in small-molecule activator-stimulated glucose uptake in mouse skeletal muscle
Objective: Small-molecule activators targeting the allosteric drug and metabolite (ADaM) site of AMPK enhance insulin-independent glucose uptake in skeletal muscle and lower glucose in preclinical mod...
www.biorxiv.org
September 30, 2025 at 10:42 AM
Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by NNF Center for Basic Metabolic Research
Great visit to Novo Nordisk Foundation Center for Genomic Mechanisms of Disease in Boston at Broad Institute. Delighted to see great collaborations with Novo Nordisk Foundation Center for Basic Metabolic Research @cbmr.science @novo-nordisk.bsky.social
September 29, 2025 at 9:45 AM
Great visit to Novo Nordisk Foundation Center for Genomic Mechanisms of Disease in Boston at Broad Institute. Delighted to see great collaborations with Novo Nordisk Foundation Center for Basic Metabolic Research @cbmr.science @novo-nordisk.bsky.social
Reposted by NNF Center for Basic Metabolic Research
Remember to sign up for the Gut-Brain Axis @keystonesymposia.bsky.social meeting in March 2026!
Upcoming deadlines:
Scholarship Deadline: November 18, 2025
Short Talk Abstract Deadline: November 18, 2025
Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers
keysym.us/KSGutBrain26
Upcoming deadlines:
Scholarship Deadline: November 18, 2025
Short Talk Abstract Deadline: November 18, 2025
Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers
keysym.us/KSGutBrain26
September 24, 2025 at 8:51 AM
Remember to sign up for the Gut-Brain Axis @keystonesymposia.bsky.social meeting in March 2026!
Upcoming deadlines:
Scholarship Deadline: November 18, 2025
Short Talk Abstract Deadline: November 18, 2025
Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers
keysym.us/KSGutBrain26
Upcoming deadlines:
Scholarship Deadline: November 18, 2025
Short Talk Abstract Deadline: November 18, 2025
Organizers: Martin G. Myers, Jr., Darleen A. Sandoval and Tune H Pers
keysym.us/KSGutBrain26
Could the season you were conceived determine your lifelong health?
@camillascheele.bsky.social & Taylah Gaynor ask why cold temperatures during the pre-conception period are associated with higher BAT density and activity and point to a possible epigenetic reprogramming of the father's sperm.
1/2
@camillascheele.bsky.social & Taylah Gaynor ask why cold temperatures during the pre-conception period are associated with higher BAT density and activity and point to a possible epigenetic reprogramming of the father's sperm.
1/2
September 29, 2025 at 8:56 AM
Could the season you were conceived determine your lifelong health?
@camillascheele.bsky.social & Taylah Gaynor ask why cold temperatures during the pre-conception period are associated with higher BAT density and activity and point to a possible epigenetic reprogramming of the father's sperm.
1/2
@camillascheele.bsky.social & Taylah Gaynor ask why cold temperatures during the pre-conception period are associated with higher BAT density and activity and point to a possible epigenetic reprogramming of the father's sperm.
1/2
Reposted by NNF Center for Basic Metabolic Research
💡Meet Assoc. Prof. @adeshmukh.bsky.social ( @cbmr.science), #EFSD/ @novo-nordisk.bsky.social Future Leaders Awardee. His work uncovers exercise-induced peptides & #proteins that improve insulin sensitivity in #T2D.
📅 See him at #EASD2025 (18 Sept, 12:45 CEST, Milan Hall).
📖 doi.org/10.1016/j.ce...
📅 See him at #EASD2025 (18 Sept, 12:45 CEST, Milan Hall).
📖 doi.org/10.1016/j.ce...
September 2, 2025 at 1:07 PM
💡Meet Assoc. Prof. @adeshmukh.bsky.social ( @cbmr.science), #EFSD/ @novo-nordisk.bsky.social Future Leaders Awardee. His work uncovers exercise-induced peptides & #proteins that improve insulin sensitivity in #T2D.
📅 See him at #EASD2025 (18 Sept, 12:45 CEST, Milan Hall).
📖 doi.org/10.1016/j.ce...
📅 See him at #EASD2025 (18 Sept, 12:45 CEST, Milan Hall).
📖 doi.org/10.1016/j.ce...
Reposted by NNF Center for Basic Metabolic Research
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827
The mechanism and unique molecular/cellular features of the potent and selective AMPK inhibitor BAY-3827 are unraveled.
www.science.org
September 9, 2025 at 3:17 PM
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
www.science.org/doi/full/10....
Reposted by NNF Center for Basic Metabolic Research
Are you using metabolic tolerance tests in your research? 💉Are you interested in metabolites? Or do you study the effects of exercise? 🏃🏻♂️➡️ 1/4
September 17, 2025 at 1:07 PM
Are you using metabolic tolerance tests in your research? 💉Are you interested in metabolites? Or do you study the effects of exercise? 🏃🏻♂️➡️ 1/4
Reposted by NNF Center for Basic Metabolic Research
Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 7, 2025 at 3:02 PM
Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by NNF Center for Basic Metabolic Research
@jphysiol.bsky.social, and several other journals, has a 'Journal Club' format targeted to early-career researchers. It is a great opportunity for young scientists to get started with scientific writing and cultivating independent thinking. Check it out! 1/3
Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️
physoc.onlinelibrary.wiley.com/doi/10.1113/...
August 8, 2025 at 12:15 PM
@jphysiol.bsky.social, and several other journals, has a 'Journal Club' format targeted to early-career researchers. It is a great opportunity for young scientists to get started with scientific writing and cultivating independent thinking. Check it out! 1/3
Reposted by NNF Center for Basic Metabolic Research
A must read!
@cellpress.bsky.social Review 🚨 ‘Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy’
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
August 8, 2025 at 6:31 AM
A must read!
@cellpress.bsky.social Review 🚨 ‘Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy’
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
August 7, 2025 at 3:19 PM
@cellpress.bsky.social Review 🚨 ‘Brain control of energy homeostasis: Implications for anti-obesity pharmacotherapy’
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
Lead author: @johansenvbi.bsky.social
Senior author: @clemmensenc.bsky.social
Read it here: www.cell.com/cell/fulltex...
Reposted by NNF Center for Basic Metabolic Research
Looking for a Postdoc position? (great program with 3-year funding and running costs)
@clemmensenc.bsky.social has a fantastic project in wonderful Copenhagen at the fantastic @cbmr.science research center
Being a program alumni I can can highly recommend the program and the Clemmensen lab :)
@clemmensenc.bsky.social has a fantastic project in wonderful Copenhagen at the fantastic @cbmr.science research center
Being a program alumni I can can highly recommend the program and the Clemmensen lab :)
Kickstart your research career in Copenhagen with a PhD or Postdoctoral fellowship at CBMR!
Four PhD and four Postdoc positions are currently available:
cbmr.ku.dk/join-us/fell...
#phdposition #postdocposition
Four PhD and four Postdoc positions are currently available:
cbmr.ku.dk/join-us/fell...
#phdposition #postdocposition
August 1, 2025 at 8:18 AM
Looking for a Postdoc position? (great program with 3-year funding and running costs)
@clemmensenc.bsky.social has a fantastic project in wonderful Copenhagen at the fantastic @cbmr.science research center
Being a program alumni I can can highly recommend the program and the Clemmensen lab :)
@clemmensenc.bsky.social has a fantastic project in wonderful Copenhagen at the fantastic @cbmr.science research center
Being a program alumni I can can highly recommend the program and the Clemmensen lab :)