@brumbaugh-lab.bsky.social
The @isscr.org and @stemcellnetwork.ca have launched an important initiative to understand the needs of both employers and the future workforce. Check out the information below and consider applying to join the working group or nominate someone that you feel could provide good perspective!
The ISSCR and Stem Cell Network are seeking nominations to form a working group of early career scientists and senior trainees in stem cell and regenerative medicine research who will provide perspectives on global workforce development. Nominations are due 5 December 👉https://ow.ly/cwau50XnYnF
November 15, 2025 at 4:22 AM
The @isscr.org and @stemcellnetwork.ca have launched an important initiative to understand the needs of both employers and the future workforce. Check out the information below and consider applying to join the working group or nominate someone that you feel could provide good perspective!
Reposted
There are many ways to make your voice heard and participate in all that the #ISSCR2026 Annual Meeting has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1lxby1coomp @isscr.org
November 4, 2025 at 1:41 AM
There are many ways to make your voice heard and participate in all that the #ISSCR2026 Annual Meeting has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1lxby1coomp @isscr.org
Fun project with @distefanolab.bsky.social looking at RNA regulation in cell fate decisions. Check out the great summary below and see the full work in @natbiotech.nature.com: www.nature.com/articles/s41...
October 29, 2025 at 2:45 AM
Fun project with @distefanolab.bsky.social looking at RNA regulation in cell fate decisions. Check out the great summary below and see the full work in @natbiotech.nature.com: www.nature.com/articles/s41...
Reposted
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
go.nature.com
October 28, 2025 at 6:50 PM
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Check out this new preprint with @distefanolab.bsky.social lab! The manuscript focuses on RNA processing in the form of sequestration into P-bodies in the context of development.
New preprint from the lab! With @brumbaugh-lab.bsky.social , we show that P-bodies sequester developmentally relevant RNAs to influence cell fate. miRNAs direct this conserved regulatory process, and manipulating it enhances totipotency and germ cell programming. www.biorxiv.org/content/10.1...
Selective RNA sequestration in biomolecular condensates directs cell fate transitions
Recent studies have emphasized the significance of biomolecular condensates in modulating gene expression through RNA processing and translational control. However, the functional roles of RNA condens...
www.biorxiv.org
May 13, 2025 at 3:12 AM
Check out this new preprint with @distefanolab.bsky.social lab! The manuscript focuses on RNA processing in the form of sequestration into P-bodies in the context of development.
Thanks to @isscr.org for this wonderful recognition! And thanks to my colleagues and ISSCR for thoughtfully and carefully working on important policy and regulatory matters. Read more about the award and my fellow honorees. invt.io/1bxbk540w9k @isscr.org
I am a 2025 ISSCR Public Service Award Honoree.
Learn more
invt.io
March 27, 2025 at 1:00 AM
Thanks to @isscr.org for this wonderful recognition! And thanks to my colleagues and ISSCR for thoughtfully and carefully working on important policy and regulatory matters. Read more about the award and my fellow honorees. invt.io/1bxbk540w9k @isscr.org
Thanks to @cp-cellchembiol.bsky.social, @iamzico.bsky.social and Ramesh Shivdasani for this thoughtful discussion of our work!
🔦Spotlight of Peter Dempsey, @brumbaugh-lab.bsky.social et al paper: Epigenetic fluidity meets phenotypic malleability in intestinal epithelial cells by @iamzico.bsky.social and Ramesh Shivdasani at @danafarber.bsky.social http://dlvr.it/TJfVRZ
March 27, 2025 at 12:54 AM
Thanks to @cp-cellchembiol.bsky.social, @iamzico.bsky.social and Ramesh Shivdasani for this thoughtful discussion of our work!
Reposted
Our work on the regulation is out www.cell.com/stem-cell-re...! Congrats to our collaborators in the Vierbuchen and Mezey labs. It turns out that genetic variation has to be very much considered if you want to harness stem cells safely in biomedicine. #pluripotency #epigenetics #stemcells
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naive pluripotent stem cells
Pluripotent stem cells are susceptible to acquiring detrimental epigenetic abnormalities,
posing a hurdle to their safe use in biomedical applications. Using pluripotent cells
with defined genetic bac...
www.cell.com
March 13, 2025 at 8:41 PM
Our work on the regulation is out www.cell.com/stem-cell-re...! Congrats to our collaborators in the Vierbuchen and Mezey labs. It turns out that genetic variation has to be very much considered if you want to harness stem cells safely in biomedicine. #pluripotency #epigenetics #stemcells
Reposted
💫NEW: @brumbaugh-lab.bsky.social, Dempsey & co show that #H3K36 methylation maintains #intestinal epithelial fate commitment, whereas its suppression induces a plastic state and expression of genes involved in #regeneration.
👉🏿https://rdcu.be/eayN3
www.nature.com/articles/s41...
👉🏿https://rdcu.be/eayN3
www.nature.com/articles/s41...
H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium - Nature Cell Biology
Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state and expression of genes ...
www.nature.com
February 19, 2025 at 9:35 PM
💫NEW: @brumbaugh-lab.bsky.social, Dempsey & co show that #H3K36 methylation maintains #intestinal epithelial fate commitment, whereas its suppression induces a plastic state and expression of genes involved in #regeneration.
👉🏿https://rdcu.be/eayN3
www.nature.com/articles/s41...
👉🏿https://rdcu.be/eayN3
www.nature.com/articles/s41...
Reposted
🥂Congrats to @brumbaugh-lab.bsky.social & co for their new study in @naturecellbiology.bsky.social showing that H3K36 methylation maintains #intestinal epithelial fate commitment and is involved in #regeneration.
rdcu.be/d8awu
www.nature.com/articles/s41...
rdcu.be/d8awu
www.nature.com/articles/s41...
H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium
Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...
rdcu.be
January 31, 2025 at 1:49 PM
🥂Congrats to @brumbaugh-lab.bsky.social & co for their new study in @naturecellbiology.bsky.social showing that H3K36 methylation maintains #intestinal epithelial fate commitment and is involved in #regeneration.
rdcu.be/d8awu
www.nature.com/articles/s41...
rdcu.be/d8awu
www.nature.com/articles/s41...
Reposted
1/ Pleased to share our review, published today
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
Biomolecular condensates in immune cell fate - Nature Reviews Immunology
Recent studies suggest that biomolecular condensates — membrane-less assemblies of proteins and nucleic acids — are involved in regulating gene expression to ensure proper immune cell development. Thi...
www.nature.com
January 28, 2025 at 4:40 PM
1/ Pleased to share our review, published today
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
@natrevimmunol.bsky.social, highlighting how biomolecular condensates enhance the precision and flexibility of gene regulatory networks that guide fate decisions during normal and pathological immune cell development. www.nature.com/articles/s41...
Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium
Nature Cell Biology - Pashos et al. show that H3K36 methylation maintains intestinal epithelial fate commitment, whereas its suppression, which is also observed upon injury, induces a plastic state...
rdcu.be
January 10, 2025 at 5:22 AM
Our new paper defining the role of H3K36 methylation in regulating cell fate and plasticity is available online: rdcu.be/d5AEc
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!
Thanks to our entire team for their tireless work and to the editors at @naturecellbiology.bsky.social for the opportunity!