OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇

Droplet outbursts from onion cutting | PNAS www.pnas.org/doi/10.1073/...

Translation landscape of stress granules pubmed.ncbi.nlm.nih.gov/41042876/ #cryoem

Structural basis for mTORC1 activation on the lysosomal membrane pubmed.ncbi.nlm.nih.gov/40963021/ #cryoem

Excited to share our new preprint co-led by @jnoms.bsky.social!

Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.

“A transposon-like strategy for proteins” - A News & Views by Barbara Di Ventura highlights recent work @science.org on using transposition, normally considered a DNA-based process, for protein semisynthesis and site-specific modification

www.nature.com/articles/s41...

After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it.
🔗 www.pnas.org/doi/10.1073/...

Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀

Nuclear Phase Separation Drives NPM1-mutant Acute Myeloid Leukemia https://www.biorxiv.org/content/10.1101/2025.05.23.655671v1

Unicore identifies single-copy protein structures across genomes using Foldseek, bypassing slow structure predictions by utilizing 3Di predictions from ProstT5, enabling rapid phylogenetic inference at the tree-of-life scale. 1/n
📄 www.biorxiv.org/content/10.1...
💾 github.com/steineggerla...

AI Trick #1 for coming up new ideas: Think alone first!
AI is persuasive – and able to spit out a lot of content quickly – so going to it first can severely constrain your ability to think differently. @emollick.bsky.social also talked about this on the @nightsciencepod.bsky.social.

We are very happy that XiaoYan's (Andy!) paper is out, congratulations to all authors
@cellpress.bsky.social
@xiaoyan52802927.bsky.social
www.cell.com/cell/fulltex...
Demixing of TDP-43 inside stress granules generates pathological aggregates linked to ALS/FTD
@mpi-cbg.de @biotec-tud.bsky.social

Now published! Big congrats to first author @gginell.bsky.social

We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...

If u ever had to depict proteins as schematics in papers, u know the dilemma: how to create a pretty “blob”?
If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein.
Think I’ve finally found a way.

Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...

The recording of the talks is now available at youtube.com/playlist?lis...