Bianca Introini
@bianca-introini.bsky.social
Structural Biologist | Ion channels and membrane proteins enthusiast | Curious to see what’s inside cells nuclei | Cryo-EM and Cryo-ET | Post doc at Max Planck Institute of Biophysics in @becklab.bsky.social
Great work by @tzujingyang.bsky.social and @melaniemcdowell.bsky.social!!
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
July 14, 2025 at 1:00 PM
Great work by @tzujingyang.bsky.social and @melaniemcdowell.bsky.social!!
Reposted by Bianca Introini
Happy 99th birthday to the man who gave voice to the wild. 🎉
Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace.
You've inspired generations to fall in love with nature.
Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace.
You've inspired generations to fall in love with nature.
May 8, 2025 at 7:09 AM
Happy 99th birthday to the man who gave voice to the wild. 🎉
Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace.
You've inspired generations to fall in love with nature.
Sir David Attenborough, thank you for a lifetime dedicated to the natural world, and for sharing its story with wisdom, wonder, and grace.
You've inspired generations to fall in love with nature.
Reposted by Bianca Introini
Super excited to share this as my first post with the 🦋 world! In my first co-correspondent article, we (@Mayra Borrero @Agnieszka Chacińska @IMOL Institute) look at the roles of lipids in mitochondrial protein import complexes (spoiler: there are plenty!) &call for methods (spoiler: there are few!)
Available online - the Forum "#Lipids: emerging actors in mitochondrial protein import" from Vanessa Linke, Agnieszka Chacinska, et al.
#ProteinLipidInteractions #MembraneComplexes #LipidScrambling
Read it here: authors.elsevier.com/a/1kxPM_M0e4...
#ProteinLipidInteractions #MembraneComplexes #LipidScrambling
Read it here: authors.elsevier.com/a/1kxPM_M0e4...
April 18, 2025 at 6:21 PM
Super excited to share this as my first post with the 🦋 world! In my first co-correspondent article, we (@Mayra Borrero @Agnieszka Chacińska @IMOL Institute) look at the roles of lipids in mitochondrial protein import complexes (spoiler: there are plenty!) &call for methods (spoiler: there are few!)
Reposted by Bianca Introini
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
April 11, 2025 at 9:04 AM
New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
Reposted by Bianca Introini
After the start of the AIDS epidemic, scientists revealed the atomic structures of the molecules in HIV, helping to design treatments
Explore how PDB structures help our understanding of HIV at PDB-101 #CROI2025 pdb101.rcsb.org/brow...
Images are free for use
Explore how PDB structures help our understanding of HIV at PDB-101 #CROI2025 pdb101.rcsb.org/brow...
Images are free for use
PDB101: Browse: HIV and AIDS
PDB-101: Training, Outreach, and Education portal of RCSB PDB
pdb101.rcsb.org
March 10, 2025 at 7:10 PM
After the start of the AIDS epidemic, scientists revealed the atomic structures of the molecules in HIV, helping to design treatments
Explore how PDB structures help our understanding of HIV at PDB-101 #CROI2025 pdb101.rcsb.org/brow...
Images are free for use
Explore how PDB structures help our understanding of HIV at PDB-101 #CROI2025 pdb101.rcsb.org/brow...
Images are free for use
Reposted by Bianca Introini
Zhi Yang Tan & @shujuncai.bsky.social's comparative study of G0 (quiescent) and interphase fission yeast cells is out in @jcellsci.bsky.social doi.org/10.1242/jcs.263654. This study combines multiple cell-biological analyses with in situ cryo-ET. Raw data: www.ebi.ac.uk/empiar/EMPIAR-10339
March 4, 2025 at 5:30 PM
Zhi Yang Tan & @shujuncai.bsky.social's comparative study of G0 (quiescent) and interphase fission yeast cells is out in @jcellsci.bsky.social doi.org/10.1242/jcs.263654. This study combines multiple cell-biological analyses with in situ cryo-ET. Raw data: www.ebi.ac.uk/empiar/EMPIAR-10339
Reposted by Bianca Introini
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
February 12, 2025 at 10:05 PM
Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️
Reposted by Bianca Introini
It turns out this works well for improving segmentation, and Cellpose3 offers a general solution for many segmentation tasks. Please see the full paper for all the details. www.nature.com/articles/s41...
Cellpose3: one-click image restoration for improved cellular segmentation - Nature Methods
Cellpose3 employs deep-learning-based approaches for image restoration to improve cellular segmentation and shows strong generalized performance even on images degraded by noise, blurring or undersamp...
www.nature.com
February 12, 2025 at 2:39 PM
It turns out this works well for improving segmentation, and Cellpose3 offers a general solution for many segmentation tasks. Please see the full paper for all the details. www.nature.com/articles/s41...
Reposted by Bianca Introini
After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 12, 2025 at 11:41 AM
After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Bianca Introini
Hot from the press for #CellMigration + #Nucleus aficionados
Karling @helenweavers.bsky.social lab show *in vivo* how immune cell adapt quickly to confined microenvironments during motility.
Live-cell imaging, image analysis, #Drosophila !
Full @emboreports.org
www.embopress.org/doi/full/10....
Karling @helenweavers.bsky.social lab show *in vivo* how immune cell adapt quickly to confined microenvironments during motility.
Live-cell imaging, image analysis, #Drosophila !
Full @emboreports.org
www.embopress.org/doi/full/10....
February 10, 2025 at 5:50 AM
Hot from the press for #CellMigration + #Nucleus aficionados
Karling @helenweavers.bsky.social lab show *in vivo* how immune cell adapt quickly to confined microenvironments during motility.
Live-cell imaging, image analysis, #Drosophila !
Full @emboreports.org
www.embopress.org/doi/full/10....
Karling @helenweavers.bsky.social lab show *in vivo* how immune cell adapt quickly to confined microenvironments during motility.
Live-cell imaging, image analysis, #Drosophila !
Full @emboreports.org
www.embopress.org/doi/full/10....
These days at EMBL in Heidelberg for the EMBO Workshop “In situ structural biology: expanding the toolbox for structural cell biology” were amazing!
I showed my work on the tetrameric serotonin receptor:
www.embopress.org/doi/full/10....
#EMBOinsitu
I showed my work on the tetrameric serotonin receptor:
www.embopress.org/doi/full/10....
#EMBOinsitu
February 7, 2025 at 9:35 AM
These days at EMBL in Heidelberg for the EMBO Workshop “In situ structural biology: expanding the toolbox for structural cell biology” were amazing!
I showed my work on the tetrameric serotonin receptor:
www.embopress.org/doi/full/10....
#EMBOinsitu
I showed my work on the tetrameric serotonin receptor:
www.embopress.org/doi/full/10....
#EMBOinsitu
Reposted by Bianca Introini
#CellMigration happens all the time in our bodies. This may (or not) rely on adhesion molecules
#Cancer cells switch strategies during metastasis to invade other tissues
Naomi Wee (naomiwee.com) did this neat movie to explain it:
www.youtube.com/watch?v=D9aD...
#SciSky 🧪🔬 @cellcommlab.bsky.social
#Cancer cells switch strategies during metastasis to invade other tissues
Naomi Wee (naomiwee.com) did this neat movie to explain it:
www.youtube.com/watch?v=D9aD...
#SciSky 🧪🔬 @cellcommlab.bsky.social
February 6, 2025 at 10:44 AM
#CellMigration happens all the time in our bodies. This may (or not) rely on adhesion molecules
#Cancer cells switch strategies during metastasis to invade other tissues
Naomi Wee (naomiwee.com) did this neat movie to explain it:
www.youtube.com/watch?v=D9aD...
#SciSky 🧪🔬 @cellcommlab.bsky.social
#Cancer cells switch strategies during metastasis to invade other tissues
Naomi Wee (naomiwee.com) did this neat movie to explain it:
www.youtube.com/watch?v=D9aD...
#SciSky 🧪🔬 @cellcommlab.bsky.social
I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...
Cryo-EM structure of the NDH–PSI–LHCI supercomplex from Spinacia oleracea - Nature Structural & Molecular Biology
Here, the authors report the structure of the nicotinamide adenine dinucleotide phosphate dehydrogenase–photosystem I–light-harvesting complex I supercomplex, providing insights into subunit interacti...
www.nature.com
January 27, 2025 at 12:18 PM
I am very happy to share our latest work on the detailed cryo-EM structure of the NDH-PSI supercomplex of spinach. Thanks to Werner Kühlbrandt, Alex Hahn and @mpibp.bsky.social ! 🍃❄️🔬
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...
You can find the paper in open access in Nature Structural and Molecular Biology:
www.nature.com/articles/s41...