BaglaenkoLab
@baglaenkolab.bsky.social
The Baglaenko Lab of Immunogenetics in the Division of Human Genetics at Cincinnati Children's Hospital is focused on developing new experimental and computational approaches to answer the most difficult questions in inflammatory and infectious diseases.
Reposted by BaglaenkoLab
Two #CRISPR talks on Feb3!
1️⃣ Stephan Riesenberg (Group Leader, Max Planck Leipzig): CRISPR-mediated generation of genetic variants for functional analysis.
2️⃣ Yuriy Baglaenko @baglaenkolab.bsky.social: Causal variants with CRISPR editing in primary human cells www.varianteffect.org/seminar-seri...
1️⃣ Stephan Riesenberg (Group Leader, Max Planck Leipzig): CRISPR-mediated generation of genetic variants for functional analysis.
2️⃣ Yuriy Baglaenko @baglaenkolab.bsky.social: Causal variants with CRISPR editing in primary human cells www.varianteffect.org/seminar-seri...
January 28, 2026 at 5:50 PM
Two #CRISPR talks on Feb3!
1️⃣ Stephan Riesenberg (Group Leader, Max Planck Leipzig): CRISPR-mediated generation of genetic variants for functional analysis.
2️⃣ Yuriy Baglaenko @baglaenkolab.bsky.social: Causal variants with CRISPR editing in primary human cells www.varianteffect.org/seminar-seri...
1️⃣ Stephan Riesenberg (Group Leader, Max Planck Leipzig): CRISPR-mediated generation of genetic variants for functional analysis.
2️⃣ Yuriy Baglaenko @baglaenkolab.bsky.social: Causal variants with CRISPR editing in primary human cells www.varianteffect.org/seminar-seri...
Reposted by BaglaenkoLab
Coming up! with Yuriy Baglaenko @baglaenkolab.bsky.social and Stephan Riesenberg @mpi-eva-leipzig.bsky.social
Details ℹ️ ➡️ www.varianteffect.org/seminar-seri...
Details ℹ️ ➡️ www.varianteffect.org/seminar-seri...
January 20, 2026 at 6:05 PM
Coming up! with Yuriy Baglaenko @baglaenkolab.bsky.social and Stephan Riesenberg @mpi-eva-leipzig.bsky.social
Details ℹ️ ➡️ www.varianteffect.org/seminar-seri...
Details ℹ️ ➡️ www.varianteffect.org/seminar-seri...
We recently pushed an updated to our protospacer Base editing design tool (baglaenkolab.shinyapps.io/snpGuide/) to allow for genome modification near a variant regardless or transition. If the region is important, so are the nucleotides around it. Hope this helps somebody out.
snpGuide v0.4
baglaenkolab.shinyapps.io
January 12, 2026 at 9:38 PM
We recently pushed an updated to our protospacer Base editing design tool (baglaenkolab.shinyapps.io/snpGuide/) to allow for genome modification near a variant regardless or transition. If the region is important, so are the nucleotides around it. Hope this helps somebody out.
Reposted by BaglaenkoLab
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - @uclpophealthsci.bsky.social go.nature.com/4a39S6X
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - Nature Biotechnology
Virus-like particles are engineered to edit human hematopoietic cells in vivo.
go.nature.com
December 8, 2025 at 6:53 PM
In vivo gene editing of human hematopoietic stem and progenitor cells using envelope-engineered virus-like particles - @uclpophealthsci.bsky.social go.nature.com/4a39S6X
Reposted by BaglaenkoLab
Nature research paper: Precisely defining disease variant effects in CRISPR-edited single cells
go.nature.com/44M3ygX
go.nature.com/44M3ygX
Precisely defining disease variant effects in CRISPR-edited single cells - Nature
A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of CRISPR edits to test the functional effects of genetic variants on cell state and function.
go.nature.com
July 29, 2025 at 6:38 PM
Nature research paper: Precisely defining disease variant effects in CRISPR-edited single cells
go.nature.com/44M3ygX
go.nature.com/44M3ygX
I am very excited to share our publication, out now in Nature, detailing our developed CRAFTseq methodology for capturing and analysing single cell genomic DNA amplicons alongside the transcriptome and cell surface protein expression.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Precisely defining disease variant effects in CRISPR-edited single cells - Nature
A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of CRISPR edits to test the functional effects of genetic variants o...
www.nature.com
July 23, 2025 at 3:21 PM
I am very excited to share our publication, out now in Nature, detailing our developed CRAFTseq methodology for capturing and analysing single cell genomic DNA amplicons alongside the transcriptome and cell surface protein expression.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
My lab thinks a lot about CRISPR editing variants of interest in primary human cells. We made a little tool to help. Hopefully, someone else can get some use out of it. baglaenkolab.shinyapps.io/snpGuide/
github.com/ybaglaenko/s...
github.com/ybaglaenko/s...
shiny.io
June 2, 2025 at 8:19 PM
My lab thinks a lot about CRISPR editing variants of interest in primary human cells. We made a little tool to help. Hopefully, someone else can get some use out of it. baglaenkolab.shinyapps.io/snpGuide/
github.com/ybaglaenko/s...
github.com/ybaglaenko/s...