a. villars
@avillars.bsky.social
Currently Postdoc in Dagmar Iber lab 🐁, formerly working on cell extrusion as a phD student in Romain Levayer lab 🪰
Interested cell decision making and mechanics during development
Interested cell decision making and mechanics during development
Reposted by a. villars
Many cells during development are exposed to caspase activation and yet survive. Why some die and not others ? We found out that the memory of previous caspase activation bias significantly later death comitment and bias death distribution and single cell decision
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
May 21, 2025 at 9:40 AM
Many cells during development are exposed to caspase activation and yet survive. Why some die and not others ? We found out that the memory of previous caspase activation bias significantly later death comitment and bias death distribution and single cell decision
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by a. villars
The effector caspases drive cell death, but their activation can often be survived, so how do cells make this decision? Our new preprint from @levayerr.bsky.social shows that instantaneous caspase activity is important, but past activation has a key role to play!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
May 21, 2025 at 8:52 AM
The effector caspases drive cell death, but their activation can often be survived, so how do cells make this decision? Our new preprint from @levayerr.bsky.social shows that instantaneous caspase activity is important, but past activation has a key role to play!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by a. villars
How does an #embryo build an energy-efficient #fractal #lung in time for the first breath at birth? 🫁
Discover the mechanical forces shaping the bronchial tree in our latest preprint: #LungDevelopment #Mechanobiology
doi.org/10.1101/2025...
👇Thread 🧵(1/9)
Discover the mechanical forces shaping the bronchial tree in our latest preprint: #LungDevelopment #Mechanobiology
doi.org/10.1101/2025...
👇Thread 🧵(1/9)
January 15, 2025 at 8:27 AM
How does an #embryo build an energy-efficient #fractal #lung in time for the first breath at birth? 🫁
Discover the mechanical forces shaping the bronchial tree in our latest preprint: #LungDevelopment #Mechanobiology
doi.org/10.1101/2025...
👇Thread 🧵(1/9)
Discover the mechanical forces shaping the bronchial tree in our latest preprint: #LungDevelopment #Mechanobiology
doi.org/10.1101/2025...
👇Thread 🧵(1/9)
Reposted by a. villars
Our paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer" is now out in
@naturephysics.bsky.social :
rdcu.be/d5rTP
#BladderCancer #Cancer #Tumor #Biomechanics #Morphometry #ComputationalModeling
@naturephysics.bsky.social :
rdcu.be/d5rTP
#BladderCancer #Cancer #Tumor #Biomechanics #Morphometry #ComputationalModeling
Morphometry and mechanical instability at the onset of epithelial bladder cancer
Nature Physics - Carcinoma subtypes are normally linked to specific genetic alterations, but tissue mechanical changes also play a role. Now, aberrant morphologies resembling bladder carcinoma are...
rdcu.be
January 7, 2025 at 12:00 PM
Our paper "Morphometry and mechanical instability at the onset of epithelial bladder cancer" is now out in
@naturephysics.bsky.social :
rdcu.be/d5rTP
#BladderCancer #Cancer #Tumor #Biomechanics #Morphometry #ComputationalModeling
@naturephysics.bsky.social :
rdcu.be/d5rTP
#BladderCancer #Cancer #Tumor #Biomechanics #Morphometry #ComputationalModeling
Reposted by a. villars
Inserm is opening up 67 tenure positions (Researchers junior and senior), covering disciplines dedicated to biomedical research and human health.
Deadline: January 20, 2025
pro.inserm.fr/rubriques/co...
Deadline: January 20, 2025
pro.inserm.fr/rubriques/co...
Competitive recruitment for researcher CRCN 2025 - Inserm pro
In 2025, Inserm is opening up 67 tenure positions (Researchers junior and senior), covering disciplines dedicated to biomedical research and human health. Registration deadline: January 20, 2025.
pro.inserm.fr
January 6, 2025 at 3:20 PM
Inserm is opening up 67 tenure positions (Researchers junior and senior), covering disciplines dedicated to biomedical research and human health.
Deadline: January 20, 2025
pro.inserm.fr/rubriques/co...
Deadline: January 20, 2025
pro.inserm.fr/rubriques/co...
Reposted by a. villars
Wishing you all the best for 2025 ! ...and a little late thread on our recent preprint studying how tissue growth is affected by mild induction of apoptosis. Drosophila wing disc readjusts global tissue size by modulating dev. time without local proliferation boost.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Developmental delay ensures global tissue size robustness upon local induction of apoptosis
The capacity of our tissues to cope with external and internal stress relies on the tight coupling between cell proliferation, cell growth and cell death. This coupling is assumed to be based on compe...
www.biorxiv.org
January 5, 2025 at 10:07 PM
Wishing you all the best for 2025 ! ...and a little late thread on our recent preprint studying how tissue growth is affected by mild induction of apoptosis. Drosophila wing disc readjusts global tissue size by modulating dev. time without local proliferation boost.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by a. villars
🌞 Eastern sessions: New this season! Happening bi-weekly on Wednesdays to better suit attendees in Eastern time zones. Explore the schedule for an exciting lineup of speakers and look for the ☀️ symbol in the flyers for individual sessions. [3/4]
December 30, 2024 at 10:48 AM
🌞 Eastern sessions: New this season! Happening bi-weekly on Wednesdays to better suit attendees in Eastern time zones. Explore the schedule for an exciting lineup of speakers and look for the ☀️ symbol in the flyers for individual sessions. [3/4]
Reposted by a. villars
Looking for a job still connected to acamedia and research ? Do you like interacting with a lot of people, outreach activity, organising scientific events ? Do you have good writing and organisation skills ? We may have a job for you👇 (permanent position)
emploi.pasteur.fr/offre-de-emp...
🙏RT
emploi.pasteur.fr/offre-de-emp...
🙏RT
December 21, 2024 at 1:19 PM
Looking for a job still connected to acamedia and research ? Do you like interacting with a lot of people, outreach activity, organising scientific events ? Do you have good writing and organisation skills ? We may have a job for you👇 (permanent position)
emploi.pasteur.fr/offre-de-emp...
🙏RT
emploi.pasteur.fr/offre-de-emp...
🙏RT
Reposted by a. villars
Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)
December 18, 2024 at 7:33 AM
Have you ever wondered how your back formed? The human embryo makes a neural tube (future spinal cord) and somites (trunk muscle/bone) from ~d20. They’re formed at the same time and place, so we used human Trunk-like Structures (hTLS) to investigate their ‘co-development’… (1/7)
Reposted by a. villars
Short-range Fgf signalling patterns hindbrain progenitors to induce the neurogenesis-to-oligodendrogenesis switch
Read this #OpenAccess Research Article by Tim Yeung and David Wilkinson @crick.ac.uk:
https://doi.org/10.1242/dev.204256
Read this #OpenAccess Research Article by Tim Yeung and David Wilkinson @crick.ac.uk:
https://doi.org/10.1242/dev.204256
December 19, 2024 at 6:53 AM
Short-range Fgf signalling patterns hindbrain progenitors to induce the neurogenesis-to-oligodendrogenesis switch
Read this #OpenAccess Research Article by Tim Yeung and David Wilkinson @crick.ac.uk:
https://doi.org/10.1242/dev.204256
Read this #OpenAccess Research Article by Tim Yeung and David Wilkinson @crick.ac.uk:
https://doi.org/10.1242/dev.204256
Reposted by a. villars
🦈 🦈 Catshark embryo (S canicula) around stage 28 🦈🦈
December 4, 2024 at 7:46 AM
🦈 🦈 Catshark embryo (S canicula) around stage 28 🦈🦈
Reposted by a. villars
Mix two motors of opposite polarity with microtubules and they will partition space !
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
November 27, 2024 at 1:42 PM
Mix two motors of opposite polarity with microtubules and they will partition space !
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns.
#morphogenesis
doi.org/10.1073/pnas...
(1/n)
Reposted by a. villars
Hello Bluesky 🦋
I’m excited to speak at next week’s VGZT! Please join in case you want to know more about my work on the metabolic control of germ layer proportions #devbio #metabolism #stemcellmodels @vgzt2021.bsky.social
I’m excited to speak at next week’s VGZT! Please join in case you want to know more about my work on the metabolic control of germ layer proportions #devbio #metabolism #stemcellmodels @vgzt2021.bsky.social
Next week, we’re back with two unique development talks: mouse gastruloids 🐭 with Kristina Stapornwongkul and turtles 🐢 with Agáta Horáčková & Barbora Straková. Mark your calendar—you won’t want to miss this!
🗓️ Dec 5, 12:30 EST / 18:30 CET / 17:30 UTC 🕥
🗓️ Dec 5, 12:30 EST / 18:30 CET / 17:30 UTC 🕥
November 28, 2024 at 8:27 PM
Hello Bluesky 🦋
I’m excited to speak at next week’s VGZT! Please join in case you want to know more about my work on the metabolic control of germ layer proportions #devbio #metabolism #stemcellmodels @vgzt2021.bsky.social
I’m excited to speak at next week’s VGZT! Please join in case you want to know more about my work on the metabolic control of germ layer proportions #devbio #metabolism #stemcellmodels @vgzt2021.bsky.social
Reposted by a. villars
Check out how #neuralcrest cells 🔬 migrate (animal= #zebrafish, white cells=sox10+, start=10 somites stage, anterior=top)
November 21, 2024 at 2:01 PM
Check out how #neuralcrest cells 🔬 migrate (animal= #zebrafish, white cells=sox10+, start=10 somites stage, anterior=top)
Reposted by a. villars
Great work by @omdrozdowski.bsky.social who found that the bubbly vertex model naturally leads to cell bulging and extrusion at topological (pentagonal) defects in curved epithelia. Read the preprint at arxiv.org/abs/2411.07141
November 19, 2024 at 5:56 PM
Great work by @omdrozdowski.bsky.social who found that the bubbly vertex model naturally leads to cell bulging and extrusion at topological (pentagonal) defects in curved epithelia. Read the preprint at arxiv.org/abs/2411.07141
Reposted by a. villars
You asked for it...
November 19, 2024 at 11:31 PM
You asked for it...
Reposted by a. villars
🚨Preprint alert 🚨Do you need a highly sensitive kinase biosensor? Want to multiplex multiple sensors or look at nanoscale activity architecture? Our far-red chemigenetic kinase biosensors are what you are looking for. Thanks to everyone involved! tinyurl.com/d36e2t4m
February 13, 2024 at 6:02 AM
🚨Preprint alert 🚨Do you need a highly sensitive kinase biosensor? Want to multiplex multiple sensors or look at nanoscale activity architecture? Our far-red chemigenetic kinase biosensors are what you are looking for. Thanks to everyone involved! tinyurl.com/d36e2t4m
Reposted by a. villars
Timely neurogenesis enables increased nuclear packing order during neuronal lamination https://www.biorxiv.org/content/10.1101/2024.11.12.623216v1
Timely neurogenesis enables increased nuclear packing order during neuronal lamination https://www.biorxiv.org/content/10.1101/2024.11.12.623216v1
The coordination of cell proliferation, migration, and differentiation is crucial for organogenesis
www.biorxiv.org
November 15, 2024 at 5:31 AM
Timely neurogenesis enables increased nuclear packing order during neuronal lamination https://www.biorxiv.org/content/10.1101/2024.11.12.623216v1
Reposted by a. villars
Hello! 👋 I’m Christopher, a reproductive biologist and group leader at IBDM, France 🇫🇷
My lab uses #LiveImaging to study how the dynamic #ovary makes healthy #eggs 🔬🥚
Here’s a video from my postdoc in the Schuh lab, where we visualised #ovulation live in isolated mouse follicles 💥
📄 bit.ly/3Ya8dEL
My lab uses #LiveImaging to study how the dynamic #ovary makes healthy #eggs 🔬🥚
Here’s a video from my postdoc in the Schuh lab, where we visualised #ovulation live in isolated mouse follicles 💥
📄 bit.ly/3Ya8dEL
November 14, 2024 at 9:48 AM
Hello! 👋 I’m Christopher, a reproductive biologist and group leader at IBDM, France 🇫🇷
My lab uses #LiveImaging to study how the dynamic #ovary makes healthy #eggs 🔬🥚
Here’s a video from my postdoc in the Schuh lab, where we visualised #ovulation live in isolated mouse follicles 💥
📄 bit.ly/3Ya8dEL
My lab uses #LiveImaging to study how the dynamic #ovary makes healthy #eggs 🔬🥚
Here’s a video from my postdoc in the Schuh lab, where we visualised #ovulation live in isolated mouse follicles 💥
📄 bit.ly/3Ya8dEL
Reposted by a. villars
🚀Thrilled to announce #inTRACKtive: a web-based tool for exploring massive cell-tracking datasets, no software installation required! Open your browser and dive into terabytes of developmental biology data 🐭🪰🪱🪲🐠
Preprint:
biorxiv.org/content/10.1...
Repository:
github.com/royerlab/inT...
🧵1/n
Preprint:
biorxiv.org/content/10.1...
Repository:
github.com/royerlab/inT...
🧵1/n
November 13, 2024 at 7:53 PM
🚀Thrilled to announce #inTRACKtive: a web-based tool for exploring massive cell-tracking datasets, no software installation required! Open your browser and dive into terabytes of developmental biology data 🐭🪰🪱🪲🐠
Preprint:
biorxiv.org/content/10.1...
Repository:
github.com/royerlab/inT...
🧵1/n
Preprint:
biorxiv.org/content/10.1...
Repository:
github.com/royerlab/inT...
🧵1/n
Reposted by a. villars
Our most recent work looked at the mechanical effects on competition between two model bacteria competing for space and resources within microchannels.
November 13, 2024 at 7:05 PM
Our most recent work looked at the mechanical effects on competition between two model bacteria competing for space and resources within microchannels.
Reposted by a. villars
Hi Everyone! 👋 Allow me to introduce myself. I'm Kate. I'm a postdoc studying early mammalian development, mechanics, and reproductive aging. Check out one of my favorite developmental stages in a mouse embryo in this video:
November 14, 2024 at 1:09 AM
Hi Everyone! 👋 Allow me to introduce myself. I'm Kate. I'm a postdoc studying early mammalian development, mechanics, and reproductive aging. Check out one of my favorite developmental stages in a mouse embryo in this video:
Reposted by a. villars
Do you work in #DevBio and want to introduce the fascinating world of developmental biology to your family and friends? You can show them this science documentary, produced by the British Society for Developmental Biology, The Company of Biologists and Cambridge Filmworks!
📽️ youtu.be/avrmIs3vPUQ?...
📽️ youtu.be/avrmIs3vPUQ?...
BSDB - The Fascinating World of Developmental Biology (full length)
YouTube video by The Company of Biologists
youtu.be
November 9, 2024 at 10:06 AM
Do you work in #DevBio and want to introduce the fascinating world of developmental biology to your family and friends? You can show them this science documentary, produced by the British Society for Developmental Biology, The Company of Biologists and Cambridge Filmworks!
📽️ youtu.be/avrmIs3vPUQ?...
📽️ youtu.be/avrmIs3vPUQ?...
Reposted by a. villars
Welcome to our Bluesky account. With so many of our community members now present on Bluesky, we felt it was the right time to join. We will use this account to bring you news from the Company, our journals and our community sites.
November 12, 2024 at 2:22 PM
Welcome to our Bluesky account. With so many of our community members now present on Bluesky, we felt it was the right time to join. We will use this account to bring you news from the Company, our journals and our community sites.
Reposted by a. villars
🚨🚨🚨
Call is now open!!!
Wanna become our new beloved colleague and be part of a stimulating (and friendly) scientific community ??? We are perfectly located in beautiful Paris with exciting work environment and state-of-the-art core facilities
APPLY 👇👇👇👇👇
Call is now open!!!
Wanna become our new beloved colleague and be part of a stimulating (and friendly) scientific community ??? We are perfectly located in beautiful Paris with exciting work environment and state-of-the-art core facilities
APPLY 👇👇👇👇👇
November 12, 2024 at 7:37 PM
🚨🚨🚨
Call is now open!!!
Wanna become our new beloved colleague and be part of a stimulating (and friendly) scientific community ??? We are perfectly located in beautiful Paris with exciting work environment and state-of-the-art core facilities
APPLY 👇👇👇👇👇
Call is now open!!!
Wanna become our new beloved colleague and be part of a stimulating (and friendly) scientific community ??? We are perfectly located in beautiful Paris with exciting work environment and state-of-the-art core facilities
APPLY 👇👇👇👇👇