Alexander Tendu
atendu.bsky.social
Alexander Tendu
@atendu.bsky.social
Emerging viruses, Virus Characterization, Arboviruses.
@upcite.bsky.social
Interesting and good work on arbovirus coinfection. However, if cell entry is a low barrier (as some have shown), Don’t we need to redefine active (co)infection as being different from just (co)occurrence of pathogens? Replication counts.
February 13, 2025 at 12:05 PM
Reposted by Alexander Tendu
🦠 Mpox: a better understanding of tecovirimat resistance
🔬 Scientists at the Institut Pasteur have uncovered how a viral enzyme interacts with tecovirimat. This breakthrough paves the way for new antiviral therapies.
📄 Study published in @naturemicrobiol.bsky.social #Mpox #tecovirimat
Mpox: a better understanding of tecovirimat resistance
A virus originally found in animals, mpox – which causes the disease of the same name – is now circulating in humans. Since 2022, it has been the cause of major epidemics spreading outside endemic are...
www.pasteur.fr
February 12, 2025 at 12:35 PM
February 2, 2025 at 4:58 PM
Reposted by Alexander Tendu
Fabulous work with colleagues in Burundi, who took up Mpox sequencing to understand the situation AND are willing to share pre-publication, shows the expanding tree, and evidence for several introductions not taking off. In progress virological.org/t/preliminar...
Preliminary analysis of 98 genomic sequences of MPXV clade Ib cases from Burundi, July to September 2024
Preliminary analysis of 98 genomic sequences of MPXV clade Ib cases from Burundi, July to September 2024 Introduction A large mpox clade Ib virus outbreak started in the province of South Kivu in th...
virological.org
November 21, 2024 at 7:52 AM
Reposted by Alexander Tendu
Hot off the press: "Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations" www.sciencedirect.com/science/arti...

See below for @suguru-nishijima.bsky.social 's thread on the preprint!

#microsky #microbiome
November 13, 2024 at 4:29 PM
Reposted by Alexander Tendu
🦇🦠If you ever wondered about the zoonotic risk bat-associated parasites might pose and their potential role in pathogen spillover look into our new paper in @TrendsParasitol

www.cell.com/trends/paras...

🕷️📷: @NikolaRahme
🦇🪰📷: @tszentivanyi
November 8, 2024 at 1:30 PM
Reposted by Alexander Tendu

"Compressing long-term gene evolution to laboratory time spans at scale ... would enable the systematic detection of additional structural and functional demands governing biology...& principles by which gene diversity was generated in the first place."
www.science.org/doi/10.1126/...
Continuous evolution of user-defined genes at 1 million times the genomic mutation rate
When nature evolves a gene over eons at scale, it produces a diversity of homologous sequences with patterns of conservation and change that contain rich structural, functional, and historical informa...
www.science.org
November 9, 2024 at 12:01 AM
Reposted by Alexander Tendu
After editing, this very short letter to New Scientist is even shorter now. But I think it gets the point across! @faecalmatters.bsky.social
November 11, 2024 at 10:23 PM
The perfect conclusion to a criticism doesn’t exi…
November 9, 2024 at 6:05 AM
Reposted by Alexander Tendu
Dear fellow microbiologists, have you ever successfully pooled 16S and ITS amplicons in the same library to be sequenced together? Any tips to share? Thanks! 🧪🦠🧬
November 5, 2024 at 8:53 AM
Reposted by Alexander Tendu
And this isn’t just theory. We’ve already use R10 for #H5N1 cases in #Cambodia to detect a new reassortant, and nail down that transmission was bird-to-human, not human-to-human. That’s a BIG deal for outbreak response—speed and confidence when it counts.

More here: www.medrxiv.org/content/10.1...
Emergence of a Novel Reassortant Clade 2.3.2.1c Avian Influenza A/H5N1 Virus Associated with Human Cases in Cambodia
After nearly a decade without reported human A/H5N1 infections, Cambodia faced a sudden resurgence with 16 cases between February 2023 and August 2024, all caused by A/H5 clade 2.3.2.1c viruses. Fourt...
www.medrxiv.org
November 8, 2024 at 2:45 PM
Reposted by Alexander Tendu
Here is something to distract you from the gloom: What can metagenomics tell us about the taxonomic composition of lichen symbioses? A peer-reviewed version of our analysis of >400 lichen metagenomes from around the world is now out in @PLOSBiology 1/12 doi.org/10.1371/jour...
🧬 🖥️ 🧪 🦠 🧫 #SymbioSky
November 7, 2024 at 10:16 PM
Post peer review: Work we did in Yunnan Province China during the SARS-CoV2 pandemic. Myotis laniger is a potential host for SARSr-CoVs

www.sciencedirect.com/science/arti...
Differential prevalence and risk factors for infection with coronaviruses in bats collected from Yunnan Province, China
Coronaviruses (CoVs) pose a threat to human health globally, as highlighted by severe acute respiratory syndrome (SARS), Middle East respiratory syndr…
www.sciencedirect.com
October 29, 2024 at 6:33 AM
Yes! Contaminating genes in metagenomics may independently correlate with your target pathogen load. Food for thought
Small amounts of misassembly can have disproportionate effects on pangenome-based metagenomic analyses www.biorxiv.org/content/10.1... #jcampubs
October 18, 2024 at 1:57 AM
Reposted by Alexander Tendu
Intragenomic conflicts with plasmids and chromosomal mobile genetic elements drive the evolution of natural transformation within species (PLOS Biology)

from @epcrocha.bsky.social and colleagues

journals.plos.org/plosbiology/...

Great paper looking at phyologenetics+genetics of transformation
October 15, 2024 at 1:30 PM
“…that if he had a gallon of urine and put a shot glass of wine into it, he still had a gallon of urine. On the other hand, if he had a gallon of wine and put a shot glass of urine into that, he now had a second gallon of urine”

This should be a guiding tenet for all journals if you ask me.
The journal “Scientific Reports” is put out by a large, respected publisher and is supposed to review its manuscripts so as not to publish obvious junk.

That doesn’t seem to be true any more. Are they going to do anything about it?
Cleaning up
www.science.org
October 18, 2024 at 1:46 AM
Reposted by Alexander Tendu
Complete genomes of Asgard archaea reveal diverse integrated and mobile genetic elements - out today in Genome Research

from @luisvalentin.bsky.social @archaeal.bsky.social @valdeanda.bsky.social

A look at (a) MGEs, (b) methylation, (c) defense systems in Asgards

genome.cshlp.org/content/earl...
October 16, 2024 at 1:42 PM
Reposted by Alexander Tendu
Computational genomics manual linsalrob.github.io/Computationa... and associated YouTube videos www.youtube.com/playlist?lis...
ComputationalGenomicsManual
Robs manual for the computational genomics and bioinformatics class.
linsalrob.github.io
October 5, 2024 at 4:18 AM