Postdoc at the University of Cambridge
Visiting Researcher at the British Antarctic Survey
College Research Associate at Wolfson College
https://laser.ceb.cam.ac.uk/
Excited to see how this impacts biology & medicine!
Read the full story here 👇
www.biorxiv.org/content/10.1...
Excited to see how this impacts biology & medicine!
Read the full story here 👇
www.biorxiv.org/content/10.1...
📊 Found 30% of cells express low-abundance c-kit.
🧬 This subpopulation was invisible to standard flow cytometry, but smFC revealed it.
📊 Found 30% of cells express low-abundance c-kit.
🧬 This subpopulation was invisible to standard flow cytometry, but smFC revealed it.
✅ Digital precision down to ~2–3 molecules/cell
✅ 10–80× improved detection limits vs. conventional FC
✅ Quantification of membrane proteins in high throughput, single-cell detail
✅ Digital precision down to ~2–3 molecules/cell
✅ 10–80× improved detection limits vs. conventional FC
✅ Quantification of membrane proteins in high throughput, single-cell detail
🔬 High-NA oblique plane microscopy (OPM)
💧 Microfluidics
✨ Superbright, large Stokes shift dyes
→ enabling optical sectioning + photon efficiency needed for single-molecule detection in flowing cells.
🔬 High-NA oblique plane microscopy (OPM)
💧 Microfluidics
✨ Superbright, large Stokes shift dyes
→ enabling optical sectioning + photon efficiency needed for single-molecule detection in flowing cells.
❌ It can’t detect proteins expressed at very low levels (<100–1000 molecules/cell).
That means many weak but biologically crucial signals are invisible.
❌ It can’t detect proteins expressed at very low levels (<100–1000 molecules/cell).
That means many weak but biologically crucial signals are invisible.