Astbury Biostructure Laboratory
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astbury-bsl.bsky.social
Astbury Biostructure Laboratory
@astbury-bsl.bsky.social
#CryoEM #CryoET
@universityofleeds.bsky.social

Funded access via @instruct-eric.bsky.social

Find out more about our training: http://bit.ly/3Szodyw
Reposted by Astbury Biostructure Laboratory
📆Save the date: 20-21 April 2026

#AstburyConvo26 is back with a bold new theme: Designing Biology.

Expect cutting-edge talks and the chance to shape the future of molecular science.

Register now: astburyconversation.leeds.ac.uk

@astburycentre.bsky.social @universityofleeds.bsky.social
November 11, 2025 at 4:14 PM
Our brilliant @louieaspinall.bsky.social and Tom are representing our Facility at #PSDI in Basel sharing how Cryo-EM at Leeds can support your drug discovery projects.

If you’re at the conference, come say hi before it wraps up!! 👋
November 11, 2025 at 11:13 AM
Reposted by Astbury Biostructure Laboratory
🚨 Abstract submission extended to Oct 21!
Join us for the Austrian Cryo-EM Symposium (Nov 11–12) at @istaresearch.bsky.social / ISTA 🇦🇹

Explore cutting-edge cryo-EM, meet top speakers, and visit beautiful Vienna.
👉 cryoem-symposium.pages.ist.ac.at
October 17, 2025 at 1:51 PM
Reposted by Astbury Biostructure Laboratory
Below (by @landerlab.bsky.social) is the 2nd #cryosparc recipe on @biorxivpreprint.bsky.social in a month. I remain worried about closed-source software affecting progress in #cryoEM. We should develop new algorithms instead!

#OpenSoftwareAcceleratesScience

www.biorxiv.org/content/10.1...
www.biorxiv.org
October 5, 2025 at 8:20 AM
Reposted by Astbury Biostructure Laboratory
Was lucky to see this presented at the NYC cryoEM meeting earlier this year - super cool stuff!
August 22, 2025 at 9:37 PM
🚨 We’re hiring! 🚨

We’re looking for a Correlative Imaging Scientist to join our EM team at ABSL!

You will be developing and supporting cryo-EM & cryo-CLEM workflows across multiple imaging platforms (FIB-SEM, cryo-confocal, cryo-EM).

Any questions? Get in touch!

jobs.leeds.ac.uk/Vacancy.aspx...
Job Opportunity at University of Leeds: Correlative Imaging Scientist
Are you a creative postdoctoral-scientist keen to explore novel in-situ biology with cryogenic electron tomography? Do you have a background in imaging technologies and/or image processing?We are look...
jobs.leeds.ac.uk
August 11, 2025 at 9:46 AM
Delighted to see our publication with industry partners out! 🎉
Huge shoutout to @jbrwhite.bsky.social and @oksana-degtjarik.bsky.social for their contributions to the structural work!
Many thanks to @chingshinhuang.bsky.social & the whole team for an excellent collaboration!
#CryoEM #drugdiscovery
Working with @astbury-bsl.bsky.social, we report cryo-EM structures of CD163 in its apo state and in complex with haptoglobin–hemoglobin (HpHb), and propose a framework of how CD163-mediated endocytosis clears different isoforms of HpHb. Please check it out on @plosbiology.org!
The #macrophage CD163 receptor clears free #hemoglobin in the bloodstream by binding the HpHb complex. The #cryoEM structure of CD163-HpHb complex, by @chingshinhuang.bsky.social &co, reveals how CD163-mediated endocytosis clears different HpHb isoforms @plosbiology.org 🧪 plos.io/4nNBbGI
July 21, 2025 at 1:35 PM
Reposted by Astbury Biostructure Laboratory
We are proud to share our latest preprint: "(-)-Englerin A binds a conserved lipid site of TRPC5 and exposes a Met-aromatic motif in channel activation".

www.biorxiv.org/content/10.1...
July 13, 2025 at 1:16 PM
🚨 Applications now open!
Join us in Leeds for the Wellcome-MRC Cryo-EM Training Course
📅 1–4 Sept 2025 | 🧊 Beginners tailored
🔬 Hands-on single-particle cryo-EM
👉 More info and to apply: forms.office.com/e/QHYmbcsZ33
Microsoft Forms
forms.office.com
June 18, 2025 at 12:22 PM
A great read on how flexibility and air–water interface interactions impact SPA cryo-EM data quality! Congratulations @isobelhirst.bsky.social @stemuench.bsky.social @scarfflab.bsky.social and the team!
June 2, 2025 at 5:32 PM
Wonderful #PintOfScience evening with @maddie-gilbert.bsky.social and @richardallenart.bsky.social making sense of memory loss! The memory test results may already have slipped our minds…😅
Huge thanks to our own @c-hawksworth.bsky.social for helping organise such a great event!🍺
May 19, 2025 at 9:55 PM
Reposted by Astbury Biostructure Laboratory
Beautiful and inspiring talk by Sheena Radford of the @radford-lab.bsky.social at the Astbury Centre for Structural Molecular Biology (@astbury-bsl.bsky.social) from the University of Leeds (@universityofleeds.bsky.social) at our annual Bijvoet Symposium!
May 12, 2025 at 10:11 AM
The perfect gift doesn’t exi… Oh wait!

Those tiny replicas of our Titan Krios microscopes are absolutely adorable! 🥹❄️
Thank you so much @snowentific.bsky.social!
Wishing you all the best in your next adventure - you will be missed!
May 7, 2025 at 11:25 AM
Reposted by Astbury Biostructure Laboratory
“The Website” is here! It can be intimidating getting into analysis of #CryoET data, and software is evolving all the time👩‍💻🚀. @phaips.vd.st & @florentwaltz.bsky.social put our lab’s workflows into an online guide. We hope this helps lower the bar to joining #TeamTomo. Feedback much appreciated! 🧪🧶🧬🔬
Hey #TeamTomo,
Ever been in need of a tutorial about the fundamentals of cryo-electron tomography? From preprocessing raw frames to high-res subtomogram averaging?
That's why @florentwaltz.bsky.social and I made this website!

tomoguide.github.io

Follow the thread 1 /🧵
#CryoET #CryoEM 🔬🧪
Welcome to TomoGuide
A step-by-step Cryo-ET guide
tomoguide.github.io
May 7, 2025 at 10:56 AM
Exciting to see our time-resolved #cryoEM device developed by @stemuench.bsky.social & colleagues in action at the CCPEM Spring Symposium!
Brilliant talk by @scarfflab.bsky.social showing how it helped to visualize the elusive actomyosin primed complex & demonstrate the swinging lever mechanism.
April 25, 2025 at 4:40 PM
Huge shout out to @jenkinsjj.bsky.social for his excellent talk on the #cryoET structure of Tau filaments from human brain tissue at CCPEM Spring Symposium in Nottingham! #cryo-EM @diamondlightsource.bsky.social @ccpem.bsky.social
April 24, 2025 at 5:31 PM
Reposted by Astbury Biostructure Laboratory
It's great to be at the CCPEM conference in Nottingham this week, with talks from many Instruct facilities including @astburycentre.bsky.social, @astbury-bsl.bsky.social, @diamondlightsource.bsky.social, and @ox.ac.uk!

Find out more about the Instruct-UK centre - instruct-eric.org/centres/inst...
April 24, 2025 at 10:48 AM
Another week, another training course wrapped up ✅
Huge thanks to our fantastic participants for sticking with us through the reschedule, and to our amazing lecturers & tutors for making it a success: @leicstructbio.bsky.social @diamondlightsource.bsky.social @uofglasgow.bsky.social
& Birkbeck, UoL
April 15, 2025 at 9:42 AM
Reposted by Astbury Biostructure Laboratory
I started on this around 2006 so only taken 20 years! The project itself started over 30 years ago. Great to finally see the elusive structure.
April 10, 2025 at 1:46 PM
🔬 Exciting to see our custom time-resolved cryo-EM device featured in Nature!
A groundbreaking look at the swinging lever mechanism of myosin in action!
Huge congrats to @scarfflab.bsky.social @stemuench.bsky.social @snmcmillan.bsky.social @davidklebl.bsky.social and everyone involved!

#cryoEM
April 10, 2025 at 10:17 AM
Reposted by Astbury Biostructure Laboratory
#CryoSPARC v4.7 is out! 🚀 
Featuring a new automatic Micrograph Junk Detector that labels and rejects contaminants, new tools for curating subsets of particles, performance and stability fixes, and more!
Full changelog: cryosparc.com/updates

#cryoEM
April 9, 2025 at 2:14 PM
🔬Sibling rivalry alert!
Our Krios 2 is finally catching up with Krios 1 with a shiny new Selectris energy filter! ⚡
Exciting times ahead!

Huge thanks to @thermofishersci.bsky.social for the upgrade! 🙌
#cryoEM #cryoET
March 18, 2025 at 5:17 PM
Reposted by Astbury Biostructure Laboratory
Excited to report our latest research on new “molecular glues” that specifically lock the BRCC36 isopeptidase complex (BRISC) in an autoinhibited state and reduce interferon signalling. This first-of-its-kind approach could reshape how we target large deubiquitylase (DUB) complexes.

rdcu.be/edRwF
March 17, 2025 at 8:58 PM
🎉 And that’s a wrap!

The Wellcome-MRC Cryo-EM in Structural Biology 2025 course in Leeds was a fantastic week of learning, hands-on training, and great discussions.

Huge thanks to our amazing instructors, speakers & enthusiastic participants for making it such a success! #CryoEM
March 11, 2025 at 3:59 PM
Reposted by Astbury Biostructure Laboratory
📢 4-year funded PhD opportunity at the Aston Institute for Membrane Excellence, starting in October 2025. The project will focus on studying protein-lipid interactions in mechanosensitive channels📢

📅 Application deadline: 7th April 2025

@astonaime.bsky.social

tinyurl.com/4arujyaw
Investigation of lipid-protein interactions within mechanosensitive ion channels at Aston University on FindAPhD.com
PhD Project - Investigation of lipid-protein interactions within mechanosensitive ion channels at Aston University, listed on FindAPhD.com
tinyurl.com
February 28, 2025 at 9:16 AM