Alessandro Nascimento
@asnascimento.bsky.social
Associate Professor @ University of Sao Paulo. Structural biologist. Protein crystallographer. Interested in protein-ligand interactions and modeling
Reposted by Alessandro Nascimento
Picard management tip: If they know their jobs, leave them alone. If they don't, help them learn.
November 11, 2025 at 7:22 PM
Picard management tip: If they know their jobs, leave them alone. If they don't, help them learn.
Reposted by Alessandro Nascimento
🚨 Three PDRA posts @imperialchemistry.bsky.social with me + collaborators to transform materials discovery.
Focus:
💻 Comp Chem
🤖 AI in Chem
🧠 Neurosymbolic Learning
🗓️ Apply by 11 Nov 2025
🔗 jobs.ac.uk/job/DPB378 (click "Apply" to find individual post details)
#chemsky #compchem #chempostdoc
Focus:
💻 Comp Chem
🤖 AI in Chem
🧠 Neurosymbolic Learning
🗓️ Apply by 11 Nov 2025
🔗 jobs.ac.uk/job/DPB378 (click "Apply" to find individual post details)
#chemsky #compchem #chempostdoc
Research Associate positions in Computational Chemistry, AI in Chemistry, and in Neurosymbolic Learning for Chemistry at Imperial College London
An opportunity for an academic position as a Research Associate positions in Computational Chemistry, AI in Chemistry, and in Neurosymbolic Learning for Chemistry is available, as advertised on jobs.a...
jobs.ac.uk
October 17, 2025 at 8:39 AM
🚨 Three PDRA posts @imperialchemistry.bsky.social with me + collaborators to transform materials discovery.
Focus:
💻 Comp Chem
🤖 AI in Chem
🧠 Neurosymbolic Learning
🗓️ Apply by 11 Nov 2025
🔗 jobs.ac.uk/job/DPB378 (click "Apply" to find individual post details)
#chemsky #compchem #chempostdoc
Focus:
💻 Comp Chem
🤖 AI in Chem
🧠 Neurosymbolic Learning
🗓️ Apply by 11 Nov 2025
🔗 jobs.ac.uk/job/DPB378 (click "Apply" to find individual post details)
#chemsky #compchem #chempostdoc
Reposted by Alessandro Nascimento
New paper out in PNAS Nexus!
Molecules aren’t flat — so why should our models be?🧬
Our latest work "Stereochemistry-aware string-based molecular generation,” explores how considering stereochemistry changes the way machine learning models design molecules.
Link: doi.org/10.1093/pnas...
[1/4]
Molecules aren’t flat — so why should our models be?🧬
Our latest work "Stereochemistry-aware string-based molecular generation,” explores how considering stereochemistry changes the way machine learning models design molecules.
Link: doi.org/10.1093/pnas...
[1/4]
Stereochemistry-aware string-based molecular generation
Abstract. This study investigates the impact of incorporating stereochemical information, a crucial aspect of computational drug discovery and materials de
doi.org
November 5, 2025 at 6:01 PM
New paper out in PNAS Nexus!
Molecules aren’t flat — so why should our models be?🧬
Our latest work "Stereochemistry-aware string-based molecular generation,” explores how considering stereochemistry changes the way machine learning models design molecules.
Link: doi.org/10.1093/pnas...
[1/4]
Molecules aren’t flat — so why should our models be?🧬
Our latest work "Stereochemistry-aware string-based molecular generation,” explores how considering stereochemistry changes the way machine learning models design molecules.
Link: doi.org/10.1093/pnas...
[1/4]
Reposted by Alessandro Nascimento
Last call - open til Oct 30!
Are you excited about #MachineLearning and developing new architectures for Molecular Biology? Joint us for the next chapter of BioEmu at @msftresearch.bsky.social AI for Science - Berlin DE or Cambridge UK.
aka.ms/bioemu-ml
Are you excited about #MachineLearning and developing new architectures for Molecular Biology? Joint us for the next chapter of BioEmu at @msftresearch.bsky.social AI for Science - Berlin DE or Cambridge UK.
aka.ms/bioemu-ml
Search Jobs | Microsoft Careers
aka.ms
October 27, 2025 at 6:58 PM
Last call - open til Oct 30!
Are you excited about #MachineLearning and developing new architectures for Molecular Biology? Joint us for the next chapter of BioEmu at @msftresearch.bsky.social AI for Science - Berlin DE or Cambridge UK.
aka.ms/bioemu-ml
Are you excited about #MachineLearning and developing new architectures for Molecular Biology? Joint us for the next chapter of BioEmu at @msftresearch.bsky.social AI for Science - Berlin DE or Cambridge UK.
aka.ms/bioemu-ml
😮😮😮😮
Baker lab builds a calcium channel entirely from scratch. This should enable cellular behaviors to be altered in entirely new ways.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Bottom-up design of Ca2+ channels from defined selectivity filter geometry - Nature
De novo design of Ca2+ channels with ion selectivity that can assemble appropriately and mediate Ca2+ conductance when expressed in cells is described.
www.nature.com
October 25, 2025 at 10:24 PM
😮😮😮😮
Reposted by Alessandro Nascimento
We’re Hiring Professor (all ranks) in Synthetic Biology and AI-Enabled Biodesign at the School of Biological and Health Systems Engineering, Arizona State University.📍 Tempe, Arizona
Apply here: apply.interfolio.com/175856
Apply here: apply.interfolio.com/175856
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 24, 2025 at 4:11 PM
We’re Hiring Professor (all ranks) in Synthetic Biology and AI-Enabled Biodesign at the School of Biological and Health Systems Engineering, Arizona State University.📍 Tempe, Arizona
Apply here: apply.interfolio.com/175856
Apply here: apply.interfolio.com/175856
Reposted by Alessandro Nascimento
Opportunity for computational chemist at Inductive Bio (USA: New York City, San Francisco, or Boston) #CompChem #cheminformatics #ADMET #ChemJobs #chemsky 🧪
www.inductive.bio/careers?ashb...
www.inductive.bio/careers?ashb...
We're Hiring | Inductive Bio
Inductive Bio is accelerating small molecule drug discovery with cutting-edge AI and proprietary data. Join our fast-growing team backed by top investors like a16z and Lux.
www.inductive.bio
October 23, 2025 at 6:14 AM
Opportunity for computational chemist at Inductive Bio (USA: New York City, San Francisco, or Boston) #CompChem #cheminformatics #ADMET #ChemJobs #chemsky 🧪
www.inductive.bio/careers?ashb...
www.inductive.bio/careers?ashb...
Reposted by Alessandro Nascimento
Opportunity in computational structural biology at ISTA (Vienna Austria) duration: 5 years with possibility of permanent contract #StructBiol #cryoEM #cryoET #chemsky 🧪
ista.ac.at/en/job/tenur...
ista.ac.at/en/job/tenur...
Tenure-based Research Staff Scientist Position in Computational Structural Biology
ISTA (www.ista.ac.at) is seeking a highly skilled Staff Scientist in Computational Structural Biology to support and advance the Institute’s structural biology research through the development and imp...
ista.ac.at
October 16, 2025 at 6:30 AM
Opportunity in computational structural biology at ISTA (Vienna Austria) duration: 5 years with possibility of permanent contract #StructBiol #cryoEM #cryoET #chemsky 🧪
ista.ac.at/en/job/tenur...
ista.ac.at/en/job/tenur...
Reposted by Alessandro Nascimento
Opportunity in computer-aided drug design at Johnson & Johnson (USA: San Diego CA/Spring House PA) ref: R-036349 #CADD #cheminformatics #CompChem #ChemJobs #chemsky 🧪
www.careers.jnj.com/en/jobs/r-03...
www.careers.jnj.com/en/jobs/r-03...
Senior Scientist, Computer-Aided Drug Design (CADD) - In Silico Discovery
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments...
www.careers.jnj.com
October 10, 2025 at 6:45 AM
Opportunity in computer-aided drug design at Johnson & Johnson (USA: San Diego CA/Spring House PA) ref: R-036349 #CADD #cheminformatics #CompChem #ChemJobs #chemsky 🧪
www.careers.jnj.com/en/jobs/r-03...
www.careers.jnj.com/en/jobs/r-03...
😂😂😂
October 7, 2025 at 5:53 PM
😂😂😂
Reposted by Alessandro Nascimento
Bioinformaticists need a set of Greek theater masks. 🧪 🧬 🖥️
October 6, 2025 at 8:16 PM
Bioinformaticists need a set of Greek theater masks. 🧪 🧬 🖥️
Reposted by Alessandro Nascimento
My hero.
Dr. Jane Goodall filmed an interview with Netflix in March 2025 that she understood would only be released after her death.
October 5, 2025 at 1:03 PM
My hero.
Reposted by Alessandro Nascimento
Reposted by Alessandro Nascimento
SimpleFold: Folding Proteins is Simpler than You Think [new]
Folding Proteins is Simpler than You Think
...by using a flow-matching objective and general-purpose transformers, achieving competitive results without complex domain-specific components.
Folding Proteins is Simpler than You Think
...by using a flow-matching objective and general-purpose transformers, achieving competitive results without complex domain-specific components.
September 24, 2025 at 3:31 AM
SimpleFold: Folding Proteins is Simpler than You Think [new]
Folding Proteins is Simpler than You Think
...by using a flow-matching objective and general-purpose transformers, achieving competitive results without complex domain-specific components.
Folding Proteins is Simpler than You Think
...by using a flow-matching objective and general-purpose transformers, achieving competitive results without complex domain-specific components.
Reposted by Alessandro Nascimento
Postdoc position available in the BioEmu team at @msftresearch.bsky.social AI for Science - Berlin DE or Cambridge UK. Looking for candidates with backgrounds in #MachineLearning #AI Biophysics or Bioinformatics
jobs.careers.microsoft.com/global/en/jo...
jobs.careers.microsoft.com/global/en/jo...
September 24, 2025 at 1:06 PM
Postdoc position available in the BioEmu team at @msftresearch.bsky.social AI for Science - Berlin DE or Cambridge UK. Looking for candidates with backgrounds in #MachineLearning #AI Biophysics or Bioinformatics
jobs.careers.microsoft.com/global/en/jo...
jobs.careers.microsoft.com/global/en/jo...
😮😮😮
Now this is interesting! Apple does protein structure prediction. macinchem.org/2025/09/24/s...
SimpleFold: Folding Proteins is Simpler than You Think – Macs in Chemistry
macinchem.org
September 24, 2025 at 11:54 PM
😮😮😮
Reposted by Alessandro Nascimento
The Plans
**My new book is out! 👉GreatBigUniverse.net
**My new book is out! 👉GreatBigUniverse.net
September 18, 2025 at 6:15 PM
The Plans
**My new book is out! 👉GreatBigUniverse.net
**My new book is out! 👉GreatBigUniverse.net
Reposted by Alessandro Nascimento
DeepSeek R1 - the first widely used LLM to be peer reviewed and published in a research journal. And… with transparent peer reviewed!
@nature.com
www.nature.com/articles/s41...
@nature.com
www.nature.com/articles/s41...
DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning - Nature
A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing t...
www.nature.com
September 17, 2025 at 10:52 PM
DeepSeek R1 - the first widely used LLM to be peer reviewed and published in a research journal. And… with transparent peer reviewed!
@nature.com
www.nature.com/articles/s41...
@nature.com
www.nature.com/articles/s41...
And it is worth mentioning that this preprint showed that AF3 ipSAE was found to be the best predictor for experimental success for de novo designed binders:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 16, 2025 at 7:42 PM
And it is worth mentioning that this preprint showed that AF3 ipSAE was found to be the best predictor for experimental success for de novo designed binders:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alessandro Nascimento
Come be my colleague! Whitman College is searching for a tenure-track biochemist to join the chemistry department and help with the biochem/biophysics/molbio program. My chemistry colleagues are the absolute best—please consider applying! Apps due in 1 week.
apply.interfolio.com/171535
apply.interfolio.com/171535
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 15, 2025 at 9:46 PM
Come be my colleague! Whitman College is searching for a tenure-track biochemist to join the chemistry department and help with the biochem/biophysics/molbio program. My chemistry colleagues are the absolute best—please consider applying! Apps due in 1 week.
apply.interfolio.com/171535
apply.interfolio.com/171535
Reposted by Alessandro Nascimento
Chocolate intake is associated with the number of Nobel Prize recipients.
Source NEJM : www.nejm.org/doi/full/10....
Source NEJM : www.nejm.org/doi/full/10....
September 14, 2025 at 2:48 PM
Chocolate intake is associated with the number of Nobel Prize recipients.
Source NEJM : www.nejm.org/doi/full/10....
Source NEJM : www.nejm.org/doi/full/10....
Happy programmer’s day!
To all the builders, creators, and problem-solvers: Happy #ProgrammersDay! 🎉
September 13, 2025 at 1:34 PM
Happy programmer’s day!
Reposted by Alessandro Nascimento
If you're an undergrad and want to intern with me, this is where you need to apply!
The Microsoft Research Undergraduate Internship Program offers 12-week internships in our Redmond, NYC, or New England labs for rising juniors and seniors who are passionate about technology. Apply by October 6: msft.it/6015scgSJ
September 13, 2025 at 10:42 AM
If you're an undergrad and want to intern with me, this is where you need to apply!