Arun Thiruvalluvan
@arunthiruvalluvan.bsky.social
Postdoc studies Protein quality control, Protein aggregation and Neural development. Current: UZH and USZ 🇨🇭. Prev: reNEW_Global 🇩🇰, Univgroningen-kampinga lab and UMCG_ERIBA 🇳🇱, NCBS_Bangalore 🇮🇳.
Reposted by Arun Thiruvalluvan
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
The functional landscape of the human ubiquitinome
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...
www.biorxiv.org
October 9, 2025 at 7:07 AM
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
Reposted by Arun Thiruvalluvan
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
October 7, 2025 at 5:49 PM
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Saddened to hear the passing of John Gurdon. I had the pleasure of meeting him in early 2010 at NCBS when I was a graduate trainee, and I will never forget his amazing personality and the inspiring conversation.
“For Gurdon to continue in biology would be a complete waste of time both for him and for those who would have to teach him”
He proved them wrong! RIP John Gurdon
www.cell.com/current-biol...
He proved them wrong! RIP John Gurdon
www.cell.com/current-biol...
John Gurdon
John Gurdon is at the Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental
Biology in Cambridge. Educated at Eton and Christ Church, Oxford, he changed from
classics to zoology. Dur...
www.cell.com
October 7, 2025 at 8:09 PM
Saddened to hear the passing of John Gurdon. I had the pleasure of meeting him in early 2010 at NCBS when I was a graduate trainee, and I will never forget his amazing personality and the inspiring conversation.
Reposted by Arun Thiruvalluvan
Big day at @humantechnopole.bsky.social with today's PhD & Postdoc Symposium providing a stellar line up of speakers and poster presenters. This year's theme is 'Research in Motion: Dynamics in Time, Space, and Technology'. So much exciting science to enjoy!
September 30, 2025 at 8:53 AM
Big day at @humantechnopole.bsky.social with today's PhD & Postdoc Symposium providing a stellar line up of speakers and poster presenters. This year's theme is 'Research in Motion: Dynamics in Time, Space, and Technology'. So much exciting science to enjoy!
Reposted by Arun Thiruvalluvan
🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…
September 27, 2025 at 2:13 PM
🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…
Reposted by Arun Thiruvalluvan
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
September 22, 2025 at 9:37 AM
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
Reposted by Arun Thiruvalluvan
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
September 22, 2025 at 6:27 PM
🚀 Our new paper is out @natmethods.nature.com!
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells.
🔗 www.nature.com/articles/s41...
🧬 www.addgene.org/John_Ngo/
Reposted by Arun Thiruvalluvan
Apparently, chimpanzees consume equivalent of 1-2 standard alcoholic drinks per day in the wild via fermented fruit!! (h/t Nick Villarino)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Ethanol ingestion via frugivory in wild chimpanzees
Natural daily consumption of dietary alcohol by chimpanzees suggests human attraction to alcohol may come from our ancestral diet.
www.science.org
September 18, 2025 at 3:45 PM
Apparently, chimpanzees consume equivalent of 1-2 standard alcoholic drinks per day in the wild via fermented fruit!! (h/t Nick Villarino)
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Arun Thiruvalluvan
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
September 17, 2025 at 5:38 PM
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
Reposted by Arun Thiruvalluvan
Very happy that I had the chance to contribute to this amazing work describing the role of transposable elements in Parkinson’s Disease. 🧠🧬
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
www.biorxiv.org
September 8, 2025 at 4:36 PM
Very happy that I had the chance to contribute to this amazing work describing the role of transposable elements in Parkinson’s Disease. 🧠🧬
Reposted by Arun Thiruvalluvan
Fantastic collaboration with labs of @kirkebylab.bsky.social @mollygale.bsky.social and Roger Barker. Outstanding support from @asapresearch.parkinsonsroadmap.org
September 7, 2025 at 7:59 PM
Fantastic collaboration with labs of @kirkebylab.bsky.social @mollygale.bsky.social and Roger Barker. Outstanding support from @asapresearch.parkinsonsroadmap.org
Reposted by Arun Thiruvalluvan
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
www.biorxiv.org
September 7, 2025 at 7:59 PM
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Arun Thiruvalluvan
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.03.673956v1
September 7, 2025 at 8:15 PM
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease https://www.biorxiv.org/content/10.1101/2025.09.03.673956v1
Reposted by Arun Thiruvalluvan
New collaborative paper from our lab! We developed cell-type specific transcriptional ageing clocks using snRNA-seq data from human brain.
doi.org/10.1002/advs...
doi.org/10.1002/advs...
Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Muralidharan and colleagues develop cell-type-specific transcriptomic aging clocks using single-nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict ....
doi.org
August 29, 2025 at 6:04 PM
New collaborative paper from our lab! We developed cell-type specific transcriptional ageing clocks using snRNA-seq data from human brain.
doi.org/10.1002/advs...
doi.org/10.1002/advs...
Reposted by Arun Thiruvalluvan
New from the lab: Fatty Acid Metabolism Sets the Species-specific Tempo of Cortical Development through Protein Acetylation Dynamics. Led by amazing trio: @ryo2iwata.bsky.social , Isabel Gallego, @emirerkol.bsky.social, together with @steinaerts.bsky.social , @fendtlab.bsky.social
Species-specific Rates of Fatty Acid Metabolism Set the Scale of Temporal Patterning of Corticogenesis through Protein Acetylation Dynamics
Developmental processes display temporal differences across species, leading to divergence in organ size and composition. In the cerebral cortex, neurons of diverse identities are generated sequential...
www.biorxiv.org
September 3, 2025 at 12:19 PM
New from the lab: Fatty Acid Metabolism Sets the Species-specific Tempo of Cortical Development through Protein Acetylation Dynamics. Led by amazing trio: @ryo2iwata.bsky.social , Isabel Gallego, @emirerkol.bsky.social, together with @steinaerts.bsky.social , @fendtlab.bsky.social
Reposted by Arun Thiruvalluvan
Beautiful work from Nan Xu and the @studerl.bsky.social lab in @natcellbio.nature.com combining directed differentiation of hPSCs and genome-wide CRISPR screens to identify the epigenetic factors Menin and SUZ12 as regulators of developmental pace across germ layers.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genome-wide CRISPR screen identifies Menin and SUZ12 as regulators of human developmental timing - Nature Cell Biology
Xu et al. perform a whole-genome CRISPR-Cas9 knockout screen using directed differentiation systems. They find that MEN1 and SUZ12 modulate human developmental timing by epigenetically controlling biv...
www.nature.com
September 3, 2025 at 6:14 AM
Beautiful work from Nan Xu and the @studerl.bsky.social lab in @natcellbio.nature.com combining directed differentiation of hPSCs and genome-wide CRISPR screens to identify the epigenetic factors Menin and SUZ12 as regulators of developmental pace across germ layers.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Arun Thiruvalluvan
💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social
bit.ly/47b3Mjk
bit.ly/47b3Mjk
A multichaperone condensate enhances protein folding in the endoplasmic reticulum - Nature Cell Biology
Leder et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins.
bit.ly
August 22, 2025 at 5:36 PM
💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social
bit.ly/47b3Mjk
bit.ly/47b3Mjk
Reposted by Arun Thiruvalluvan
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent
stem cells and are dynamically regulated throughout neural differentiation. The study
examines the role of L1s...
www.cell.com
August 23, 2025 at 9:47 AM
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Reposted by Arun Thiruvalluvan
Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes - Nature Neuroscience
The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essen...
www.nature.com
August 22, 2025 at 10:15 PM
Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com!
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab.
www.nature.com/articles/s41...
Reposted by Arun Thiruvalluvan
12 examples of how developmental biology research led to fundamental discoveries for biomedical research. There are many more! Download ppt & jpg versions on @socdevbio.bsky.social website. Use & modify as needed. Poster formats are also posted to print & hang in your lab!
March 26, 2025 at 2:04 PM
12 examples of how developmental biology research led to fundamental discoveries for biomedical research. There are many more! Download ppt & jpg versions on @socdevbio.bsky.social website. Use & modify as needed. Poster formats are also posted to print & hang in your lab!
Reposted by Arun Thiruvalluvan
New paper alert! Stellar work by brilliant lead first author @annaleder.bsky.social together with project leader @masgu.bsky.social reveals a groundbreaking discovery: PDIA6 forms multi-chaperone condensates creating "folding factories" in the ER. www.nature.com/articles/s41...
August 11, 2025 at 9:10 AM
New paper alert! Stellar work by brilliant lead first author @annaleder.bsky.social together with project leader @masgu.bsky.social reveals a groundbreaking discovery: PDIA6 forms multi-chaperone condensates creating "folding factories" in the ER. www.nature.com/articles/s41...
Reposted by Arun Thiruvalluvan
Are you creative? Curious? Science-savvy?
We have a unique opportunity to join the LMB’s VisLab as a Photographer / Videographer where you’ll help communicate ground-breaking research with dynamic visuals.
Apply now: mrc.tal.net/vx/mobile-0/...
#CambridgeJobs #PhotographyJobs #ScienceCommunication
We have a unique opportunity to join the LMB’s VisLab as a Photographer / Videographer where you’ll help communicate ground-breaking research with dynamic visuals.
Apply now: mrc.tal.net/vx/mobile-0/...
#CambridgeJobs #PhotographyJobs #ScienceCommunication
July 22, 2025 at 8:19 AM
Are you creative? Curious? Science-savvy?
We have a unique opportunity to join the LMB’s VisLab as a Photographer / Videographer where you’ll help communicate ground-breaking research with dynamic visuals.
Apply now: mrc.tal.net/vx/mobile-0/...
#CambridgeJobs #PhotographyJobs #ScienceCommunication
We have a unique opportunity to join the LMB’s VisLab as a Photographer / Videographer where you’ll help communicate ground-breaking research with dynamic visuals.
Apply now: mrc.tal.net/vx/mobile-0/...
#CambridgeJobs #PhotographyJobs #ScienceCommunication
Reposted by Arun Thiruvalluvan
This is so cool! It’s beautiful to see exactly the kind of elegant genetic locus swapping experiments I’ve been hoping to see in the field 🤩 Nice work Debby and team!
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature
HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...
www.nature.com
May 20, 2025 at 8:59 AM
This is so cool! It’s beautiful to see exactly the kind of elegant genetic locus swapping experiments I’ve been hoping to see in the field 🤩 Nice work Debby and team!
Reposted by Arun Thiruvalluvan
We’re proud to announce a new collaboration between ASAP’s CRN Cloud & @alleninstitute.org’s Brain Cell Atlas to help researchers use a common language when studying brain cells and unlock insights into #Parkinsons & other #neurodegenerative diseases.
🧪Explore: portal.brain-map.org/atlases-and-...
🧪Explore: portal.brain-map.org/atlases-and-...
July 16, 2025 at 3:20 PM
We’re proud to announce a new collaboration between ASAP’s CRN Cloud & @alleninstitute.org’s Brain Cell Atlas to help researchers use a common language when studying brain cells and unlock insights into #Parkinsons & other #neurodegenerative diseases.
🧪Explore: portal.brain-map.org/atlases-and-...
🧪Explore: portal.brain-map.org/atlases-and-...
Reposted by Arun Thiruvalluvan
A 🧵 to walk those interested through this paper...
Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Repeat-element RNAs integrate a neuronal growth circuit
SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are
induced by nerve lesion to regulate protein synthesis and enhance axonal growth.
www.cell.com
May 16, 2025 at 4:50 PM
A 🧵 to walk those interested through this paper...