Apu Akkad
@apuid.bsky.social
Physician - Transplant Infectious Disease #TxID, Asst Prof of Medicine @keckmedusc | Boston sports fan | views my own
#IDsky #Medsky
#IDsky #Medsky
Reposted by Apu Akkad
And people are saying the child didn’t die of “measles.” Yet another tragedy
A 2nd child dies of measles in TX. Cause? Acute respiratory failure.
“This is a tragedy, an absolutely needless death,” said Dr. Peter Marks, former FDA official. Vaccines prevent measles, not vitamin A or cod liver oil.
shorturl.at/gZ4c2 #BlueSky #MedSky #IDSky #EMSky #SciSky #PedSky #NurseSky
“This is a tragedy, an absolutely needless death,” said Dr. Peter Marks, former FDA official. Vaccines prevent measles, not vitamin A or cod liver oil.
shorturl.at/gZ4c2 #BlueSky #MedSky #IDSky #EMSky #SciSky #PedSky #NurseSky
A Second Child Dies of Measles in Texas
It is the second confirmed measles death in the U.S. in a decade. If the outbreak continues at the current pace, the nation may lose its elimination status.
shorturl.at
April 6, 2025 at 6:04 PM
And people are saying the child didn’t die of “measles.” Yet another tragedy
Reposted by Apu Akkad
From @drtoddlee.bsky.social @dremilymcd.bsky.social @angelahuttner.bsky.social @josemolinagb.bsky.social et al in @jama.com Network Open:
Systematic review & Non-inferiority Meta-Analysis of 7 vs 14 days for GNR BSI
4 RCTs, 7 non-inf to 14
#IDSky #ShorterIsBetter
jamanetwork.com/journals/jam...
Systematic review & Non-inferiority Meta-Analysis of 7 vs 14 days for GNR BSI
4 RCTs, 7 non-inf to 14
#IDSky #ShorterIsBetter
jamanetwork.com/journals/jam...
March 23, 2025 at 5:20 PM
From @drtoddlee.bsky.social @dremilymcd.bsky.social @angelahuttner.bsky.social @josemolinagb.bsky.social et al in @jama.com Network Open:
Systematic review & Non-inferiority Meta-Analysis of 7 vs 14 days for GNR BSI
4 RCTs, 7 non-inf to 14
#IDSky #ShorterIsBetter
jamanetwork.com/journals/jam...
Systematic review & Non-inferiority Meta-Analysis of 7 vs 14 days for GNR BSI
4 RCTs, 7 non-inf to 14
#IDSky #ShorterIsBetter
jamanetwork.com/journals/jam...
Reposted by Apu Akkad
Prevalence of injecting-related bacterial and fungal infection among people who inject drugs: a systematic review and meta-analysis
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Prevalence of injecting-related bacterial and fungal infection among people who inject drugs: a systematic review and meta-analysis
Despite increasing burden of injecting-related bacterial and fungal infection, there has been no recent synthesis of their epidemiology. We performed a systematic review and meta-analysis evaluating prevalence and incidence of injecting-related infection among people who inject drugs.
buff.ly
March 2, 2025 at 10:11 PM
Prevalence of injecting-related bacterial and fungal infection among people who inject drugs: a systematic review and meta-analysis
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Reposted by Apu Akkad
If someone thinks the measles outbreak and childhood death in Texas are "not unusual" or "happens all the time", they are deeply misinformed. h/t @adamratnermd.bsky.social for the inspiration.
blogs.jwatch.org/hiv-id-obser...
blogs.jwatch.org/hiv-id-obser...
Tragic Childhood Death from Measles Reminds Us That Some Don't Understand Either the Medical Significance or the Human Heart
My ID colleague Dr. Adam Ratner, Chief of Pediatric ID at NYU Medical Center, just published an insightful and remarkably timely book called Booster Shots: The Urgent Lessons of Measles and the Uncer...
blogs.jwatch.org
February 27, 2025 at 9:14 PM
If someone thinks the measles outbreak and childhood death in Texas are "not unusual" or "happens all the time", they are deeply misinformed. h/t @adamratnermd.bsky.social for the inspiration.
blogs.jwatch.org/hiv-id-obser...
blogs.jwatch.org/hiv-id-obser...
Madness for sure!
We’re not just treating asymptomatic bacteriuria—we’re also treating asymptomatic pyuria and nitrituria(ASPN). Madness!
🆕💫Study found ASPN led to 40% more unnecessary antibiotic use than ASB. Time to rethink our approach! #IDsky
cambridge.org/core/journals/…www.cambridge.org/core/journal...09
🆕💫Study found ASPN led to 40% more unnecessary antibiotic use than ASB. Time to rethink our approach! #IDsky
cambridge.org/core/journals/…www.cambridge.org/core/journal...09
February 19, 2025 at 8:46 PM
Madness for sure!
Reposted by Apu Akkad
New pre-print from folks @ Copenhagen University Hospital:
🔬 28-month WGS surveillance
🦠 7,760 patient infections
📊 27.1% genetically related, 69% w/ epi link
💰 €1.25M net savings/year if acted upon/prevented!
#IDSky more great evidence for WGS for IP&C
📄: www.medrxiv.org/content/10.1...
🔬 28-month WGS surveillance
🦠 7,760 patient infections
📊 27.1% genetically related, 69% w/ epi link
💰 €1.25M net savings/year if acted upon/prevented!
#IDSky more great evidence for WGS for IP&C
📄: www.medrxiv.org/content/10.1...
February 19, 2025 at 1:50 AM
New pre-print from folks @ Copenhagen University Hospital:
🔬 28-month WGS surveillance
🦠 7,760 patient infections
📊 27.1% genetically related, 69% w/ epi link
💰 €1.25M net savings/year if acted upon/prevented!
#IDSky more great evidence for WGS for IP&C
📄: www.medrxiv.org/content/10.1...
🔬 28-month WGS surveillance
🦠 7,760 patient infections
📊 27.1% genetically related, 69% w/ epi link
💰 €1.25M net savings/year if acted upon/prevented!
#IDSky more great evidence for WGS for IP&C
📄: www.medrxiv.org/content/10.1...
Nice collaborative study on valley fever prophylaxis in solid organ (non lung) transplant recipients
#IDsky #TxID
onlinelibrary.wiley.com/doi/10.1111/...
#IDsky #TxID
onlinelibrary.wiley.com/doi/10.1111/...
Coccidioidomycosis Prophylaxis in Liver, Kidney, and Heart Transplant Recipients Residing in Endemic Areas Within the United States
Our data suggests that abdominal organ transplant recipients residing in CM-endemic areas with no prior CM exposure may not require CM prophylaxis. Therefore, we recommend implementing a shared decis...
onlinelibrary.wiley.com
February 18, 2025 at 4:31 PM
Nice collaborative study on valley fever prophylaxis in solid organ (non lung) transplant recipients
#IDsky #TxID
onlinelibrary.wiley.com/doi/10.1111/...
#IDsky #TxID
onlinelibrary.wiley.com/doi/10.1111/...
But at least none of them will have autism, isn’t that right, RFK?
Measles cases rising in a Texas County. Measles hospitalizations rising, all in unvaccinated patients. Most are children. There are many things that RFK Jr could do to try to control this outbreak. I suspect he will do none of them.
#PedSky #MedSky
www.usatoday.com/story/news/h...
#PedSky #MedSky
www.usatoday.com/story/news/h...
Measles cases are rising in the US as Texas outbreak spreads: Here's what to know
Texas state health officials confirmed 24 cases of measles, as New Mexico announced its first case this year in a county on the state border.
www.usatoday.com
February 14, 2025 at 10:58 PM
But at least none of them will have autism, isn’t that right, RFK?
Very true. Cocci serologies not always reliable, especially in the immunocompromised hosts.
Ag helpful, but if truly high suspicion — I’d start treatment.
#TxID#IDsky
Ag helpful, but if truly high suspicion — I’d start treatment.
#TxID#IDsky
Coccidioides serology is not very reliable to diagnose coccidioidomycosis in hematological malignancy patients, and that's why antigen test should always be added.
#IDSky #MedMyco #IDOnc #TxID
#IDSky #MedMyco #IDOnc #TxID
Sensitivity of Coccidioides serologic tests among culture-proven coccidioidomycosis patients with hematological malignancy compared to a matched immunocompetent cohort
Abstract. Coccidioidomycosis is associated with an increased risk of mortality and morbidity among immunosuppressed patients. The sensitivity of current co
academic.oup.com
February 9, 2025 at 8:02 PM
Very true. Cocci serologies not always reliable, especially in the immunocompromised hosts.
Ag helpful, but if truly high suspicion — I’d start treatment.
#TxID#IDsky
Ag helpful, but if truly high suspicion — I’d start treatment.
#TxID#IDsky
Not sure why the mavs wanted to get rid of Luka so badly….there must be a lot more to this story
February 2, 2025 at 10:09 PM
Not sure why the mavs wanted to get rid of Luka so badly….there must be a lot more to this story
Can anyone explain what the Trump admin is trying to accomplish by doing this?? Of course they want censorship and to “MAHA” however hiv and Sti treatments are all factual and based on significant evidence, and do not seem to be going against any pseudoscience. Purge all current information?
‼️ CDC STI guidelines, Doxypep, PrEP guidelines all seem to be GONE ‼️
I have the STI, HIV, and ACIP ones. Working on seeing if @pidsociety.bsky.social or @idsainfo.bsky.social can host copies of things.
Does anybody have the cdc doxy pep guidelines downloaded on their computer?
#idsky #pedsidsky
I have the STI, HIV, and ACIP ones. Working on seeing if @pidsociety.bsky.social or @idsainfo.bsky.social can host copies of things.
Does anybody have the cdc doxy pep guidelines downloaded on their computer?
#idsky #pedsidsky
February 1, 2025 at 5:35 PM
Can anyone explain what the Trump admin is trying to accomplish by doing this?? Of course they want censorship and to “MAHA” however hiv and Sti treatments are all factual and based on significant evidence, and do not seem to be going against any pseudoscience. Purge all current information?
jamanetwork.com/journals/jam...
Important for physicians to not sit on the sidelines during this important time. Mass amounts of medical information and FACTs are being deleted, censored from the public and healthcare alike. This admin promised transparency but instead are getting censorship.
Important for physicians to not sit on the sidelines during this important time. Mass amounts of medical information and FACTs are being deleted, censored from the public and healthcare alike. This admin promised transparency but instead are getting censorship.
How Should Health Care and Public Health Respond to the New US Administration?
This Viewpoint discusses scientific, medical, and public health actions, including withdrawing from the World Health Organization, taken so far during the first week of the Trump administration.
jamanetwork.com
February 1, 2025 at 5:28 PM
jamanetwork.com/journals/jam...
Important for physicians to not sit on the sidelines during this important time. Mass amounts of medical information and FACTs are being deleted, censored from the public and healthcare alike. This admin promised transparency but instead are getting censorship.
Important for physicians to not sit on the sidelines during this important time. Mass amounts of medical information and FACTs are being deleted, censored from the public and healthcare alike. This admin promised transparency but instead are getting censorship.
I’m very scared to see what happens to PubMed
February 1, 2025 at 5:07 PM
Reposted by Apu Akkad
Post-hoc analysis of 📷 📷 study in MSSA/MRSA bacteremia:
Persistent fever = indicator for complicated infection
Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)
🚫 assn between ⬆️CRP/WBC and mortality
#IDSky
academic.oup.com/ofid/advance...
Persistent fever = indicator for complicated infection
Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)
🚫 assn between ⬆️CRP/WBC and mortality
#IDSky
academic.oup.com/ofid/advance...
Association of daily body temperature, white blood cell count, and C-reactive protein with mortality and persistent bacteremia in patients with Staphylococcus aureus bacteremia: a post-hoc analysis of...
AbstractIntroduction. Classification of patients with Staphylococcus aureus bacteremia (SAB) as complicated versus uncomplicated is based on a combination
academic.oup.com
January 31, 2025 at 2:33 AM
Post-hoc analysis of 📷 📷 study in MSSA/MRSA bacteremia:
Persistent fever = indicator for complicated infection
Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)
🚫 assn between ⬆️CRP/WBC and mortality
#IDSky
academic.oup.com/ofid/advance...
Persistent fever = indicator for complicated infection
Fever on Day 4️⃣: aOR (3.7 (95% CI: 1.58-8.67)) mortality
Fever on Day 7️⃣: aOR: (8.78 (95% CI: 2.78-27.7)
🚫 assn between ⬆️CRP/WBC and mortality
#IDSky
academic.oup.com/ofid/advance...
67 active cases of TB, likely to represent many more. Important for CDC to be on top of this, if they are allowed to..
1/27/25 CIDRAP: Kansas tuberculosis outbreak now largest in US buff.ly/42vlCLH
The largest US Tuberculosis outbreak is happening in Kansas City now with 67 active TB cases and 79 latent cases reported since the beginning of 2024.
#medsky #IDsky 🛟😷
The largest US Tuberculosis outbreak is happening in Kansas City now with 67 active TB cases and 79 latent cases reported since the beginning of 2024.
#medsky #IDsky 🛟😷
Kansas tuberculosis outbreak now largest in US
Sixty-seven active TB cases and 79 latent TB cases have been reported in 2 Kansas counties since the beginning of 2024.
buff.ly
January 29, 2025 at 10:06 PM
67 active cases of TB, likely to represent many more. Important for CDC to be on top of this, if they are allowed to..
Reposted by Apu Akkad
How to prevent infections in the increasingly immunocompromised traveler? Part 1 (non-transplant) is out now! Stay tuned for part 2!
@ritawilson.bsky.social @andhen25.bsky.social @ou.edu
#IDSky #TxID
journals.sagepub.com/doi/10.1177/...
@ritawilson.bsky.social @andhen25.bsky.social @ou.edu
#IDSky #TxID
journals.sagepub.com/doi/10.1177/...
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
January 23, 2025 at 12:56 PM
How to prevent infections in the increasingly immunocompromised traveler? Part 1 (non-transplant) is out now! Stay tuned for part 2!
@ritawilson.bsky.social @andhen25.bsky.social @ou.edu
#IDSky #TxID
journals.sagepub.com/doi/10.1177/...
@ritawilson.bsky.social @andhen25.bsky.social @ou.edu
#IDSky #TxID
journals.sagepub.com/doi/10.1177/...
Very nice study on a very important and common issue. Does this hold true in the SOT population as well?
Out now in @thetxidjournal.bsky.social!
T-SPOT.TB is more likely to produce actionable results than QFT-TB in patients with cancer being screened for latent TB.
#TxID #IDSky
onlinelibrary.wiley.com/doi/10.1111/...
T-SPOT.TB is more likely to produce actionable results than QFT-TB in patients with cancer being screened for latent TB.
#TxID #IDSky
onlinelibrary.wiley.com/doi/10.1111/...
January 18, 2025 at 5:07 PM
Very nice study on a very important and common issue. Does this hold true in the SOT population as well?
Excellent review on herpesviruses post car T.
Out now, everything you need to know, that is known and not known, about herpesviruses after CAR T and BsAb, in our review with Dr Emily Siegrist and Dr Roy Chemaly!
@mdanderson.bsky.social @ou.edu
#IDSky #TxID
www.mdpi.com/1999-4915/17...
@mdanderson.bsky.social @ou.edu
#IDSky #TxID
www.mdpi.com/1999-4915/17...
Herpesvirus Infections After Chimeric Antigen Receptor T-Cell Therapy and Bispecific Antibodies: A Review
In this narrative review, we explore the burden and risk factors of various herpesvirus infections in patients receiving chimeric antigen receptor T-cell (CAR-T) therapy or bispecific antibodies (BsAb...
www.mdpi.com
January 18, 2025 at 5:03 PM
Excellent review on herpesviruses post car T.
Exciting new field. Recent review I wrote as well. Fungal diagnostics always a challenge but new promising methods starting to be utilized.
#IDsky #TxIDsky
www.mdpi.com/2309-608X/11...
#IDsky #TxIDsky
www.mdpi.com/2309-608X/11...
January 18, 2025 at 5:01 PM
Exciting new field. Recent review I wrote as well. Fungal diagnostics always a challenge but new promising methods starting to be utilized.
#IDsky #TxIDsky
www.mdpi.com/2309-608X/11...
#IDsky #TxIDsky
www.mdpi.com/2309-608X/11...
This is basically better than a current patriots game for a pats fan
Brady in the booth AND Gronk at halftime?
Is this what a concussion feels like?
Is this what a concussion feels like?
January 12, 2025 at 11:32 PM
This is basically better than a current patriots game for a pats fan
Everyone in LA expresses their immense gratitude to @lafd.bsky.social for their tremendous courage and commitment to putting out the #LAwildfires
January 12, 2025 at 7:57 PM
Everyone in LA expresses their immense gratitude to @lafd.bsky.social for their tremendous courage and commitment to putting out the #LAwildfires
Reposted by Apu Akkad
The Emerging Threat of H5N1 to Human Health
@michaelisonmd.bsky.social and @drjeannem.bsky.social in @nejm.org
www.nejm.org/doi/full/10....
@michaelisonmd.bsky.social and @drjeannem.bsky.social in @nejm.org
www.nejm.org/doi/full/10....
The Emerging Threat of H5N1 to Human Health | NEJM
Highly pathogenic avian influenza (HPAI) A(H5N1) emerged in 1997.1 Since then, it has spread globally by migratory birds, resulting in infections in animals on every continent. HPAI A(H5N1) clade 2...
www.nejm.org
January 1, 2025 at 4:38 PM
The Emerging Threat of H5N1 to Human Health
@michaelisonmd.bsky.social and @drjeannem.bsky.social in @nejm.org
www.nejm.org/doi/full/10....
@michaelisonmd.bsky.social and @drjeannem.bsky.social in @nejm.org
www.nejm.org/doi/full/10....