Anjali Hinch
@anjalihinch.bsky.social
Statistical and Experimental Geneticist @ Oxford University | Henry Dale, Wellcome-Beit & Royal Society Fellow | Group Leader, Dunn School of Pathology, Oxford
germlinegenomics.web.ox.ac.uk
germlinegenomics.web.ox.ac.uk
Pinned
Anjali Hinch
@anjalihinch.bsky.social
· Nov 26
Welcome to Bluesky, friends and colleagues from population genetics and meiosis. Great to see you all here!
Reposted by Anjali Hinch
Yet another outstanding recruit to @dunnschool.bsky.social!
Really looking forward to having Alex Borodavka as a new colleague
Really looking forward to having Alex Borodavka as a new colleague
We are delighted to announce that Alex Borodavka will soon be joining us as Associate Professor!
The Borodavka group investigates RNA viruses, particularly rotaviruses, and how their genomes are segmented to ensure successful replication.
Find out more: www.path.ox.ac.uk/news-article...
The Borodavka group investigates RNA viruses, particularly rotaviruses, and how their genomes are segmented to ensure successful replication.
Find out more: www.path.ox.ac.uk/news-article...
Alexander Borodavka appointed Associate Professor of Cell and Molecular Biology - Dunn School
Dr. Borodavka’s recruitment further strengthens the department’s research on viral biology and infection.
www.path.ox.ac.uk
October 17, 2025 at 4:59 PM
Yet another outstanding recruit to @dunnschool.bsky.social!
Really looking forward to having Alex Borodavka as a new colleague
Really looking forward to having Alex Borodavka as a new colleague
Reposted by Anjali Hinch
Congratulations to the Dunn School postdocs starting their independent research groups across the UK, Germany and China 🥳
- Iqbal Dulloo (@iqbaldulloo.bsky.social)
- Marion Schuller (@schullerm.bsky.social)
- Yongxu Lu
- João Monteiro
www.path.ox.ac.uk/news-article...
- Iqbal Dulloo (@iqbaldulloo.bsky.social)
- Marion Schuller (@schullerm.bsky.social)
- Yongxu Lu
- João Monteiro
www.path.ox.ac.uk/news-article...
Dunn School postdocs start new PI positions - Dunn School
Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.
www.path.ox.ac.uk
October 14, 2025 at 2:44 PM
Congratulations to the Dunn School postdocs starting their independent research groups across the UK, Germany and China 🥳
- Iqbal Dulloo (@iqbaldulloo.bsky.social)
- Marion Schuller (@schullerm.bsky.social)
- Yongxu Lu
- João Monteiro
www.path.ox.ac.uk/news-article...
- Iqbal Dulloo (@iqbaldulloo.bsky.social)
- Marion Schuller (@schullerm.bsky.social)
- Yongxu Lu
- João Monteiro
www.path.ox.ac.uk/news-article...
Reposted by Anjali Hinch
A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]
Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...
Somatic mutation and selection at population scale - Nature
A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.
www.nature.com
October 9, 2025 at 3:29 PM
A short thread. For years, I have been surprised by how much confusion our discovery of clones carrying cancer-driver mutations in normal tissues has caused in the cancer community. Typical questions like: (1) if you see these mutations in normal cells, are they really cancer drivers?... [1/4]
Reposted by Anjali Hinch
🔁 Please share - we remind the SMBE community that the Call for Symposia for SMBE2026 in Copenhagen is open.
We invite you to submit a symposium proposal to help shape the scientific content of our annual meeting.
🗓️ Deadline: October 15th
More information: smbe2026.org/symposia
#SMBE2026
We invite you to submit a symposium proposal to help shape the scientific content of our annual meeting.
🗓️ Deadline: October 15th
More information: smbe2026.org/symposia
#SMBE2026
October 1, 2025 at 8:33 AM
🔁 Please share - we remind the SMBE community that the Call for Symposia for SMBE2026 in Copenhagen is open.
We invite you to submit a symposium proposal to help shape the scientific content of our annual meeting.
🗓️ Deadline: October 15th
More information: smbe2026.org/symposia
#SMBE2026
We invite you to submit a symposium proposal to help shape the scientific content of our annual meeting.
🗓️ Deadline: October 15th
More information: smbe2026.org/symposia
#SMBE2026
Reposted by Anjali Hinch
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Collateral mutagenesis funnels multiple sources of DNA damage into a ubiquitous mutational signature
Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...
www.biorxiv.org
September 2, 2025 at 11:44 AM
In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
Reposted by Anjali Hinch
Another exciting opportunity @dunnschool.bsky.social !
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
We're hiring (again)!
We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)
If you have a great record and exciting plans, consider joining our thriving and welcoming department
www.path.ox.ac.uk/vacancy/asso...
We are looking for an associate professor in cell and molecular biology, with a particular focus on immunology (defined broadly)
If you have a great record and exciting plans, consider joining our thriving and welcoming department
www.path.ox.ac.uk/vacancy/asso...
September 10, 2025 at 1:34 PM
Another exciting opportunity @dunnschool.bsky.social !
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health
Please help us find great applicants
Reposted by Anjali Hinch
Our PhD studentship programme is officially open; pass it on
If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...
Great science and a great environment!
www.path.ox.ac.uk/news-article...
If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...
Great science and a great environment!
www.path.ox.ac.uk/news-article...
Applications now open for our PhD studentship programme - Dunn School
Applications are now open to apply for our four year, fully-funded PhD programme in Molecular Cell Biology in Health and Disease.
www.path.ox.ac.uk
September 8, 2025 at 11:15 AM
Our PhD studentship programme is officially open; pass it on
If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...
Great science and a great environment!
www.path.ox.ac.uk/news-article...
If you are looking for a fully-funded PhD in the mechanisms underlying human disease, here are the details...
Great science and a great environment!
www.path.ox.ac.uk/news-article...
Reposted by Anjali Hinch
Delighted to see this paper with @anaignatieva.bsky.social now published in Genetics!
academic.oup.com/genetics/adv...
We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵
academic.oup.com/genetics/adv...
We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵
Phantom epistasis through the lens of genealogies
Abstract. Phantom epistasis arises when, in the course of testing for gene-by-gene interactions, the omission of a causal variant with a purely additive ef
academic.oup.com
September 10, 2025 at 4:31 PM
Delighted to see this paper with @anaignatieva.bsky.social now published in Genetics!
academic.oup.com/genetics/adv...
We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵
academic.oup.com/genetics/adv...
We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵
Reposted by Anjali Hinch
SINGER, our ARG inference method, is finally published and freely available online:
doi.org/10.1038/s415...
It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...
doi.org/10.1038/s415...
It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...
Robust and accurate Bayesian inference of genome-wide genealogies for hundreds of genomes - Nature Genetics
SINGER is a method for creating ancestral recombination graphs to understand the genealogical history of genomes. The method has increased speed, and thus scalability, without sacrificing accuracy.
doi.org
September 11, 2025 at 3:50 AM
SINGER, our ARG inference method, is finally published and freely available online:
doi.org/10.1038/s415...
It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...
doi.org/10.1038/s415...
It was a long journey – 16 months from initial submission to acceptance. Is it just me, or has peer review gotten more arduous lately? 4+ rounds of review isn't so unusual these days...
Reposted by Anjali Hinch
New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...
Insight into Meiotic DNA End Resection: Mechanisms and Regulation
Meiosis generates reproductive cells with a reduced genome complement, with most species using homologous recombination to promote accurate meiotic ch…
www.sciencedirect.com
August 16, 2025 at 7:32 PM
New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...
Reposted by Anjali Hinch
📣 Applications now open 📣
We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!
Please share!
www.path.ox.ac.uk/work-with-us...
We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!
Please share!
www.path.ox.ac.uk/work-with-us...
July 30, 2025 at 1:51 PM
📣 Applications now open 📣
We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!
Please share!
www.path.ox.ac.uk/work-with-us...
We are seeking outstanding ECRs looking for a stimulating and supportive environment in which to establish their research group as externally-funded fellows, in any area or cell or molecular biology underlying disease!
Please share!
www.path.ox.ac.uk/work-with-us...
Reposted by Anjali Hinch
The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs:
probgen2026.github.io
Please help spread the news.
probgen2026.github.io
Please help spread the news.
Home - ProbGen 2026
Your Site Description
probgen2026.github.io
June 6, 2025 at 5:52 PM
The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs:
probgen2026.github.io
Please help spread the news.
probgen2026.github.io
Please help spread the news.
Reposted by Anjali Hinch
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Postdoctoral Research Associate in the Blackford Group
A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th
candidate.hr-manager.net
May 29, 2025 at 11:26 AM
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Reposted by Anjali Hinch
A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social
www.jobs.cam.ac.uk/job/51488/
www.jobs.cam.ac.uk/job/51488/
Research Assistant / Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant / Research Associate (Fixed Term) in the Department of Plant Sciences at the University of Cambridge.
www.jobs.cam.ac.uk
May 30, 2025 at 12:13 PM
A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @camplantsci.bsky.social
www.jobs.cam.ac.uk/job/51488/
www.jobs.cam.ac.uk/job/51488/
Wonderful talk by Yun today on the present and future of protein and DNA large language models. Spectacular!
Thrilled to see my digital art on the cover of Trends Genet. The two binary strings represent reverse-complementary DNA sequences (00=A, 01=C, 10=G, 11=T) and the connecting rectangles represent “embeddings” learned by DNA language models. Pls check out our article as well: doi.org/10.1016/j.ti...
May 30, 2025 at 6:33 PM
Wonderful talk by Yun today on the present and future of protein and DNA large language models. Spectacular!
Reposted by Anjali Hinch
Both translational and fundamental curiosity-driven research are needed to fuel the incredible progress we're seeing in genomic medicine; an important message in this article and and some lovely quotes from @sarahlwynn.bsky.social
www.ft.com/content/25dd...
www.ft.com/content/25dd...
Curiosity underlies a breakthrough in rare disease
We must recognise and protect the pipelines that lead from research to real-world benefit
www.ft.com
May 29, 2025 at 8:44 AM
Both translational and fundamental curiosity-driven research are needed to fuel the incredible progress we're seeing in genomic medicine; an important message in this article and and some lovely quotes from @sarahlwynn.bsky.social
www.ft.com/content/25dd...
www.ft.com/content/25dd...
Reposted by Anjali Hinch
Delighted to announce that Prof. Kevin Foster has been elected Fellow of @royalsociety.org!
This honour recognises the unique way he combines maths, ecology, evolution and microbiology to study microbial communities
Many congratulations Kevin!
Find out more: www.path.ox.ac.uk/news-article...
This honour recognises the unique way he combines maths, ecology, evolution and microbiology to study microbial communities
Many congratulations Kevin!
Find out more: www.path.ox.ac.uk/news-article...
Kevin Foster elected Fellow of the Royal Society - Dunn School
Many congratulations to Kevin for this prestigious honour, recognising his contribution to integrate ecological and evolutionary principles into microbiology to understand the human microbiome and oth...
www.path.ox.ac.uk
May 20, 2025 at 9:13 AM
Delighted to announce that Prof. Kevin Foster has been elected Fellow of @royalsociety.org!
This honour recognises the unique way he combines maths, ecology, evolution and microbiology to study microbial communities
Many congratulations Kevin!
Find out more: www.path.ox.ac.uk/news-article...
This honour recognises the unique way he combines maths, ecology, evolution and microbiology to study microbial communities
Many congratulations Kevin!
Find out more: www.path.ox.ac.uk/news-article...
Reposted by Anjali Hinch
Save the date! ProbGen 2026 will be hosted at UC Berkeley, March 25 to March 28, 2026. Featuring keynote speakers @jkpritch.bsky.social and Sally Otto. More details soon...
May 7, 2025 at 3:27 PM
Save the date! ProbGen 2026 will be hosted at UC Berkeley, March 25 to March 28, 2026. Featuring keynote speakers @jkpritch.bsky.social and Sally Otto. More details soon...
Reposted by Anjali Hinch
Amidst all the terrible and terrifying news, so lovely to hear of
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
April 29, 2025 at 8:52 PM
Amidst all the terrible and terrifying news, so lovely to hear of
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
@jkpritch.bsky.social's election to the National Academy of Sciences. Congratulations!
Reposted by Anjali Hinch
Nature research paper: Towards multimodal foundation models in molecular cell biology
https://go.nature.com/3YvGcbJ
https://go.nature.com/3YvGcbJ
Towards multimodal foundation models in molecular cell biology - Nature
The development of multimodal foundation models, pretrained on diverse omics datasets, to unravel the intricate complexities of molecular cell biology is envisioned.
go.nature.com
April 21, 2025 at 10:20 AM
Nature research paper: Towards multimodal foundation models in molecular cell biology
https://go.nature.com/3YvGcbJ
https://go.nature.com/3YvGcbJ
Reposted by Anjali Hinch
Tonight at 5.30pm on the BBC! 📺
The Foster group here at the the Dunn School will bring the science of the microbiome to ‘Operation Ouch!’, a popular children programme presented by Doctors Chris and Xand Van Tulleken. One to watch with your little ones! 👣🦠
www.path.ox.ac.uk/news-article...
The Foster group here at the the Dunn School will bring the science of the microbiome to ‘Operation Ouch!’, a popular children programme presented by Doctors Chris and Xand Van Tulleken. One to watch with your little ones! 👣🦠
www.path.ox.ac.uk/news-article...
March 5, 2025 at 4:39 PM
Tonight at 5.30pm on the BBC! 📺
The Foster group here at the the Dunn School will bring the science of the microbiome to ‘Operation Ouch!’, a popular children programme presented by Doctors Chris and Xand Van Tulleken. One to watch with your little ones! 👣🦠
www.path.ox.ac.uk/news-article...
The Foster group here at the the Dunn School will bring the science of the microbiome to ‘Operation Ouch!’, a popular children programme presented by Doctors Chris and Xand Van Tulleken. One to watch with your little ones! 👣🦠
www.path.ox.ac.uk/news-article...
Reposted by Anjali Hinch
Come work with me! Great opportunity for an enthusiastic Comms or events professional!
We are recruiting a centenary communications and events officer!
We have a spectacular history and our research has saved millions of lives. But we think the best is still to come. Help us mark this special occasion!
Deadline is the 17th of March. Please share!
my.corehr.com/pls/uoxrecru...
We have a spectacular history and our research has saved millions of lives. But we think the best is still to come. Help us mark this special occasion!
Deadline is the 17th of March. Please share!
my.corehr.com/pls/uoxrecru...
February 18, 2025 at 5:05 PM
Come work with me! Great opportunity for an enthusiastic Comms or events professional!
Reposted by Anjali Hinch
What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX
https://www.biorxiv.org/content/10.1101/2025.02.14.638102v1?ct=
t.co
February 18, 2025 at 2:51 PM
What an amazing discovery from Scott Kennedy's lab! A new splicing system that recognizes transposons and removes them from mRNAs! t.co/3p3wyxkYXX
Reposted by Anjali Hinch
New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social!
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
February 12, 2025 at 5:15 PM
New preprint from the @gerlichlab.bsky.social @imbavienna.bsky.social!
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵
How do DNA breaks locate homology sites in the vast space of the human genome? We show how cohesin guides homology search for faithful repair!
Read more 👉 https://doi.org/10.1101/2025.02.10
Follow along for key insights! 🧵