A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as hypbeaone A from Hypericum beanii.

Fluorescence imaging has become an indispensable tool in modern biology, enabling the visualisation of dynamic molecular processes with spatial and temporal precision. Traditional strategies rely heav...

Please take the time to complete our survey. Your feedback is important.

🚨 Looking for a new research opportunity?🚨 We are looking to recruit two talented postdocs to join our group based at the Molecular Science Research Hub at Imperial College London: - Both to join ou...

A modular synthetic strategy for the preparation of intrinsically fluorescent unnatural α-amino acids by C-2 oxidation and alkenylation of a tryptophan-derived tetrahydro-β-carboline is described.…

A series of unnatural amino acids featuring conjugated aryl–alkyne side chains was synthesized from tyrosine via a one-pot hydroxyl group activation and copper-free Sonogashira cross-coupling. This ef...

A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products, such as shimianolide A from Chloranthus…

A modular synthetic strategy for the preparation of intrinsically fluorescent unnatural α-amino acids by C-2 oxidation and alkenylation of a tryptophan-derived tetrahydro-β-carboline is described. Thi...

A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as melichuniione A from Melicope chunii.

We report two synthetic strategies for the preparation of dibenzofuran α-amino acids, expanding the structural toolbox of fluorescent probes. The strategies involved dibenzofuran synthesis via a Pd(II)-catalyzed C–O cyclization, alongside an efficient Negishi coupling approach for faster access to analogues. These rigid tyrosine mimics possess enhanced fluorescent properties compared to proteinogenic amino acids as demonstrated by application of the lead compound as a FRET donor for monitoring peptide hydrolysis by a serine protease.

To overcome the limitations of using large extrinsic chromophores for biological imaging, fluorescent unnatural α-amino acids have been widely adopted as intrinsic peptidic probes. Although various cl...

The sphingosine-1-phosphate-5 (S1P5) receptor is one of the five membrane G protein-coupled receptors that are activated by the lysophospholipid, sphingosine-1-phosphate, resulting in regulation of ma...

PhD Project - PhD in Chemistry - Development of Organic Synthetic Methods for the Discovery of Novel Fluorescent- and Radionuclide-Based Imaging Agents at University of Glasgow, listed on FindAPhD.com

This Special Issue will highlight the significant research activities at Primarily Undergraduate Institutions (PUIs) in the United States and their unique focus on fostering student engagement in STEM...

areppim X-Y scatter chart and statistics of the number of science Nobel prize winners (chemistry, physics and physiology or medicine) per capita, 1901 to 2024, the per capita index calculated as the n...

Serine recombinases are proposed to catalyse DNA site-specific recombination by a unique mechanism called subunit rotation. Here, the authors use single molecule FRET to provide direct structural and ...