Andrew Plygawko
@andrewplygawko.bsky.social
Postdoc in Kyra Campbell's lab at the University of Sheffield - EMT, polarity and midgut morphology.
Board game fan (not that I ever win) and musician (to the annoyance of everyone around me) when I'm not at the microscope
Board game fan (not that I ever win) and musician (to the annoyance of everyone around me) when I'm not at the microscope
Reposted by Andrew Plygawko
Check out new work @plosbiology.org from Daniel St Johnston´s lab visualizing how secretory cargo is targeted to apical vs. basolateral domains in #epithelial cells in real time. Nice collaboration highlighting the power of #RUSH in #Drosophila!
How are specific cargos targeted to apical & basolateral domains within #EpithelialCells? This study uses a novel #vesicle tracking software "MSP-tracker" to show that the secretory pathway in #Drosophila follicle cells is unexpectedly spatially organized @plosbiology.org 🧪 plos.io/3EfJsBp
April 18, 2025 at 10:02 AM
Check out new work @plosbiology.org from Daniel St Johnston´s lab visualizing how secretory cargo is targeted to apical vs. basolateral domains in #epithelial cells in real time. Nice collaboration highlighting the power of #RUSH in #Drosophila!
Reposted by Andrew Plygawko
🚨 Abstracts are due next week! 🚨
Submit your abstract to give a talk or poster at YEN 2025 by the 12th April!
Share this opportunity with dev bio and stem cell PhD students. The conference is FREE and full of great science.
We are looking forward to seeing you there!
Submit your abstract to give a talk or poster at YEN 2025 by the 12th April!
Share this opportunity with dev bio and stem cell PhD students. The conference is FREE and full of great science.
We are looking forward to seeing you there!
April 6, 2025 at 6:12 PM
🚨 Abstracts are due next week! 🚨
Submit your abstract to give a talk or poster at YEN 2025 by the 12th April!
Share this opportunity with dev bio and stem cell PhD students. The conference is FREE and full of great science.
We are looking forward to seeing you there!
Submit your abstract to give a talk or poster at YEN 2025 by the 12th April!
Share this opportunity with dev bio and stem cell PhD students. The conference is FREE and full of great science.
We are looking forward to seeing you there!
Reposted by Andrew Plygawko
Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...
March 19, 2025 at 5:31 PM
Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...
Reposted by Andrew Plygawko
I am thrilled to announce our latest #SingleCell manuscript: www.biorxiv.org/content/10.1...
We show that overactivation of Hh #signaling induces an EMT-like hybrid state in #Drosophila follicle cells. However, when we simultaneously overactivate EGFR/RAS signaling the cells form a lethal #cancer!
We show that overactivation of Hh #signaling induces an EMT-like hybrid state in #Drosophila follicle cells. However, when we simultaneously overactivate EGFR/RAS signaling the cells form a lethal #cancer!
Independent signaling pathways provide a fail-safe mechanism to prevent tumorigenesis
Controlled signaling activity is vital for normal tissue homeostasis and oncogenic signaling activation facilitates tumorigenesis. Here we use single-cell transcriptomics to investigate the effects of...
www.biorxiv.org
March 7, 2025 at 8:06 AM
I am thrilled to announce our latest #SingleCell manuscript: www.biorxiv.org/content/10.1...
We show that overactivation of Hh #signaling induces an EMT-like hybrid state in #Drosophila follicle cells. However, when we simultaneously overactivate EGFR/RAS signaling the cells form a lethal #cancer!
We show that overactivation of Hh #signaling induces an EMT-like hybrid state in #Drosophila follicle cells. However, when we simultaneously overactivate EGFR/RAS signaling the cells form a lethal #cancer!
Reposted by Andrew Plygawko
Spatial transcriptomics in fly brain and body. Wonderful collaboration with @steinaerts.bsky.social led by @jasperjanssens.bsky.social @pierremangeol.bsky.social Nikolai Hecker & Gabriele Partel - look at mRNA patterns in muscles and brains spatialfly.aertslab.org
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
March 6, 2025 at 8:58 AM
Spatial transcriptomics in fly brain and body. Wonderful collaboration with @steinaerts.bsky.social led by @jasperjanssens.bsky.social @pierremangeol.bsky.social Nikolai Hecker & Gabriele Partel - look at mRNA patterns in muscles and brains spatialfly.aertslab.org
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by Andrew Plygawko
An amazing system - trialed in our Facility @mvls-srf.bsky.social - with some stunning examples of what it can do, including from Ignacio (Nacho) Fernandez of the Sanz Lab, SMB @uofgmvls.bsky.social.
ZEISS LSM Lightfield 4D | High-speed Light Field Microscopy
Experience instant volumetric high-speed imaging of living organisms. Extend your LSM with Lightfield 4D for fast volume acquisition of dynamic processes.
www.zeiss.com
March 5, 2025 at 6:10 PM
An amazing system - trialed in our Facility @mvls-srf.bsky.social - with some stunning examples of what it can do, including from Ignacio (Nacho) Fernandez of the Sanz Lab, SMB @uofgmvls.bsky.social.
Reposted by Andrew Plygawko
Excited to welcome all our Dev Bio friends (and maybe even some Cell Biologists)
to Sheffield for the Northern(ish) England Developmental Biology meeting 10th July. We have some great speakers from the places in England where you get called Duck or Love and plenty of slots for ECR talks.
to Sheffield for the Northern(ish) England Developmental Biology meeting 10th July. We have some great speakers from the places in England where you get called Duck or Love and plenty of slots for ECR talks.
Development folks: the next Northern England Developmental Biology @bsdb.bsky.social @biologists.bsky.social meeting will take place on the 10th of July in Sheffield. Great speaker line-up, cheap registration fee and plenty of slots for ECR talks. Registration deadline=31/5, see poster for details
February 27, 2025 at 10:16 PM
Excited to welcome all our Dev Bio friends (and maybe even some Cell Biologists)
to Sheffield for the Northern(ish) England Developmental Biology meeting 10th July. We have some great speakers from the places in England where you get called Duck or Love and plenty of slots for ECR talks.
to Sheffield for the Northern(ish) England Developmental Biology meeting 10th July. We have some great speakers from the places in England where you get called Duck or Love and plenty of slots for ECR talks.
Reposted by Andrew Plygawko
The Northern England Developmental Biology @bsdb.bsky.social @biologists.bsky.social meeting takes place on July 10th in Sheffield. Register by May 31st - its gonna be cool 😎 (see the poster below for details)!
Development folks: the next Northern England Developmental Biology @bsdb.bsky.social @biologists.bsky.social meeting will take place on the 10th of July in Sheffield. Great speaker line-up, cheap registration fee and plenty of slots for ECR talks. Registration deadline=31/5, see poster for details
February 27, 2025 at 10:13 AM
The Northern England Developmental Biology @bsdb.bsky.social @biologists.bsky.social meeting takes place on July 10th in Sheffield. Register by May 31st - its gonna be cool 😎 (see the poster below for details)!
Reposted by Andrew Plygawko
Development folks: the next Northern England Developmental Biology @bsdb.bsky.social @biologists.bsky.social meeting will take place on the 10th of July in Sheffield. Great speaker line-up, cheap registration fee and plenty of slots for ECR talks. Registration deadline=31/5, see poster for details
February 20, 2025 at 1:53 PM
Development folks: the next Northern England Developmental Biology @bsdb.bsky.social @biologists.bsky.social meeting will take place on the 10th of July in Sheffield. Great speaker line-up, cheap registration fee and plenty of slots for ECR talks. Registration deadline=31/5, see poster for details
Reposted by Andrew Plygawko
After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
February 12, 2025 at 11:41 AM
After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Andrew Plygawko
New! 15y after the classic Aigouy et al "Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium..." from lab of much missed Suzanne Eaton, we provide our take from post-doc Sara Tan "Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing".
rdcu.be/d81Vn
rdcu.be/d81Vn
February 8, 2025 at 4:46 PM
New! 15y after the classic Aigouy et al "Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium..." from lab of much missed Suzanne Eaton, we provide our take from post-doc Sara Tan "Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing".
rdcu.be/d81Vn
rdcu.be/d81Vn
Reposted by Andrew Plygawko
Registration and abstract submission for YEN 2025 is officially open!
We are looking forward to seeing you at the 17th Young Embryologist Network Conference on the 19th May 2025.
Attendence is FREE thanks to our amazing sponsors: @biologists.bsky.social @10xgenomics.bsky.social and Azenta.
We are looking forward to seeing you at the 17th Young Embryologist Network Conference on the 19th May 2025.
Attendence is FREE thanks to our amazing sponsors: @biologists.bsky.social @10xgenomics.bsky.social and Azenta.
January 30, 2025 at 4:36 PM
Registration and abstract submission for YEN 2025 is officially open!
We are looking forward to seeing you at the 17th Young Embryologist Network Conference on the 19th May 2025.
Attendence is FREE thanks to our amazing sponsors: @biologists.bsky.social @10xgenomics.bsky.social and Azenta.
We are looking forward to seeing you at the 17th Young Embryologist Network Conference on the 19th May 2025.
Attendence is FREE thanks to our amazing sponsors: @biologists.bsky.social @10xgenomics.bsky.social and Azenta.
Reposted by Andrew Plygawko
Research Assistant/Associate Position in the lab. Fully funded until February 2028. Please apply if you are passionate about inter-organ signalling and intestinal biology...And off course, our wonderful Drosophila!
Position details and application link below
www.jobs.gla.ac.uk/job/research...
Position details and application link below
www.jobs.gla.ac.uk/job/research...
Research Assistant/Associate - Intestinal biology and interorgan signaling
Job Purpose We have a fully funded Research Assistant/Associate position available in the laboratory of Professor Julia Cordero. You will contribute to a project studying interorgan signaling coo...
www.jobs.gla.ac.uk
January 23, 2025 at 10:56 PM
Research Assistant/Associate Position in the lab. Fully funded until February 2028. Please apply if you are passionate about inter-organ signalling and intestinal biology...And off course, our wonderful Drosophila!
Position details and application link below
www.jobs.gla.ac.uk/job/research...
Position details and application link below
www.jobs.gla.ac.uk/job/research...
Reposted by Andrew Plygawko
Top Trumps - but make it science 🤓 I had the most fun designing these, and I've written about how you could use it in your outreach programme!
I'm keen to spread the word to any educators/academics who might be interested - please share 🤗 @nc3rs.bsky.social
thenode.biologists.com/biological-r...
I'm keen to spread the word to any educators/academics who might be interested - please share 🤗 @nc3rs.bsky.social
thenode.biologists.com/biological-r...
Biological Research Trump Cards: from fruit flies to stem cells... who will come out on top? - the Node
In 2023 I was awarded a NC3Rs 20th Anniversary Public Engagement Award to develop and print a "Biological Research Trump Cards" game. I have now designed
thenode.biologists.com
January 6, 2025 at 8:50 PM
Top Trumps - but make it science 🤓 I had the most fun designing these, and I've written about how you could use it in your outreach programme!
I'm keen to spread the word to any educators/academics who might be interested - please share 🤗 @nc3rs.bsky.social
thenode.biologists.com/biological-r...
I'm keen to spread the word to any educators/academics who might be interested - please share 🤗 @nc3rs.bsky.social
thenode.biologists.com/biological-r...
Reposted by Andrew Plygawko
Our new preprint is online www.biorxiv.org/content/10.1...
E-cadherin endocytosis promotes non-canonical EGFR:STAT signalling to induce cell death and inhibit heterochromatinisation
Signalling molecules often contribute to several signalling pathways that produce distinct transcriptional outputs and cellular phenotypes. One of the major unanswered questions in cell biology is how...
www.biorxiv.org
December 20, 2024 at 12:53 AM
Our new preprint is online www.biorxiv.org/content/10.1...
Reposted by Andrew Plygawko
"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 12, 2024 at 10:21 PM
"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...