David Strutt
@struttlab.bsky.social
Cell and developmental biology at the University of Sheffield unravelling the mysteries of planar polarity using Drosophila
Please do get in touch is you want to join our molecular and cellular biology community. Also look at out Development, Regeneration and Neurophysiology cluster, if that's a better fit:
sheffield.ac.uk/biosciences/...
We of course welcome people (like me!) that straddle the two
sheffield.ac.uk/biosciences/...
We of course welcome people (like me!) that straddle the two
January 30, 2026 at 3:51 PM
Please do get in touch is you want to join our molecular and cellular biology community. Also look at out Development, Regeneration and Neurophysiology cluster, if that's a better fit:
sheffield.ac.uk/biosciences/...
We of course welcome people (like me!) that straddle the two
sheffield.ac.uk/biosciences/...
We of course welcome people (like me!) that straddle the two
Reposted by David Strutt
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships to join our friendly & collaborative environment, in areas related to gene expression, mechanistic cell biology & cancer biology.
For more info 👇
sheffield.ac.uk/biosciences/...
For more info 👇
sheffield.ac.uk/biosciences/...
January 30, 2026 at 1:52 PM
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships to join our friendly & collaborative environment, in areas related to gene expression, mechanistic cell biology & cancer biology.
For more info 👇
sheffield.ac.uk/biosciences/...
For more info 👇
sheffield.ac.uk/biosciences/...
Reposted by David Strutt
Next Monday, 3rd Feb at 2:30 pm, we are welcoming Prof. David Strutt from the University of Sheffield. This talk will be in person at PDN. Please come and join us if you are around Cambridge! Looking forward to seeing you soon👋
January 29, 2026 at 4:01 PM
Next Monday, 3rd Feb at 2:30 pm, we are welcoming Prof. David Strutt from the University of Sheffield. This talk will be in person at PDN. Please come and join us if you are around Cambridge! Looking forward to seeing you soon👋
It's taken a while but final version of Alex's manuscript now out in eLife. We're proud of it – it was a difficult project with hard assays. Even the eLife editor admits it's 'useful' – and I'm not sure how often you see a genuinely useful paper these days?!
elifesciences.org/articles/107...
elifesciences.org/articles/107...
December 8, 2025 at 1:26 PM
It's taken a while but final version of Alex's manuscript now out in eLife. We're proud of it – it was a difficult project with hard assays. Even the eLife editor admits it's 'useful' – and I'm not sure how often you see a genuinely useful paper these days?!
elifesciences.org/articles/107...
elifesciences.org/articles/107...
Reposted by David Strutt
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
November 12, 2025 at 10:16 AM
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships (IRFs) to join our friendly and collaborative environment, in areas related to developmental biology, stem cells and regenerative biology, and neuroscience.
Reposted by David Strutt
Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression.
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression
The conserved atypical cadherin fat (ft) controls cellular processes such as growth, planar cell polarity, and mitochondrial function, in organisms ranging from fruit flies to mammals. Working at the ...
doi.org
May 10, 2025 at 11:27 AM
Fat cadherin cleavage releases a transcriptionally active nuclear fragment to regulate target gene expression.
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
New preprint from Helen McNeill and colleagues
doi.org/10.1101/2025...
Reposted by David Strutt
Job Alert 🔊🔊
Looking for your first or next Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential for this post tinyurl.com/2p9rndfy
Looking for your first or next Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential for this post tinyurl.com/2p9rndfy
May 8, 2025 at 11:54 AM
Job Alert 🔊🔊
Looking for your first or next Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential for this post tinyurl.com/2p9rndfy
Looking for your first or next Postdoc position? Then don't look further, apply to this opportunity to join our lab to tackle the next big challenges in the Wnt signalling field. Experience in protein biochemistry and in vitro cell biology is essential for this post tinyurl.com/2p9rndfy
Reposted by David Strutt
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis
During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
www.science.org
May 6, 2025 at 8:39 PM
My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...
Reposted by David Strutt
Development folks: the next Northern England Developmental Biology @bsdb.bsky.social @biologists.bsky.social meeting will take place on the 10th of July in Sheffield. Great speaker line-up, cheap registration fee and plenty of slots for ECR talks. Registration deadline=31/5, see poster for details
February 20, 2025 at 1:53 PM
Development folks: the next Northern England Developmental Biology @bsdb.bsky.social @biologists.bsky.social meeting will take place on the 10th of July in Sheffield. Great speaker line-up, cheap registration fee and plenty of slots for ECR talks. Registration deadline=31/5, see poster for details
New! 15y after the classic Aigouy et al "Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium..." from lab of much missed Suzanne Eaton, we provide our take from post-doc Sara Tan "Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing".
rdcu.be/d81Vn
rdcu.be/d81Vn
February 8, 2025 at 4:46 PM
New! 15y after the classic Aigouy et al "Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium..." from lab of much missed Suzanne Eaton, we provide our take from post-doc Sara Tan "Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing".
rdcu.be/d81Vn
rdcu.be/d81Vn
Reposted by David Strutt
Now that my lab has moved to Emory I want you to join us in Atlanta. We have an NIH-funded postdoc position available to study Planar Cell Polarity (PCP) signaling using vestibular hair cells of the mouse as a model.
Please repost and/or DM for details
Please repost and/or DM for details
February 4, 2025 at 5:08 PM
Now that my lab has moved to Emory I want you to join us in Atlanta. We have an NIH-funded postdoc position available to study Planar Cell Polarity (PCP) signaling using vestibular hair cells of the mouse as a model.
Please repost and/or DM for details
Please repost and/or DM for details
My quote of the day (or possibly the week/month/year):
‘Building organisms is about bringing #SelfOrganization under control’
I’m going to borrow this to use in my talks
‘Building organisms is about bringing #SelfOrganization under control’
I’m going to borrow this to use in my talks
First. The potential of a gene on its own is bigger than what is revealed by its loss of function.
Two. Don’t be fooled by deterministic genetic control. Underneath there is a capacity for #SelfOrganization which is the essence of biological systems.
Building organisms is @ bringing SO under control
Two. Don’t be fooled by deterministic genetic control. Underneath there is a capacity for #SelfOrganization which is the essence of biological systems.
Building organisms is @ bringing SO under control
January 26, 2025 at 10:06 AM
My quote of the day (or possibly the week/month/year):
‘Building organisms is about bringing #SelfOrganization under control’
I’m going to borrow this to use in my talks
‘Building organisms is about bringing #SelfOrganization under control’
I’m going to borrow this to use in my talks
Drosophila cell culture people: we've been using Qiagen Effectene to transfect S2 cells with ~30% efficiency, but latest batch is only giving us <1% efficiency (so no use to us!!). Qiagen don't seem to have a solution.
Anyone got suggestions for other (good!) fly cell culture transfection reagents?
Anyone got suggestions for other (good!) fly cell culture transfection reagents?
January 6, 2025 at 10:47 AM
Drosophila cell culture people: we've been using Qiagen Effectene to transfect S2 cells with ~30% efficiency, but latest batch is only giving us <1% efficiency (so no use to us!!). Qiagen don't seem to have a solution.
Anyone got suggestions for other (good!) fly cell culture transfection reagents?
Anyone got suggestions for other (good!) fly cell culture transfection reagents?
A little pre-Christmas reading for my planar polarity follower(s) – I’m sure there’s at least one of you!
The Fat-Dachsous planar polarity pathway competes with hinge contraction to orient polarized cell behaviors during Drosophila wing morphogenesis.
Current Biology
doi.org/10.1016/j.cu...
The Fat-Dachsous planar polarity pathway competes with hinge contraction to orient polarized cell behaviors during Drosophila wing morphogenesis.
Current Biology
doi.org/10.1016/j.cu...
The Fat-Dachsous planar polarity pathway competes with hinge contraction to orient polarized cell behaviors during Drosophila wing morphogenesis
Morphogenesis involves interactions between biochemical and mechanical cues. Trinidad et al. show that during Drosophila pupal wing morphogenesis, Fat-Dachsous planar polarity competes with tissue tension to control oriented cell behaviors. Moreover, junctional tension stabilizes Fat-Dachsous, supporting the existence of biomechanical feedback.
www.cell.com
December 21, 2024 at 8:30 AM
A little pre-Christmas reading for my planar polarity follower(s) – I’m sure there’s at least one of you!
The Fat-Dachsous planar polarity pathway competes with hinge contraction to orient polarized cell behaviors during Drosophila wing morphogenesis.
Current Biology
doi.org/10.1016/j.cu...
The Fat-Dachsous planar polarity pathway competes with hinge contraction to orient polarized cell behaviors during Drosophila wing morphogenesis.
Current Biology
doi.org/10.1016/j.cu...
Dodged that pre- Christmas bullet. Mycoplasma, not Covid.
December 19, 2024 at 7:41 PM
Dodged that pre- Christmas bullet. Mycoplasma, not Covid.
Reposted by David Strutt
Please spread the word!
We are looking for postdoc(s) interested in quantitative problems in Development and Regeneration. Previous experience in quantitative biology is not required. We will support you and provide a great training environment if you are committed to learn new things.
We are looking for postdoc(s) interested in quantitative problems in Development and Regeneration. Previous experience in quantitative biology is not required. We will support you and provide a great training environment if you are committed to learn new things.
December 12, 2024 at 2:03 PM
Please spread the word!
We are looking for postdoc(s) interested in quantitative problems in Development and Regeneration. Previous experience in quantitative biology is not required. We will support you and provide a great training environment if you are committed to learn new things.
We are looking for postdoc(s) interested in quantitative problems in Development and Regeneration. Previous experience in quantitative biology is not required. We will support you and provide a great training environment if you are committed to learn new things.
Reposted by David Strutt
Only 3 days left to apply! Postdoc positions available in the Röper lab at the University of Cambridge!
@PDN_Cambridge
Discover the role that supracellular cytoskeletal assemblies and crosstalk play in sculpting organs in Drosophila or human organoids in culture!
Links below!
@PDN_Cambridge
Discover the role that supracellular cytoskeletal assemblies and crosstalk play in sculpting organs in Drosophila or human organoids in culture!
Links below!
November 26, 2024 at 11:28 AM
Only 3 days left to apply! Postdoc positions available in the Röper lab at the University of Cambridge!
@PDN_Cambridge
Discover the role that supracellular cytoskeletal assemblies and crosstalk play in sculpting organs in Drosophila or human organoids in culture!
Links below!
@PDN_Cambridge
Discover the role that supracellular cytoskeletal assemblies and crosstalk play in sculpting organs in Drosophila or human organoids in culture!
Links below!
Reposted by David Strutt
Morphogenesis alert! Stoked for our new paper with the inimitable @shinuoweng.bsky.social! See her Skeetorial (👇) about the work in @currentbiology.bsky.social exploring the coupling of subcellular and tissue-level forces during convergent extension.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
December 2, 2024 at 6:10 PM
Morphogenesis alert! Stoked for our new paper with the inimitable @shinuoweng.bsky.social! See her Skeetorial (👇) about the work in @currentbiology.bsky.social exploring the coupling of subcellular and tissue-level forces during convergent extension.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by David Strutt
Are you an early career researcher in the Wnt field and at a career stage where you hope to make a transition to start your independent research group? Then this your opportunity! We have an invited ECR speaker slot at the upcoming Oxford WntUK 2025 meeting!! Details below 👇👇
November 14, 2024 at 10:44 AM
Are you an early career researcher in the Wnt field and at a career stage where you hope to make a transition to start your independent research group? Then this your opportunity! We have an invited ECR speaker slot at the upcoming Oxford WntUK 2025 meeting!! Details below 👇👇
Reposted by David Strutt
The 2nd WntUK meeting will be held at @WorcCollegeOx @UniofOxford on Monday 24th March 2025.
Registration and abstract submission opens soon.
Wnt researchers of all levels and disciplines welcome from the UK and beyond!
Registration and abstract submission opens soon.
Wnt researchers of all levels and disciplines welcome from the UK and beyond!
a budweiser light is lit up on a counter
ALT: a budweiser light is lit up on a counter
media.tenor.com
November 13, 2024 at 11:25 PM
The 2nd WntUK meeting will be held at @WorcCollegeOx @UniofOxford on Monday 24th March 2025.
Registration and abstract submission opens soon.
Wnt researchers of all levels and disciplines welcome from the UK and beyond!
Registration and abstract submission opens soon.
Wnt researchers of all levels and disciplines welcome from the UK and beyond!
Reposted by David Strutt
Postdoc position available in the Röper lab at the University of Cambridge @PDN_Cambridge!
Join us and discover the role that control of cytoskeletal dynamics, crosstalk and cell adhesion play in the formation of the nephron tube in human renal organoids!
jobs.cam.ac.uk/job/48947/
Join us and discover the role that control of cytoskeletal dynamics, crosstalk and cell adhesion play in the formation of the nephron tube in human renal organoids!
jobs.cam.ac.uk/job/48947/
November 14, 2024 at 12:59 AM
Postdoc position available in the Röper lab at the University of Cambridge @PDN_Cambridge!
Join us and discover the role that control of cytoskeletal dynamics, crosstalk and cell adhesion play in the formation of the nephron tube in human renal organoids!
jobs.cam.ac.uk/job/48947/
Join us and discover the role that control of cytoskeletal dynamics, crosstalk and cell adhesion play in the formation of the nephron tube in human renal organoids!
jobs.cam.ac.uk/job/48947/
Reposted by David Strutt
📢We have a 3y postdoc position available in our interdisciplinary team at the Institut Curie.
Join us if you're interested in epithelial tissue morphogenesis using live imaging, quantitative biology & (opto)genetics.
institut-curie.org/team/bellaiche
Please spread the word.
Join us if you're interested in epithelial tissue morphogenesis using live imaging, quantitative biology & (opto)genetics.
institut-curie.org/team/bellaiche
Please spread the word.
October 31, 2024 at 5:16 PM
📢We have a 3y postdoc position available in our interdisciplinary team at the Institut Curie.
Join us if you're interested in epithelial tissue morphogenesis using live imaging, quantitative biology & (opto)genetics.
institut-curie.org/team/bellaiche
Please spread the word.
Join us if you're interested in epithelial tissue morphogenesis using live imaging, quantitative biology & (opto)genetics.
institut-curie.org/team/bellaiche
Please spread the word.
Our latest on planar polarity mechanisms. Painstaking work by Alexandre Carayon, investigating mechanisms of cell-scale polarisation in the fly wing. Enjoy it (if this is your thing)!
October 15, 2024 at 8:57 AM
Our latest on planar polarity mechanisms. Painstaking work by Alexandre Carayon, investigating mechanisms of cell-scale polarisation in the fly wing. Enjoy it (if this is your thing)!
Reposted by David Strutt
Evidence for strong cell-scale signalling during planar polarisation in the Drosophila wing https://www.biorxiv.org/content/10.1101/2024.10.14.618159v1
Evidence for strong cell-scale signalling during planar polarisation in the Drosophila wing https://www.biorxiv.org/content/10.1101/2024.10.14.618159v1
In developing epithelia, cells become planar polarised with asymmetric localisation of the core plan
www.biorxiv.org
October 14, 2024 at 6:30 PM
Evidence for strong cell-scale signalling during planar polarisation in the Drosophila wing https://www.biorxiv.org/content/10.1101/2024.10.14.618159v1
Reposted by David Strutt
Rho/Rok-dependent regulation of actomyosin contractility at tricellular junctions controls epithelial permeability in Drosophila https://www.biorxiv.org/content/10.1101/2024.10.04.616625v1
Rho/Rok-dependent regulation of actomyosin contractility at tricellular junctions controls epithelial permeability in Drosophila https://www.biorxiv.org/content/10.1101/2024.10.04.616625v1
Cell contacts in epithelia are remodeled to regulate paracellular permeability and to control passag
www.biorxiv.org
October 5, 2024 at 5:30 PM
Rho/Rok-dependent regulation of actomyosin contractility at tricellular junctions controls epithelial permeability in Drosophila https://www.biorxiv.org/content/10.1101/2024.10.04.616625v1