Alfred Kim
@alhkim.bsky.social
Founder/Director @WUSTL_Lupus @WUSTLMed | Assoc Program Director @WashUMedRheum.bsky.social | Chief Medical Officer, Kypha, Inc | Complement, Lupus
ORCID iD: 0000-0003-4074-0516
https://profiles.wustl.edu/en/persons/alfred-kim
ORCID iD: 0000-0003-4074-0516
https://profiles.wustl.edu/en/persons/alfred-kim
Reposted by Alfred Kim
The old version and the new (Powerpoint-friendly, content edits by @alhkim.bsky.social ) version of the lupus overview graphic ~
#MedSky #RheumSky (do we still use hashtags here? i feel old 👵)
#MedSky #RheumSky (do we still use hashtags here? i feel old 👵)
September 30, 2025 at 2:22 PM
The old version and the new (Powerpoint-friendly, content edits by @alhkim.bsky.social ) version of the lupus overview graphic ~
#MedSky #RheumSky (do we still use hashtags here? i feel old 👵)
#MedSky #RheumSky (do we still use hashtags here? i feel old 👵)
Reposted by Alfred Kim
Recording an episode of @freelyfiltered.bsky.social with @kidneyboy.bsky.social and @jenniejlin.bsky.social with special guests @alhkim.bsky.social Koyal Jain and Brad Rovin
No surprises on what recent #NephJC study we are discussing 👑
No surprises on what recent #NephJC study we are discussing 👑
March 21, 2025 at 2:20 AM
Recording an episode of @freelyfiltered.bsky.social with @kidneyboy.bsky.social and @jenniejlin.bsky.social with special guests @alhkim.bsky.social Koyal Jain and Brad Rovin
No surprises on what recent #NephJC study we are discussing 👑
No surprises on what recent #NephJC study we are discussing 👑
Reposted by Alfred Kim
NIH indirects case update:
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
February 21, 2025 at 3:19 PM
NIH indirects case update:
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
Hearing ongoing now, and I'll try to live tweet some notable exchanges.
Prior to more detailed arguments, Judge Kelley starts off with a few point questions to both sides:
(I'm paraphrasing here)
Reposted by Alfred Kim
COMING UP at 10am, the preliminary injunction hearing in the consolidated Boston cases against NIH (Mass v., AAU v., AAMC v.).
Oral argument time is divided thus:
Oral argument time is divided thus:
February 21, 2025 at 2:28 PM
COMING UP at 10am, the preliminary injunction hearing in the consolidated Boston cases against NIH (Mass v., AAU v., AAMC v.).
Oral argument time is divided thus:
Oral argument time is divided thus:
Reposted by Alfred Kim
🆕 #Obinutuzumab (Obi) in Lupus Nephritis: the REGENCY Trial
Phase 3 RCT: Obi vs PBO
🫘 Pts w/ SLE nephritis Class III/IV ± 5
🎲 Randomized 1:1 to OBI v PBO (+MMF/steroids)
📊 Obi: ⇡rate of renal response and improved renal outcomes
#LupusNephritis #RheumSky #NephSky #MedSky #Lupus
Phase 3 RCT: Obi vs PBO
🫘 Pts w/ SLE nephritis Class III/IV ± 5
🎲 Randomized 1:1 to OBI v PBO (+MMF/steroids)
📊 Obi: ⇡rate of renal response and improved renal outcomes
#LupusNephritis #RheumSky #NephSky #MedSky #Lupus
February 12, 2025 at 10:16 PM
🆕 #Obinutuzumab (Obi) in Lupus Nephritis: the REGENCY Trial
Phase 3 RCT: Obi vs PBO
🫘 Pts w/ SLE nephritis Class III/IV ± 5
🎲 Randomized 1:1 to OBI v PBO (+MMF/steroids)
📊 Obi: ⇡rate of renal response and improved renal outcomes
#LupusNephritis #RheumSky #NephSky #MedSky #Lupus
Phase 3 RCT: Obi vs PBO
🫘 Pts w/ SLE nephritis Class III/IV ± 5
🎲 Randomized 1:1 to OBI v PBO (+MMF/steroids)
📊 Obi: ⇡rate of renal response and improved renal outcomes
#LupusNephritis #RheumSky #NephSky #MedSky #Lupus
Reposted by Alfred Kim
This will kill science in the US. This is how China wins. Why is this not on the news? Why are people not more upset about this?
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 1:43 AM
This will kill science in the US. This is how China wins. Why is this not on the news? Why are people not more upset about this?
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Reposted by Alfred Kim
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
NOT-OD-24-110: Notice of Legislative Mandates in Effect for FY 2024
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Legislative Mandates in Effect for FY 2024 NOT-OD-24-110. NIH
grants.nih.gov
February 8, 2025 at 12:56 AM
On changes to #NIH indirect rates, there is a law in place that prohibits NIH from making such changes without the approval of Congress. See Division D, Title II Section 224 of The Further Consolidated Appropriations Act, 2024 (Public Law No: 118-47) grants.nih.gov/grants/guide...
Reposted by Alfred Kim
This is a massive hit to academic medical centers - probably unilaterally cuts their NIH dollars by 20%. Lots of folks are going to lose their jobs:
February 8, 2025 at 12:36 AM
This is a massive hit to academic medical centers - probably unilaterally cuts their NIH dollars by 20%. Lots of folks are going to lose their jobs:
Reposted by Alfred Kim
Last year 90% of members of the US Air Force didn’t even fly planes! MaSIvE GOverNMeNt wAsTE!! Or - they do all the other essential things to keep the mission running, including really boring things like cutting paychecks, cooking, and even being pediatricians to airmen/women’s kids
February 8, 2025 at 12:59 AM
Last year 90% of members of the US Air Force didn’t even fly planes! MaSIvE GOverNMeNt wAsTE!! Or - they do all the other essential things to keep the mission running, including really boring things like cutting paychecks, cooking, and even being pediatricians to airmen/women’s kids
Holy shit…ALL indirect rates for NIH grants slashed to 15% (if I’m reading this correctly?)
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:59 AM
Holy shit…ALL indirect rates for NIH grants slashed to 15% (if I’m reading this correctly?)
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Reposted by Alfred Kim
I’ve seen this film before.
@alhkim.bsky.social @jeffsparks.bsky.social @kristenyoung.bsky.social @situationrheum.bsky.social
@alhkim.bsky.social @jeffsparks.bsky.social @kristenyoung.bsky.social @situationrheum.bsky.social
NIH Director-to-be Jay Bhattacharya demonstrating his commitment to scientific integrity by uhhh creating a "journal" only he & his buddies can submit to where every paper is autoaccepted & his buddies are also the editors & the peer reviewers who get paid $500 to write 4 sentence uncritical reviews
There's "being wrong in early in a pandemic" wrong and then there's "doubling down over and over again until you find yourself in bed with RFK Jr. and founding a whole-ass journal to discredit all of academic publishing along with all of medicine" wrong.
publichealth.realclearjournals.org
publichealth.realclearjournals.org
February 6, 2025 at 2:22 AM
I’ve seen this film before.
@alhkim.bsky.social @jeffsparks.bsky.social @kristenyoung.bsky.social @situationrheum.bsky.social
@alhkim.bsky.social @jeffsparks.bsky.social @kristenyoung.bsky.social @situationrheum.bsky.social
Reposted by Alfred Kim
“A group of researchers and students at the Harvard T.H. Chan School of Public Health is gathered today for a data preservation marathon, scraping and downloading data related to health equity from U.S. government agency websites before they disappear.”
Researchers rush to preserve federal health databases before they disappear from government websites
Journalists have long relied on federal health data for their reporting. We include several tips that they can use to help researchers preserve the data.
journalistsresource.org
February 1, 2025 at 3:04 AM
“A group of researchers and students at the Harvard T.H. Chan School of Public Health is gathered today for a data preservation marathon, scraping and downloading data related to health equity from U.S. government agency websites before they disappear.”
Reposted by Alfred Kim
This is a big deal, y'all. Federal health websites are being stripped of content or removed in their entirety. Stick with this thread for a look at what's disappeared so far! 1/x
January 31, 2025 at 7:28 PM
This is a big deal, y'all. Federal health websites are being stripped of content or removed in their entirety. Stick with this thread for a look at what's disappeared so far! 1/x
Reposted by Alfred Kim
What pediatric rheumatology workshop would adult rheumatologists find most useful at a conference?
January 18, 2025 at 2:31 PM
What pediatric rheumatology workshop would adult rheumatologists find most useful at a conference?
Reposted by Alfred Kim
🎆4 years in the making! Thrilled to share the 1st spatial single cell aging clock ⏰ www.nature.com/articles/s41...
We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain 🧠
Led by Eric Sun and awesome collaboration w/ @brunetlab.bsky.social🧵
We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain 🧠
Led by Eric Sun and awesome collaboration w/ @brunetlab.bsky.social🧵
December 18, 2024 at 10:19 PM
🎆4 years in the making! Thrilled to share the 1st spatial single cell aging clock ⏰ www.nature.com/articles/s41...
We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain 🧠
Led by Eric Sun and awesome collaboration w/ @brunetlab.bsky.social🧵
We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain 🧠
Led by Eric Sun and awesome collaboration w/ @brunetlab.bsky.social🧵
Look who’s migrated over to @bsky.app: @zahitouma.bsky.social!! You better give him a follow.
December 13, 2024 at 9:39 PM
Look who’s migrated over to @bsky.app: @zahitouma.bsky.social!! You better give him a follow.
Reposted by Alfred Kim
If you want to understand why healthcare pricing is horrific, the first thing to know is that our system puts 100% of the credit risk for deductibles, copays and co-insurance on hospitals and doctors. That's insane.
We have turned them into Sub Prime Lenders 🧵
We have turned them into Sub Prime Lenders 🧵
December 10, 2024 at 6:46 PM
If you want to understand why healthcare pricing is horrific, the first thing to know is that our system puts 100% of the credit risk for deductibles, copays and co-insurance on hospitals and doctors. That's insane.
We have turned them into Sub Prime Lenders 🧵
We have turned them into Sub Prime Lenders 🧵
Andrea continues to delve deeply into the utility of urinary biomarkers for lupus nephritis. We both provide deeper insight into this massive unmet need in lupus nephritis on @medpagetoday.bsky.social: nam10.safelinks.protection.outlook.com?url=https%3A...
December 10, 2024 at 5:15 AM
Andrea continues to delve deeply into the utility of urinary biomarkers for lupus nephritis. We both provide deeper insight into this massive unmet need in lupus nephritis on @medpagetoday.bsky.social: nam10.safelinks.protection.outlook.com?url=https%3A...
Reposted by Alfred Kim
Surprise case of immunotactoid glomerulopathy in a biopsy for longstanding proteinuria thought to be due to chronic HTN. ~30nm microtubular structures. IgG2-kappa restricted. MGRS lesions, often associated with lymphoma bit.ly/3NNpwVd. #renalpath #pathsky #nephsky
December 8, 2024 at 7:31 PM
Surprise case of immunotactoid glomerulopathy in a biopsy for longstanding proteinuria thought to be due to chronic HTN. ~30nm microtubular structures. IgG2-kappa restricted. MGRS lesions, often associated with lymphoma bit.ly/3NNpwVd. #renalpath #pathsky #nephsky
Reposted by Alfred Kim
Our latest paper is out, led by Dr Vanessa Kronzer-
Using data from the Mayo Clinic and Mass General Brigham Biobanks, we found strong gene-respiratory disease interactions for risk of rheumatoid arthritis
ard.bmj.com/content/earl...
Using data from the Mayo Clinic and Mass General Brigham Biobanks, we found strong gene-respiratory disease interactions for risk of rheumatoid arthritis
ard.bmj.com/content/earl...
Uncovering specific genetic-respiratory disease endotypes for rheumatoid arthritis risk
Objective We aimed to identify specific genetic-respiratory disease endotypes for rheumatoid arthritis (RA) risk.
Methods This case–control study used the Mass General Brigham (MGB) and Mayo Clinic (...
ard.bmj.com
November 24, 2024 at 6:55 PM
Our latest paper is out, led by Dr Vanessa Kronzer-
Using data from the Mayo Clinic and Mass General Brigham Biobanks, we found strong gene-respiratory disease interactions for risk of rheumatoid arthritis
ard.bmj.com/content/earl...
Using data from the Mayo Clinic and Mass General Brigham Biobanks, we found strong gene-respiratory disease interactions for risk of rheumatoid arthritis
ard.bmj.com/content/earl...
Reposted by Alfred Kim
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
November 23, 2024 at 3:50 PM
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
Reposted by Alfred Kim
🗣️GO TO SLEep!🗣️ My first and best advice to my patients was captured in this #ACR24 gem, “Chasing Zzzs in Rheumatic Disease…” by dear friends @alhkim.bsky.social @yvonne-lee.bsky.social and Patty Katz. Let’s get into it!
November 21, 2024 at 6:37 PM
🗣️GO TO SLEep!🗣️ My first and best advice to my patients was captured in this #ACR24 gem, “Chasing Zzzs in Rheumatic Disease…” by dear friends @alhkim.bsky.social @yvonne-lee.bsky.social and Patty Katz. Let’s get into it!
Reposted by Alfred Kim
#ACR24 lupus nephritis guideline puts nickel down on choosing CNI if proteinuria >3 grams based on post-hoc analysis of BLISS-LN. Hopefully a head-to-head comparison of adding BEL or CNI or OBI will happen at some point
November 18, 2024 at 3:55 PM
#ACR24 lupus nephritis guideline puts nickel down on choosing CNI if proteinuria >3 grams based on post-hoc analysis of BLISS-LN. Hopefully a head-to-head comparison of adding BEL or CNI or OBI will happen at some point
Reposted by Alfred Kim
Targeting autoreactive TRBV9+ T cells using TRBV9xCD3 bispecific T cell engaging antibodies. Controlling ankylosing spondylitis and celiac disease without increasing the risk of infection? Let's go. Join us at Room 150, 3:00 PM. #precisionimmunotherapy #ACR24
November 17, 2024 at 7:16 PM
Targeting autoreactive TRBV9+ T cells using TRBV9xCD3 bispecific T cell engaging antibodies. Controlling ankylosing spondylitis and celiac disease without increasing the risk of infection? Let's go. Join us at Room 150, 3:00 PM. #precisionimmunotherapy #ACR24