Alex Leunig
@alexleunig.bsky.social
Cardiovascular Immunology PostDoc @SwirskiLab @MountSinaiNYC | MD @LMUMunich
Reposted by Alex Leunig
Accelerated #CardiacAging in Space flight?
👉3D #HeartOnAChip 30-d ISS travel
hiPSC-Cardiomyocyte in hydrogel (decellularized🐷🫀ECM +reduced #GrapheneOxide)
6 mini🫀/PDMS post array per chamber
4 chambers +giant magnetoresistive sensor per plate habitat
@pnas.org 2024
www.pnas.org/doi/10.1073/...
👉3D #HeartOnAChip 30-d ISS travel
hiPSC-Cardiomyocyte in hydrogel (decellularized🐷🫀ECM +reduced #GrapheneOxide)
6 mini🫀/PDMS post array per chamber
4 chambers +giant magnetoresistive sensor per plate habitat
@pnas.org 2024
www.pnas.org/doi/10.1073/...
December 15, 2024 at 8:39 PM
Accelerated #CardiacAging in Space flight?
👉3D #HeartOnAChip 30-d ISS travel
hiPSC-Cardiomyocyte in hydrogel (decellularized🐷🫀ECM +reduced #GrapheneOxide)
6 mini🫀/PDMS post array per chamber
4 chambers +giant magnetoresistive sensor per plate habitat
@pnas.org 2024
www.pnas.org/doi/10.1073/...
👉3D #HeartOnAChip 30-d ISS travel
hiPSC-Cardiomyocyte in hydrogel (decellularized🐷🫀ECM +reduced #GrapheneOxide)
6 mini🫀/PDMS post array per chamber
4 chambers +giant magnetoresistive sensor per plate habitat
@pnas.org 2024
www.pnas.org/doi/10.1073/...
Reposted by Alex Leunig
There are now nearly 5000 papers on #interoception. And the output over the last 4 years is more than the previous 59. 🤯
December 9, 2024 at 12:58 AM
There are now nearly 5000 papers on #interoception. And the output over the last 4 years is more than the previous 59. 🤯
Reposted by Alex Leunig
A study in Nature Neuroscience identifies a prefrontal–pontomedullary pathway that slows breathing and reduces anxiety in mice. The findings explain a circuit basis for top-down control of breathing, which can influence emotional states. Ÿ”’ https://go.nature.com/3CUtPy3
December 6, 2024 at 8:02 PM
A study in Nature Neuroscience identifies a prefrontal–pontomedullary pathway that slows breathing and reduces anxiety in mice. The findings explain a circuit basis for top-down control of breathing, which can influence emotional states. Ÿ”’ https://go.nature.com/3CUtPy3
Reposted by Alex Leunig
Hello, #MedSky community! We’re excited to begin our Bluesky journey.
Here is a sampling of the trusted, influential, and essential information you can expect when you follow us:
Here is a sampling of the trusted, influential, and essential information you can expect when you follow us:
December 6, 2024 at 8:24 PM
Hello, #MedSky community! We’re excited to begin our Bluesky journey.
Here is a sampling of the trusted, influential, and essential information you can expect when you follow us:
Here is a sampling of the trusted, influential, and essential information you can expect when you follow us:
Reposted by Alex Leunig
Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Perception of Temperature Even in the Absence of Actual Change is Sufficient to Drive Transgenerational Epigenetic Inheritance
Can processes occurring in one individuals nervous system influence the physiology of the descendants? Here we explored the provocative hypothesis that parents sensation or perception of environmental...
www.biorxiv.org
December 5, 2024 at 7:32 PM
Scared to share this after 10 freaking years of waiting, but here we go: We found that temperature *perception* can change the biology of the next generations, even when “it’s just in the parents' head”. Read how C. elegans neurons control epigenetic inheritance!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Alex Leunig
Great collaborative work spearheaded by M. Ardissino showing that, among those sustaining early-onset myocardial infarction, a CAD polygenic risk score was the strongest among assessed predictors of recurrent events www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
November 30, 2024 at 2:24 PM
Great collaborative work spearheaded by M. Ardissino showing that, among those sustaining early-onset myocardial infarction, a CAD polygenic risk score was the strongest among assessed predictors of recurrent events www.ahajournals.org/doi/10.1161/... @ahajournals.bsky.social
Reposted by Alex Leunig
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance
Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we ...
www.science.org
November 30, 2024 at 4:19 PM
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Alex Leunig
We are delighted to share our latest findings in @natureportfolio.bsky.social! We describe cardiogenic regulation of sleep after cardiac injury.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Myocardial infarction augments sleep to limit cardiac inflammation and damage - Nature
Studies in humans and mice show that myocardial infarction recruits monocytes to the brain’s thalamus, promoting sleep, which in turn restricts cardiac inflammation and sympathetic sign...
www.nature.com
November 14, 2024 at 5:13 PM
We are delighted to share our latest findings in @natureportfolio.bsky.social! We describe cardiogenic regulation of sleep after cardiac injury.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alex Leunig
PRESS RELEASE 👉 New research by the Icahn School of Medicine at Mount Sinai's Pacific Huynh, @mcalpinelab.bsky.social, et al. first to demo how heart & brain communicate w/ each other thru immune system to promote sleep & recovery after major cardiovascular event👉 www.mountsinai.org/about/newsro...
November 18, 2024 at 4:51 PM
PRESS RELEASE 👉 New research by the Icahn School of Medicine at Mount Sinai's Pacific Huynh, @mcalpinelab.bsky.social, et al. first to demo how heart & brain communicate w/ each other thru immune system to promote sleep & recovery after major cardiovascular event👉 www.mountsinai.org/about/newsro...