Sahib Khalsa
@skhalsa.bsky.social
Psychiatrist and neuroscientist studying the role of interoception in mental health. Director of Anxiety Disorders Research, UCLA Psychiatry. Opinions my own.
Thrilled to be a part of this meta-analytic effort to determine the effects of mindfulness and other forms of contemplative training on self reported interoception. See thread below from the lead author Isaac Treves. While the effect is clear, there are many open questions remaining
How does mindfulness change body awareness? Excited to share our meta-analysis on mindfulness training and #interoception. www.nature.com/articles/s41...
November 7, 2025 at 3:00 PM
Thrilled to be a part of this meta-analytic effort to determine the effects of mindfulness and other forms of contemplative training on self reported interoception. See thread below from the lead author Isaac Treves. While the effect is clear, there are many open questions remaining
Reposted by Sahib Khalsa
Cortical and subcortical mapping (n=90) of the human allostatic–interoceptive system using 7 Tesla fMRI, building up the same group’s earlier study on n=700 with 3 Tesla. www.nature.com/articles/s41...
Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI - Nature Neuroscience
The brain is constantly monitoring the systems in the body. Here the authors use 7 Tesla functional magnetic resonance imaging to map a large-scale brain system for body regulation in humans, includin...
www.nature.com
October 27, 2025 at 4:17 AM
Cortical and subcortical mapping (n=90) of the human allostatic–interoceptive system using 7 Tesla fMRI, building up the same group’s earlier study on n=700 with 3 Tesla. www.nature.com/articles/s41...
Reposted by Sahib Khalsa
Such a nice collection of brain-body interaction articles in the special issue of @currentbiology.bsky.social. Love the beautiful vagus nerve on the cover by Andreas Vesalius www.cell.com/current-biol...
October 22, 2025 at 6:44 PM
Such a nice collection of brain-body interaction articles in the special issue of @currentbiology.bsky.social. Love the beautiful vagus nerve on the cover by Andreas Vesalius www.cell.com/current-biol...
This is a very nice cross-species articulation of findings and challenges in body-brain and brain-body processing. Recommended reading for anyone interested in dipping their toes into this broad and rapidly developing area!
New essay in @currentbiology.bsky.social special brain-body issue! Fly lab meets psychiatrist: how bodily signals shape cognition and mental health. Great collaboration with Albino Oliveira-Maia showing @champalimaudf.bsky.social discovery ↔️ clinic at its best. www.cell.com/current-biol...
From cognition in the body to the body in cognition
Carlos Ribeiro and Albino Oliveira-Maia propose how brain–body interactions may inform
the study of ‘higher’ cognitive functions such as learning and memory across model
systems.
www.cell.com
October 20, 2025 at 10:19 PM
This is a very nice cross-species articulation of findings and challenges in body-brain and brain-body processing. Recommended reading for anyone interested in dipping their toes into this broad and rapidly developing area!
Reposted by Sahib Khalsa
TIL that Dale invented the heartbeat counting task, not Schandry, and that it was known from the very first study that people underestimated their heart rate. It was orginally called a heart rate estimation task! journals.sagepub.com/doi/pdf/10.2...
October 17, 2025 at 4:57 AM
TIL that Dale invented the heartbeat counting task, not Schandry, and that it was known from the very first study that people underestimated their heart rate. It was orginally called a heart rate estimation task! journals.sagepub.com/doi/pdf/10.2...
Reposted by Sahib Khalsa
📢 Join us at the Crick to start your lab!
💸 Generous core funding to give your ideas wings
🔬 Outstanding facilities to realise your nerdiest dreams
🙌 Supportive colleagues who lift you and your science up
Happy to answer questions! Please repost!
💸 Generous core funding to give your ideas wings
🔬 Outstanding facilities to realise your nerdiest dreams
🙌 Supportive colleagues who lift you and your science up
Happy to answer questions! Please repost!
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:57 PM
📢 Join us at the Crick to start your lab!
💸 Generous core funding to give your ideas wings
🔬 Outstanding facilities to realise your nerdiest dreams
🙌 Supportive colleagues who lift you and your science up
Happy to answer questions! Please repost!
💸 Generous core funding to give your ideas wings
🔬 Outstanding facilities to realise your nerdiest dreams
🙌 Supportive colleagues who lift you and your science up
Happy to answer questions! Please repost!
Reposted by Sahib Khalsa
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 5:35 PM
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Reposted by Sahib Khalsa
This World Mental Health Day, I’m reflecting on the science, people, and shared responsibility to build a future where mental health is supported and prioritized.
Understanding the brain and the physiological mechanisms behind mental health is important to confront mental health challenges.
Understanding the brain and the physiological mechanisms behind mental health is important to confront mental health challenges.
October 10, 2025 at 9:20 PM
This World Mental Health Day, I’m reflecting on the science, people, and shared responsibility to build a future where mental health is supported and prioritized.
Understanding the brain and the physiological mechanisms behind mental health is important to confront mental health challenges.
Understanding the brain and the physiological mechanisms behind mental health is important to confront mental health challenges.
Reposted by Sahib Khalsa
Save the date 📆. On Oct 22/23, @nationalacademies.org will hold a stellar virtual workshop on brain/body interations (open to all).
www.nationalacademies.org/en/our-work/...
www.nationalacademies.org/en/our-work/...
September 26, 2025 at 6:55 PM
Save the date 📆. On Oct 22/23, @nationalacademies.org will hold a stellar virtual workshop on brain/body interations (open to all).
www.nationalacademies.org/en/our-work/...
www.nationalacademies.org/en/our-work/...
Even after recovery, relapse is heartbreakingly common in anorexia nervosa. Could the answer lie in the gut’s hidden signals? 🧵
September 22, 2025 at 8:14 PM
Even after recovery, relapse is heartbreakingly common in anorexia nervosa. Could the answer lie in the gut’s hidden signals? 🧵
Reposted by Sahib Khalsa
How do perceptual processes contribute to the development of psychiatric illness? @skhalsa.bsky.social and I have compiled this volume with experts from across the world to begin to answer this question.
What if many psychiatric disorders share the same hidden glitch in how the brain infers reality? In a new volume, Al Powers and I gather experts to examine how disrupted sensory inference across #vision, #touch, #proprioception and #interoception might unify our understanding.
September 18, 2025 at 10:35 AM
How do perceptual processes contribute to the development of psychiatric illness? @skhalsa.bsky.social and I have compiled this volume with experts from across the world to begin to answer this question.
What if many psychiatric disorders share the same hidden glitch in how the brain infers reality? In a new volume, Al Powers and I gather experts to examine how disrupted sensory inference across #vision, #touch, #proprioception and #interoception might unify our understanding.
September 17, 2025 at 6:32 AM
What if many psychiatric disorders share the same hidden glitch in how the brain infers reality? In a new volume, Al Powers and I gather experts to examine how disrupted sensory inference across #vision, #touch, #proprioception and #interoception might unify our understanding.
Highly recommended reading for anyone interested in #interoception especially from a public-facing standpoint
🇺🇸Inner Sense, US / Canada 🇨🇦 edition hits the shelves in less than a month, and is available to preorder NOW!
greystonebooks.com/products/inn...
Please share!
#innersense #interoception #mindbodyconnection #science #mentalhealth #mindandbody
greystonebooks.com/products/inn...
Please share!
#innersense #interoception #mindbodyconnection #science #mentalhealth #mindandbody
September 8, 2025 at 7:59 PM
Highly recommended reading for anyone interested in #interoception especially from a public-facing standpoint
This is an incredible tool for visualizing real-time activity of internal organ system dynamics in zebra fish - I trust it’s only a matter of time until we see a suite of “functional body connectivity” papers during various interoceptive perturbations… #interoception
Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...
September 8, 2025 at 7:56 PM
This is an incredible tool for visualizing real-time activity of internal organ system dynamics in zebra fish - I trust it’s only a matter of time until we see a suite of “functional body connectivity” papers during various interoceptive perturbations… #interoception
Reposted by Sahib Khalsa
🎉 Happy to share our latest paper on #Physiology&Behavior @elsevierconnect.bsky.social
Together with Luigi Micillo, Nicola Cellini and Giovanna Mioni we explored the link between cardiac #interoception and time perception
🧵in the comments
Together with Luigi Micillo, Nicola Cellini and Giovanna Mioni we explored the link between cardiac #interoception and time perception
🧵in the comments
In the heart of time: investigating the link between cardiac activity and interoception in explicit and implicit timing
Recent research suggests that our sense of time is influenced by interoceptive abilities. Efficient access to bodily signals, measured objectively (in…
www.sciencedirect.com
August 23, 2025 at 7:48 AM
🎉 Happy to share our latest paper on #Physiology&Behavior @elsevierconnect.bsky.social
Together with Luigi Micillo, Nicola Cellini and Giovanna Mioni we explored the link between cardiac #interoception and time perception
🧵in the comments
Together with Luigi Micillo, Nicola Cellini and Giovanna Mioni we explored the link between cardiac #interoception and time perception
🧵in the comments
Interesting molecular parallel to our human ISO findings: β-adrenergic and GABAergic modulation engage posterior insula, but using these states to guide action triggers zif268 plasticity in anterior insula. www.eneuro.org/content/12/8...
The Use of Internal States to Guide Behavior Is Associated with Functional Engagement of the Anterior Insula in Male Rats
Interoception and associated subjective states shape adaptive behaviors. In humans, interoceptive information is hierarchically processed in the insular cortex (IC), being integrated first in the post...
www.eneuro.org
August 13, 2025 at 10:11 PM
Interesting molecular parallel to our human ISO findings: β-adrenergic and GABAergic modulation engage posterior insula, but using these states to guide action triggers zif268 plasticity in anterior insula. www.eneuro.org/content/12/8...
Reposted by Sahib Khalsa
Public access to the first fly connectome that spans the whole CNS - BANC!: codex.flywire.ai?dataset=banc
Different from prior connectomes - it is brain + cord (think spinal cord)
We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
Different from prior connectomes - it is brain + cord (think spinal cord)
We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
August 2, 2025 at 2:30 PM
Public access to the first fly connectome that spans the whole CNS - BANC!: codex.flywire.ai?dataset=banc
Different from prior connectomes - it is brain + cord (think spinal cord)
We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
Different from prior connectomes - it is brain + cord (think spinal cord)
We use it to ‘embody’ the system and find it resembles ‘subsumption architecture’ doi.org/10.1101/2025...
Postdoc job alert! I’m looking for someone with a PhD in neuroscience/psychology, psychiatry, biomed engineering, computational modeling or a related field to join my NIH-funded team at UCLA studying the neural & computational mechanisms of #interoception in anorexia nervosa 1/2
August 7, 2025 at 4:25 PM
Postdoc job alert! I’m looking for someone with a PhD in neuroscience/psychology, psychiatry, biomed engineering, computational modeling or a related field to join my NIH-funded team at UCLA studying the neural & computational mechanisms of #interoception in anorexia nervosa 1/2
In the aftermath of last night’s west coast tsunami warning this article on emergency alerts rings true. Thankfully there does not appear to have been much damage theconversation.com/emergency-al...
theconversation.com
July 30, 2025 at 2:57 PM
In the aftermath of last night’s west coast tsunami warning this article on emergency alerts rings true. Thankfully there does not appear to have been much damage theconversation.com/emergency-al...
Who needs podcasts when you have AI? Voila: the latest podcast on one of my papers, brought to you by NotebookLM! It’s not great (& gets a bit repetitive when you run several papers through it), but when you realize all they did was feed the paper into it, and generated a user-friendly output, whoa…
Will AI revolutionize or undermine mental health care?
Today's Deep Dive focuses on opportunities & risks of using large language models in psychiatric care & research.
By @skhalsa.bsky.social, @pshrink.bsky.social, @royperlis.bsky.social, @mpwpaulus.bsky.social et al
youtu.be/i8RfTa-dCU0?...
Today's Deep Dive focuses on opportunities & risks of using large language models in psychiatric care & research.
By @skhalsa.bsky.social, @pshrink.bsky.social, @royperlis.bsky.social, @mpwpaulus.bsky.social et al
youtu.be/i8RfTa-dCU0?...
Will AI revolutionize or undermine mental health care?
YouTube video by NPP - Digital Psychiatry and Neuroscience (DPN)
youtu.be
July 29, 2025 at 6:04 PM
Who needs podcasts when you have AI? Voila: the latest podcast on one of my papers, brought to you by NotebookLM! It’s not great (& gets a bit repetitive when you run several papers through it), but when you realize all they did was feed the paper into it, and generated a user-friendly output, whoa…
Reposted by Sahib Khalsa
@peterkok.bsky.social and I wrote a book chapter on how layer specific fMRI can shine light on disorders hallmarked by perceptual disturbances. This is part of a series on Perceptual Dysregulation in Psychiatric Nosology edited by @skhalsa.bsky.social and Al Powers link.springer.com/chapter/10.1...
How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders
Perceptual disturbances occur across various sensory domains and contribute to significant suffering in numerous psychiatric and neurological conditions. Despite decades of research into the neural me...
link.springer.com
July 15, 2025 at 10:00 AM
@peterkok.bsky.social and I wrote a book chapter on how layer specific fMRI can shine light on disorders hallmarked by perceptual disturbances. This is part of a series on Perceptual Dysregulation in Psychiatric Nosology edited by @skhalsa.bsky.social and Al Powers link.springer.com/chapter/10.1...
Latest article from our group articulating a harmonized vision for interoceptive neuroscience research, with my stellar co-authors who are also physician-scientists. It was a genuine privilege to work on this with them. More of this kind of empirical collaboration is needed!!
🚨 New publication!
Proud to share our latest article exploring how a “𝑟𝑜𝑣𝑖𝑛𝑔 𝑙𝑒𝑛𝑠” multidisciplinary approach can bridge the gap between animal and human research in interoception & mental health.
👉 Read here : www.sciencedirect.com/science/arti...
Proud to share our latest article exploring how a “𝑟𝑜𝑣𝑖𝑛𝑔 𝑙𝑒𝑛𝑠” multidisciplinary approach can bridge the gap between animal and human research in interoception & mental health.
👉 Read here : www.sciencedirect.com/science/arti...
July 7, 2025 at 7:34 PM
Latest article from our group articulating a harmonized vision for interoceptive neuroscience research, with my stellar co-authors who are also physician-scientists. It was a genuine privilege to work on this with them. More of this kind of empirical collaboration is needed!!
Reposted by Sahib Khalsa
🚨 New paper out!
Phase confusion: How inconsistent cardiac labeling obscures interoception research 🫀🧠
We unpack methodological incosistencies and propose a way forward with the HEARTS framework.
In Biol. Psychol. - Open Access:
🔗 shorturl.at/YJhyn
1st paper of great @angeliacaparco.bsky.social!
Phase confusion: How inconsistent cardiac labeling obscures interoception research 🫀🧠
We unpack methodological incosistencies and propose a way forward with the HEARTS framework.
In Biol. Psychol. - Open Access:
🔗 shorturl.at/YJhyn
1st paper of great @angeliacaparco.bsky.social!
July 4, 2025 at 9:11 AM
🚨 New paper out!
Phase confusion: How inconsistent cardiac labeling obscures interoception research 🫀🧠
We unpack methodological incosistencies and propose a way forward with the HEARTS framework.
In Biol. Psychol. - Open Access:
🔗 shorturl.at/YJhyn
1st paper of great @angeliacaparco.bsky.social!
Phase confusion: How inconsistent cardiac labeling obscures interoception research 🫀🧠
We unpack methodological incosistencies and propose a way forward with the HEARTS framework.
In Biol. Psychol. - Open Access:
🔗 shorturl.at/YJhyn
1st paper of great @angeliacaparco.bsky.social!
What if 'gut feeling' was more than a metaphor, and the key to treating obesity and gastrointestinal disorders? This new commentary, born from the 2024 NIDDK workshop on Interoceptive Contributions to Obesity & DGBI is now out in Gastroenterology: sciencedirect.com/science/arti...
June 24, 2025 at 11:36 PM
What if 'gut feeling' was more than a metaphor, and the key to treating obesity and gastrointestinal disorders? This new commentary, born from the 2024 NIDDK workshop on Interoceptive Contributions to Obesity & DGBI is now out in Gastroenterology: sciencedirect.com/science/arti...
Can inflammation reveal why some individuals with depression can't feel joy? In this latest work led by Jonathan Savitz, Mike Irwin, and @mpwpaulus.bsky.social published in the American Journal of Psychiatry, we attempted to address just that:
psychiatryonline.org/doi/10.1176/...
psychiatryonline.org/doi/10.1176/...
June 9, 2025 at 8:33 PM
Can inflammation reveal why some individuals with depression can't feel joy? In this latest work led by Jonathan Savitz, Mike Irwin, and @mpwpaulus.bsky.social published in the American Journal of Psychiatry, we attempted to address just that:
psychiatryonline.org/doi/10.1176/...
psychiatryonline.org/doi/10.1176/...