Alberto Reale
@albertoreale.bsky.social
MD PhD, postdoc doing translational research on viral vectors for cancer, vaccines, and genetic diseases. Also, big history and ancient languages nerd. Italy
Pinned
Just a quick summary of my research activity.. if you've never heard about #oncolyticviruses (OVs for friends), they are viruses that can be used as anticancer drugs. How is that possible? Well, it turns out that among the many differences between malignant and normal cells/
Check out our latest publication on how to deliver #oncolyticviruses to the #centralnervoussystem, by using cells that have a natural capability to move into the brain crossing the blood brain barrier 🧪
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Redirecting the route: Monocyte-mediated delivery of oHSV-1 across a human BBB-on-chip model
Oncolytic viruses (OVs) that selectively replicate within cancer cells represent a promising therapeutic strategy for refractory or difficult-to-treat…
www.sciencedirect.com
November 3, 2025 at 11:26 PM
Check out our latest publication on how to deliver #oncolyticviruses to the #centralnervoussystem, by using cells that have a natural capability to move into the brain crossing the blood brain barrier 🧪
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
In hamsters, ##sarscov2 infects the brain stem chronically and triggers degenerative-like changes #longcovid @daniellebeckman.bsky.social @buonsenso.bsky.social @elisaperego78.bsky.social @longcovidadvoc.com @thecovidinfoguy.bsky.social @winslowsp.bsky.social pubmed.ncbi.nlm.nih.gov/40695836/
Hamsters with long COVID present distinct transcriptomic profiles associated with neurodegenerative processes in brainstem - PubMed
Following infection with SARS-CoV-2, patients may experience with one or more symptoms that appear or persist over time. Neurological symptoms associated with long COVID include anxiety, depression, a...
pubmed.ncbi.nlm.nih.gov
July 30, 2025 at 10:46 AM
In hamsters, ##sarscov2 infects the brain stem chronically and triggers degenerative-like changes #longcovid @daniellebeckman.bsky.social @buonsenso.bsky.social @elisaperego78.bsky.social @longcovidadvoc.com @thecovidinfoguy.bsky.social @winslowsp.bsky.social pubmed.ncbi.nlm.nih.gov/40695836/
For those who are interested in #LongCovid #MECFS I have seen that an anti-CD19 antibody (depleting B lymphocytes) showed promise in treating the condition. Then wouldn't it be time to test anti-CD19 #CAR-T cells? They work very well against autoimmune diseases
July 11, 2025 at 10:47 AM
For those who are interested in #LongCovid #MECFS I have seen that an anti-CD19 antibody (depleting B lymphocytes) showed promise in treating the condition. Then wouldn't it be time to test anti-CD19 #CAR-T cells? They work very well against autoimmune diseases
Update: it seems that the Austrian #covid honeymoon might be over as the RNA load increases not dramatically, but steadily. Things might be on track to repeat the constant increase that was seen last summer @winslowsp.bsky.social @ryanhisner.bsky.social @elisaperego78.bsky.social
Genuine question for those actually interested in monitoring #covid.. I've been following wastewater data from Austria abwassermonitoring.at/dashboard/ . Why Austria? Well, because it's close to Italy and I can't find any data from Italy. Over the last 2 years it has been pretty standard
Abwassermonitoring
abwassermonitoring.at
May 21, 2025 at 6:48 PM
Update: it seems that the Austrian #covid honeymoon might be over as the RNA load increases not dramatically, but steadily. Things might be on track to repeat the constant increase that was seen last summer @winslowsp.bsky.social @ryanhisner.bsky.social @elisaperego78.bsky.social
Genuine question for those actually interested in monitoring #covid.. I've been following wastewater data from Austria abwassermonitoring.at/dashboard/ . Why Austria? Well, because it's close to Italy and I can't find any data from Italy. Over the last 2 years it has been pretty standard
Abwassermonitoring
abwassermonitoring.at
May 7, 2025 at 11:03 AM
Genuine question for those actually interested in monitoring #covid.. I've been following wastewater data from Austria abwassermonitoring.at/dashboard/ . Why Austria? Well, because it's close to Italy and I can't find any data from Italy. Over the last 2 years it has been pretty standard
So many scientists are here on bluesky, so either you or someone you know could be interested in submitting a paper in this special issue of "Pharmaceutics" devoted to #oncolyticviruses as drug delivery platforms! (Where I serve as guest editor) 🧪 #medsky #sciencesky
www.mdpi.com/journal/phar...
www.mdpi.com/journal/phar...
www.mdpi.com
April 29, 2025 at 7:34 AM
So many scientists are here on bluesky, so either you or someone you know could be interested in submitting a paper in this special issue of "Pharmaceutics" devoted to #oncolyticviruses as drug delivery platforms! (Where I serve as guest editor) 🧪 #medsky #sciencesky
www.mdpi.com/journal/phar...
www.mdpi.com/journal/phar...
Se è vero (non ci si può mai fidare) si affacciano alcune domande: non era meglio semplicemente non cantarla? Più provocatoriamente se il "mood" del coro era questo, potevano cantare direttamente l'Horst-Wessel-Lied, che dava anche un tocco più internazionale.
Il coro cambia Fischia il vento: via le parole “rossa” e “fascista", la bandiera diventa “italica”
https://genova.repubblica.it/cronaca/2025/04/24/news/la_spezia_il_coro_cambia_fischia_il_vento_via_le_parole_rossa_e_fascista_la_bandiera_diventa_italica_resistenza_25_a-424146858/?rss
https://genova.repubblica.it/cronaca/2025/04/24/news/la_spezia_il_coro_cambia_fischia_il_vento_via_le_parole_rossa_e_fascista_la_bandiera_diventa_italica_resistenza_25_a-424146858/?rss
April 24, 2025 at 4:34 PM
Se è vero (non ci si può mai fidare) si affacciano alcune domande: non era meglio semplicemente non cantarla? Più provocatoriamente se il "mood" del coro era questo, potevano cantare direttamente l'Horst-Wessel-Lied, che dava anche un tocco più internazionale.
"It's a cold" /s
The number of American adults in the labour force with a disability since Covid
April 9, 2025 at 11:11 AM
"It's a cold" /s
Very important considerations on the persistence of SARS-CoV2 and how it can be associated with neurological symptoms.
April 6, 2025 at 2:21 PM
Very important considerations on the persistence of SARS-CoV2 and how it can be associated with neurological symptoms.
Il paradosso di un paese che non ha gli occhi per piangere ma investe 25 miliardi in armi, e crea uno scudo aereo chiamato "lo scudo di Achille", scegliendo anche un eroe eponimo che notoriamente è finito ammazzato. E dire che ne avevano di possibilità mitologiche..
La Grèce investit 25 milliards d’euros dans sa défense et lance un dôme de protection aérienne, le « bouclier d’Achille »
La Grèce investit 25 milliards d’euros dans sa défense et lance un dôme de protection aérienne, le « bouclier d’Achille »
Le premier ministre Kyriakos Mitsotakis a présenté sa feuille de route de modernisation des forces armées grecques sur douze ans. Le pays membre de l’OTAN est déjà l’une des nations européennes de l’alliance transatlantique qui consacre la plus forte part de son PIB aux dépenses militaires.
www.lemonde.fr
April 4, 2025 at 11:55 AM
Il paradosso di un paese che non ha gli occhi per piangere ma investe 25 miliardi in armi, e crea uno scudo aereo chiamato "lo scudo di Achille", scegliendo anche un eroe eponimo che notoriamente è finito ammazzato. E dire che ne avevano di possibilità mitologiche..
#sciencesky #science Has anyone else been wondering why some (very) outlandish stuff appears as trending articles on #pubmed? Is it the same for all? For example for me these days, the top trending article is a disturbing 1859 case report of rabies in a 10-yr old girl bitten by a polecat.
March 30, 2025 at 12:06 PM
#sciencesky #science Has anyone else been wondering why some (very) outlandish stuff appears as trending articles on #pubmed? Is it the same for all? For example for me these days, the top trending article is a disturbing 1859 case report of rabies in a 10-yr old girl bitten by a polecat.
"Uno studio ha mostrato che la paura per l'AfD (estrema destra tedesca per chi non sapesse) è circa il doppio della paura dell'immigrazione. Nel documento preliminare Cdu-Spd per nuovo governo all'estremismo di destra non è dedicata neanche una parola, all'immigrazione due pagine"
Eine Studie hat gezeigt, dass die Angst vor der AfD fast doppelt so groß ist wie die vor Migration. Im Sondierungspapier von Union und SPD wurde Rechtsextremismus mit keinem Wort erwähnt, Migration bekam fast zwei Seiten.
March 11, 2025 at 4:30 PM
"Uno studio ha mostrato che la paura per l'AfD (estrema destra tedesca per chi non sapesse) è circa il doppio della paura dell'immigrazione. Nel documento preliminare Cdu-Spd per nuovo governo all'estremismo di destra non è dedicata neanche una parola, all'immigrazione due pagine"
The fact that in the absence of high vaccination rates measles makes a comeback, has nothing surprising at all. Here, multiple social factors are at work. Not all viruses are the same, for some viruses the immunity induced by current vaccines doesn't prevent infection but reduces severity/
An unvaccinated NJ traveler who returned to the US infected with #measles went to 3 health facilities earlier this month seeking care before being diagnosed. Not surprisingly, additional cases are now being detected.
Measles will spread if we give it the chance. www.nj.com/healthfit/20...
Measles will spread if we give it the chance. www.nj.com/healthfit/20...
New measles cases tied to N.J. patient who visited 3 health facilities
The New Jersey Department of Health confirmed an initial measles case on Feb. 14 in an unvaccinated individual, and by Feb. 20, two additional cases were identified in people who had close contact wit...
www.nj.com
February 28, 2025 at 12:03 PM
The fact that in the absence of high vaccination rates measles makes a comeback, has nothing surprising at all. Here, multiple social factors are at work. Not all viruses are the same, for some viruses the immunity induced by current vaccines doesn't prevent infection but reduces severity/
@volksverpetzer.de Daraus habe ich jetzt erfahren, dass es nach @derstandard.at eine islamistische Terrorwelle in Österreich gibt.. Was denken Sie darüber?
Wie die Terrorwelle Österreich trifft: @janmichaelmarchart.bsky.social erklärt, wieso die neue Welle an islamistischen Anschlägen so schwer zu stoppen ist und, was der Staat tun kann.
Das ganze Video findet ihr hier: https://www.youtube.com/watch?v=xW0_Pbv8Gkc
Das ganze Video findet ihr hier: https://www.youtube.com/watch?v=xW0_Pbv8Gkc
February 26, 2025 at 10:17 AM
@volksverpetzer.de Daraus habe ich jetzt erfahren, dass es nach @derstandard.at eine islamistische Terrorwelle in Österreich gibt.. Was denken Sie darüber?
If you want to sound cool and get general praise in international politics, just blame Europe. "Europe is shit" - almost nobody's going to be angry and you'll get a lot of nodding from Europeans themselves. The problem is that usually in the headlines they don't specify WHY Europe is so bad
February 18, 2025 at 8:53 AM
If you want to sound cool and get general praise in international politics, just blame Europe. "Europe is shit" - almost nobody's going to be angry and you'll get a lot of nodding from Europeans themselves. The problem is that usually in the headlines they don't specify WHY Europe is so bad
"Negli ultimi giorni ci sono state aggressioni col coltello a Brema, Lubecca (...) diverse a Dortmund e a Berlino. In parte con morti, sparatorie con la polizia, vittime casuali. Probabilmente non hai sentito parlare di nessuno di questi casi" (gli aggressori erano tedeschi)
In den vergangenen Tagen gab es Messerangriffe in Bremen, Lübeck, Ratingen, Erfurt, mehrere in Dortmund und in Berlin. Teilweise mit Toten, mit Schusswechsel mit der Polizei, willkürliche Opfer. Von keinem hast du wahrscheinlich gehört. Rate mal, warum. www.volksverpetzer.de/analyse/mani...
So manipuliert man dich über Messerangriffe
In den vergangenen Tagen gab es Messerangriffe in Bremen, Lübeck, Ratingen, Erfurt, mehrere in Dortmund und in Berlin. Teilweise mit Toten, mit Schusswechsel mit der Polizei. Von keinem hast du wahrsc...
www.volksverpetzer.de
February 16, 2025 at 11:01 AM
"Negli ultimi giorni ci sono state aggressioni col coltello a Brema, Lubecca (...) diverse a Dortmund e a Berlino. In parte con morti, sparatorie con la polizia, vittime casuali. Probabilmente non hai sentito parlare di nessuno di questi casi" (gli aggressori erano tedeschi)
Un aspetto poco ricordato è che faceva parte dell'ideologia nazista l'oppressione a tutti i costi, l'idea che chi avesse abbandonato qualsiasi scrupolo, morale, diplomatico, politico, avrebbe vinto e dominato il mondo. L'esito è stata non solo la distruzione ma anche la auto-distruzione
#27gennaio 1945 avanguardie sovietiche liberano Auschwitz. È l'unica ricorrenza civile che unisce l'Europa ricorda la storica Anna Foa. Occasione per battersi contro razzismo, antisemitismo, guerra. Una #giornatadellamemoria contro le atrocità, dice al Corriere. Per stare dalla parte dell'umanità
January 27, 2025 at 10:50 AM
Un aspetto poco ricordato è che faceva parte dell'ideologia nazista l'oppressione a tutti i costi, l'idea che chi avesse abbandonato qualsiasi scrupolo, morale, diplomatico, politico, avrebbe vinto e dominato il mondo. L'esito è stata non solo la distruzione ma anche la auto-distruzione
I agree, it is becoming a great place to find scholars from different disciplines. I guess we'll have to cope with the reduced amount of anti-vaxx anti-science accounts.. We can make it 🧪
Personally, I love it here 🦋 - and for science 🧪 its wonderful!
And its also increasingly getting better & better for other diverse and interesting random posts (non-science) as more and more join - lets hope the overall engagement and positivity remains!
www.nature.com/articles/d41...
And its also increasingly getting better & better for other diverse and interesting random posts (non-science) as more and more join - lets hope the overall engagement and positivity remains!
www.nature.com/articles/d41...
Bluesky’s science takeover: 70% of Nature poll respondents use platform
Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.
www.nature.com
January 24, 2025 at 3:40 PM
I agree, it is becoming a great place to find scholars from different disciplines. I guess we'll have to cope with the reduced amount of anti-vaxx anti-science accounts.. We can make it 🧪
Lo dico? Che brutta fine che ha fatto la Svezia. La revoca della cittadinanza a me evoca sempre una parola tedesca: Ausbürgerung. Cercatela se volete
ilpost.link/XgoZMz82VE
ilpost.link/XgoZMz82VE
La Svezia vorrebbe revocare la cittadinanza a chi considera una minaccia per lo Stato - Il Post
È una proposta su cui sono d'accordo diversi partiti, anche se il governo di destra vorrebbe criteri più ampi che comprendano i membri delle gang criminali
ilpost.link
January 16, 2025 at 2:30 PM
Lo dico? Che brutta fine che ha fatto la Svezia. La revoca della cittadinanza a me evoca sempre una parola tedesca: Ausbürgerung. Cercatela se volete
ilpost.link/XgoZMz82VE
ilpost.link/XgoZMz82VE
Just (re)sharing our latest work on #oncolyticviruses for #glioblastoma, in which we show a powerful immunogenic response to oncolytic HSV1 in an immunocompetent, orthotopic mouse model pubmed.ncbi.nlm.nih.gov/39334370/. Feel free to ask if you want to know more 🧪
An oncolytic HSV-1 vector induces a therapeutic adaptive immune response against glioblastoma - PubMed
EGFP-oHSV1 demonstrates potent antitumoral activity in an immunocompetent GBM model as a monotherapy, resulting from direct cell killing combined with the stimulation of a protective adaptive immune r...
pubmed.ncbi.nlm.nih.gov
January 8, 2025 at 12:43 PM
Just (re)sharing our latest work on #oncolyticviruses for #glioblastoma, in which we show a powerful immunogenic response to oncolytic HSV1 in an immunocompetent, orthotopic mouse model pubmed.ncbi.nlm.nih.gov/39334370/. Feel free to ask if you want to know more 🧪
The main issue with the current understanding of #sarscov2 is that everyone focused only on the acute infection. Both people and authorities became used to thinking that we have a problem with the virus when a lot of people end up in ICU with pneumonia./
December 23, 2024 at 12:23 PM
The main issue with the current understanding of #sarscov2 is that everyone focused only on the acute infection. Both people and authorities became used to thinking that we have a problem with the virus when a lot of people end up in ICU with pneumonia./
A man who came back to Italy after travelling to #Congo has died of "fever with haemorrhage". Diagnostic investigations are ongoing www.quotidianosanita.it/m/regioni-e-...
Segnalato in Veneto un decesso di una persona rientrata recentemente dal Congo. In corso accertamenti. Attivate misure di sanità pubblica
Sono in corso gli accertamenti diagnostici, che consentiranno di fare luce sull’eziologia della malattia, in collaborazione con l’Istituto “Lazzaro Spallanzani”. In attesa delle verifiche sono state a...
www.quotidianosanita.it
December 17, 2024 at 9:43 PM
A man who came back to Italy after travelling to #Congo has died of "fever with haemorrhage". Diagnostic investigations are ongoing www.quotidianosanita.it/m/regioni-e-...
This is the journal #science reminding us that #sarscov2 induces endothelial dysfunction, which can lead to problems in virtually any organ. Unfortunately, this can happen even if the primary infection is "mild", with an increased risk of vascular diseases like stroke, infarction/
Infection with #SARSCoV2 has highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of #COVID19 and potentially to the longer-term consequences associated with #LongCovid.
Learn more in a new #SciencePerspective:
Learn more in a new #SciencePerspective:
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
scim.ag
December 17, 2024 at 7:53 PM