Alberto Reale
@albertoreale.bsky.social
MD PhD, postdoc doing translational research on viral vectors for cancer, vaccines, and genetic diseases. Also, big history and ancient languages nerd. Italy
The somewhat uncomfortable question is, are these continuous outbreaks of hemorrhagic fever viruses favouring the evolution of variants which are more infectious to humans?
November 16, 2025 at 12:18 PM
The somewhat uncomfortable question is, are these continuous outbreaks of hemorrhagic fever viruses favouring the evolution of variants which are more infectious to humans?
Katholisch? In Dänemark?
November 9, 2025 at 9:34 PM
Katholisch? In Dänemark?
Partial good news is that there is a good match with this year's vaccine strains, at least so I read.
November 9, 2025 at 8:50 PM
Partial good news is that there is a good match with this year's vaccine strains, at least so I read.
Even if, there are complicated research approaches and a few patients in the world have been apparently cured with blood stem cell transplant that they needed for other reasons like cancer. But this integration is something very specific for HIV, not a relevant mechanism for SARS-CoV2
November 9, 2025 at 9:30 AM
Even if, there are complicated research approaches and a few patients in the world have been apparently cured with blood stem cell transplant that they needed for other reasons like cancer. But this integration is something very specific for HIV, not a relevant mechanism for SARS-CoV2
You won't remove the virus from the body (how do you remove something that has become part of your DNA?) but you will prevent it from replicating. In this sense, we do have a cure for AIDS, the immune deficiency which is the end stage of the HIV infection, we don't have a cure for HIV infection/
November 9, 2025 at 9:30 AM
You won't remove the virus from the body (how do you remove something that has become part of your DNA?) but you will prevent it from replicating. In this sense, we do have a cure for AIDS, the immune deficiency which is the end stage of the HIV infection, we don't have a cure for HIV infection/
Hi, I'm a virologist.. HIV is a VERY peculiar virus because it has the ability to integrate into the genome of the infected cell, where it can remain even if it isn't producing any viral proteins. Thus, even if you hit pharmacologically several proteins essential for its replication/
November 9, 2025 at 9:30 AM
Hi, I'm a virologist.. HIV is a VERY peculiar virus because it has the ability to integrate into the genome of the infected cell, where it can remain even if it isn't producing any viral proteins. Thus, even if you hit pharmacologically several proteins essential for its replication/
Deve essere una specie di regola, "se avviene in Africa (soprattutto a sud del Sahara) non è grave"
November 7, 2025 at 8:07 AM
Deve essere una specie di regola, "se avviene in Africa (soprattutto a sud del Sahara) non è grave"
Possibile! In vari decenni di vita in Italia (nord Italia) non l'ho mai sentito
November 6, 2025 at 7:08 AM
Possibile! In vari decenni di vita in Italia (nord Italia) non l'ho mai sentito
Ottimo italiano ma l'espressione giusta è "mi fa uscire di testa" o "mi manda fuori di testa" 😉
November 6, 2025 at 6:51 AM
Ottimo italiano ma l'espressione giusta è "mi fa uscire di testa" o "mi manda fuori di testa" 😉
@daniellebeckman.bsky.social showed in her microscopy pictures that SARS CoV2 might enter the CNS inside infected leukocytes, this same mechanism can also be exploited to get a beneficial effect
November 3, 2025 at 11:31 PM
@daniellebeckman.bsky.social showed in her microscopy pictures that SARS CoV2 might enter the CNS inside infected leukocytes, this same mechanism can also be exploited to get a beneficial effect
You know, on a historical scale, it's not so optimistic. Things change and they can change a lot; balances of power that seemed unshakeable can collapse suddenly. The problem is the historical scale, one could be legitimately angry that maybe this will happen in 10 years, maybe in 50 years or more
October 24, 2025 at 6:07 PM
You know, on a historical scale, it's not so optimistic. Things change and they can change a lot; balances of power that seemed unshakeable can collapse suddenly. The problem is the historical scale, one could be legitimately angry that maybe this will happen in 10 years, maybe in 50 years or more
Unfortunately, it's not so easy. People might have their boss making unpleasant remarks on the mask and be scared that this can have a negative impact on their career. They might be afraid that in general being "the weird one" could isolate them and again, damage their career..
October 22, 2025 at 1:39 PM
Unfortunately, it's not so easy. People might have their boss making unpleasant remarks on the mask and be scared that this can have a negative impact on their career. They might be afraid that in general being "the weird one" could isolate them and again, damage their career..
Something drawn during the Nazi occupation, but when it was becoming clear that they were losing? Say, 1944..
September 12, 2025 at 5:59 PM
Something drawn during the Nazi occupation, but when it was becoming clear that they were losing? Say, 1944..
Is this something universal in ALL viruses of fungi? That they don't have an extracellular phase? This sounds really exceptional
August 30, 2025 at 5:23 PM
Is this something universal in ALL viruses of fungi? That they don't have an extracellular phase? This sounds really exceptional
1.Qxg6+ Kxg6 2.Bd3+ Kh5 3.Nf4#
August 22, 2025 at 8:45 PM
1.Qxg6+ Kxg6 2.Bd3+ Kh5 3.Nf4#
Sewage systems, sorry
August 22, 2025 at 1:18 PM
Sewage systems, sorry
And also, how come when people really exercised their immunity (I mean before there were sewage system), the average life expectancy was <40?
August 22, 2025 at 1:18 PM
And also, how come when people really exercised their immunity (I mean before there were sewage system), the average life expectancy was <40?
Abschiebungen und Grenzkontrollen sind genau das, was die ältesten Staaten der Welt wie Deutschland und Italien derzeit brauchen (ironisch).
August 22, 2025 at 8:12 AM
Abschiebungen und Grenzkontrollen sind genau das, was die ältesten Staaten der Welt wie Deutschland und Italien derzeit brauchen (ironisch).
If I had the possibility- I work on somewhat different stuff - I would explore the possibility of using anti-CD19 CAR-T cells for severe LC patients. It is likely an autoimmune disease and CAR-T are working extremely well against autoimmunity which is resistant to other treatments.
August 18, 2025 at 5:27 PM
If I had the possibility- I work on somewhat different stuff - I would explore the possibility of using anti-CD19 CAR-T cells for severe LC patients. It is likely an autoimmune disease and CAR-T are working extremely well against autoimmunity which is resistant to other treatments.
Are there also viruses that kill fungi? That could be used as therapeutics? This is kind of something I've had on my mind for a few years 😄
August 16, 2025 at 11:05 PM
Are there also viruses that kill fungi? That could be used as therapeutics? This is kind of something I've had on my mind for a few years 😄
Is the woman in the picture trying to do a nasal swab *through a surgical mask*?
August 12, 2025 at 7:42 PM
Is the woman in the picture trying to do a nasal swab *through a surgical mask*?
That's clearly a very learned reference to Middle English (medieval) when this kind of spelling was common! 😃
August 11, 2025 at 10:25 AM
That's clearly a very learned reference to Middle English (medieval) when this kind of spelling was common! 😃
E io che pensavo che tanta gente che lavora in estate non potesse fare più di 2 settimane di ferie..
August 10, 2025 at 9:20 AM
E io che pensavo che tanta gente che lavora in estate non potesse fare più di 2 settimane di ferie..