Ali D. Güler
@aguler.bsky.social
Dad, husband, member of the Güler circadian neurometabolism lab at UVA 🧪 ☘️
Pinned
Reposted by Ali D. Güler
#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...
Circadian variation in MGMT promoter methylation and expression predicts sensitivity to temozolomide in glioblastoma - Journal of Neuro-Oncology
Purpose Recent studies show that glioblastoma (GBM) is more sensitive to temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent ...
link.springer.com
October 22, 2025 at 1:04 PM
#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...
Reposted by Ali D. Güler
I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
jeremymberg.github.io
October 6, 2025 at 11:28 PM
I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
Deafening Quiet from the Scientific Establishment
jeremymberg.github.io/jeremyberg.g...
1/14
Reposted by Ali D. Güler
Interested in a tenure track position teaching and doing research with undergrads at a PUI? We are looking for a broadly-defined microbiologist who can teach Med Micro and Immunology. Apply at universityofscrantonjobs.com/postings/8308. Pls share widely to feeds (& on twitter if you still tweet)! 🦠
October 1, 2025 at 1:44 PM
Interested in a tenure track position teaching and doing research with undergrads at a PUI? We are looking for a broadly-defined microbiologist who can teach Med Micro and Immunology. Apply at universityofscrantonjobs.com/postings/8308. Pls share widely to feeds (& on twitter if you still tweet)! 🦠
Reposted by Ali D. Güler
I am not a political pawn. I am a living, breathing human being who has dedicated her life to a scientific problem that I believe matters for human health. The article below tells our story; I hope you will read it and share it www.nytimes.com/2025/09/14/m...
Trump Is Shutting Down the War On Cancer
www.nytimes.com
September 14, 2025 at 2:26 PM
I am not a political pawn. I am a living, breathing human being who has dedicated her life to a scientific problem that I believe matters for human health. The article below tells our story; I hope you will read it and share it www.nytimes.com/2025/09/14/m...
Reposted by Ali D. Güler
Don't miss this opportunity to be our colleague! Very exciting initiative here at UVA!
🚨 We’re hiring! 🧪 @uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 5, 2025 at 2:27 PM
Don't miss this opportunity to be our colleague! Very exciting initiative here at UVA!
Reposted by Ali D. Güler
Come be my colleague! Happy to answer any questions about what it's like living in Charlottesville and being in the department.
🚨 We’re hiring! 🧪 @uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 5, 2025 at 2:30 PM
Come be my colleague! Happy to answer any questions about what it's like living in Charlottesville and being in the department.
Reposted by Ali D. Güler
We welcome applicants working on:
• Neural circuits & plasticity
• Glia & brain interactions
• Behavioral genetics & genomics
…and more!
Join a highly interdisciplinary department with access to state-of-the-art imaging, genomics, metabolomics, and computing resources.
• Neural circuits & plasticity
• Glia & brain interactions
• Behavioral genetics & genomics
…and more!
Join a highly interdisciplinary department with access to state-of-the-art imaging, genomics, metabolomics, and computing resources.
September 4, 2025 at 9:02 PM
We welcome applicants working on:
• Neural circuits & plasticity
• Glia & brain interactions
• Behavioral genetics & genomics
…and more!
Join a highly interdisciplinary department with access to state-of-the-art imaging, genomics, metabolomics, and computing resources.
• Neural circuits & plasticity
• Glia & brain interactions
• Behavioral genetics & genomics
…and more!
Join a highly interdisciplinary department with access to state-of-the-art imaging, genomics, metabolomics, and computing resources.
Reposted by Ali D. Güler
At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more... in beautiful Charlottesville, VA. 🌄
Apply today & help shape the future of neuroscience:
👉 apply.interfolio.com/172892
Apply today & help shape the future of neuroscience:
👉 apply.interfolio.com/172892
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 4, 2025 at 9:02 PM
At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more... in beautiful Charlottesville, VA. 🌄
Apply today & help shape the future of neuroscience:
👉 apply.interfolio.com/172892
Apply today & help shape the future of neuroscience:
👉 apply.interfolio.com/172892
Reposted by Ali D. Güler
🚨 We’re hiring! 🧪 @uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 4, 2025 at 9:02 PM
🚨 We’re hiring! 🧪 @uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
🚨 We’re hiring! 🧪 @uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 4, 2025 at 9:02 PM
🚨 We’re hiring! 🧪 @uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA
Reposted by Ali D. Güler
It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit.
You all have my sympathies. Unfair doesn’t even begin to describe it.
You all have my sympathies. Unfair doesn’t even begin to describe it.
August 18, 2025 at 4:14 AM
It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit.
You all have my sympathies. Unfair doesn’t even begin to describe it.
You all have my sympathies. Unfair doesn’t even begin to describe it.
Reposted by Ali D. Güler
GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits https://www.biorxiv.org/content/10.1101/2025.08.12.669936v1
August 16, 2025 at 1:15 AM
GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits https://www.biorxiv.org/content/10.1101/2025.08.12.669936v1
Reposted by Ali D. Güler
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
August 10, 2025 at 1:19 PM
Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...
Reposted by Ali D. Güler
These are the most challenging times for early-career scientists and engineers.
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
August 11, 2025 at 11:54 AM
These are the most challenging times for early-career scientists and engineers.
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.
We found 437 of them.
Download it freely here: research.jhu.edu/rdt/funding-...
Reposted by Ali D. Güler
My team has updated our free database of POSTDOC fellowships.
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
August 10, 2025 at 7:50 PM
My team has updated our free database of POSTDOC fellowships.
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.
Download this updated and expanded database here: research.jhu.edu/rdt/funding-...
Reposted by Ali D. Güler
The updated version of the database of PhD fellowships produced and maintained by my team can be downloaded by anyone here:
research.jhu.edu/rdt/funding-...
For each of the 187 fellowships, you will find a short description, deadline, $ amount, link, etc.
Good luck!
research.jhu.edu/rdt/funding-...
For each of the 187 fellowships, you will find a short description, deadline, $ amount, link, etc.
Good luck!
August 8, 2025 at 10:59 AM
The updated version of the database of PhD fellowships produced and maintained by my team can be downloaded by anyone here:
research.jhu.edu/rdt/funding-...
For each of the 187 fellowships, you will find a short description, deadline, $ amount, link, etc.
Good luck!
research.jhu.edu/rdt/funding-...
For each of the 187 fellowships, you will find a short description, deadline, $ amount, link, etc.
Good luck!
Reposted by Ali D. Güler
It doesn't matter if the Executive Order is illegal. The NIH has demonstrated consistently that it will follow orders from the OMB. Expect immediate action from the NIH on this order.
As I told you months ago, the old NIH is gone.
As I told you months ago, the old NIH is gone.
August 8, 2025 at 1:07 AM
It doesn't matter if the Executive Order is illegal. The NIH has demonstrated consistently that it will follow orders from the OMB. Expect immediate action from the NIH on this order.
As I told you months ago, the old NIH is gone.
As I told you months ago, the old NIH is gone.
Reposted by Ali D. Güler
Reposted by Ali D. Güler
People who were overweight or had obesity lost a substantial amount of weight after taking a daily pill made by Eli Lilly, the company reported Wednesday. If the pill is approved by the FDA, it'll provide an alternative to weight-loss injectables like Ozempic.
Pill Causes Major Weight Loss in Eli Lilly Trial’s Results
The company said it planned to seek Food and Drug Administration approval for the drug, orforglipron, before the end of the year.
nyti.ms
August 7, 2025 at 5:20 PM
People who were overweight or had obesity lost a substantial amount of weight after taking a daily pill made by Eli Lilly, the company reported Wednesday. If the pill is approved by the FDA, it'll provide an alternative to weight-loss injectables like Ozempic.
Reposted by Ali D. Güler
"What struck me was that many of my colleagues at universities [last week] were like, ‘Oh, my God, they’re stopping grants!’ And it seemed to activate people in a way that I hadn’t seen before.
Whereas a lot of us at NIH thought, ‘Oh, they just did another thing [to stop grants].’” 🧪
Whereas a lot of us at NIH thought, ‘Oh, they just did another thing [to stop grants].’” 🧪
‘It’s really, really bad right now’: NIH scientists dismayed by Trump cuts
Researchers say scientific community is in state of whiplash and accuse president of trying to ‘destroy’ vital work
www.theguardian.com
August 7, 2025 at 4:29 PM
"What struck me was that many of my colleagues at universities [last week] were like, ‘Oh, my God, they’re stopping grants!’ And it seemed to activate people in a way that I hadn’t seen before.
Whereas a lot of us at NIH thought, ‘Oh, they just did another thing [to stop grants].’” 🧪
Whereas a lot of us at NIH thought, ‘Oh, they just did another thing [to stop grants].’” 🧪
Reposted by Ali D. Güler
#JNeurosci: Stritzel et al. found that brief nighttime exposure to dim red light conditions widely used in rodent research caused circadian disruption and red light stimuli were detected by the rodent visual system. @colorado.edu @vulintus.com
https://doi.org/10.1523/JNEUROSCI.0157-25.2025
https://doi.org/10.1523/JNEUROSCI.0157-25.2025
July 30, 2025 at 2:32 PM
#JNeurosci: Stritzel et al. found that brief nighttime exposure to dim red light conditions widely used in rodent research caused circadian disruption and red light stimuli were detected by the rodent visual system. @colorado.edu @vulintus.com
https://doi.org/10.1523/JNEUROSCI.0157-25.2025
https://doi.org/10.1523/JNEUROSCI.0157-25.2025
Reposted by Ali D. Güler
If they really had our backs, they would take steps RIGHT NOW to stop the NIH from continuing with the multi year mandate pushed by Vought and the OMB.
“To the scientists wondering if there will even be an NIH by the end of this administration, this committee’s resounding message is: ‘Yes, Congress has your back’,” said @murray.senate.gov
We’re not near the finish line yet - but this is a strong step in the right direction.
zurl.co/AzSK7
We’re not near the finish line yet - but this is a strong step in the right direction.
zurl.co/AzSK7
‘Congress has your back’: US senators tell scientists they want to protect NIH budget
Senate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law. Senate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law.
www.nature.com
August 4, 2025 at 7:50 PM
If they really had our backs, they would take steps RIGHT NOW to stop the NIH from continuing with the multi year mandate pushed by Vought and the OMB.
Reposted by Ali D. Güler
Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...
Low-dose metformin requires brain Rap1 for its antidiabetic action
Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.
www.science.org
July 31, 2025 at 6:52 PM
Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...
Reposted by Ali D. Güler
Houston researchers found that low-dose metformin needs Rap1 in the brain to lower blood sugar.
Without brain Rap1, metformin doesn’t work, but other diabetes drugs still do.
The ventromedial hypothalamus is the key control site.
www.science.org/doi/10.1126/...
Without brain Rap1, metformin doesn’t work, but other diabetes drugs still do.
The ventromedial hypothalamus is the key control site.
www.science.org/doi/10.1126/...
Low-dose metformin requires brain Rap1 for its antidiabetic action
Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.
www.science.org
August 1, 2025 at 3:52 PM
Houston researchers found that low-dose metformin needs Rap1 in the brain to lower blood sugar.
Without brain Rap1, metformin doesn’t work, but other diabetes drugs still do.
The ventromedial hypothalamus is the key control site.
www.science.org/doi/10.1126/...
Without brain Rap1, metformin doesn’t work, but other diabetes drugs still do.
The ventromedial hypothalamus is the key control site.
www.science.org/doi/10.1126/...
Reposted by Ali D. Güler
Blame the damn human not the poor mouse!
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...
Don't blame the poor mouse, blame the stupid human who chose the molecular target!
'The fault, Dear Reader, lies not in the mice but in our targets'
open.substack.com
August 2, 2025 at 12:01 AM
Blame the damn human not the poor mouse!
open.substack.com/pub/zendudes...
open.substack.com/pub/zendudes...