Adil Khan
@adil-khan.bsky.social
Programming plants for space | ARC Centre of Excellence in Plants for Space | The University of Western Australia
Reposted by Adil Khan
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics
Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.
www.nature.com
November 18, 2025 at 12:00 PM
Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9
Reposted by Adil Khan
Big update: My the first Lloyd Lab conceived and conducted study has been accepted and published:
Start Right to End Right: Authentic Open Reading Frame Selection Matters for Nonsense-Mediated Decay Target Identification
www.mdpi.com/2073-4425/16...
Now larger and better than the pre-print
Start Right to End Right: Authentic Open Reading Frame Selection Matters for Nonsense-Mediated Decay Target Identification
www.mdpi.com/2073-4425/16...
Now larger and better than the pre-print
www.mdpi.com
November 6, 2025 at 2:14 PM
Big update: My the first Lloyd Lab conceived and conducted study has been accepted and published:
Start Right to End Right: Authentic Open Reading Frame Selection Matters for Nonsense-Mediated Decay Target Identification
www.mdpi.com/2073-4425/16...
Now larger and better than the pre-print
Start Right to End Right: Authentic Open Reading Frame Selection Matters for Nonsense-Mediated Decay Target Identification
www.mdpi.com/2073-4425/16...
Now larger and better than the pre-print
Reposted by Adil Khan
I am delighted to share our latest work on memory gene circuits for plants. This work was led by the phenomenal PhD student @patrickgong.bsky.social
A lot of debugging & highlights how even simple components in synthetic biology can have unexpected properties.
www.biorxiv.org/content/10.1...
A lot of debugging & highlights how even simple components in synthetic biology can have unexpected properties.
www.biorxiv.org/content/10.1...
CREation of an expanded plant memory gene circuit toolkit
Genetic circuits rely on modular, well-characterized genetic parts to achieve predictable cellular behaviour. Despite their widespread adoption, biological parts are complex and when used in a new mol...
www.biorxiv.org
October 31, 2025 at 9:24 AM
I am delighted to share our latest work on memory gene circuits for plants. This work was led by the phenomenal PhD student @patrickgong.bsky.social
A lot of debugging & highlights how even simple components in synthetic biology can have unexpected properties.
www.biorxiv.org/content/10.1...
A lot of debugging & highlights how even simple components in synthetic biology can have unexpected properties.
www.biorxiv.org/content/10.1...
Reposted by Adil Khan
Just a few days left to apply! (closes Aug 25)
We're hiring! Need a microscopy wizard to help build the world’s first synthetic plant chromosome! Bring your lights, lasers, & lens-craft to characterise new artificial chromosomes. Join our ARIA-funded project at UWA in Perth & @plants4space.bsky.social. Apply: bit.ly/3GKSRSA
August 19, 2025 at 6:30 AM
Just a few days left to apply! (closes Aug 25)
Reposted by Adil Khan
🎵 Every move you make, every telomere you shake, every strand you break, we’ll be watchin’ you...🎵 Advanced-imaging guru needed to keep a close eye on plant synthetic chromosomes in our ARIA research project at UWA in Perth & @plants4space.bsky.social. Apply now: bit.ly/3GKSRSA
August 1, 2025 at 8:24 AM
🎵 Every move you make, every telomere you shake, every strand you break, we’ll be watchin’ you...🎵 Advanced-imaging guru needed to keep a close eye on plant synthetic chromosomes in our ARIA research project at UWA in Perth & @plants4space.bsky.social. Apply now: bit.ly/3GKSRSA
Reposted by Adil Khan
Happy to see our latest work out in @molbioevol.bsky.social. We revisit the evolution of 5-methylcytosine across neglected eukaryotic supergroups, establishing an ancestral repressive role silencing genome invaders, both transposons and viral elements👾: academic.oup.com/mbe/advance-... 🧵 1/7
Repressive cytosine methylation is a marker of viral gene transfer across divergent eukaryotes
Abstract. Cytosine DNA methylation patterns vary widely across eukaryotes, with its ancestral roles being understood to have included both transposable ele
academic.oup.com
July 28, 2025 at 10:03 AM
Happy to see our latest work out in @molbioevol.bsky.social. We revisit the evolution of 5-methylcytosine across neglected eukaryotic supergroups, establishing an ancestral repressive role silencing genome invaders, both transposons and viral elements👾: academic.oup.com/mbe/advance-... 🧵 1/7
Reposted by Adil Khan
We're hiring! Need a microscopy wizard to help build the world’s first synthetic plant chromosome! Bring your lights, lasers, & lens-craft to characterise new artificial chromosomes. Join our ARIA-funded project at UWA in Perth & @plants4space.bsky.social. Apply: bit.ly/3GKSRSA
July 16, 2025 at 2:29 AM
We're hiring! Need a microscopy wizard to help build the world’s first synthetic plant chromosome! Bring your lights, lasers, & lens-craft to characterise new artificial chromosomes. Join our ARIA-funded project at UWA in Perth & @plants4space.bsky.social. Apply: bit.ly/3GKSRSA
Reposted by Adil Khan
Come join us at UWA & @plants4space.bsky.social on the @aria-research.bsky.social funded project to build the first synthetic chromosome for plants!
We are looking for specific expertise with microscopy to look at the synthetic chromosome we are building.
external.jobs.uwa.edu.au/cw/en/job/52...
We are looking for specific expertise with microscopy to look at the synthetic chromosome we are building.
external.jobs.uwa.edu.au/cw/en/job/52...
Prospective staff : Jobs at UWA : The University Of Western Australia
external.jobs.uwa.edu.au
July 15, 2025 at 8:34 AM
Come join us at UWA & @plants4space.bsky.social on the @aria-research.bsky.social funded project to build the first synthetic chromosome for plants!
We are looking for specific expertise with microscopy to look at the synthetic chromosome we are building.
external.jobs.uwa.edu.au/cw/en/job/52...
We are looking for specific expertise with microscopy to look at the synthetic chromosome we are building.
external.jobs.uwa.edu.au/cw/en/job/52...
Reposted by Adil Khan
We're hiring for 2 postdocs to work in our lab in London on the newly announced Wellcome Trust SynHG project. If you know people looking to work on big-scale ambitious science like this, please RT and share this with them. Apply by 7/20, interviews in Aug. imperial.ac.uk/jobs/search-...
June 30, 2025 at 2:34 PM
We're hiring for 2 postdocs to work in our lab in London on the newly announced Wellcome Trust SynHG project. If you know people looking to work on big-scale ambitious science like this, please RT and share this with them. Apply by 7/20, interviews in Aug. imperial.ac.uk/jobs/search-...
Reposted by Adil Khan
Recombinases your thing? In the latest from my lab, Veronica Greco shows how @nanopore sequencing + automated liquid handling provides the perfect platform for characterising these systems at scale! Awesome collaboration with @jennbrophy.bsky.social @sarah-guiziou.bsky.social doi.org/10.1101/2025...
May 29, 2025 at 6:49 AM
Recombinases your thing? In the latest from my lab, Veronica Greco shows how @nanopore sequencing + automated liquid handling provides the perfect platform for characterising these systems at scale! Awesome collaboration with @jennbrophy.bsky.social @sarah-guiziou.bsky.social doi.org/10.1101/2025...
Reposted by Adil Khan
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
May 2, 2025 at 2:39 PM
I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design
Please repost for reach 💚
Reposted by Adil Khan
#PlantScience Research Weekly: April 11, 2025. plantae.org/plant-scienc... 150 years of Arabidopsis genetics; Rewiring plant traits with synthetic circuits; Expansion microscopy in protoplasts and intact roots; Carbonic anhydrase mutation uncouples WUE and photosynthesis (1/2)
April 11, 2025 at 8:03 AM
#PlantScience Research Weekly: April 11, 2025. plantae.org/plant-scienc... 150 years of Arabidopsis genetics; Rewiring plant traits with synthetic circuits; Expansion microscopy in protoplasts and intact roots; Carbonic anhydrase mutation uncouples WUE and photosynthesis (1/2)
Reposted by Adil Khan
Programmable and reversible CRISPRi-based genetic circuits function in a variety of plants go.nature.com/4bpCNQa
rdcu.be/egMmm
rdcu.be/egMmm
CRISPRi-based circuits to control gene expression in plants - Nature Biotechnology
Programmable and reversible CRISPRi-based genetic circuits function in a variety of plants.
go.nature.com
April 9, 2025 at 10:09 PM
Programmable and reversible CRISPRi-based genetic circuits function in a variety of plants go.nature.com/4bpCNQa
rdcu.be/egMmm
rdcu.be/egMmm
Reposted by Adil Khan
Thank you @aemonten.bsky.social !
This was the child of the great @adil-khan.bsky.social ! A huge effort of development and refinement
This was the child of the great @adil-khan.bsky.social ! A huge effort of development and refinement
April 9, 2025 at 11:45 PM
Thank you @aemonten.bsky.social !
This was the child of the great @adil-khan.bsky.social ! A huge effort of development and refinement
This was the child of the great @adil-khan.bsky.social ! A huge effort of development and refinement
Reposted by Adil Khan
Engineering resistance with help from Liverworts, Mosses and Ferns
@Phil_Carella @JohnInnesCentre www.jic.ac.uk/research-imp...
@Phil_Carella @JohnInnesCentre www.jic.ac.uk/research-imp...
Engineering resistance with help from Liverworts, Mosses and Ferns | John Innes Centre
Plant diversity and synthetic biology offer solutions to the global challenge of crop protection Non-flowering plants such as liverworts, mosses, and ferns belong to divergent lineages with ancient…
www.jic.ac.uk
March 24, 2025 at 11:47 AM
Engineering resistance with help from Liverworts, Mosses and Ferns
@Phil_Carella @JohnInnesCentre www.jic.ac.uk/research-imp...
@Phil_Carella @JohnInnesCentre www.jic.ac.uk/research-imp...
Reposted by Adil Khan
Our new review in @theplantjournal.bsky.social on synthetic gene circuits is out! I am super proud of this. I hope that it acts as a useful resource for people new to gene circuits.
The switch-liker's guide to plant synthetic gene circuits
onlinelibrary.wiley.com/doi/10.1111/...
The switch-liker's guide to plant synthetic gene circuits
onlinelibrary.wiley.com/doi/10.1111/...
The switch‐liker's guide to plant synthetic gene circuits
Synthetic gene circuits have the potential to revolutionise how plants can be engineered by allowing highly customised gene expression patterns to be designed. Gene circuits can sense and integrate m....
onlinelibrary.wiley.com
March 9, 2025 at 1:15 AM
Our new review in @theplantjournal.bsky.social on synthetic gene circuits is out! I am super proud of this. I hope that it acts as a useful resource for people new to gene circuits.
The switch-liker's guide to plant synthetic gene circuits
onlinelibrary.wiley.com/doi/10.1111/...
The switch-liker's guide to plant synthetic gene circuits
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Adil Khan
If you're struggling to assemble large DNA constructs, check out Chengsong's DASH system, which combines Golden Gate cloning, recombineering, and site-specific recombinases to build multigene constructs of ~100kb.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
March 7, 2025 at 6:57 PM
If you're struggling to assemble large DNA constructs, check out Chengsong's DASH system, which combines Golden Gate cloning, recombineering, and site-specific recombinases to build multigene constructs of ~100kb.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Adil Khan
Engineering a New Generation of Gene Editors: Integrating Synthetic Biology and AI Innovations
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Engineering a New Generation of Gene Editors: Integrating Synthetic Biology and AI Innovations
CRISPR-Cas technology has revolutionized biology by enabling precise DNA and RNA edits with ease. However, significant challenges remain for translating this technology into clinical applications. Tra...
pubs.acs.org
March 2, 2025 at 11:15 AM
Engineering a New Generation of Gene Editors: Integrating Synthetic Biology and AI Innovations
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Reposted by Adil Khan
📜 Synthetic gene circuits in plants: recent advances and challenges
🧑🔬 @adil-khan.bsky.social, @ryanlister.bsky.social
📔 Quantitative Plant Biology
🔗 www.cambridge.org/core/product...
#️⃣ #PlantScience #PlantSynBio #PlantSynthBio #SynBio
🧑🔬 @adil-khan.bsky.social, @ryanlister.bsky.social
📔 Quantitative Plant Biology
🔗 www.cambridge.org/core/product...
#️⃣ #PlantScience #PlantSynBio #PlantSynthBio #SynBio
Synthetic gene circuits in plants: recent advances and challenges | Quantitative Plant Biology | Cambridge Core
Synthetic gene circuits in plants: recent advances and challenges - Volume 6
www.cambridge.org
February 28, 2025 at 6:01 AM
📜 Synthetic gene circuits in plants: recent advances and challenges
🧑🔬 @adil-khan.bsky.social, @ryanlister.bsky.social
📔 Quantitative Plant Biology
🔗 www.cambridge.org/core/product...
#️⃣ #PlantScience #PlantSynBio #PlantSynthBio #SynBio
🧑🔬 @adil-khan.bsky.social, @ryanlister.bsky.social
📔 Quantitative Plant Biology
🔗 www.cambridge.org/core/product...
#️⃣ #PlantScience #PlantSynBio #PlantSynthBio #SynBio
Happy to share our new review on plant synthetic circuits in Quantitative Plant Biology
We explore the latest advances & challenges in the field.
www.cambridge.org/core/journal...
#synbio #plants
We explore the latest advances & challenges in the field.
www.cambridge.org/core/journal...
#synbio #plants
Synthetic gene circuits in plants: recent advances and challenges | Quantitative Plant Biology | Cambridge Core
Synthetic gene circuits in plants: recent advances and challenges - Volume 6
www.cambridge.org
February 27, 2025 at 6:28 PM
Happy to share our new review on plant synthetic circuits in Quantitative Plant Biology
We explore the latest advances & challenges in the field.
www.cambridge.org/core/journal...
#synbio #plants
We explore the latest advances & challenges in the field.
www.cambridge.org/core/journal...
#synbio #plants
Reposted by Adil Khan
New review on plant synthetic gene circuits by their pioneer @adil-khan.bsky.social
Synthetic gene circuits in plants: recent advances and challenges
www.cambridge.org/core/journal...
Synthetic gene circuits in plants: recent advances and challenges
www.cambridge.org/core/journal...
Synthetic gene circuits in plants: recent advances and challenges | Quantitative Plant Biology | Cambridge Core
Synthetic gene circuits in plants: recent advances and challenges - Volume 6
www.cambridge.org
February 27, 2025 at 11:17 AM
New review on plant synthetic gene circuits by their pioneer @adil-khan.bsky.social
Synthetic gene circuits in plants: recent advances and challenges
www.cambridge.org/core/journal...
Synthetic gene circuits in plants: recent advances and challenges
www.cambridge.org/core/journal...
Reposted by Adil Khan
AI-directed gene fusing prolongs the evolutionary half-life of synthetic gene circuits
doi.org/10.1101/2025...
doi.org/10.1101/2025...
February 13, 2025 at 6:22 AM
AI-directed gene fusing prolongs the evolutionary half-life of synthetic gene circuits
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Adil Khan
We’re looking for 3 postdocs to join our lab and work on engineering plant gene expression, metabolism and growth. If you have enthusiasm & skills in synthetic biology or metabolic engineering, apply by Jan 31.
www.jobs.cam.ac.uk/job/49767/
www.jobs.cam.ac.uk/job/49773/
www.jobs.cam.ac.uk/job/49769/
www.jobs.cam.ac.uk/job/49767/
www.jobs.cam.ac.uk/job/49773/
www.jobs.cam.ac.uk/job/49769/
January 2, 2025 at 4:15 PM
We’re looking for 3 postdocs to join our lab and work on engineering plant gene expression, metabolism and growth. If you have enthusiasm & skills in synthetic biology or metabolic engineering, apply by Jan 31.
www.jobs.cam.ac.uk/job/49767/
www.jobs.cam.ac.uk/job/49773/
www.jobs.cam.ac.uk/job/49769/
www.jobs.cam.ac.uk/job/49767/
www.jobs.cam.ac.uk/job/49773/
www.jobs.cam.ac.uk/job/49769/
Reposted by Adil Khan
🌱 Demirer Lab 🌱 @caltech.edu is looking for passionate graduate students to join us! Explore our exciting research for a sustainable future: demirerlab.com 🌏 🌱 🦠
📢 Apply here to CCE or BBE: t.co/cIv8Hbfy0Z and mention your interest in our lab in your statement.
🗓️ Application deadline: Dec 1
📢 Apply here to CCE or BBE: t.co/cIv8Hbfy0Z and mention your interest in our lab in your statement.
🗓️ Application deadline: Dec 1
November 26, 2024 at 11:09 PM
🌱 Demirer Lab 🌱 @caltech.edu is looking for passionate graduate students to join us! Explore our exciting research for a sustainable future: demirerlab.com 🌏 🌱 🦠
📢 Apply here to CCE or BBE: t.co/cIv8Hbfy0Z and mention your interest in our lab in your statement.
🗓️ Application deadline: Dec 1
📢 Apply here to CCE or BBE: t.co/cIv8Hbfy0Z and mention your interest in our lab in your statement.
🗓️ Application deadline: Dec 1
Reposted by Adil Khan
Mapping enhancer-gene regulatory interactions from single-cell data https://www.biorxiv.org/content/10.1101/2024.11.23.624931v1
Mapping enhancer-gene regulatory interactions from single-cell data https://www.biorxiv.org/content/10.1101/2024.11.23.624931v1
Mapping enhancers and their target genes in specific cell types is crucial for understanding gene re
www.biorxiv.org
November 24, 2024 at 10:32 AM
Mapping enhancer-gene regulatory interactions from single-cell data https://www.biorxiv.org/content/10.1101/2024.11.23.624931v1