Pavel Moudrý
@3reak.bsky.social
Group leader at Institute of Molecular and Translational Medicine, Palacký University Olomouc
Former postdoc @barteklab.bsky.social.
My group explores DNA replication dynamics in response to PARP inhibitors.
Former postdoc @barteklab.bsky.social.
My group explores DNA replication dynamics in response to PARP inhibitors.
Reposted by Pavel Moudrý
A mini review explores the molecular drivers of replication fork acceleration and their consequences for genome stability, innate immunity, and cancer. @3reak.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
The need for speed: drivers and consequences of accelerated replication forks - Communications Biology
A mini review explores molecular drivers of replication fork acceleration and their consequences for genome stability, innate immunity, and cancer.
www.nature.com
November 6, 2025 at 6:25 PM
A mini review explores the molecular drivers of replication fork acceleration and their consequences for genome stability, innate immunity, and cancer. @3reak.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Pavel Moudrý
New preprint from the lab for any DNA repair or replication stress geeks out there!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A nuclease-driven mechanism of post-replicative ssDNA gap suppression.
The persistence of post-replicative ssDNA gaps following PRIMPOL-mediated replication repriming is linked to chemosensitivity, and in all models reported to date the nuclease MRE11 has been implicated...
www.biorxiv.org
October 22, 2025 at 6:56 PM
New preprint from the lab for any DNA repair or replication stress geeks out there!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Pavel Moudrý
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Postdoctoral Research Associate in the Blackford Group
A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th
candidate.hr-manager.net
May 29, 2025 at 11:26 AM
We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Please get in touch with your CV if you are interested; closing date: 27th June 2025.
More details here: candidate.hr-manager.net/ApplicationI...
Reposted by Pavel Moudrý
Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...
May 21, 2025 at 3:57 PM
Sharing our latest work tracking DNA damage inheritance by Live+QIBC www.nature.com/articles/s41.... Huge congrats to @apanagopoulos.bsky.social, M. Stout and all co-authors for this tour de force! Beautifully summarized by @s-j-aitken.bsky.social & E. Reilly www.nature.com/articles/d41...
🧬 Zbývá už jen poslední měsíc na přihlášení na PhD pozici zaměřenou na výzkum replikace DNA. Přidej se k našemu týmu a podílej se na špičkovém biomedicínském výzkumu!
📍Ústav Molekulární a Translační Medicíny, UPOL Olomouc
📅 Deadline: 15.5.2025
www.researchjobs.cz/job/phd-pozi...
📍Ústav Molekulární a Translační Medicíny, UPOL Olomouc
📅 Deadline: 15.5.2025
www.researchjobs.cz/job/phd-pozi...
PhD pozice ve výzkumu replikace DNA
Ve výzkumné skupině DNA replication dynamics na Ústavu molekulární a translační medicíny Lékařské fakulty Univerzity Palackého v Olomouci nabízíme pozici pro PhD studenta. Disertační práce na téma …
www.researchjobs.cz
April 15, 2025 at 7:36 AM
🧬 Zbývá už jen poslední měsíc na přihlášení na PhD pozici zaměřenou na výzkum replikace DNA. Přidej se k našemu týmu a podílej se na špičkovém biomedicínském výzkumu!
📍Ústav Molekulární a Translační Medicíny, UPOL Olomouc
📅 Deadline: 15.5.2025
www.researchjobs.cz/job/phd-pozi...
📍Ústav Molekulární a Translační Medicíny, UPOL Olomouc
📅 Deadline: 15.5.2025
www.researchjobs.cz/job/phd-pozi...
Our new preprint is now on bioRxiv! 📄 We introduce qAID, an AI-based workflow for automated analysis of DNA replication dynamics. Glad to have contributed a small part to this study.
Quantitative AI-based DNA fiber workflow to study replication stress https://www.biorxiv.org/content/10.1101/2025.03.27.645743v1
March 30, 2025 at 10:33 AM
Our new preprint is now on bioRxiv! 📄 We introduce qAID, an AI-based workflow for automated analysis of DNA replication dynamics. Glad to have contributed a small part to this study.
Reposted by Pavel Moudrý
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
March 30, 2025 at 9:54 AM
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
Reposted by Pavel Moudrý
Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading.
www.biorxiv.org/content/10.1...
Brief teaser:
www.biorxiv.org/content/10.1...
Brief teaser:
PAF15-PCNA assembly exhaustion governs lagging strand replication and replisome integrity
Genome replication in eukaryotic cells is surveyed by the S-phase checkpoint, which orchestrates sequential replication origin activation to avoid exhaustion of hitherto poorly defined rate-limiting r...
www.biorxiv.org
March 20, 2025 at 8:09 AM
Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading.
www.biorxiv.org/content/10.1...
Brief teaser:
www.biorxiv.org/content/10.1...
Brief teaser:
Reposted by Pavel Moudrý
For all of you who cannot access pubmed, here is a good alternative:
europepmc.org
europepmc.org
Europe PMCHome - Europe PMC
Europe PMC is an archive of life sciences journal literature.
europepmc.org
March 2, 2025 at 9:56 AM
For all of you who cannot access pubmed, here is a good alternative:
europepmc.org
europepmc.org