Zoë A.P. Williams
@zapwilliams.bsky.social
PhD Student @UCC and @APC Microbiome studying the mechanistic underpinnings of exercise in Alzheimer's Disease - passionate about all things 🧠🏃♀🦠
Reposted by Zoë A.P. Williams
Several years before onset of symptoms of multiple sclerosis, there is evidence of central nervous system myelin injury
nature.com/articles/s41...
nature.com/articles/s41...
Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis - Nature Medicine
Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.
nature.com
October 20, 2025 at 4:24 PM
Several years before onset of symptoms of multiple sclerosis, there is evidence of central nervous system myelin injury
nature.com/articles/s41...
nature.com/articles/s41...
Honoured to have been awarded best poster at the @apcmicrobiomeirel.bsky.social symposium !!
A big thank you to everyone who stopped by for the fascinating conversations, and to the organizers for putting together a wonderful day of science❤️
A big thank you to everyone who stopped by for the fascinating conversations, and to the organizers for putting together a wonderful day of science❤️
October 10, 2025 at 3:11 PM
Honoured to have been awarded best poster at the @apcmicrobiomeirel.bsky.social symposium !!
A big thank you to everyone who stopped by for the fascinating conversations, and to the organizers for putting together a wonderful day of science❤️
A big thank you to everyone who stopped by for the fascinating conversations, and to the organizers for putting together a wonderful day of science❤️
Reposted by Zoë A.P. Williams
Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Paternal exercise confers endurance capacity to offspring through sperm microRNAs
Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic
health via sperm microRNAs that reprogram gene expression in early embryos, revealing
how exercise benefits c...
www.cell.com
October 6, 2025 at 3:17 PM
Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...
www.cell.com/cell-metabol...
Reposted by Zoë A.P. Williams
How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
October 2, 2025 at 6:56 PM
How exercise promotes the immune system vs cancer, working through a gut bacteria metabolite
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Reposted by Zoë A.P. Williams
New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com
#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence
#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence
New landscape of the diagnosis of Alzheimer's disease
Alzheimer's disease involves a drastic departure from the cognitive, functional, and
behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent
cause of disability to individu...
www.thelancet.com
September 23, 2025 at 7:25 PM
New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com
#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence
#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence
Grateful for the opportunity to present my research at the UCC College of Medicine and Health Research Day, and honoured to have received a reward for my talk!!
A huge thanks to the organizers for making this day possible 🌟 It’s always inspiring to see the incredible research being done @ucc.ie
A huge thanks to the organizers for making this day possible 🌟 It’s always inspiring to see the incredible research being done @ucc.ie
September 3, 2025 at 6:21 PM
Grateful for the opportunity to present my research at the UCC College of Medicine and Health Research Day, and honoured to have received a reward for my talk!!
A huge thanks to the organizers for making this day possible 🌟 It’s always inspiring to see the incredible research being done @ucc.ie
A huge thanks to the organizers for making this day possible 🌟 It’s always inspiring to see the incredible research being done @ucc.ie
Reposted by Zoë A.P. Williams
*cracks knuckles*
okay so you know how the media has a problem with taking snippets of scientific studies out of context and writing articles which mislead the public?
now imagine a computer program is doing that when you ask it questions about scientific literature but also it makes stuff up.
okay so you know how the media has a problem with taking snippets of scientific studies out of context and writing articles which mislead the public?
now imagine a computer program is doing that when you ask it questions about scientific literature but also it makes stuff up.
September 2, 2025 at 8:41 PM
*cracks knuckles*
okay so you know how the media has a problem with taking snippets of scientific studies out of context and writing articles which mislead the public?
now imagine a computer program is doing that when you ask it questions about scientific literature but also it makes stuff up.
okay so you know how the media has a problem with taking snippets of scientific studies out of context and writing articles which mislead the public?
now imagine a computer program is doing that when you ask it questions about scientific literature but also it makes stuff up.
Reposted by Zoë A.P. Williams
⚛️🧪 folks--how do you keep your directories organized and uncluttered? I've got a billion papers I want to read/reference, too many project directories in a few different places (GH repos and stashes Documents folder), and old versions of other people's codes I need, which all needs reorganizing...
August 28, 2025 at 8:52 PM
⚛️🧪 folks--how do you keep your directories organized and uncluttered? I've got a billion papers I want to read/reference, too many project directories in a few different places (GH repos and stashes Documents folder), and old versions of other people's codes I need, which all needs reorganizing...
Reposted by Zoë A.P. Williams
A key thing worth knowing about the AI super intelligence claims is that scientists who study cognition are clear we don’t even have a model of human intelligence, so how can you look at an AI and say it’s the same or better? We confuse lots of metaphors for cognition with knowing how it happens.
August 21, 2025 at 7:19 AM
A key thing worth knowing about the AI super intelligence claims is that scientists who study cognition are clear we don’t even have a model of human intelligence, so how can you look at an AI and say it’s the same or better? We confuse lots of metaphors for cognition with knowing how it happens.
Reposted by Zoë A.P. Williams
Altered Cholesterol Uptake by Neurons in Alzheimer’s Disease Linked to APOE4 Variant www.recercasantpau.cat/en/now/alter... by @irsantpau.bsky.social
#Alzheimers #dementia #health #science #neuroscience
#Alzheimers #dementia #health #science #neuroscience
August 7, 2025 at 7:59 PM
Altered Cholesterol Uptake by Neurons in Alzheimer’s Disease Linked to APOE4 Variant www.recercasantpau.cat/en/now/alter... by @irsantpau.bsky.social
#Alzheimers #dementia #health #science #neuroscience
#Alzheimers #dementia #health #science #neuroscience
Reposted by Zoë A.P. Williams
Interesting paper from the Goodman Lab:
Identification of medication–microbiome interactions that affect gut infection www.nature.com/articles/s41...
Identification of medication–microbiome interactions that affect gut infection www.nature.com/articles/s41...
Identification of medication–microbiome interactions that affect gut infection - Nature
An analysis of prescription medications shows that several non-antibiotic drugs, such as the heart medication digoxin, can reduce the immune response to pathogens and increase the risk of gastrointest...
www.nature.com
July 20, 2025 at 7:22 PM
Interesting paper from the Goodman Lab:
Identification of medication–microbiome interactions that affect gut infection www.nature.com/articles/s41...
Identification of medication–microbiome interactions that affect gut infection www.nature.com/articles/s41...
4 pathways
Mental health: Psychiatric conditions leading to cognitive decline
Encephalopathy: Brain dysfunction conditions that escalate over time
Mild cognitive impairment: Gradual cognitive decline progression
Vascular disease: Cardiovascular conditions that contribute to dementia risk
Mental health: Psychiatric conditions leading to cognitive decline
Encephalopathy: Brain dysfunction conditions that escalate over time
Mild cognitive impairment: Gradual cognitive decline progression
Vascular disease: Cardiovascular conditions that contribute to dementia risk
July 12, 2025 at 8:16 AM
4 pathways
Mental health: Psychiatric conditions leading to cognitive decline
Encephalopathy: Brain dysfunction conditions that escalate over time
Mild cognitive impairment: Gradual cognitive decline progression
Vascular disease: Cardiovascular conditions that contribute to dementia risk
Mental health: Psychiatric conditions leading to cognitive decline
Encephalopathy: Brain dysfunction conditions that escalate over time
Mild cognitive impairment: Gradual cognitive decline progression
Vascular disease: Cardiovascular conditions that contribute to dementia risk
Reposted by Zoë A.P. Williams
Exciting Senior Scientist 👩🔬 👨🔬 role available in my research group 🧠 🦠 - Closing date Tuesday 5th August 2025.
Please Share
@apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social
Full details here
my.corehr.com/pls/uccrecru...
Please Share
@apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social
Full details here
my.corehr.com/pls/uccrecru...
July 7, 2025 at 11:20 AM
Exciting Senior Scientist 👩🔬 👨🔬 role available in my research group 🧠 🦠 - Closing date Tuesday 5th August 2025.
Please Share
@apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social
Full details here
my.corehr.com/pls/uccrecru...
Please Share
@apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social
Full details here
my.corehr.com/pls/uccrecru...
Reposted by Zoë A.P. Williams
Reposted by Zoë A.P. Williams
{tinytable} is a dead simple, ultra-flexible, and dependency-free #Rstats 📦 to turn data frames into beautiful tables: html, word, pdf, latex, typst, markdown, etc.
v0.10.0 has cool new features and important bug fixes. Check out the detailed tutorials at:
vincentarelbundock.github.io/tinytable/
v0.10.0 has cool new features and important bug fixes. Check out the detailed tutorials at:
vincentarelbundock.github.io/tinytable/
July 3, 2025 at 12:59 PM
{tinytable} is a dead simple, ultra-flexible, and dependency-free #Rstats 📦 to turn data frames into beautiful tables: html, word, pdf, latex, typst, markdown, etc.
v0.10.0 has cool new features and important bug fixes. Check out the detailed tutorials at:
vincentarelbundock.github.io/tinytable/
v0.10.0 has cool new features and important bug fixes. Check out the detailed tutorials at:
vincentarelbundock.github.io/tinytable/
Reposted by Zoë A.P. Williams
Proud to share my new review from my MSCA-INSPIRE @inspiremsca.bsky.social
"Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?"
www.nature.com/articles/s41...
@jfcryan.bsky.social
@apcmicrobiomeirel.bsky.social
@ucc.ie
"Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?"
www.nature.com/articles/s41...
@jfcryan.bsky.social
@apcmicrobiomeirel.bsky.social
@ucc.ie
Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms? - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?
www.nature.com
July 4, 2025 at 8:48 AM
Proud to share my new review from my MSCA-INSPIRE @inspiremsca.bsky.social
"Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?"
www.nature.com/articles/s41...
@jfcryan.bsky.social
@apcmicrobiomeirel.bsky.social
@ucc.ie
"Host-microbiome relationship in depression: can human induced pluripotent stem cells play a role in unravelling mechanisms?"
www.nature.com/articles/s41...
@jfcryan.bsky.social
@apcmicrobiomeirel.bsky.social
@ucc.ie
Reposted by Zoë A.P. Williams
p-tau217, the breakthrough blood biomarker for Alzheimer's, picks up risk the earliest and its performance surpasses all other tau biomarkers, across ancestries
www.nature.com/articles/s43...
My review erictopol.substack.com/p/the-breakt...
www.nature.com/articles/s43...
My review erictopol.substack.com/p/the-breakt...
Comprehensive evaluation of plasma tau biomarkers for detecting and monitoring Alzheimer’s disease in a multicenter and multiethnic aging population - Nature Aging
Lan et al. demonstrate the high performance of plasma p-tau217 in detecting and tracking multiple aspects of Alzheimer’s disease pathology, outperforming other plasma tau biomarkers across two Chinese...
www.nature.com
June 23, 2025 at 1:33 PM
p-tau217, the breakthrough blood biomarker for Alzheimer's, picks up risk the earliest and its performance surpasses all other tau biomarkers, across ancestries
www.nature.com/articles/s43...
My review erictopol.substack.com/p/the-breakt...
www.nature.com/articles/s43...
My review erictopol.substack.com/p/the-breakt...
Reposted by Zoë A.P. Williams
This is wild!
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
June 23, 2025 at 6:55 PM
This is wild!
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Engineering E. coli bacteria to turn plastic waste into paracetamol (Tylenol)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Zoë A.P. Williams
Why do some people who have mutations of familial Alzheimer's not get the disease?
They have protective genomic variants.
A first-rate review
@thelancetneuro.bsky.social
thelancet.com/journals/lan...
They have protective genomic variants.
A first-rate review
@thelancetneuro.bsky.social
thelancet.com/journals/lan...
June 14, 2025 at 4:50 PM
Why do some people who have mutations of familial Alzheimer's not get the disease?
They have protective genomic variants.
A first-rate review
@thelancetneuro.bsky.social
thelancet.com/journals/lan...
They have protective genomic variants.
A first-rate review
@thelancetneuro.bsky.social
thelancet.com/journals/lan...
Reposted by Zoë A.P. Williams
Metformin boosts mitochondria and neurogenesis via AMPK/mTOR/SIRT3 in POLG mutant organoids https://www.biorxiv.org/content/10.1101/2025.06.08.658480v1
June 9, 2025 at 11:16 AM
Metformin boosts mitochondria and neurogenesis via AMPK/mTOR/SIRT3 in POLG mutant organoids https://www.biorxiv.org/content/10.1101/2025.06.08.658480v1
Reposted by Zoë A.P. Williams
📣 Happy to share our review on host-microbiome genomics!
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
June 4, 2025 at 11:02 PM
📣 Happy to share our review on host-microbiome genomics!
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
We synthesize the growing field exploring interactions between human genetics and the microbiome, building a roadmap for mapping the dialogue between our genes and microbes
Out now in Nature Reviews Genetics👇
www.nature.com/articles/s41...
Reposted by Zoë A.P. Williams
We rely on deep sleep to clear the brain's metabolic waste products (that can induce inflammation), which decreases with aging.
Now there's a discovery of a non-invasive way method to augment waste clearance in aged mice @nature.com
www.nature.com/articles/s41...
Now there's a discovery of a non-invasive way method to augment waste clearance in aged mice @nature.com
www.nature.com/articles/s41...
Increased CSF drainage by non-invasive manipulation of cervical lymphatics - Nature
The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.
www.nature.com
June 4, 2025 at 5:30 PM
We rely on deep sleep to clear the brain's metabolic waste products (that can induce inflammation), which decreases with aging.
Now there's a discovery of a non-invasive way method to augment waste clearance in aged mice @nature.com
www.nature.com/articles/s41...
Now there's a discovery of a non-invasive way method to augment waste clearance in aged mice @nature.com
www.nature.com/articles/s41...
Reposted by Zoë A.P. Williams
The gutting of US biomedical research with loss of ~2,500 grants affecting research for cancer, Alzheimer’s, infectious disease, global health and much more
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
June 4, 2025 at 2:03 PM
The gutting of US biomedical research with loss of ~2,500 grants affecting research for cancer, Alzheimer’s, infectious disease, global health and much more
www.nytimes.com/interactive/...
www.nytimes.com/interactive/...
Reposted by Zoë A.P. Williams
Inkscape plugin to rescale figures without distorting the text, and other useful features!
github.com/burghoff/Sci...
github.com/burghoff/Sci...
June 2, 2025 at 12:15 PM
Inkscape plugin to rescale figures without distorting the text, and other useful features!
github.com/burghoff/Sci...
github.com/burghoff/Sci...