Zam Kassiri
@zamkassiri.bsky.social
Professor, Cardiac and vascular matrix remodeling. Deputy Editor AJPHeart. U of Alberta, Dept Physiology #ualberta www.kassirilab.com
Reposted by Zam Kassiri
ADAM17 Sheddase #Atherosclerosis
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...
January 18, 2026 at 1:44 PM
ADAM17 Sheddase #Atherosclerosis
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...
Myh11+ Smooth Muscle Cell Adam17 KO🐭+HFD➡️
⏫Lesion burden
⏫Aortic valve dysfunction
⏫Foamy SMCs
Adam17-deficient aortic SMCs➡️
⏫Lipid uptake (CD36 SRA1 LAL)
⏬Lipid efflux (ABCA1)
@zamkassiri.bsky.social #Atherosclerosis 2025
www.sciencedirect.com/science/arti...
suppressing fibroblast activity too early after MI -> not good; suppressing myoFB activity after the early pos-MI phase -> Great! And the benefits lasted for 4 weeks (in mice)!
Extreme hard work by PhD student, Yingxi Li and great collab with Engineering (L Westover).CVR2026 doi: 10.1093/cvr/cvaf256
Extreme hard work by PhD student, Yingxi Li and great collab with Engineering (L Westover).CVR2026 doi: 10.1093/cvr/cvaf256
January 15, 2026 at 6:03 PM
suppressing fibroblast activity too early after MI -> not good; suppressing myoFB activity after the early pos-MI phase -> Great! And the benefits lasted for 4 weeks (in mice)!
Extreme hard work by PhD student, Yingxi Li and great collab with Engineering (L Westover).CVR2026 doi: 10.1093/cvr/cvaf256
Extreme hard work by PhD student, Yingxi Li and great collab with Engineering (L Westover).CVR2026 doi: 10.1093/cvr/cvaf256
Finally in Publication: knockdown of ADAM17 in smooth muscle cells markedly worsened atherosclerosis (in LDLR-KO mice) even though plasma hyperlipidemia remained unchanged. Arterial cells are critical players in atherosclerosis development. (Atherosclerosis. 2025 doi: 10.1016/j.atherosclerosis)
January 15, 2026 at 5:45 PM
Finally in Publication: knockdown of ADAM17 in smooth muscle cells markedly worsened atherosclerosis (in LDLR-KO mice) even though plasma hyperlipidemia remained unchanged. Arterial cells are critical players in atherosclerosis development. (Atherosclerosis. 2025 doi: 10.1016/j.atherosclerosis)
Reposted by Zam Kassiri
it appears your manuscript "in preparation" was not published in 2025 after all, mr. bond
December 22, 2025 at 12:45 PM
it appears your manuscript "in preparation" was not published in 2025 after all, mr. bond
Reposted by Zam Kassiri
While in Chicago, I took a tour around the Obama Presidential Center. I can’t wait for you all to visit in June 2026. Here’s a sneak peek:
December 18, 2025 at 4:50 PM
While in Chicago, I took a tour around the Obama Presidential Center. I can’t wait for you all to visit in June 2026. Here’s a sneak peek:
Reposted by Zam Kassiri
#OTD in 1961, AP names Wilma Rudolph Female Athlete of the Year for the 2nd consecutive year
Rudolph overcame childhood polio to become the fastest woman runner in the world; first American woman to win 3 track/field gold medals in a single Olympiad, Rome 1960.
#WomenInSport #champion #inspiration
Rudolph overcame childhood polio to become the fastest woman runner in the world; first American woman to win 3 track/field gold medals in a single Olympiad, Rome 1960.
#WomenInSport #champion #inspiration
December 17, 2025 at 6:06 PM
#OTD in 1961, AP names Wilma Rudolph Female Athlete of the Year for the 2nd consecutive year
Rudolph overcame childhood polio to become the fastest woman runner in the world; first American woman to win 3 track/field gold medals in a single Olympiad, Rome 1960.
#WomenInSport #champion #inspiration
Rudolph overcame childhood polio to become the fastest woman runner in the world; first American woman to win 3 track/field gold medals in a single Olympiad, Rome 1960.
#WomenInSport #champion #inspiration
Reposted by Zam Kassiri
it's more of a comment than a ques
December 12, 2025 at 6:43 AM
it's more of a comment than a ques
Reposted by Zam Kassiri
Adding one original sentence to the recommendation letter that Chatgpt composed
December 6, 2025 at 11:51 AM
Adding one original sentence to the recommendation letter that Chatgpt composed
Reposted by Zam Kassiri
I’m happy that my PhD time will count at some point in my life. Or death.
November 26, 2025 at 5:09 PM
I’m happy that my PhD time will count at some point in my life. Or death.
Reposted by Zam Kassiri
So excited to share this as a new junior PI:
My brand-new lab website! 🎉🪰🌀
www.bischofflab.com
Please pass it on to young, motivated researchers looking for PhD positions 😊
And for the #FluorescenceFriday community: don’t miss the SciArt Gallery!
#CellBio #DevBio #PhDjob #PhDposition #Science
My brand-new lab website! 🎉🪰🌀
www.bischofflab.com
Please pass it on to young, motivated researchers looking for PhD positions 😊
And for the #FluorescenceFriday community: don’t miss the SciArt Gallery!
#CellBio #DevBio #PhDjob #PhDposition #Science
November 27, 2025 at 8:26 AM
So excited to share this as a new junior PI:
My brand-new lab website! 🎉🪰🌀
www.bischofflab.com
Please pass it on to young, motivated researchers looking for PhD positions 😊
And for the #FluorescenceFriday community: don’t miss the SciArt Gallery!
#CellBio #DevBio #PhDjob #PhDposition #Science
My brand-new lab website! 🎉🪰🌀
www.bischofflab.com
Please pass it on to young, motivated researchers looking for PhD positions 😊
And for the #FluorescenceFriday community: don’t miss the SciArt Gallery!
#CellBio #DevBio #PhDjob #PhDposition #Science
Reposted by Zam Kassiri
I swore an oath to the Constitution in 1986. I've upheld it through 25 years of service and every day since I retired.
If Trump's trying to intimidate me, it won’t work. I’ve given too much to our country to be silenced by bullies who care more about power than the Constitution.
If Trump's trying to intimidate me, it won’t work. I’ve given too much to our country to be silenced by bullies who care more about power than the Constitution.
November 24, 2025 at 8:27 PM
I swore an oath to the Constitution in 1986. I've upheld it through 25 years of service and every day since I retired.
If Trump's trying to intimidate me, it won’t work. I’ve given too much to our country to be silenced by bullies who care more about power than the Constitution.
If Trump's trying to intimidate me, it won’t work. I’ve given too much to our country to be silenced by bullies who care more about power than the Constitution.
Reposted by Zam Kassiri
After you help your boss convert a doc to PDF
November 22, 2025 at 4:55 PM
After you help your boss convert a doc to PDF
Reposted by Zam Kassiri
Excellent speech by @charliejane.bsky.social about imagination in service to society. Great stuff.
buttondown.com/charliejane/...
buttondown.com/charliejane/...
November 22, 2025 at 6:31 PM
Excellent speech by @charliejane.bsky.social about imagination in service to society. Great stuff.
buttondown.com/charliejane/...
buttondown.com/charliejane/...
Reposted by Zam Kassiri
Very proud to share our lab’s recently published work in AJP-Heart
Early in my NIH K08 on #EndMT, we found an interesting signal in COL8A1 in athero, w/ biphasic response to TNF
🙏🏻 to ⭐️ postdoc Qian Li for leading us here (& @haoyin.bsky.social for summary!)
journals.physiology.org/doi/full/10....
Early in my NIH K08 on #EndMT, we found an interesting signal in COL8A1 in athero, w/ biphasic response to TNF
🙏🏻 to ⭐️ postdoc Qian Li for leading us here (& @haoyin.bsky.social for summary!)
journals.physiology.org/doi/full/10....
November 21, 2025 at 1:54 PM
Very proud to share our lab’s recently published work in AJP-Heart
Early in my NIH K08 on #EndMT, we found an interesting signal in COL8A1 in athero, w/ biphasic response to TNF
🙏🏻 to ⭐️ postdoc Qian Li for leading us here (& @haoyin.bsky.social for summary!)
journals.physiology.org/doi/full/10....
Early in my NIH K08 on #EndMT, we found an interesting signal in COL8A1 in athero, w/ biphasic response to TNF
🙏🏻 to ⭐️ postdoc Qian Li for leading us here (& @haoyin.bsky.social for summary!)
journals.physiology.org/doi/full/10....
Reposted by Zam Kassiri
If you read only one obit of James Watson, read this one
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
James Watson, dead at 97, was a scientific legend and a pariah among his peers
James Watson, the co-discoverer of the structure of DNA who died Thursday at 97, was a scientific legend and a pariah among his peers.
www.statnews.com
November 9, 2025 at 11:56 AM
If you read only one obit of James Watson, read this one
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
www.statnews.com/2025/11/07/j...
(From the late Sharon Begley, for @statnews.com )
Reposted by Zam Kassiri
🎥 Hear from Roxana Mehran as she breaks down the key findings and clinical implications of the DECAF Trial – straight from #AHA25
#ESCTVOntheRoad
#ESCTVOntheRoad
November 9, 2025 at 3:53 PM
🎥 Hear from Roxana Mehran as she breaks down the key findings and clinical implications of the DECAF Trial – straight from #AHA25
#ESCTVOntheRoad
#ESCTVOntheRoad
Reposted by Zam Kassiri
Engage with the editors of American Heart Association Journals every day at #AHA25! These interactive sessions will provide invaluable insights into the latest trends, future directions, and the editorial process.
Go to https://www.ahajournals.org/AHASessions and mark your calendars today!
Go to https://www.ahajournals.org/AHASessions and mark your calendars today!
November 8, 2025 at 5:19 PM
Engage with the editors of American Heart Association Journals every day at #AHA25! These interactive sessions will provide invaluable insights into the latest trends, future directions, and the editorial process.
Go to https://www.ahajournals.org/AHASessions and mark your calendars today!
Go to https://www.ahajournals.org/AHASessions and mark your calendars today!
Reposted by Zam Kassiri
#AHA25: VITAL-AF trial: Stressor-associated atrial fibrillation (AF) carries similar risks of stroke, bleeding, and death as primary AF ; yet patients are less likely to receive oral anticoagulation, even when stroke risk is high. https://ahajrnls.org/4nJRQJQ
November 8, 2025 at 5:36 PM
#AHA25: VITAL-AF trial: Stressor-associated atrial fibrillation (AF) carries similar risks of stroke, bleeding, and death as primary AF ; yet patients are less likely to receive oral anticoagulation, even when stroke risk is high. https://ahajrnls.org/4nJRQJQ
Reposted by Zam Kassiri
Here the authors propose T cell-derived sCD52 as a therapeutic target to mitigate #obesity-associated #MASLD and glucose intolerance www.sciencedirect.com/science/arti...
Protective role of soluble CD52 in obesity-associated steatotic liver disease and glucose dysregulation in mice.
Soluble CD52 (sCD52) derived from activated CD4+ T cells regulates T cell immunity under autoimmune conditions; however, its role in obesity-associate…
www.sciencedirect.com
November 5, 2025 at 12:05 PM
Here the authors propose T cell-derived sCD52 as a therapeutic target to mitigate #obesity-associated #MASLD and glucose intolerance www.sciencedirect.com/science/arti...
Reposted by Zam Kassiri
CDC Figures It Easier To Start Tracking People Without Measles
CDC Figures It Easier To Start Tracking People Without Measles
ATLANTA—As the agency struggles to manage a measles caseload that has erupted to its largest size in decades, the Centers for Disease Control and Prevention stated Monday that at this point, it would ...
theonion.com
November 4, 2025 at 9:00 PM
CDC Figures It Easier To Start Tracking People Without Measles
Reposted by Zam Kassiri
Robert Munsch has donated his personal archives of stories and materials to the Guelph Public Library.
This is wonderful for such a valuable archive to be given to a public municipal library.
www.guelphpl.ca/Modules/News...
This is wonderful for such a valuable archive to be given to a public municipal library.
www.guelphpl.ca/Modules/News...
Robert Munsch donates his archives to Guelph Public Library
Robert Munsch donates his archives to Guelph Public Library
www.guelphpl.ca
November 4, 2025 at 11:31 PM
Robert Munsch has donated his personal archives of stories and materials to the Guelph Public Library.
This is wonderful for such a valuable archive to be given to a public municipal library.
www.guelphpl.ca/Modules/News...
This is wonderful for such a valuable archive to be given to a public municipal library.
www.guelphpl.ca/Modules/News...
Reposted by Zam Kassiri
November 4, 2025 at 11:20 AM