Yizhou Hu(Eugene)
@yizhoueugene.bsky.social
Researcher；System Medicine，developmental plasticity in nervous system cancers， psoriatic skin ；@Karolinska Inst. ， @Wihuri Inst. & Univ. of Helsinki
Pinned
Our study on neuroblastoma developmental plasticity is the cover story in the latest issue of Dev. Cell @cp-devcell.bsky.social .The Chinese-ink Taiji (Yin–Yang) cover to echo cell-state transitions. Huge thanks to the editors, co-authors. #Neuroblastoma www.cell.com/developmenta...
Reposted by Yizhou Hu(Eugene)
New preprint from
@gocastelobranco.bsky.social lab!! We use MPRA & scCRISPRi/a to interrogate possible functions of GWAS-identified Multiple sclerosis risk SNPs in iPSC-derived oligodendrocytes.
www.biorxiv.org/content/10.1...
@gocastelobranco.bsky.social lab!! We use MPRA & scCRISPRi/a to interrogate possible functions of GWAS-identified Multiple sclerosis risk SNPs in iPSC-derived oligodendrocytes.
www.biorxiv.org/content/10.1...
www.biorxiv.org
November 13, 2025 at 8:35 AM
New preprint from
@gocastelobranco.bsky.social lab!! We use MPRA & scCRISPRi/a to interrogate possible functions of GWAS-identified Multiple sclerosis risk SNPs in iPSC-derived oligodendrocytes.
www.biorxiv.org/content/10.1...
@gocastelobranco.bsky.social lab!! We use MPRA & scCRISPRi/a to interrogate possible functions of GWAS-identified Multiple sclerosis risk SNPs in iPSC-derived oligodendrocytes.
www.biorxiv.org/content/10.1...
Reposted by Yizhou Hu(Eugene)
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Spatial dynamics of brain development and neuroinflammation - Nature
A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.
www.nature.com
November 5, 2025 at 4:03 PM
Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Yizhou Hu(Eugene)
GUANACO: A Unified Web-Based Platform for Single-Cell Multi-Omics Data Visualization https://www.biorxiv.org/content/10.1101/2025.09.18.677070v1
September 21, 2025 at 12:47 PM
GUANACO: A Unified Web-Based Platform for Single-Cell Multi-Omics Data Visualization https://www.biorxiv.org/content/10.1101/2025.09.18.677070v1
Thrilled to collaborate on cosupervising this work! GUANACO puts single-cell MultiOmics visualization in reach for bench scientists: built-in stats, no code for publication-ready figures. pls explore more functions from the link 👇Congrats to the team!
🚀 Introducing GUANACO – our new bioinformatics tool for intuitive, interactive visualization of single-cell multiomics data.
🧬 No coding needed
📊 Built-in stats tools
🎨 High-quality figures in clicks
💻 Lightweight & deployable
Perfect for bench scientists!
👉 DEMO: guanaco-demo.chen-sysimeta-lab.com
🧬 No coding needed
📊 Built-in stats tools
🎨 High-quality figures in clicks
💻 Lightweight & deployable
Perfect for bench scientists!
👉 DEMO: guanaco-demo.chen-sysimeta-lab.com
GUANACO: A Unified Web-Based Platform for Single-Cell Multi-Omics Data Visualization https://www.biorxiv.org/content/10.1101/2025.09.18.677070v1
September 22, 2025 at 6:14 AM
Thrilled to collaborate on cosupervising this work! GUANACO puts single-cell MultiOmics visualization in reach for bench scientists: built-in stats, no code for publication-ready figures. pls explore more functions from the link 👇Congrats to the team!
Reposted by Yizhou Hu(Eugene)
A few weeks ago, I had to discuss about DynaTag, a smart tweak to CUT&Tag that enables single-cell transcription factor mapping with just a buffer change.
Opening a number of future avenues.
📰 Via
@GenomeWeb
: lnkd.in/djYm_sGg
#epigenetics #singlecell
Opening a number of future avenues.
📰 Via
@GenomeWeb
: lnkd.in/djYm_sGg
#epigenetics #singlecell
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
September 10, 2025 at 4:37 PM
A few weeks ago, I had to discuss about DynaTag, a smart tweak to CUT&Tag that enables single-cell transcription factor mapping with just a buffer change.
Opening a number of future avenues.
📰 Via
@GenomeWeb
: lnkd.in/djYm_sGg
#epigenetics #singlecell
Opening a number of future avenues.
📰 Via
@GenomeWeb
: lnkd.in/djYm_sGg
#epigenetics #singlecell
Our study on neuroblastoma developmental plasticity is the cover story in the latest issue of Dev. Cell @cp-devcell.bsky.social .The Chinese-ink Taiji (Yin–Yang) cover to echo cell-state transitions. Huge thanks to the editors, co-authors. #Neuroblastoma www.cell.com/developmenta...
September 10, 2025 at 2:25 PM
Our study on neuroblastoma developmental plasticity is the cover story in the latest issue of Dev. Cell @cp-devcell.bsky.social .The Chinese-ink Taiji (Yin–Yang) cover to echo cell-state transitions. Huge thanks to the editors, co-authors. #Neuroblastoma www.cell.com/developmenta...
Reposted by Yizhou Hu(Eugene)
Postdoc in Computational Biology – Auditory Pathways & Sensory Disorders @LallemendLab to study how peripheral/central auditory pathways (circuit, cellular, molecular) are altered in tinnitus & age-related hearing loss. #scRNAseq, #barcode-lineage-tracing, #translational
ki.varbi.com/what:job/job...
ki.varbi.com/what:job/job...
Postdoctoral studies in single-cell and computational biology
Postdoctoral studies in single-cell and computational biology Do you want to contribute to top quality medical research? A postdoctoral position is available in the laboratory of Professor Francois
ki.varbi.com
June 2, 2025 at 10:21 AM
Postdoc in Computational Biology – Auditory Pathways & Sensory Disorders @LallemendLab to study how peripheral/central auditory pathways (circuit, cellular, molecular) are altered in tinnitus & age-related hearing loss. #scRNAseq, #barcode-lineage-tracing, #translational
ki.varbi.com/what:job/job...
ki.varbi.com/what:job/job...
Reposted by Yizhou Hu(Eugene)
Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...
Postdoc in Single Cell Genomics, Jens Hjerling-Leffler group, Karolinska Institutet
Do you want to contribute to top quality medical research? The position is located within The Division of Molecular Neurobiology in the lab of Professor Jens Hjerling-Leffler at the Department of Medi
ki.varbi.com
June 2, 2025 at 5:20 PM
Postdoc positions available in my lab @ki.se Sweden - exciting science, fantastic environment and great quality of life. I take mentoring seriously - 7/7 postdocs that left my lab has faculty positions today. Existing datasets and funds to build new ones available. ki.varbi.com/en/what:job/...
Reposted by Yizhou Hu(Eugene)
Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors! #NatureNeuroscience #EntericNervousSystem rdcu.be/eoqXz
The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine
Nature Neuroscience - The neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of...
rdcu.be
May 29, 2025 at 11:28 AM
Check out our new study on the innermost nervous system of the body—the submucosal plexus. We define three neuronal classes, map their connectivity, and uncover their stepwise development via phenotypic switching. Congrats to all authors! #NatureNeuroscience #EntericNervousSystem rdcu.be/eoqXz
Reposted by Yizhou Hu(Eugene)
If you want to run MERFISH spatial transcriptomics and you search for the optimized probe codebooks, here they are: www.science.org/doi/10.1126/...
Boosting multiplexing capabilities for error-robust spatial transcriptomic methods using a set exchange approach
Using an algorithm, highly optimized error-robust codebooks for spatial transcriptomic methods can systematically be produced.
www.science.org
May 20, 2025 at 5:14 PM
If you want to run MERFISH spatial transcriptomics and you search for the optimized probe codebooks, here they are: www.science.org/doi/10.1126/...
Reposted by Yizhou Hu(Eugene)
🎫 Exclusive event: One-day symposium on #Brain #Tumor #Plasticity
🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social
Few spots available. Register here: ui.ungpd.com/Events/ed387...
🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social
Few spots available. Register here: ui.ungpd.com/Events/ed387...
Brain Tumor Plasticity
A growing body of evidence emphasizes the presence of significant intra-tumoral phenotypic diversity and plasticity within brain tumors. Inherent plasticity introduces an additional layer of intricacy...
ui.ungpd.com
May 12, 2025 at 12:42 PM
🎫 Exclusive event: One-day symposium on #Brain #Tumor #Plasticity
🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social
Few spots available. Register here: ui.ungpd.com/Events/ed387...
🕣September 16, 2025. The Royal Swedish Academy of Sciences, Stockholm @scienceacademyswe.bsky.social
Few spots available. Register here: ui.ungpd.com/Events/ed387...
Reposted by Yizhou Hu(Eugene)
Epichrom 2025 !
After 3 years, Epichrom is revived and will take place in Stockholm on the 12th of June. Great opportunity to share your research and hear about latest epigenetics/chromatin research in Sweden.
Registration is free of charge
www.bartosovic-lab.com/epichrom
After 3 years, Epichrom is revived and will take place in Stockholm on the 12th of June. Great opportunity to share your research and hear about latest epigenetics/chromatin research in Sweden.
Registration is free of charge
www.bartosovic-lab.com/epichrom
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
May 7, 2025 at 5:23 AM
Epichrom 2025 !
After 3 years, Epichrom is revived and will take place in Stockholm on the 12th of June. Great opportunity to share your research and hear about latest epigenetics/chromatin research in Sweden.
Registration is free of charge
www.bartosovic-lab.com/epichrom
After 3 years, Epichrom is revived and will take place in Stockholm on the 12th of June. Great opportunity to share your research and hear about latest epigenetics/chromatin research in Sweden.
Registration is free of charge
www.bartosovic-lab.com/epichrom
Thank you @ki.se for sharing our @cp-devcell.bsky.social study on neuroblastoma developmental plasticity! 🙏🚀
A study published in @cp-devcell.bsky.social points to new treatment strategies for the #childhoodcancer #neuroblastoma. Researchers have identified key transcription factor ‘switches’ that can be targeted to lock the cancer into a less aggressive state. #CancerResearch 🧪 doi.org/10.1016/j.de...
Redirecting
doi.org
May 12, 2025 at 3:13 PM
Thank you @ki.se for sharing our @cp-devcell.bsky.social study on neuroblastoma developmental plasticity! 🙏🚀
1/9 🚀 Our latest findings in
@cp-devcell.bsky.social : #Neuroblastoma cells aren’t locked into one single fate—they flip between developmental programs, driving tumor heterogeneity and malignancy. www.sciencedirect.com/science/arti...
@cp-devcell.bsky.social : #Neuroblastoma cells aren’t locked into one single fate—they flip between developmental programs, driving tumor heterogeneity and malignancy. www.sciencedirect.com/science/arti...
Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity
Neuroblastoma, the most prevalent extracranial pediatric solid tumor, arises from neural crest progeny cells. It exhibits substantial developmental pl…
www.sciencedirect.com
May 9, 2025 at 10:02 PM
1/9 🚀 Our latest findings in
@cp-devcell.bsky.social : #Neuroblastoma cells aren’t locked into one single fate—they flip between developmental programs, driving tumor heterogeneity and malignancy. www.sciencedirect.com/science/arti...
@cp-devcell.bsky.social : #Neuroblastoma cells aren’t locked into one single fate—they flip between developmental programs, driving tumor heterogeneity and malignancy. www.sciencedirect.com/science/arti...
Reposted by Yizhou Hu(Eugene)
Join us at the Nobel Symposium
Multiple Sclerosis: Past, Present and Future Treatment
June 5th, 2025 | Jacob Berzelius lecture hall @ki.se | Stockholm, Sweden
free registration at:
jirango.com/cview/web/f0...
Multiple Sclerosis: Past, Present and Future Treatment
June 5th, 2025 | Jacob Berzelius lecture hall @ki.se | Stockholm, Sweden
free registration at:
jirango.com/cview/web/f0...
May 5, 2025 at 10:48 AM
Join us at the Nobel Symposium
Multiple Sclerosis: Past, Present and Future Treatment
June 5th, 2025 | Jacob Berzelius lecture hall @ki.se | Stockholm, Sweden
free registration at:
jirango.com/cview/web/f0...
Multiple Sclerosis: Past, Present and Future Treatment
June 5th, 2025 | Jacob Berzelius lecture hall @ki.se | Stockholm, Sweden
free registration at:
jirango.com/cview/web/f0...
Reposted by Yizhou Hu(Eugene)
How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord - Nature Neuroscience
Zhang et al. identify unimodal neural representations in the spinal cord of cutaneous mechanical and heat stimuli gated by a shared feed-forward local inhibitory neuron type and a neural transition du...
www.nature.com
March 24, 2025 at 4:07 PM
How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
New mug, #science_doesn’t_care_what_U_believe
March 13, 2025 at 2:43 PM
New mug, #science_doesn’t_care_what_U_believe