Huge congratulations, Sara! Dream Team!🎉🎉🎉

Big congrats, Gonçalo!🎉🎉

Thank you, Susanne! Your help made this possible.

9/9🙏 Thanks to our collaborators:
@schlisio-lab.bsky.social
, Prof. Arthur Tischler (@tuftsmedicalcenter.bsky.social), Prof. Ronald de Krijger (
@themaximacenter.bsky.social
), and all the other amazing team members!

8/9 Our enhanced neural-network tool, scCAMEL, now aligns cross-species, multimodal data in a single workflow—empowering comprehensive mapping of tumor plasticity. sccamel.readthedocs.io/en/latest/

7/9 Spatial maps reveal clonal pockets of bridge & neural‑crest‑like cells encircled by TAMs & CAFs that sustain aggressiveness—micro‑environment is a Dev. state‑specific partner‑in‑crime.

6/9 Functional hits 👉 E2F7-networks fuel de‑differentiation, while HMX1 can force differentiation—unless MYCN amplification blocks it.---> Dev. state‑specific vulnerabilities = therapeutic targets.

5/9 🔑 Enhancer–gene regulatory networks uncover 121 core TF gene patterns organized into five principal patterns: Cell Cycle, ADRN-meta, ADRN-neu, Mes-Prog, and Mes-immune.

4/9 The enhancer‑primed epigenetic landscape gives neuroblastoma cells the "latent" capacity to shift between developmental programs.

3/9 We traced 7 NBL cell states back to the trunk neural crest lineage. A previously less-appreciated “bridge” state acts as the hub for state switching and, together with neural‑crest‑like cells, dominates high‑risk NBL.

2/9 In collaboration with
@patrikernfors.bsky.social
and Jian Wang’s team, we integrated single-cell and spatial transcriptomics from patient tumors and scRNA+ATAC data from mouse spontaneous models to construct a high-resolution disease atlas.