Yasu Okamoto
@yasuokamoto.bsky.social
Chemist working on Artificial metalloenzyme, Bioinorganic chemistry, Protein engineering. Institute for Molecular Science🇯🇵<-Tohoku Univ.🇯🇵<- Univ. Basel🇨🇭<-Osaka Univ.🇯🇵(Univ. Texas🇺🇸)
HP: https://sites.google.com/view/y-okamoto-chemistry/home
HP: https://sites.google.com/view/y-okamoto-chemistry/home
Pinned
Yasu Okamoto
@yasuokamoto.bsky.social
· Aug 1
Our latest paper is finally published in @natcomms.nature.com (doi.org/10.1038/s414...) !! We successfully constructed synthetic multinuclear metal complexes using only proteins.
Reposted by Yasu Okamoto
Our latest work on the nitrogenase-like methylthio-alkane reductase, which specifically reduces reduces carbon-sulfide bonds is now out @natcatal.nature.com: doi.org/10.1038/s419.... We find for the first time large #nitrogenase metalloclusters (P- and L-cluster) outside nitrogenases.
October 23, 2025 at 10:09 AM
Our latest work on the nitrogenase-like methylthio-alkane reductase, which specifically reduces reduces carbon-sulfide bonds is now out @natcatal.nature.com: doi.org/10.1038/s419.... We find for the first time large #nitrogenase metalloclusters (P- and L-cluster) outside nitrogenases.
Reposted by Yasu Okamoto
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
September 4, 2025 at 10:03 AM
📣 The ERC Starting Grant call results are out!
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!
➡️ buff.ly/IsafuFh
#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Reposted by Yasu Okamoto
New molecular design absorbs 2 photons to store 2 positive and 2 negative charges
100 ns lifetime, 3 eV energy storage, and 37% quantum yield
A step toward multi-electron photochemistry
Mathis Brändlin and @bjoernpfund.bsky.social in @natchem.nature.com
www.nature.com/articles/s41...
100 ns lifetime, 3 eV energy storage, and 37% quantum yield
A step toward multi-electron photochemistry
Mathis Brändlin and @bjoernpfund.bsky.social in @natchem.nature.com
www.nature.com/articles/s41...
Photoinduced double charge accumulation in a molecular compound - Nature Chemistry
The photoinduced accumulation of redox equivalents is a challenging requirement for artificial photosynthesis. Now a molecule has been developed in which the sequential absorption of photons results i...
www.nature.com
August 27, 2025 at 8:14 AM
New molecular design absorbs 2 photons to store 2 positive and 2 negative charges
100 ns lifetime, 3 eV energy storage, and 37% quantum yield
A step toward multi-electron photochemistry
Mathis Brändlin and @bjoernpfund.bsky.social in @natchem.nature.com
www.nature.com/articles/s41...
100 ns lifetime, 3 eV energy storage, and 37% quantum yield
A step toward multi-electron photochemistry
Mathis Brändlin and @bjoernpfund.bsky.social in @natchem.nature.com
www.nature.com/articles/s41...
Our latest paper is finally published in @natcomms.nature.com (doi.org/10.1038/s414...) !! We successfully constructed synthetic multinuclear metal complexes using only proteins.
August 1, 2025 at 6:16 AM
Our latest paper is finally published in @natcomms.nature.com (doi.org/10.1038/s414...) !! We successfully constructed synthetic multinuclear metal complexes using only proteins.
Reposted by Yasu Okamoto
Excited to share that our Concept article on the chemogenetic protein translocation tool "SLIPT-PM" is now out in ChemBioChem! We review its development, key features, current applications, and future challenges in chemical biology.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com
July 29, 2025 at 12:08 AM
Excited to share that our Concept article on the chemogenetic protein translocation tool "SLIPT-PM" is now out in ChemBioChem! We review its development, key features, current applications, and future challenges in chemical biology.
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Yasu Okamoto
The fourth talk of the 5th Virtual ChemBioTalks will be given by @cathleenzeymer.bsky.social. She will talk about her group’s exciting research under the title “Design and directed evolution of artificial photoenzymes”.
Make sure to register for free: https://cvent.me/G1geWW
Make sure to register for free: https://cvent.me/G1geWW
July 24, 2025 at 10:51 AM
The fourth talk of the 5th Virtual ChemBioTalks will be given by @cathleenzeymer.bsky.social. She will talk about her group’s exciting research under the title “Design and directed evolution of artificial photoenzymes”.
Make sure to register for free: https://cvent.me/G1geWW
Make sure to register for free: https://cvent.me/G1geWW
Reposted by Yasu Okamoto
Excited to share that our new paper is out in
@jacs.acspublications.org !
We introduce a new design principle for fluorogenic antigen probes, using an intramolecular reaction between a thiol-reactive fluorophore and a cysteine engineered into a DARPin.
pubs.acs.org/doi/10.1021/...
@jacs.acspublications.org !
We introduce a new design principle for fluorogenic antigen probes, using an intramolecular reaction between a thiol-reactive fluorophore and a cysteine engineered into a DARPin.
pubs.acs.org/doi/10.1021/...
Design of Antigen-Targeting Fluorogenic Probes Utilizing Intramolecular Addition Reaction of Protein-Dye Hybrids
Fluorogenic probes for antigens are useful for various purposes, including medical diagnostics and imaging, but achieving a rapid, large fluorescence increase is difficult. Here, we report a new class...
pubs.acs.org
July 24, 2025 at 12:31 AM
Excited to share that our new paper is out in
@jacs.acspublications.org !
We introduce a new design principle for fluorogenic antigen probes, using an intramolecular reaction between a thiol-reactive fluorophore and a cysteine engineered into a DARPin.
pubs.acs.org/doi/10.1021/...
@jacs.acspublications.org !
We introduce a new design principle for fluorogenic antigen probes, using an intramolecular reaction between a thiol-reactive fluorophore and a cysteine engineered into a DARPin.
pubs.acs.org/doi/10.1021/...
Reposted by Yasu Okamoto
JOB ALERT! 🚨 Are you interested in organic synthesis and catalysis? We have an open PhD position in our group at Philipps-Universität Marburg in Germany. 👩🔬👨🔬 Deadline: 10th August 2025. For more details and to submit an application, please refer to the official posting here: lnkd.in/e_f3Xerq
#chemsky
#chemsky
July 20, 2025 at 9:49 AM
JOB ALERT! 🚨 Are you interested in organic synthesis and catalysis? We have an open PhD position in our group at Philipps-Universität Marburg in Germany. 👩🔬👨🔬 Deadline: 10th August 2025. For more details and to submit an application, please refer to the official posting here: lnkd.in/e_f3Xerq
#chemsky
#chemsky
Reposted by Yasu Okamoto
We show how photoredox catalysis can bypass Kasha’s rule, enabling reactions from higher excited states.
This work, led by the exceptional @bjoernpfund.bsky.social, offers new insights into photochemical reactivity.
Published in JACS @jacs.acspublications.org
bit.ly/3IysmjX
This work, led by the exceptional @bjoernpfund.bsky.social, offers new insights into photochemical reactivity.
Published in JACS @jacs.acspublications.org
bit.ly/3IysmjX
Breaking Kasha’s Rule to Enable Higher Reactivity in Photoredox Catalysis
Nearly all photochemical transformations known to date follow Kasha’s rule, implying that reactions occur only from the lowest electronically excited state of a given spin multiplicity due to the fast...
bit.ly
July 18, 2025 at 7:00 AM
We show how photoredox catalysis can bypass Kasha’s rule, enabling reactions from higher excited states.
This work, led by the exceptional @bjoernpfund.bsky.social, offers new insights into photochemical reactivity.
Published in JACS @jacs.acspublications.org
bit.ly/3IysmjX
This work, led by the exceptional @bjoernpfund.bsky.social, offers new insights into photochemical reactivity.
Published in JACS @jacs.acspublications.org
bit.ly/3IysmjX
Reposted by Yasu Okamoto
Molecular recording of cellular protein kinase activity with chemical labeling:
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
Molecular recording of cellular protein kinase activity with chemical labeling - Nature Chemical Biology
Molecular recorders based on kinase activity-dependent protein labeling track specific kinase activities to understand their link to cellular phenotypes in heterogeneous cell populations and in vivo.
www.nature.com
July 10, 2025 at 5:46 PM
Molecular recording of cellular protein kinase activity with chemical labeling:
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
www.nature.com/articles/s41...
Congratulations to De-en Sun and the entire team.
Grateful for the opportunity to present our photo-driven artificial metalloenzyme at #Biotrans2025. It was wonderful to reconnect with old colleagues and meet new friends!
July 7, 2025 at 9:04 AM
Grateful for the opportunity to present our photo-driven artificial metalloenzyme at #Biotrans2025. It was wonderful to reconnect with old colleagues and meet new friends!
So many impressive and inspiring presentations at Repartzyme! Amazing to see how rapidly and significantly the field is progressing. Thrilled to meet many of my scientific heroes from my undergraduate days.
July 7, 2025 at 9:04 AM
So many impressive and inspiring presentations at Repartzyme! Amazing to see how rapidly and significantly the field is progressing. Thrilled to meet many of my scientific heroes from my undergraduate days.
Very happy to be back in Basel🇨🇭 for a while!
June 29, 2025 at 11:04 PM
Very happy to be back in Basel🇨🇭 for a while!
Reposted by Yasu Okamoto
Professor Oliver Wenger has received an Advanced Grant for his research projects in photochemistry, which involve chemical reactions triggered by light. This plays a part in processes such as the conversion of solar energy into other forms of energy.
@wengeroliver.bsky.social
@wengeroliver.bsky.social
June 17, 2025 at 10:19 AM
Professor Oliver Wenger has received an Advanced Grant for his research projects in photochemistry, which involve chemical reactions triggered by light. This plays a part in processes such as the conversion of solar energy into other forms of energy.
@wengeroliver.bsky.social
@wengeroliver.bsky.social
Reposted by Yasu Okamoto
Professor Thomas Ward's ERC project "Bionix" explores new ways of producing nitrate, which plays a key role in global agriculture as a plant nutrient in fertilizers. Professor Ward and his team aim to establish an efficient process that uses significantly less energy and produces fewer emissions.
June 17, 2025 at 10:19 AM
Professor Thomas Ward's ERC project "Bionix" explores new ways of producing nitrate, which plays a key role in global agriculture as a plant nutrient in fertilizers. Professor Ward and his team aim to establish an efficient process that uses significantly less energy and produces fewer emissions.
Reposted by Yasu Okamoto
New cover design @naturesynthesis.bsky.social
I really had fun visualizing the Turner Lab’s research and am grateful that they let me take a playful approach. We turned one-pot multienzyme cascade reactions into a marble run—perfect for an animated cover!
Research behind the cover ▶️ rdcu.be/ealKn
I really had fun visualizing the Turner Lab’s research and am grateful that they let me take a playful approach. We turned one-pot multienzyme cascade reactions into a marble run—perfect for an animated cover!
Research behind the cover ▶️ rdcu.be/ealKn
February 18, 2025 at 12:29 PM
New cover design @naturesynthesis.bsky.social
I really had fun visualizing the Turner Lab’s research and am grateful that they let me take a playful approach. We turned one-pot multienzyme cascade reactions into a marble run—perfect for an animated cover!
Research behind the cover ▶️ rdcu.be/ealKn
I really had fun visualizing the Turner Lab’s research and am grateful that they let me take a playful approach. We turned one-pot multienzyme cascade reactions into a marble run—perfect for an animated cover!
Research behind the cover ▶️ rdcu.be/ealKn
Reposted by Yasu Okamoto
Come and join us in Marburg
Exciting opportunity! Max Planck Institute for Terrestrial Microbiology is looking for a Head of the DNA-Biofoundry MaxGENESYS. Join us in vibrant #Marburg - apply by 15 February 2025. #ScienceJobs #SyntheticBiology #Biofoundry @maxplanck.de
January 25, 2025 at 5:26 PM
Come and join us in Marburg
Reposted by Yasu Okamoto
当グループ(@東大医)で博士研究員を募集しています。細胞外小胞/細胞間コミュニケーションの理解や操作を可能とする合成生物学研究に興味のある方はぜひご検討ください。もちろん学振PDの応募などの相談にものれます。ご興味があればお気軽にDMください！https://www.m.u-tokyo.ac.jp/news/jobs/20250121.pdf
January 21, 2025 at 1:11 AM
当グループ(@東大医)で博士研究員を募集しています。細胞外小胞/細胞間コミュニケーションの理解や操作を可能とする合成生物学研究に興味のある方はぜひご検討ください。もちろん学振PDの応募などの相談にものれます。ご興味があればお気軽にDMください！https://www.m.u-tokyo.ac.jp/news/jobs/20250121.pdf
Reposted by Yasu Okamoto
The 2025 Chemistry Faculty Jobs List has 462 tenure-track positions and 77 teaching positions: bit.ly/facultychemj... #facultychemjobs chemjobs chemsky
The 2025 Chemistry Faculty Jobs List
bit.ly
January 14, 2025 at 8:41 PM
The 2025 Chemistry Faculty Jobs List has 462 tenure-track positions and 77 teaching positions: bit.ly/facultychemj... #facultychemjobs chemjobs chemsky
Reposted by Yasu Okamoto
By incorporating two cofactors into the four binding sites of streptavidin, we engineered programmable artifical enzymes for tandem abiotic transformations including an enantioselective formal C–H hydroxylation and a photooxidation-Michael addition. onlinelibrary.wiley.com/doi/10.1002/... #chemsky
January 7, 2025 at 9:32 AM
By incorporating two cofactors into the four binding sites of streptavidin, we engineered programmable artifical enzymes for tandem abiotic transformations including an enantioselective formal C–H hydroxylation and a photooxidation-Michael addition. onlinelibrary.wiley.com/doi/10.1002/... #chemsky
📣 Our website got a fresh makeover! 🔍 Check out our updated lab website!
sites.google.com/view/y-okamo...
sites.google.com/view/y-okamo...
Designer Biomolecular Chemistry - English
Member
Staff
Assoc. Prof. (PI) : Yasunori Okamoto
Assist. Prof. : –
Administrative assistant : Ayaka Noda
Research assistant : Tomoko Etoh
Student
It's you. Apply now！
sites.google.com
December 13, 2024 at 3:39 AM
📣 Our website got a fresh makeover! 🔍 Check out our updated lab website!
sites.google.com/view/y-okamo...
sites.google.com/view/y-okamo...
Reposted by Yasu Okamoto
Today, several #NobelPrize Laureates arrive in Stockholm, warmly welcomed by Hans Ellegren. Here we see David Baker stepping off the plane at Arlanda.
This week is packed with inspiration, press conferences and lectures, so stay tuned! 🌟
@uofwa.bsky.social @hhmi.bsky.social
#Science #AcademicSky
This week is packed with inspiration, press conferences and lectures, so stay tuned! 🌟
@uofwa.bsky.social @hhmi.bsky.social
#Science #AcademicSky
December 5, 2024 at 12:48 PM
Today, several #NobelPrize Laureates arrive in Stockholm, warmly welcomed by Hans Ellegren. Here we see David Baker stepping off the plane at Arlanda.
This week is packed with inspiration, press conferences and lectures, so stay tuned! 🌟
@uofwa.bsky.social @hhmi.bsky.social
#Science #AcademicSky
This week is packed with inspiration, press conferences and lectures, so stay tuned! 🌟
@uofwa.bsky.social @hhmi.bsky.social
#Science #AcademicSky
Reposted by Yasu Okamoto
The next frontier of T cell therapeutics when the T also stands for tissue-targeting, such as brain or local immune response, via synthetic gene circuits
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
science.org/doi/10.1126/...
December 5, 2024 at 7:22 PM
The next frontier of T cell therapeutics when the T also stands for tissue-targeting, such as brain or local immune response, via synthetic gene circuits
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
science.org/doi/10.1126/...
science.org/doi/10.1126/...
Reposted by Yasu Okamoto
One more week till the deadline - Please reach out if you have any questions or want to know more. Thanks
We're recruiting two PDRAs (one computational and one experimental) to join the project "Designer metallo coiled coils for use in MRI" - closing date Dec.12th. Please get in touch if you'd like to know more. @uobchemistry.bsky.social
www.jobs.ac.uk/job/DKS611/r...
www.jobs.ac.uk/job/DKS605/r...
www.jobs.ac.uk/job/DKS611/r...
www.jobs.ac.uk/job/DKS605/r...
Research Fellow at University of Birmingham
Looking for a new job opportunity in academia? Check out this job opening for a Research Fellow on jobs.ac.uk!
www.jobs.ac.uk
December 5, 2024 at 11:18 AM
One more week till the deadline - Please reach out if you have any questions or want to know more. Thanks