Warre Dhondt
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warred.bsky.social
Warre Dhondt
@warred.bsky.social
120 followers 430 following 2 posts
PhD student structural biology/computational biophysics @VIB-IRC and CMM, UGent. Working on cytokine receptors.
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janfelix.bsky.social
Now published @cp-cellreports.bsky.social! Antibody-mediated TGF-β1 activation for the treatment of diseases caused by deleterious T cell activity: www.cell.com/cell-reports...
Fantastic collaboration & massive effort from Sophie Lucas Lab @ de Duve Institute. #CryoEM with @savvideslab.bsky.social.
September 2, 2025 at 11:25 AM
Reposted by Warre Dhondt
sjorsscheres.bsky.social
Fantastic work by the group of @matteoall.bsky.social : a SUN5:Nesprin3 complex at the head:tail junction of sperm cells. 🤯 #teamtomo

www.biorxiv.org/content/10.1...
In-cell structure of a LINC complex reveals the molecular basis for membrane remodelling and head-to-tail coupling in sperm cells
In eukaryotic cells, LINC complexes physically bridge the two nuclear membranes to cytoskeletal filaments, transmitting mechanical forces to the nucleus. Due to their dynamic and membrane-embedded nat...
www.biorxiv.org
August 5, 2025 at 6:14 AM
Reposted by Warre Dhondt
rezamehdipour.bsky.social
This work is the result of a fantastic collaboration with@matteoall.bsky.social!
@warred.bsky.social, @a-dsantos.bsky.social , @alisterburt.bsky.social , @tom-hale.bsky.social, @mrclmb.bsky.social,
August 5, 2025 at 12:41 PM
Reposted by Warre Dhondt
rezamehdipour.bsky.social
We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!!
www.biorxiv.org/content/10.1...
August 5, 2025 at 12:41 PM
Reposted by Warre Dhondt
delalamo.xyz
This structure is absolutely _nuts_. Lipids are captured marching through the tunnel
a, Overview of the lipids observed in the LPD-3 complex, shown perpendicular to the membrane. Proteins are shown as a cartoon representation and the uninterpreted cryo-EM density is shown in orange. LPD-3 is coloured teal, Spigot is coloured yellow and lipids are shown as black sticks. b, Magnified view of the tunnel entrance, coloured as in a. c, Clipped view to show the lipid-transport tunnel. LPD-3 and Spigot are shown as a surface representation, coloured as in a, and lipids are shown as white sticks. d, The organization of lipids within the tunnel. Ionizable residues that interact with lipid head groups are labelled and shown as sticks. Lipids are shown as grey or gold sticks. e, The LPD-3 complex viewed parallel to the membrane. The arrows indicate the location of the four hydration portals. Modelled proteins are shown as a surface representation and are coloured as in a. f, Magnified view of a lipid within the tunnel. Residues that interact with the lipid headgroup are shown as sticks. g, Sliced views of the LPD-3 tunnel, showing the locations of the hydration portals. Slices are sequential from left to right and progress from RBG-1 to RBG-6.
April 26, 2025 at 10:02 AM
Reposted by Warre Dhondt
savvideslab.bsky.social
Delighted to share our reanalysis of cryo-EM data in EMPIAR-10930, now at:

journals.plos.org/plosbiology/... ;

revealing the ALK-ALKAL2 assembly with 2:1 stoichiometry and resolving the conundrum introduced by the originally reported 2:2 complex. ALK/LTK-cytokine signalling getting clearer!
Reanalysis of cryo-EM data reveals ALK-cytokine assemblies with both 2:1 and 2:2 stoichiometries
The mechanistic understanding of the complex between ALK kinase and its cytokine ligand ALKAL2 has been complicated by reports of diverse stoichiometries (2:1 vs 2:2). This study reanalyzes cryo-EM da...
journals.plos.org
April 13, 2025 at 7:04 PM
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becklab.bsky.social
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
January 17, 2025 at 6:43 PM
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johnrubinstein.bsky.social
The @structurabio.bsky.social team have been preparing *Amazing* workshops and tutorials on all things related to cryo-EM image analysis, demonstrating deep talent in communication in addition to software design.
If you're interested in learning about cryo-EM do yourself a favour and have a look!
December 13, 2024 at 7:05 PM
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verenaresch.bsky.social
I sometimes forget how flexible proteins are. It becomes really apparent when you use NMR states for an animation. That poor cofactor is getting pushed around a lot 😅

#sciart #blender3d #biocatalysis
November 25, 2024 at 5:14 PM
Reposted by Warre Dhondt
brettcollins.bsky.social
An amazing cryoEM structure of the membrane-assembled lysosomal mTORC complex from the Hurley lab. @jimhurley.bsky.social
www.biorxiv.org/content/10.1...
Structure of mTORC complex by cryoEM showing electron density maps
November 17, 2024 at 1:20 AM
Reposted by Warre Dhondt
If pombe wants to be taken seriously as an organism it needs to ferment a better beverage
November 1, 2023 at 11:15 PM