Dr Samuel J Pearce
@vetmicro.bsky.social
Veterinarian | Resident in Veterinary Microbiology | PhD Candidate | Antimicrobial stewardship obsessed and writer or Resistance is Futile | Passionate about AMR, One Health, infectious disease and acute medicine
Reposted by Dr Samuel J Pearce
E. coli can spread as quickly as swine flu, new research reveals. 🦠
For the first time, scientists can predict the rate at which gut bacteria pass between people — a major step towards tackling antibiotic-resistant infections.
Read here ⤵️
sanger.ac.uk/news_item/ad...
For the first time, scientists can predict the rate at which gut bacteria pass between people — a major step towards tackling antibiotic-resistant infections.
Read here ⤵️
sanger.ac.uk/news_item/ad...
Advanced disease modelling shows some gut bacteria can spread as rapidly as viruses
Experts can now predict the transmission rate of a bacterial E. coli infection in the same way as they can for viral pandemics, which can help battling treatment-resistant infections in the future.
sanger.ac.uk
November 4, 2025 at 11:55 AM
E. coli can spread as quickly as swine flu, new research reveals. 🦠
For the first time, scientists can predict the rate at which gut bacteria pass between people — a major step towards tackling antibiotic-resistant infections.
Read here ⤵️
sanger.ac.uk/news_item/ad...
For the first time, scientists can predict the rate at which gut bacteria pass between people — a major step towards tackling antibiotic-resistant infections.
Read here ⤵️
sanger.ac.uk/news_item/ad...
One for the surgeons today. Many vets perform surgery on a regular basis, so understanding infection prevention and antimicrobial prophylaxis is key in prevent surgical site infections and promoting responsible antimicrobial use!
open.substack.com/pub/resistan...
open.substack.com/pub/resistan...
Stewardship solutions #6: Surgical solutions
All you need to know to prevent, identify and treat surgical site infections
open.substack.com
October 21, 2025 at 11:24 AM
One for the surgeons today. Many vets perform surgery on a regular basis, so understanding infection prevention and antimicrobial prophylaxis is key in prevent surgical site infections and promoting responsible antimicrobial use!
open.substack.com/pub/resistan...
open.substack.com/pub/resistan...
Reposted by Dr Samuel J Pearce
Two investigations reveal how resistant bacteria may have spread from pets to people
Molecular analysis and epidemiologic detective work helped uncover a hidden One Health link between human and pet clusters of multidrug-resistant bacterial infections.
www.cidrap.umn.edu/a...
Molecular analysis and epidemiologic detective work helped uncover a hidden One Health link between human and pet clusters of multidrug-resistant bacterial infections.
www.cidrap.umn.edu/a...
October 2, 2025 at 8:47 PM
Two investigations reveal how resistant bacteria may have spread from pets to people
Molecular analysis and epidemiologic detective work helped uncover a hidden One Health link between human and pet clusters of multidrug-resistant bacterial infections.
www.cidrap.umn.edu/a...
Molecular analysis and epidemiologic detective work helped uncover a hidden One Health link between human and pet clusters of multidrug-resistant bacterial infections.
www.cidrap.umn.edu/a...
Reposted by Dr Samuel J Pearce
Sometimes you meet absolutely incredible bioinfo-magicians.
It was a huge privilege when @shenwei356.bsky.social
joined our group for a year on an @embl.org sabbatical.
While here, he developed a new way of aligning to
millions of bacteria, called LexicMap 1/n
www.nature.com/articles/s41...
It was a huge privilege when @shenwei356.bsky.social
joined our group for a year on an @embl.org sabbatical.
While here, he developed a new way of aligning to
millions of bacteria, called LexicMap 1/n
www.nature.com/articles/s41...
Efficient sequence alignment against millions of prokaryotic genomes with LexicMap - Nature Biotechnology
LexicMap uses a fixed set of probes to efficiently query gene sequences for fast and low-memory alignment.
www.nature.com
September 10, 2025 at 9:12 AM
Sometimes you meet absolutely incredible bioinfo-magicians.
It was a huge privilege when @shenwei356.bsky.social
joined our group for a year on an @embl.org sabbatical.
While here, he developed a new way of aligning to
millions of bacteria, called LexicMap 1/n
www.nature.com/articles/s41...
It was a huge privilege when @shenwei356.bsky.social
joined our group for a year on an @embl.org sabbatical.
While here, he developed a new way of aligning to
millions of bacteria, called LexicMap 1/n
www.nature.com/articles/s41...
Reposted by Dr Samuel J Pearce
Enough is enough. The health of the country is in danger. Read our resignation letters: insidemedicine.substack.com/p/breaking-n...
Breaking News: Read three top CDC officials' resignation emails.
The end of an era.
insidemedicine.substack.com
August 28, 2025 at 3:38 AM
Enough is enough. The health of the country is in danger. Read our resignation letters: insidemedicine.substack.com/p/breaking-n...
Reposted by Dr Samuel J Pearce
"Closure of the Fleming Fund risks undermining UK leadership on AMR." BSAC is seeking urgent clarification from the Government regarding the UK’s future leadership on antimicrobial resistance (#AMR), following reports that the Fleming Fund – the UK’s flagship global AMR programme – is set to close.
Closure of the Fleming Fund risks undermining UK leadership on AMR - The British Society for Antimicrobial Chemotherapy
bsac.org.uk
July 16, 2025 at 11:56 AM
"Closure of the Fleming Fund risks undermining UK leadership on AMR." BSAC is seeking urgent clarification from the Government regarding the UK’s future leadership on antimicrobial resistance (#AMR), following reports that the Fleming Fund – the UK’s flagship global AMR programme – is set to close.
Reposted by Dr Samuel J Pearce
‘MMR vaccination uptake rate for children by the age of five in Liverpool is just 73% ... The World Health Organisation says a threshold of 95% is needed to achieve herd immunity’
Please protect child by allowing them to be vaccinated. If you are worried, talk to your doctor. Misinformation kills.
Please protect child by allowing them to be vaccinated. If you are worried, talk to your doctor. Misinformation kills.
🚨 EXCLUSIVE: A child has died after contracting measles in Liverpool, where public health officials fear a growing outbreak of the disease.
Full story: www.thetimes.com/article/bb28...
Full story: www.thetimes.com/article/bb28...
Measles outbreak kills child in Liverpool as vaccination rate plunges
The death in Liverpool, where one in four young children are not protected, is fuelling warnings that the virus could spread like ‘wildfire’
www.thetimes.com
July 13, 2025 at 7:37 AM
‘MMR vaccination uptake rate for children by the age of five in Liverpool is just 73% ... The World Health Organisation says a threshold of 95% is needed to achieve herd immunity’
Please protect child by allowing them to be vaccinated. If you are worried, talk to your doctor. Misinformation kills.
Please protect child by allowing them to be vaccinated. If you are worried, talk to your doctor. Misinformation kills.
A couple of years ago, I bought the book Why I'm No Longer Talking to White People About Race by Reno Eddo-Lodge. I'm ashamed to say I haven't read it until now. If you haven't, I recommend you do. Today, I'm committing to monthly donations to the British Veterinary Ethnicity and Diversity Society.
Racism warning as sector told to get ‘house in order’
British Veterinary Ethnicity and Diversity Society co-founder and co-author of a damning paper, Navaratnam Partheeban, says: “if we’re going to be role models f
www.vettimes.com
July 8, 2025 at 7:35 PM
A couple of years ago, I bought the book Why I'm No Longer Talking to White People About Race by Reno Eddo-Lodge. I'm ashamed to say I haven't read it until now. If you haven't, I recommend you do. Today, I'm committing to monthly donations to the British Veterinary Ethnicity and Diversity Society.
Reposted by Dr Samuel J Pearce
Springer-Nature launched a series of "Discover" journals that closely mimic MDPI titles -- sharing *identical* journal names, and likely similar business model.
What is going on, and why researcher will - as always - fall for it?
A 🧵
the-strain-on-scientific-publishing.github.io/website/post...
What is going on, and why researcher will - as always - fall for it?
A 🧵
the-strain-on-scientific-publishing.github.io/website/post...
Springer Nature Discovers MDPI – The Strain on Scientific Publishing
Home page for the paper ‘The Strain on Scientific Publishing’ by Mark A Hanson, Dan Brockington, Paolo Crosetto and Pablo Gomez Barreiro
the-strain-on-scientific-publishing.github.io
June 15, 2025 at 2:21 PM
Springer-Nature launched a series of "Discover" journals that closely mimic MDPI titles -- sharing *identical* journal names, and likely similar business model.
What is going on, and why researcher will - as always - fall for it?
A 🧵
the-strain-on-scientific-publishing.github.io/website/post...
What is going on, and why researcher will - as always - fall for it?
A 🧵
the-strain-on-scientific-publishing.github.io/website/post...
Reposted by Dr Samuel J Pearce
#OneHealthEvent
One Health Investigations of Outbreaks and Spillover Events - on Coursera is a course of 10 content modules and didactic lectures.
Find more:
www.coursera.org/learn/one-he...
#OneHealth #OneHealthResources
One Health Investigations of Outbreaks and Spillover Events - on Coursera is a course of 10 content modules and didactic lectures.
Find more:
www.coursera.org/learn/one-he...
#OneHealth #OneHealthResources
One Health Investigations of Outbreaks and Spillover Events
Offered by Johns Hopkins University. One Health is the concept that human, animal and environmental health are interconnected. Outbreaks of ... Enroll for free.
www.coursera.org
June 13, 2025 at 7:31 AM
#OneHealthEvent
One Health Investigations of Outbreaks and Spillover Events - on Coursera is a course of 10 content modules and didactic lectures.
Find more:
www.coursera.org/learn/one-he...
#OneHealth #OneHealthResources
One Health Investigations of Outbreaks and Spillover Events - on Coursera is a course of 10 content modules and didactic lectures.
Find more:
www.coursera.org/learn/one-he...
#OneHealth #OneHealthResources
Reposted by Dr Samuel J Pearce
Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight)
interpretamr.github.io/AMRrules
interpretamr.github.io/AMRrules
May 22, 2025 at 9:35 AM
Excited to share the first beta release of AMRrules at #ABPHM! (Poster 42 tonight)
interpretamr.github.io/AMRrules
interpretamr.github.io/AMRrules
Reposted by Dr Samuel J Pearce
The new version of R for AMR is ready!
🧫 Automated antibiograms
💻 Integration to WHONET
🧪 Updated CLSI and EUCAST breakpoints
💡 Free
amr-for-r.org
#biostatistics #episky #Statistics #AMR
🧫 Automated antibiograms
💻 Integration to WHONET
🧪 Updated CLSI and EUCAST breakpoints
💡 Free
amr-for-r.org
#biostatistics #episky #Statistics #AMR
Antimicrobial Resistance Data Analysis
Functions to simplify and standardise antimicrobial resistance (AMR) data analysis and to work with microbial and antimicrobial properties by using evidence-based methods, as described in <doi:10.1863...
amr-for-r.org
June 6, 2025 at 7:29 AM
The new version of R for AMR is ready!
🧫 Automated antibiograms
💻 Integration to WHONET
🧪 Updated CLSI and EUCAST breakpoints
💡 Free
amr-for-r.org
#biostatistics #episky #Statistics #AMR
🧫 Automated antibiograms
💻 Integration to WHONET
🧪 Updated CLSI and EUCAST breakpoints
💡 Free
amr-for-r.org
#biostatistics #episky #Statistics #AMR
Reposted by Dr Samuel J Pearce
Absolutely thrilled to present our latest review, where we discuss how host microenvironment and bacterial subversion strategies can undermine traditional antimicrobial sensitivity testing, and whether better models may one day get us "beyond the MIC" #IDSKy
rdcu.be/emYoh
rdcu.be/emYoh
Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing
npj Antimicrobials and Resistance - Effect of host microenvironment and bacterial lifestyles on antimicrobial sensitivity and implications for susceptibility testing
rdcu.be
May 21, 2025 at 10:43 AM
Absolutely thrilled to present our latest review, where we discuss how host microenvironment and bacterial subversion strategies can undermine traditional antimicrobial sensitivity testing, and whether better models may one day get us "beyond the MIC" #IDSKy
rdcu.be/emYoh
rdcu.be/emYoh
Just got back from my own Stag Do, on a beautiful bank holiday weekend, to find out that I am now officially a resident of the European College of Veterinary Microbiology!
May 4, 2025 at 3:13 PM
Just got back from my own Stag Do, on a beautiful bank holiday weekend, to find out that I am now officially a resident of the European College of Veterinary Microbiology!
Reposted by Dr Samuel J Pearce
🐶🐱 Companion animals need #AntimicrobialStewardship too! In our new SR/MA (led by Dr. Fiona Emdin), we examined short vs. long antibiotic durations for UTIs in dogs & cats.📉 Pooled RR for cure = 0.55 (95% CI: 0.23–1.27), very low certainty.
🔓 doi.org/10.1186/s129...
More high-quality data needed!
🔓 doi.org/10.1186/s129...
More high-quality data needed!
April 18, 2025 at 1:55 PM
🐶🐱 Companion animals need #AntimicrobialStewardship too! In our new SR/MA (led by Dr. Fiona Emdin), we examined short vs. long antibiotic durations for UTIs in dogs & cats.📉 Pooled RR for cure = 0.55 (95% CI: 0.23–1.27), very low certainty.
🔓 doi.org/10.1186/s129...
More high-quality data needed!
🔓 doi.org/10.1186/s129...
More high-quality data needed!
Reposted by Dr Samuel J Pearce
Sharing our new @thelancet.bsky.social piece on spillover prevention & #OneHealth in the WHO #PandemicAgreement. We call on states to adopt the agreement next month. Huge thanks to @alexandrafinch.bsky.social for leading this. Let's get this done and make the world a safer place! bit.ly/3E7RKeu
The promise and compromise of the WHO Pandemic Agreement for spillover prevention and One Health
As scientists, health professionals, and lawyers engaged in reducing pandemic spillover
risks, we recognise the urgent need for, and immense potential of, a robust international
agreement on pandemic ...
bit.ly
April 3, 2025 at 11:18 PM
Sharing our new @thelancet.bsky.social piece on spillover prevention & #OneHealth in the WHO #PandemicAgreement. We call on states to adopt the agreement next month. Huge thanks to @alexandrafinch.bsky.social for leading this. Let's get this done and make the world a safer place! bit.ly/3E7RKeu
Was thinking of a comparative article on beta-lactams use for pyelonephritis as NICE recommends PO cefalexin but upon reading the literature, I can't make it make sense 🤷 EUCAST only has a UTI breakpoint, PKPD suggests poor empirical choice, but clinical studies seem ok. Can #IDSky help me out here?
March 30, 2025 at 9:36 AM
Was thinking of a comparative article on beta-lactams use for pyelonephritis as NICE recommends PO cefalexin but upon reading the literature, I can't make it make sense 🤷 EUCAST only has a UTI breakpoint, PKPD suggests poor empirical choice, but clinical studies seem ok. Can #IDSky help me out here?
A month ago I started a fortnightly newsletter on veterinary infections disease, clinical microbiology and antimicrobial stewardship🦠This week covered some latest updates in small animal viral diseases, check it out here: open.substack.com/pub/resistan...
#VetSky
#VetSky
Stewardship solutions #3
Viral meningitis, FIP treatment durations and disinfectants for viruses
open.substack.com
March 29, 2025 at 10:07 AM
A month ago I started a fortnightly newsletter on veterinary infections disease, clinical microbiology and antimicrobial stewardship🦠This week covered some latest updates in small animal viral diseases, check it out here: open.substack.com/pub/resistan...
#VetSky
#VetSky
Reposted by Dr Samuel J Pearce
Humans are driving biodiversity loss among all species across the planet, one of the most exhaustive global studies on the subject ever conducted finds.
This is *us*, people: you + me. It's up to all of us to get into the fight for the natural world. 🌏
www.theguardian.com/environment/...
This is *us*, people: you + me. It's up to all of us to get into the fight for the natural world. 🌏
www.theguardian.com/environment/...
Biodiversity loss in all species and every ecosystem linked to humans – report
Sweeping synthesis of 2,000 global studies leaves no doubt about scale of problem and role of humans, say experts
www.theguardian.com
March 27, 2025 at 7:42 AM
Humans are driving biodiversity loss among all species across the planet, one of the most exhaustive global studies on the subject ever conducted finds.
This is *us*, people: you + me. It's up to all of us to get into the fight for the natural world. 🌏
www.theguardian.com/environment/...
This is *us*, people: you + me. It's up to all of us to get into the fight for the natural world. 🌏
www.theguardian.com/environment/...
Reposted by Dr Samuel J Pearce
What I don’t get is why the official position continues to be…
“…the risk to livestock and the general public is low.”
This variant of influenza seems to infect everything…how is that a low risk?
www.theguardian.com/world/2025/m...
“…the risk to livestock and the general public is low.”
This variant of influenza seems to infect everything…how is that a low risk?
www.theguardian.com/world/2025/m...
World’s first case of bird flu in sheep detected in England
H5N1 virus found in single animal in Yorkshire but risk to general public is very low, say experts
www.theguardian.com
March 24, 2025 at 3:29 PM
What I don’t get is why the official position continues to be…
“…the risk to livestock and the general public is low.”
This variant of influenza seems to infect everything…how is that a low risk?
www.theguardian.com/world/2025/m...
“…the risk to livestock and the general public is low.”
This variant of influenza seems to infect everything…how is that a low risk?
www.theguardian.com/world/2025/m...
Recently, I was asked for my opinion on a novel veterinary UTI diagnostic. While the technology is fascinating, it is a good example of why sensitivity and specificity aren't always the best measure. Read more in my latest post here: resistanceisfutile.substack.com/p/sensitivit...
#vetsky #IDsky
#vetsky #IDsky
Sensitivity and specificity answer the wrong questions
Why how we measure a diagnostic test and how we interpret them are equally important
resistanceisfutile.substack.com
March 22, 2025 at 9:58 AM
Recently, I was asked for my opinion on a novel veterinary UTI diagnostic. While the technology is fascinating, it is a good example of why sensitivity and specificity aren't always the best measure. Read more in my latest post here: resistanceisfutile.substack.com/p/sensitivit...
#vetsky #IDsky
#vetsky #IDsky
Interested in One Health or ever wondered what primary care is like on the other side?
Check out this event from Royal Society of Medicine discussing the challenges seen in human and veterinary primary care! #MedSky #VetSky #OneHealth
lnkd.in/edfazfmQ
Check out this event from Royal Society of Medicine discussing the challenges seen in human and veterinary primary care! #MedSky #VetSky #OneHealth
lnkd.in/edfazfmQ
March 17, 2025 at 8:23 AM
Interested in One Health or ever wondered what primary care is like on the other side?
Check out this event from Royal Society of Medicine discussing the challenges seen in human and veterinary primary care! #MedSky #VetSky #OneHealth
lnkd.in/edfazfmQ
Check out this event from Royal Society of Medicine discussing the challenges seen in human and veterinary primary care! #MedSky #VetSky #OneHealth
lnkd.in/edfazfmQ
Reposted by Dr Samuel J Pearce
Emerging #Sporothrix brasiliensis is fueling a cat-transmitted sporotrichosis #outbreak in Northeast Brazil. Over 1,100 cases identified in Recife's metro region (2016-2021), with zoonotic transmission linked to Rio de Janeiro strains.
Link: link.springer.com/article/10.1...
#PublicHealth #Zoonoses
Link: link.springer.com/article/10.1...
#PublicHealth #Zoonoses
Emerging Cases of Cat-Transmitted Sporotrichosis Driven by Sporothrix brasiliensis in Northeast Brazil - Mycopathologia
Cat-transmitted sporotrichosis is caused by the emerging fungal pathogen Sporothrix brasiliensis and constitutes a significant public health issue that affects people living in resource-poor urban cen...
link.springer.com
January 9, 2025 at 4:41 PM
Emerging #Sporothrix brasiliensis is fueling a cat-transmitted sporotrichosis #outbreak in Northeast Brazil. Over 1,100 cases identified in Recife's metro region (2016-2021), with zoonotic transmission linked to Rio de Janeiro strains.
Link: link.springer.com/article/10.1...
#PublicHealth #Zoonoses
Link: link.springer.com/article/10.1...
#PublicHealth #Zoonoses
Reposted by Dr Samuel J Pearce
I think one of the biggest lies we were told in medical school is that the lungs and the urinary tract are sterile... I guess lung and urinary microbiomes were not a thing yet...
#meded #medsky #foamed #idsky
www.nature.com/articles/nru...
www.nature.com/articles/s41...
#meded #medsky #foamed #idsky
www.nature.com/articles/nru...
www.nature.com/articles/s41...
The dynamic lung microbiome in health and disease - Nature Reviews Microbiology
Like the gut, the lung harbours a diverse, interacting assortment of microbiota. In this review, Natalini, Singh and Segal examine the role of the lung microbiome in health and disease and discuss fut...
www.nature.com
March 6, 2025 at 7:54 PM
I think one of the biggest lies we were told in medical school is that the lungs and the urinary tract are sterile... I guess lung and urinary microbiomes were not a thing yet...
#meded #medsky #foamed #idsky
www.nature.com/articles/nru...
www.nature.com/articles/s41...
#meded #medsky #foamed #idsky
www.nature.com/articles/nru...
www.nature.com/articles/s41...
Reposted by Dr Samuel J Pearce
A previously unknown immunological function of the proteasome is its ability to release bactericidal compounds. This discovery presents a potential paradigm shift in antimicrobial therapy. It may contribute to addressing the global challenge of #AMR.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cell-autonomous innate immunity by proteasome-derived defence peptides - Nature
Proteasomal degradation of cellular proteins generate defence peptides constitutively and in response to bacterial infection. Such peptides might provide a source of natural antibiotics that...
www.nature.com
March 6, 2025 at 7:52 PM
A previously unknown immunological function of the proteasome is its ability to release bactericidal compounds. This discovery presents a potential paradigm shift in antimicrobial therapy. It may contribute to addressing the global challenge of #AMR.
www.nature.com/articles/s41...
www.nature.com/articles/s41...