Bradley Langford
@brxad.bsky.social
PharmD/MPH Antimicrobial Stewardship Pharmacist 💊🛡️🦠🇨🇦
📘 Associate Editor @ashejournal.bsky.social
👤 https://discover.research.utoronto.ca/42775-bradley-langford
📘 Associate Editor @ashejournal.bsky.social
👤 https://discover.research.utoronto.ca/42775-bradley-langford
Reposted by Bradley Langford
Cross-sectional study of hospital antibiograms identifies areas for improvement that could help support clinical decision making & AMR monitoring:
doi.org/10.1093/jaca...
@brxad.bsky.social #JACAMRNews
doi.org/10.1093/jaca...
@brxad.bsky.social #JACAMRNews
July 8, 2025 at 10:02 AM
Cross-sectional study of hospital antibiograms identifies areas for improvement that could help support clinical decision making & AMR monitoring:
doi.org/10.1093/jaca...
@brxad.bsky.social #JACAMRNews
doi.org/10.1093/jaca...
@brxad.bsky.social #JACAMRNews
Reposted by Bradley Langford
An antibiotic audit-and-feedback intervention for family physicians targeting patients aged 65 and older was associated with a 7% reduction in antibiotic prescriptions for patients of all ages. https://ja.ma/3ImcG2W
July 1, 2025 at 4:00 PM
An antibiotic audit-and-feedback intervention for family physicians targeting patients aged 65 and older was associated with a 7% reduction in antibiotic prescriptions for patients of all ages. https://ja.ma/3ImcG2W
New in JAC AMR - our review of antibiograms from 60 hospitals found ++ variability in design
Many opportunities for improvement, for ex include:
- detail about the population
- guidance on how to interpret
-info on how duplicate patients are handled
doi.org/10.1093/jaca...
#idsky
Many opportunities for improvement, for ex include:
- detail about the population
- guidance on how to interpret
-info on how duplicate patients are handled
doi.org/10.1093/jaca...
#idsky
June 17, 2025 at 2:17 AM
New in JAC AMR - our review of antibiograms from 60 hospitals found ++ variability in design
Many opportunities for improvement, for ex include:
- detail about the population
- guidance on how to interpret
-info on how duplicate patients are handled
doi.org/10.1093/jaca...
#idsky
Many opportunities for improvement, for ex include:
- detail about the population
- guidance on how to interpret
-info on how duplicate patients are handled
doi.org/10.1093/jaca...
#idsky
🆕 Evaluating BSI in Ontario we found #AMR was associated with a 10% ⬆️ risk of death equivalent to 1.2 deaths/100,000 people/year
These estimates are lower than those in previous literature, which may be due to robust adjustment for confounding
doi.org/10.1093/cid/...
@cidjournal.bsky.social
These estimates are lower than those in previous literature, which may be due to robust adjustment for confounding
doi.org/10.1093/cid/...
@cidjournal.bsky.social
May 16, 2025 at 12:31 AM
🆕 Evaluating BSI in Ontario we found #AMR was associated with a 10% ⬆️ risk of death equivalent to 1.2 deaths/100,000 people/year
These estimates are lower than those in previous literature, which may be due to robust adjustment for confounding
doi.org/10.1093/cid/...
@cidjournal.bsky.social
These estimates are lower than those in previous literature, which may be due to robust adjustment for confounding
doi.org/10.1093/cid/...
@cidjournal.bsky.social
Reposted by Bradley Langford
From @brxad.bsky.social et al, a reminder global ID collaborations do and should continue to exist and strengthen in the current political landscape. doi.org/10.1017/ash....
April 30, 2025 at 2:32 PM
From @brxad.bsky.social et al, a reminder global ID collaborations do and should continue to exist and strengthen in the current political landscape. doi.org/10.1017/ash....
📈 New Public Health Ontario epidemiology report:
C. auris cases in Ontario are infrequent (22 cases, 2017–2024) but are gradually rising.
🧪 94% fluconazole resistant
🧪 35% amphotericin B resistant
🧪 0% echinocandin resistant
📊 Read more: bit.ly/4cIAwBg
#AntimicrobialStewardship
C. auris cases in Ontario are infrequent (22 cases, 2017–2024) but are gradually rising.
🧪 94% fluconazole resistant
🧪 35% amphotericin B resistant
🧪 0% echinocandin resistant
📊 Read more: bit.ly/4cIAwBg
#AntimicrobialStewardship
April 18, 2025 at 2:09 PM
📈 New Public Health Ontario epidemiology report:
C. auris cases in Ontario are infrequent (22 cases, 2017–2024) but are gradually rising.
🧪 94% fluconazole resistant
🧪 35% amphotericin B resistant
🧪 0% echinocandin resistant
📊 Read more: bit.ly/4cIAwBg
#AntimicrobialStewardship
C. auris cases in Ontario are infrequent (22 cases, 2017–2024) but are gradually rising.
🧪 94% fluconazole resistant
🧪 35% amphotericin B resistant
🧪 0% echinocandin resistant
📊 Read more: bit.ly/4cIAwBg
#AntimicrobialStewardship
🐶🐱 Companion animals need #AntimicrobialStewardship too! In our new SR/MA (led by Dr. Fiona Emdin), we examined short vs. long antibiotic durations for UTIs in dogs & cats.📉 Pooled RR for cure = 0.55 (95% CI: 0.23–1.27), very low certainty.
🔓 doi.org/10.1186/s129...
More high-quality data needed!
🔓 doi.org/10.1186/s129...
More high-quality data needed!
April 18, 2025 at 1:55 PM
🐶🐱 Companion animals need #AntimicrobialStewardship too! In our new SR/MA (led by Dr. Fiona Emdin), we examined short vs. long antibiotic durations for UTIs in dogs & cats.📉 Pooled RR for cure = 0.55 (95% CI: 0.23–1.27), very low certainty.
🔓 doi.org/10.1186/s129...
More high-quality data needed!
🔓 doi.org/10.1186/s129...
More high-quality data needed!
Reposted by Bradley Langford
Survey of US adults <65 yo comparing abx non-users to frequent users (>3x/year) in @jama.com Open
Frequent abx users more likely to distrust science, want abx for viral URIs, need health literacy support, be medical maximizers, and had more comorbidities
#IDSky
jamanetwork.com/journals/jam...
Frequent abx users more likely to distrust science, want abx for viral URIs, need health literacy support, be medical maximizers, and had more comorbidities
#IDSky
jamanetwork.com/journals/jam...
March 23, 2025 at 5:27 PM
Survey of US adults <65 yo comparing abx non-users to frequent users (>3x/year) in @jama.com Open
Frequent abx users more likely to distrust science, want abx for viral URIs, need health literacy support, be medical maximizers, and had more comorbidities
#IDSky
jamanetwork.com/journals/jam...
Frequent abx users more likely to distrust science, want abx for viral URIs, need health literacy support, be medical maximizers, and had more comorbidities
#IDSky
jamanetwork.com/journals/jam...
🆕 in @ashejournal.bsky.social Another example of "you get what you pay for" - hospitals with designated funding/resources to support their antibiotic stewardship program had a 3.7X higher odds of participating in AMU reporting and benchmarking
doi.org/10.1017/ash.... #IDSky
doi.org/10.1017/ash.... #IDSky
March 19, 2025 at 1:17 PM
🆕 in @ashejournal.bsky.social Another example of "you get what you pay for" - hospitals with designated funding/resources to support their antibiotic stewardship program had a 3.7X higher odds of participating in AMU reporting and benchmarking
doi.org/10.1017/ash.... #IDSky
doi.org/10.1017/ash.... #IDSky
UTI vs "UTI" ⁉️
In this cohort of patients diagnosed with "UTI" only about 30% had symptoms consistent with infection. ED setting and patients with mental status changes are key opportunities for antibiotic stewardship.
onlinelibrary.wiley.com/doi/10.1002/...
In this cohort of patients diagnosed with "UTI" only about 30% had symptoms consistent with infection. ED setting and patients with mental status changes are key opportunities for antibiotic stewardship.
onlinelibrary.wiley.com/doi/10.1002/...
Antibiotic Overprescription for “Urinary Tract Infections” Is Associated With Poor Diagnostic Stewardship and Low Adherence to Guidelines
Purpose While urinary tract infections (UTIs) are thought to be common among women, as many as 65% of UTI diagnoses may be inaccurate. To identify strategies to improve antibiotic stewardship, we so...
onlinelibrary.wiley.com
February 18, 2025 at 9:16 PM
UTI vs "UTI" ⁉️
In this cohort of patients diagnosed with "UTI" only about 30% had symptoms consistent with infection. ED setting and patients with mental status changes are key opportunities for antibiotic stewardship.
onlinelibrary.wiley.com/doi/10.1002/...
In this cohort of patients diagnosed with "UTI" only about 30% had symptoms consistent with infection. ED setting and patients with mental status changes are key opportunities for antibiotic stewardship.
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Bradley Langford
Shorter is greener! 🍃♻️
Unnecessary antibiotics contribute to greenhouse gas emmissions. Want to know how much? 👉🏻 shorturl.at/52wOT
Fantastic point! #IDSky #AMSsky
Unnecessary antibiotics contribute to greenhouse gas emmissions. Want to know how much? 👉🏻 shorturl.at/52wOT
Fantastic point! #IDSky #AMSsky
February 12, 2025 at 11:43 PM
Shorter is greener! 🍃♻️
Unnecessary antibiotics contribute to greenhouse gas emmissions. Want to know how much? 👉🏻 shorturl.at/52wOT
Fantastic point! #IDSky #AMSsky
Unnecessary antibiotics contribute to greenhouse gas emmissions. Want to know how much? 👉🏻 shorturl.at/52wOT
Fantastic point! #IDSky #AMSsky
Reposted by Bradley Langford
Local public health organizations have an important role to play in mitigating #AMR
They should be leveraged for knowledge translation/mobilization, optimizing surveillance & establishing strategic collaborations
https://doi.org/10.1093/jacamr/dlae187
@brxad.bsky.social @dianeashiru.bsky.social
They should be leveraged for knowledge translation/mobilization, optimizing surveillance & establishing strategic collaborations
https://doi.org/10.1093/jacamr/dlae187
@brxad.bsky.social @dianeashiru.bsky.social
doi.org
January 15, 2025 at 11:00 AM
Local public health organizations have an important role to play in mitigating #AMR
They should be leveraged for knowledge translation/mobilization, optimizing surveillance & establishing strategic collaborations
https://doi.org/10.1093/jacamr/dlae187
@brxad.bsky.social @dianeashiru.bsky.social
They should be leveraged for knowledge translation/mobilization, optimizing surveillance & establishing strategic collaborations
https://doi.org/10.1093/jacamr/dlae187
@brxad.bsky.social @dianeashiru.bsky.social
Reposted by Bradley Langford
CDC's Morbidity and Mortality Weekly Report (MMWR) has provided real-time data and analysis about disease outbreaks and emerging health threats without a break every week since 1960.
Until today.
Until today.
January 23, 2025 at 6:38 PM
CDC's Morbidity and Mortality Weekly Report (MMWR) has provided real-time data and analysis about disease outbreaks and emerging health threats without a break every week since 1960.
Until today.
Until today.
Reposted by Bradley Langford
Enthused that our article on BCx stewardship during the BCx shortage made the best of OFID 2024!
academic.oup.com/ofid/article...
academic.oup.com/ofid/article...
January 16, 2025 at 2:24 AM
Enthused that our article on BCx stewardship during the BCx shortage made the best of OFID 2024!
academic.oup.com/ofid/article...
academic.oup.com/ofid/article...
In order to mitigate #antimicrobialresistance, we need more stewards! This scoping review shows that local public health is a key player in knowledge dissemination, data collection & design and implementation of stewardship strategies:
doi.org/10.1093/jaca...
doi.org/10.1093/jaca...
January 13, 2025 at 9:27 PM
In order to mitigate #antimicrobialresistance, we need more stewards! This scoping review shows that local public health is a key player in knowledge dissemination, data collection & design and implementation of stewardship strategies:
doi.org/10.1093/jaca...
doi.org/10.1093/jaca...
Audit & feedback with peer comparison works to improve antibiotic prescribing in primary care. Now, health system leaders and policy-makers must take decisive steps to integrate this strategy into the healthcare system.
qualitysafety.bmj.com/content/earl...
👏 @kevinschwartz.bsky.social
qualitysafety.bmj.com/content/earl...
👏 @kevinschwartz.bsky.social
January 12, 2025 at 10:42 PM
Audit & feedback with peer comparison works to improve antibiotic prescribing in primary care. Now, health system leaders and policy-makers must take decisive steps to integrate this strategy into the healthcare system.
qualitysafety.bmj.com/content/earl...
👏 @kevinschwartz.bsky.social
qualitysafety.bmj.com/content/earl...
👏 @kevinschwartz.bsky.social
We found lower rates of bacterial infection in patients with SARS-CoV-2 compared to Flu and RSV. This is driven by lower rates of co-infection (<48h) in patients with COVID. NB: testing practices may also vary across infections and over time.
doi.org/10.1093/ofid...
@ofidjournal.bsky.social #IDSky
doi.org/10.1093/ofid...
@ofidjournal.bsky.social #IDSky
January 6, 2025 at 10:25 PM
We found lower rates of bacterial infection in patients with SARS-CoV-2 compared to Flu and RSV. This is driven by lower rates of co-infection (<48h) in patients with COVID. NB: testing practices may also vary across infections and over time.
doi.org/10.1093/ofid...
@ofidjournal.bsky.social #IDSky
doi.org/10.1093/ofid...
@ofidjournal.bsky.social #IDSky
🆕in @cidjournal.bsky.social
- our instrumental variable analysis of community-dwelling adults 66+ found that longer antibiotic courses were NOT associated with an increased benefit or harm compared to shorter courses. doi.org/10.1093/cid/...
🧵thread below #IDSky
- our instrumental variable analysis of community-dwelling adults 66+ found that longer antibiotic courses were NOT associated with an increased benefit or harm compared to shorter courses. doi.org/10.1093/cid/...
🧵thread below #IDSky
Evaluating Harms Associated with Prolonged Antibiotic Duration of Therapy in Community Dwelling Older Adults: A Cohort Study using Instrumental Variable Analysis
In this instrumental variable analysis of 117,682 community-dwelling older adults prescribed amoxicillin, cephalexin, or ciprofloxacin, longer antibiotic c
doi.org
January 6, 2025 at 3:38 PM
🆕in @cidjournal.bsky.social
- our instrumental variable analysis of community-dwelling adults 66+ found that longer antibiotic courses were NOT associated with an increased benefit or harm compared to shorter courses. doi.org/10.1093/cid/...
🧵thread below #IDSky
- our instrumental variable analysis of community-dwelling adults 66+ found that longer antibiotic courses were NOT associated with an increased benefit or harm compared to shorter courses. doi.org/10.1093/cid/...
🧵thread below #IDSky
Antibiotic stewardship programs need dedicated funding to be effective. Hospital ASPs with funding & resources use less fluoroquinolones, anti-pseudomonal agents, and clindamycin.
🆕 in @ashejournal.bsky.social
📰 doi.org/10.1017/ash....
#IDSky
🆕 in @ashejournal.bsky.social
📰 doi.org/10.1017/ash....
#IDSky
December 26, 2024 at 2:44 PM
Antibiotic stewardship programs need dedicated funding to be effective. Hospital ASPs with funding & resources use less fluoroquinolones, anti-pseudomonal agents, and clindamycin.
🆕 in @ashejournal.bsky.social
📰 doi.org/10.1017/ash....
#IDSky
🆕 in @ashejournal.bsky.social
📰 doi.org/10.1017/ash....
#IDSky
Reposted by Bradley Langford
Just a little nudge (stewards love nudges!) that if you get an abstract accepted at SHEA Spring, we subsequently publish the supplement with them all in it 🤩#IDSky
December 16, 2024 at 12:27 PM
Just a little nudge (stewards love nudges!) that if you get an abstract accepted at SHEA Spring, we subsequently publish the supplement with them all in it 🤩#IDSky
A vital step in reducing unnecessary antibiotic use is getting patients and the general public on board. Here are some simple resources from the Public Health Agency of Canada explaining how to use antibiotics wisely
📃 www.canada.ca/en/health-ca...
📃 www.canada.ca/en/health-ca...
December 23, 2024 at 9:20 PM
A vital step in reducing unnecessary antibiotic use is getting patients and the general public on board. Here are some simple resources from the Public Health Agency of Canada explaining how to use antibiotics wisely
📃 www.canada.ca/en/health-ca...
📃 www.canada.ca/en/health-ca...
Reposted by Bradley Langford
This review article provides an overview of the "basics" in leveraging ambulatory antimicrobial stewardship measures to build a sustainable program. #IDsky bit.ly/3DbzU9r
Navigating performance measures for ambulatory antimicrobial stewardship: a review of HEDIS® and other metrics the steward should know | Antimicrobial Stewardship & Healthcare Epidemiology | Cambr...
Navigating performance measures for ambulatory antimicrobial stewardship: a review of HEDIS® and other metrics the steward should know - Volume 4 Issue 1
bit.ly
December 13, 2024 at 3:41 PM
This review article provides an overview of the "basics" in leveraging ambulatory antimicrobial stewardship measures to build a sustainable program. #IDsky bit.ly/3DbzU9r
OpenAI Sora's first depiction of an antimicrobial steward defending the population from unnecessary antibiotic prescriptions! Not quite ready for a feature film. 😆
#FightAR #AntibioticResistance #IDSky
#FightAR #AntibioticResistance #IDSky
December 13, 2024 at 5:10 PM
OpenAI Sora's first depiction of an antimicrobial steward defending the population from unnecessary antibiotic prescriptions! Not quite ready for a feature film. 😆
#FightAR #AntibioticResistance #IDSky
#FightAR #AntibioticResistance #IDSky
SRMA of Antibiotic Audit and Feedback in Primary Care:
💊11% ⬇️prescribing volume
▶️23%⬇️in unnecessary initiation
💣17% ⬇️in broad-spectrum selection
🗓️13%⬇️in prolonged duration
doi.org/10.1093/cid/ci…
Great work by @kevinschwartz.bsky.social and team via @cidjournal.bsky.social
💊11% ⬇️prescribing volume
▶️23%⬇️in unnecessary initiation
💣17% ⬇️in broad-spectrum selection
🗓️13%⬇️in prolonged duration
doi.org/10.1093/cid/ci…
Great work by @kevinschwartz.bsky.social and team via @cidjournal.bsky.social
December 8, 2024 at 3:49 PM
SRMA of Antibiotic Audit and Feedback in Primary Care:
💊11% ⬇️prescribing volume
▶️23%⬇️in unnecessary initiation
💣17% ⬇️in broad-spectrum selection
🗓️13%⬇️in prolonged duration
doi.org/10.1093/cid/ci…
Great work by @kevinschwartz.bsky.social and team via @cidjournal.bsky.social
💊11% ⬇️prescribing volume
▶️23%⬇️in unnecessary initiation
💣17% ⬇️in broad-spectrum selection
🗓️13%⬇️in prolonged duration
doi.org/10.1093/cid/ci…
Great work by @kevinschwartz.bsky.social and team via @cidjournal.bsky.social