Also works for Bordatella bronchiseptica in our patients!🐕 Although I can't see it's been tested on B. pertussis in humans but other tetracyclines seem to do some good so maybe... 🤷

As someone currently writing a PhD literature review on AMR surveillance and gradually beginning to understand the wall of AMR genes in every paper I read, I wish I had a paper like this 6 months ago. Not sure I would be much help though... Yet.

Thanks for clarifying! Silly question to follow, do you use the uncomplicated UTI breakpoint for other abx for pyelo or prefer non-uti if possible? Just thinking that NICE recommendation of cefuroxime IV/co-amox PO suffers similar issues for non-uti breakpoints

This is kinda where I'm coming from too. Quinolines are favoured in VetMed and I was looking for an alternative to reduce HPCIA use. Wondered if the quinoline thing was dogma after seeing the NICE guideline but the evidence for cephs isn't helping my argument as much as I thought it would 😕

Yeah I do wonder if that's the case sometimes. What's your IV drug of choice? Cefuroxime seems to suffer the same problems but NICE has several other options

Ah my favourite podcast duo to learn AMS from the other side! I must confess, looking through that thread I realised I saw it the first time... And forgot about it 🤦 Does mean the second read was just as interesting though 😂

Sounds interesting! What dose and MIC are you using out of curiosity? This PKPD study suggests NICE doses may hit MICs anywhere from <2 to <16 (link.springer.com/article/10.1...). I will hold my hands up and say my pharmacology needs dusting off though so willing to be told otherwise 🙌