Valentin L'Hôte
@valentinlhote.bsky.social
🧑🔬 MSCA Postdoc Fellow at Umeå University 🇸🇪, Sjoerd Wanrooij's Lab
🧬 MtDNA replication and dynamics in health, senescence, and cancer
🔬 Molecular cell biology, biochemistry, medicinal/biological chemistry, microscopy, omics
🧬 MtDNA replication and dynamics in health, senescence, and cancer
🔬 Molecular cell biology, biochemistry, medicinal/biological chemistry, microscopy, omics
Reposted by Valentin L'Hôte
We’re live!
The Department of Medical Biochemistry & Biophysics at @umeauniversitet.bsky.social explores life at the molecular level: infection and structural biology, gene expression, mitochondria, neurodegeneration & biophysics for climate change.
Follow for updates & collaboration!
#Biochemistry
The Department of Medical Biochemistry & Biophysics at @umeauniversitet.bsky.social explores life at the molecular level: infection and structural biology, gene expression, mitochondria, neurodegeneration & biophysics for climate change.
Follow for updates & collaboration!
#Biochemistry
November 13, 2025 at 9:59 AM
We’re live!
The Department of Medical Biochemistry & Biophysics at @umeauniversitet.bsky.social explores life at the molecular level: infection and structural biology, gene expression, mitochondria, neurodegeneration & biophysics for climate change.
Follow for updates & collaboration!
#Biochemistry
The Department of Medical Biochemistry & Biophysics at @umeauniversitet.bsky.social explores life at the molecular level: infection and structural biology, gene expression, mitochondria, neurodegeneration & biophysics for climate change.
Follow for updates & collaboration!
#Biochemistry
Reposted by Valentin L'Hôte
Reposted by Valentin L'Hôte
A friend was offered a fantastic, five-year postdoc position at a Germany university. When the university's HR found out she is undergoing cancer treatment (with very good chances of complete recovery), they forced the PI to withdraw the offer. These stories are not uncommon from Germany. Why?
October 19, 2025 at 10:11 PM
A friend was offered a fantastic, five-year postdoc position at a Germany university. When the university's HR found out she is undergoing cancer treatment (with very good chances of complete recovery), they forced the PI to withdraw the offer. These stories are not uncommon from Germany. Why?
Reposted by Valentin L'Hôte
Highlights from yICSA at #ICSA2025Rome 🌍✨
✔️Networking Social Event 🤝
✔️Special Session with career insights from @dimiccolab.bsky.social & @narita-lab.bsky.social 🙌
Thank you to everyone who joined us!
#yICSA #Senescence #ECR
✔️Networking Social Event 🤝
✔️Special Session with career insights from @dimiccolab.bsky.social & @narita-lab.bsky.social 🙌
Thank you to everyone who joined us!
#yICSA #Senescence #ECR
September 20, 2025 at 3:38 PM
Highlights from yICSA at #ICSA2025Rome 🌍✨
✔️Networking Social Event 🤝
✔️Special Session with career insights from @dimiccolab.bsky.social & @narita-lab.bsky.social 🙌
Thank you to everyone who joined us!
#yICSA #Senescence #ECR
✔️Networking Social Event 🤝
✔️Special Session with career insights from @dimiccolab.bsky.social & @narita-lab.bsky.social 🙌
Thank you to everyone who joined us!
#yICSA #Senescence #ECR
I had a great time presenting my work on mtDNA replication and senescence from the @wanrooij20.bsky.social lab @umeauniversitet.bsky.social today at the #ICSA2025Rome conference, with super exciting discussions. Thanks a lot @icsasenescence.bsky.social and @yicsac.bsky.social !
September 18, 2025 at 4:39 PM
I had a great time presenting my work on mtDNA replication and senescence from the @wanrooij20.bsky.social lab @umeauniversitet.bsky.social today at the #ICSA2025Rome conference, with super exciting discussions. Thanks a lot @icsasenescence.bsky.social and @yicsac.bsky.social !
Reposted by Valentin L'Hôte
www.americanscientist.org/article/%E2%...
in my view the problem started when we forced basic science to be translational. this distorted it's nature and created false expectations, which in turn eroded the trust on basic science.
in my view the problem started when we forced basic science to be translational. this distorted it's nature and created false expectations, which in turn eroded the trust on basic science.
“Why Are We Funding This?”
Long-standing myths about “silly science” have contributed to the reckless slashing of government-supported research.
www.americanscientist.org
June 19, 2025 at 1:49 PM
www.americanscientist.org/article/%E2%...
in my view the problem started when we forced basic science to be translational. this distorted it's nature and created false expectations, which in turn eroded the trust on basic science.
in my view the problem started when we forced basic science to be translational. this distorted it's nature and created false expectations, which in turn eroded the trust on basic science.
Reposted by Valentin L'Hôte
Our newest paper on mitochondrial Topoisomerase 1 shows that Top1mt has only weak endoribonuclease activity and it therefore does not often generate deletions at incorporated ribonucleotides. This helps explain why ribonucleotides are tolerated in mtDNA. Read more:
academic.oup.com/nar/article-...
academic.oup.com/nar/article-...
The low endoribonuclease activity and lack of rNMP preference of human mitochondrial topoisomerase 1 protect against ribonucleotide-dependent deletions
Abstract. The incorporation of ribonucleotides (rNMPs) into the nuclear genome leads to severe genomic instability, including strand breaks and short 2–5 b
academic.oup.com
June 8, 2025 at 11:31 AM
Our newest paper on mitochondrial Topoisomerase 1 shows that Top1mt has only weak endoribonuclease activity and it therefore does not often generate deletions at incorporated ribonucleotides. This helps explain why ribonucleotides are tolerated in mtDNA. Read more:
academic.oup.com/nar/article-...
academic.oup.com/nar/article-...
On a road trip from Umeå (SE) to Rokua (FI) to attend the #Mitochondria Summer School this week!
May 19, 2025 at 12:19 PM
On a road trip from Umeå (SE) to Rokua (FI) to attend the #Mitochondria Summer School this week!
Amazing to be back at @univ-larochelle.fr today to talk about #mtDNA, #senescence and #cancer at @umrlienss.bsky.social and have exciting discussions! Going back to Sweden tomorrow, but I hope to return to La Rochelle soon.
May 12, 2025 at 9:38 PM
Amazing to be back at @univ-larochelle.fr today to talk about #mtDNA, #senescence and #cancer at @umrlienss.bsky.social and have exciting discussions! Going back to Sweden tomorrow, but I hope to return to La Rochelle soon.
Reposted by Valentin L'Hôte
Two mtDNA papers of ours in one PNAS issue:
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
April 22, 2025 at 6:41 PM
Two mtDNA papers of ours in one PNAS issue:
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...
#1 on the Y951N patient mutation of PolG, heroically spear-headed by Josefin Forslund
#2 revealing surprising dNTP imbalance & subsequent mtDNA depletion in RRM2B-deficient mice, a great collaboration with the Chabes lab
www.pnas.org/toc/pnas/122...
Reposted by Valentin L'Hôte
Good science from Josefin Forslund and our team:
The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability | PNAS www.pnas.org/doi/10.1073/...
The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
April 17, 2025 at 12:20 PM
Good science from Josefin Forslund and our team:
The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability | PNAS www.pnas.org/doi/10.1073/...
The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability | PNAS www.pnas.org/doi/10.1073/...
Reposted by Valentin L'Hôte
Hello fellow mitochondriacs! Are you passionate about mtDNA? We now offer a 2-year postdoc opportunity for studies of mtDNA instability and its signaling. Apply by May 18th to join our international team in exotic Umeå. Please share!
www.umu.se/en/work-with...
www.umu.se/en/work-with...
Postdoctoral fellowship (2 years) to study mitochondrial DNA stability
www.umu.se
April 16, 2025 at 11:43 AM
Hello fellow mitochondriacs! Are you passionate about mtDNA? We now offer a 2-year postdoc opportunity for studies of mtDNA instability and its signaling. Apply by May 18th to join our international team in exotic Umeå. Please share!
www.umu.se/en/work-with...
www.umu.se/en/work-with...
Reposted by Valentin L'Hôte
#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added!
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
November 12, 2024 at 6:35 PM
#StarterPack for the #Mitochondria research community! Very much a work in progress, comment below/reach out to be added!
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
#Mito #Mitochondriac
go.bsky.app/J6Bu5fL
Reposted by Valentin L'Hôte
Exclusive: The U.S. Department of Defense is gutting a landmark project designed to fund social science research with important implications for national security. scim.ag/41qhiuO
Pentagon guts national security program that harnessed social science
Dozens of U.S. academics lose grants from Minerva program for studies related to terrorism, drug trafficking, and other threats
scim.ag
March 2, 2025 at 7:44 PM
Exclusive: The U.S. Department of Defense is gutting a landmark project designed to fund social science research with important implications for national security. scim.ag/41qhiuO