Ancient metagenomic studies using capture or shotgun sequencing often perform pairwise alignment of individual reads against large reference databases followed by lowest common ancestor assignment for...

Neuronal firing patterning in the dentate gyrus of epilepsy patients remains unknown at the microcircuit level. Advancements in high-density CMOS-based microelectrode arrays can be harnessed to study network activity with unprecedented spatial and temporal resolution. We use novel computational methods with high-density electrophysiology recordings to spatially map network activity of human hippocampal brain slices from six patients with mesial temporal lobe epilepsy. Two slices from the dentate gyrus exhibited synchronous bursting activity in the presence of low magnesium media with kainic acid, representative of seizure-like behavior. We bridged microscale circuit dynamics with alterations in theta oscillations at the network scale. Future studies may apply this approach to spatially elucidate functional networks and their possible role in seizures.

The recognition is the highest professional distinction awarded to academic inventors.

Discover how brain organoids are helping us uncover whether early thought patterns emerge from experience or are hardwired into our DNA.

Genomic data portals collect, annotate, and make data files available to researchers and, increasingly, AI algorithms. They are run by, among others, broad data archive repositories or consortium-spec...

The Braingeneers team will to test the ability of brain organoids to solve tasks in real time

New study reveals how human astroviruses bind to humans cells and paves the way for new therapies and vaccines

Lab-grown brains don’t have to inspire horror.

Angela Brooks and her team are rewriting cancer research with FLAIR, a tool that reveals hidden RNA isoforms driving tumor growth and drug resistance—insights that could revolutionize precision medicine.

Nature Cell Biology - Programmes that support diversity, equity and inclusion (DEI) in science are under attack in the USA. Data indicate that diversity in the scientific workforce increases...

Don't forget to mark the static binary executable: chmod +x vg Docker Image: quay.io/vgteam/vg:v1.69.0 Buildable Source Tarball: vg-v1.69.0.tar.gz Includes source for vg and all submodules. Use th...

Somatic small variants in cancer genomes are identified in both short-read and long-read data.

The award includes a grant that will support Greider's research that advances her Nobel-winning discovery of the DNA caps at the ends of chromosomes called telomeres