Tobias Kletter
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tobiaskletter.bsky.social
Tobias Kletter
@tobiaskletter.bsky.social
180 followers 310 following 8 posts
PostDoc at the i3S in Porto. Interested in the spatial and temporal dynamics of cell division.
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tobiaskletter.bsky.social
Tobias Kletter @tobiaskletter.bsky.social · Jun 13
Thrilled to share our newly published work in @natcellbio.nature.com.
We found that differentiating cells tune the size and architecture of mitotic organelles through changes in cytoplasmic density.
Many thanks to my fantastic co-authors! 💥
tobiaskletter.bsky.social
I'm very grateful and honoured to be on this list! Looking forward to finally visiting Heidelberg again!
dgz.bsky.social DGZ.bsky.social @dgz.bsky.social · Oct 14
Very excited to announce the #DGZ awardees 2025. We look forward to welcoming all award winners to our meeting in Heidelberg, where they will present their work!
October 14, 2025 at 5:34 PM
Reposted by Tobias Kletter
nadjahuempf.bsky.social
Now out on bioRxiv. 🥳My research on #cytokinesis, averaging thousands of #ExM images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄 #PSFoftheGIF
September 28, 2025 at 2:15 PM
Reposted by Tobias Kletter
mpiib-berlin.mpg.de
📃 New paper alert!
The Zychlinsky Lab and @raunser-lab.bsky.social identified the first protein that converts chromatin into an immune effector: Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Now published in @nature.com:
www.nature.com/articles/s41...
Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature
Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.
www.nature.com
September 19, 2025 at 7:16 AM
Reposted by Tobias Kletter
jorgeferreira.bsky.social
New preprint from the lab! Please check it out. 🚨
Have you ever wondered how cells decide when it’s time to divide? So did we!
www.biorxiv.org/content/10.1...
Chromosome condensation mechanically primes the nucleus for mitosis
Timely and accurate transition into mitosis is essential to preserve genome integrity and avoid chromosome segregation errors. This transition depends on spatial and temporal activity patterns of the ...
www.biorxiv.org
September 3, 2025 at 10:07 AM
Reposted by Tobias Kletter
simonereber.bsky.social
FINALLY! Challenging to publish but we believe it is an important discovery: rdcu.be/eATFz

💚 Thanks to the team ‪@biswashere.bsky.social‬, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay ‪@matthewkraushar.bsky.social‬ @dshechter.bsky.social @gucklab.bsky.social @vasilyzaburdaev.bsky.social‬ 💚
Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes
Nature Communications - Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure...
rdcu.be
August 15, 2025 at 11:54 AM
Reposted by Tobias Kletter
ac-almeida.bsky.social
🔎New preprint!
We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture.
Big thanks to @ivanagasic.bsky.social and team!
Link below for all #cytoskeleton & #spheroid enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...
Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability
Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free tubul...
www.biorxiv.org
July 30, 2025 at 12:20 PM
Reposted by Tobias Kletter
manuelthery.bsky.social
EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Head of the Cell Biology and Biophysics Unit
The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...
embl.wd103.myworkdayjobs.com
July 29, 2025 at 7:50 AM
Reposted by Tobias Kletter
simonereber.bsky.social
Thanks to the Heald lab @berkeleymcb.bsky.social for a very nice News & Views on our paper on cytoplasmic density & spindle architecture! 💚
rdcu.be/ewpa1
Cytoplasmic control of spindle architecture
Nature Cell Biology - Dense crowding of macromolecules in the cytoplasm is a fundamental property of cells. A study now identifies a pathway by which cytoplasmic dilution in differentiating neurons...
rdcu.be
July 16, 2025 at 7:31 AM
tobiaskletter.bsky.social
Thrilled to share our newly published work in @natcellbio.nature.com.
We found that differentiating cells tune the size and architecture of mitotic organelles through changes in cytoplasmic density.
Many thanks to my fantastic co-authors! 💥
June 13, 2025 at 3:58 PM
Reposted by Tobias Kletter
simonereber.bsky.social
✨We are looking for a PhD student interested in physical cell bio, imaging 🔬, biochemistry, #Xenopus 🐸 & #microtubules ✨

Join us @mpiib-berlin.mpg.de!
May 19, 2025 at 8:21 PM
Reposted by Tobias Kletter
biswashere.bsky.social
Beautiful work by @mctwo.bsky.social investigating the spatio-temporal dynamics of the cytoplasm using label-free tools and 🐸 extracts!

🐸 + 🔬 + 📈 = ✨

w. @gucklab.bsky.social , @simonereber.bsky.social , @vasilyzaburdaev.bsky.social

www.biorxiv.org/content/10.1...
www.biorxiv.org
May 10, 2025 at 9:41 AM
Reposted by Tobias Kletter
granadalab.bsky.social
New work out in @naturephysics.bsky.social
Led by @NicaGutu & Malthe Nordentoft + great collaborators.

We show that circadian synchrony shapes cell growth. When coordination is lost, clock–cell cycle coupling breaks down.

May help explain paradoxes in circadian cancer biology.
📖 rdcu.be/efNaY
March 31, 2025 at 12:46 PM
Reposted by Tobias Kletter
binyammogessie.bsky.social
Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...
A versatile cohesion manipulation system reveals CENP-A dysfunction accelerates female reproductive age-related egg aneuploidy.
Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...
www.biorxiv.org
February 28, 2025 at 12:39 PM
Reposted by Tobias Kletter
olgaafonso.bsky.social
New paper alert! ‼️‼️
Super happy to share that my postdoc paper is finally out!

1/3 We looked at scaling of chromosome separation during anaphase in zebrafish embryos.
February 3, 2025 at 2:29 PM
Reposted by Tobias Kletter
jcellsci.bsky.social
Ana Almeida, Helder Rocha, Maximilian Raas, Geert Kops, Reto Gassmann, Helder Maiato @i3suporto.bsky.social, et al. dissect the relationship between kinetochore size & CENP-E dependence for chromosome alignment.

journals.biologists.com/jcs/article/...

journals.biologists.com/jcs/article/...
Phylogenetic profile of CENP-E across holocentric and monocentric taxa. (A–D) CENP-E conservation in (A) the phylum Nematoda, (B) the phylum Vertebrata, (C) the insect order Hemiptera and (D) the insect order Diptera. Lineages with an inferred CENP-E loss are highlighted with a coloured box. Holocentric lineages are indicated with ‘H’ and monocentric lineages with ‘M’, as well as with a graphic depiction of holocentric and monocentric chromosomes.
January 9, 2025 at 12:03 PM
Reposted by Tobias Kletter
simonereber.bsky.social
How did microtubules adapt to support life across 🐸 species at divergent thermal niches? 


Now online & OA @currentbiology.bsky.social

Thanks to Ella, Luca, @biswashere.bsky.social & Carolyn @mpiib-berlin.mpg.de @BirkbeckUoL
 🙌

Enjoy reading! 👉 www.cell.com/current-biol...
Mechanistic basis of temperature adaptation in microtubule dynamics across frog species
Despite tubulin’s evolutionary conservation, microtubule dynamics are highly temperature sensitive. Troman et al. use natural tubulin variants from closely related Xenopus species to show that a decrease in tubulin’s apparent activation energy and weakening of lateral lattice contacts stabilize microtubules in cold-adapted frogs.
www.cell.com
January 10, 2025 at 4:40 PM
Reposted by Tobias Kletter
minclab.bsky.social
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development.
Details below 👇👇
Please Repost !!!

@ijmonod.bsky.social @cnrs.bsky.social
January 3, 2025 at 3:33 PM
Reposted by Tobias Kletter
gabrielneurohr.bsky.social
Did you ever wonder how cytoplasmic properties influence mitotic spindle architecture? Come join us for an exciting seminar next Wednesday by @simonereber.bsky.social
December 6, 2024 at 10:50 AM
Reposted by Tobias Kletter
simonereber.bsky.social
Two positions in our lab 🐸🐛🔬 #malaria #xenopus #microtubules #biophysics #imaging #PhDlife
mpiib-berlin.mpg.de Max Planck Institute for Infection Biology @mpiib-berlin.mpg.de · Nov 15
🔭 Are you looking for a #PhD project in infectious disease research or #immunology? Do you want to be part of an excellent research environment?
👉 The 2025 call of the IMPRS-IDI graduate school is now open with 7 PhD projects in Berlin: www.mpiib-berlin.mpg.de/en/imprs-idi...
Are you looking for a PhD project? We are offering seven PhD projects in infectious disease research and immunology in Berlin. Apply by January 3
November 27, 2024 at 5:24 PM
tobiaskletter.bsky.social
Thrilled to share our latest preprint! We've discovered how cells tune spindle architecture through changes in cytoplasmic material properties. Huge thanks to
@simonereber.bsky.social, the amazing lab team, and our brilliant collaborators. Check it out!
biorxiv.org/content/10.1...
July 23, 2024 at 8:25 AM
Reposted by Tobias Kletter
biorxiv-cellbio.bsky.social
Torques within and outside the human spindle balance twist at anaphase https://www.biorxiv.org/content/10.1101/2023.12.10.570990v1
Torques within and outside the human spindle balance twist at anaphase https://www.biorxiv.org/content/10.1101/2023.12.10.570990v1
At each cell division, nanometer-scale motors and microtubules give rise to the micron-scale spindle
www.biorxiv.org
December 10, 2023 at 11:31 PM
Reposted by Tobias Kletter
guijacquemet.bsky.social
Do you work with cell migration data? Or do you track objects from microscopy video? You may be interested in my latest project:

CellTracksColab, A platform for compiling, analyzing, and exploring tracking data

www.biorxiv.org/content/10.1...

github.com/guijacquemet...
October 24, 2023 at 3:16 AM
Reposted by Tobias Kletter
biorxiv-cellbio.bsky.social
CENP-E initiates chromosome congression by opposing Aurora kinases to promote end-on microtubule attachments close to centrosomes https://www.biorxiv.org/content/10.1101/2023.10.19.563150v1
CENP-E initiates chromosome congression by opposing Aurora kinases to promote end-on microtubule attachments close to centrosomes https://www.biorxiv.org/content/10.1101/2023.10.19.563150v1
Chromosome congression to the spindle equator, which recurrently fails in cancer cells leading to an
www.biorxiv.org
October 20, 2023 at 1:33 PM
Reposted by Tobias Kletter
biorxiv-cellbio.bsky.social
Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction https://www.biorxiv.org/content/10.1101/2023.10.16.562637v1
Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction https://www.biorxiv.org/content/10.1101/2023.10.16.562637v1
Accurate chromosome segregation requires sister kinetochores to biorient, attaching to opposite spin
www.biorxiv.org
October 19, 2023 at 3:30 AM
tobiaskletter.bsky.social
Owld but gowld. #inktober
October 6, 2023 at 9:05 PM