Gogl lab
@teamgogl.bsky.social
Quantitative interactomics team located at iBV (Nice, France). We study motif-mediated interactions using innovative systems biochemical approaches. Developers of the ProfAff affinity interactomics database.
Reposted by Gogl lab
🧬 New paper in Nature Communications!
We found that POLE2,part of DNA polymerase ε,moonlights as a receptor for NPF motifs, binding 70+ proteins across replication, transcription & repair.
The interactome is more interconnected than thought.
@teamgogl.bsky.social 🇫🇮🇫🇷🇭🇺🇬🇧
www.nature.com/articles/s41...
We found that POLE2,part of DNA polymerase ε,moonlights as a receptor for NPF motifs, binding 70+ proteins across replication, transcription & repair.
The interactome is more interconnected than thought.
@teamgogl.bsky.social 🇫🇮🇫🇷🇭🇺🇬🇧
www.nature.com/articles/s41...
December 15, 2025 at 11:58 AM
🧬 New paper in Nature Communications!
We found that POLE2,part of DNA polymerase ε,moonlights as a receptor for NPF motifs, binding 70+ proteins across replication, transcription & repair.
The interactome is more interconnected than thought.
@teamgogl.bsky.social 🇫🇮🇫🇷🇭🇺🇬🇧
www.nature.com/articles/s41...
We found that POLE2,part of DNA polymerase ε,moonlights as a receptor for NPF motifs, binding 70+ proteins across replication, transcription & repair.
The interactome is more interconnected than thought.
@teamgogl.bsky.social 🇫🇮🇫🇷🇭🇺🇬🇧
www.nature.com/articles/s41...
Happy to share that our paper describing a new motif-mediated interactome is out in Nature Communications
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The non-catalytic DNA polymerase ε subunit is an NPF motif recognition protein - Nature Communications
Short linear motifs in disordered protein regions are involved numerous protein–protein interactions. Here, the authors find that the POLE2 subunit of human DNA polymerase ε acts as a motif binding pr...
www.nature.com
December 15, 2025 at 8:41 AM
Happy to share that our paper describing a new motif-mediated interactome is out in Nature Communications
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gogl lab
👏 Félicitations à Gergő Gógl, chercheur @insermpacacorse.bsky.social à l'institut de Biologie Valrose, lauréat du programme Impulscience® de la Fondation Bettencourt Schueller.
👉 Découvrez les 7 scientifiques @cnrs.fr récompensés : www.cote-azur.cnrs.fr/fr/cnrsinfo/...
@teamgogl.bsky.social
👉 Découvrez les 7 scientifiques @cnrs.fr récompensés : www.cote-azur.cnrs.fr/fr/cnrsinfo/...
@teamgogl.bsky.social
December 8, 2025 at 1:51 PM
👏 Félicitations à Gergő Gógl, chercheur @insermpacacorse.bsky.social à l'institut de Biologie Valrose, lauréat du programme Impulscience® de la Fondation Bettencourt Schueller.
👉 Découvrez les 7 scientifiques @cnrs.fr récompensés : www.cote-azur.cnrs.fr/fr/cnrsinfo/...
@teamgogl.bsky.social
👉 Découvrez les 7 scientifiques @cnrs.fr récompensés : www.cote-azur.cnrs.fr/fr/cnrsinfo/...
@teamgogl.bsky.social
Reposted by Gogl lab
I just published: ERC-Plus: jackpot science or missed chance to fix academia?
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.
medium.com/p/erc-plus-j...
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.
medium.com/p/erc-plus-j...
ERC-Plus: jackpot science or missed chance to fix academia?
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re…
medium.com
December 3, 2025 at 11:42 AM
I just published: ERC-Plus: jackpot science or missed chance to fix academia?
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.
medium.com/p/erc-plus-j...
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.
medium.com/p/erc-plus-j...
Reposted by Gogl lab
Now online! Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
In vitro-derived insights into features that drive transcription factor binding to DNA, including motif-adjacent sequence, enable prediction of chromatin states and transcription factor occupancy in cells.
dlvr.it
November 26, 2025 at 7:51 PM
Now online! Thermodynamic principles link in vitro transcription factor affinities to single-molecule chromatin states in cells
Reposted by Gogl lab
The second part of our (with @origichals.bsky.social and El Hadji) two-part review on non-covalent SUMO interactions is now published, focussing on SUMO-interacting motifs (SIMs), but discussing also other confirmed or potential SUMO-interacting elements.
Non-covalent SUMO interactions with ligases and effectors: SUMO-interacting motifs and beyond
SUMOylation, a protein post-translational modification (PTM) involving the covalent attachment of small ubiquitin-like modifier (SUMO), regulates a wide range of cellular processes. The key hallmark o...
portlandpress.com
November 24, 2025 at 9:06 PM
The second part of our (with @origichals.bsky.social and El Hadji) two-part review on non-covalent SUMO interactions is now published, focussing on SUMO-interacting motifs (SIMs), but discussing also other confirmed or potential SUMO-interacting elements.
According to ChatGPT, this is a three-stranded coiled coil.
November 13, 2025 at 8:59 AM
According to ChatGPT, this is a three-stranded coiled coil.
profaff.fr
The new ProfAff database is up and running. Although there are still many things to improve, it is a major upgrade.
The new ProfAff database is up and running. Although there are still many things to improve, it is a major upgrade.
ProfAffv2 - Protein Affinity Database
profaff.fr
October 28, 2025 at 8:04 AM
profaff.fr
The new ProfAff database is up and running. Although there are still many things to improve, it is a major upgrade.
The new ProfAff database is up and running. Although there are still many things to improve, it is a major upgrade.
Bluesky, we need your help! Why does plain eGFP partially colocalize with actin filaments in cells? (No bleed-through, observed in multiple cell lines. Whole plasmid sequenced.) #FluorescenceFriday #Microscopy
October 24, 2025 at 1:11 PM
Bluesky, we need your help! Why does plain eGFP partially colocalize with actin filaments in cells? (No bleed-through, observed in multiple cell lines. Whole plasmid sequenced.) #FluorescenceFriday #Microscopy
The Quantitative Interactomics and Disease-Related Networks team at iBV (Nice, France) is recruiting a Postdoctoral Researcher with expertise in recombinant protein technologies and biochemistry.
October 17, 2025 at 11:29 AM
The Quantitative Interactomics and Disease-Related Networks team at iBV (Nice, France) is recruiting a Postdoctoral Researcher with expertise in recombinant protein technologies and biochemistry.
The old ProfAff server served us well, but it’s time for an upgrade! Can’t wait to launch the new version from our new institute!
October 15, 2025 at 7:15 AM
The old ProfAff server served us well, but it’s time for an upgrade! Can’t wait to launch the new version from our new institute!
I am incredibly grateful to the ERC reviewers for their time and support. This recognition is a true honor and means a great deal to me. Excited to keep pushing forward the characterization of so-far unexplored motif-mediated protein–protein interactions!
September 5, 2025 at 8:43 AM
I am incredibly grateful to the ERC reviewers for their time and support. This recognition is a true honor and means a great deal to me. Excited to keep pushing forward the characterization of so-far unexplored motif-mediated protein–protein interactions!
GPT-5 seems like a pretty significant step towards PhD level. But a PhD-level researcher knows the literature, i.e., names of researchers and contents of key papers, much better. Or maybe it's only because we are working in a very niche field?
August 8, 2025 at 1:02 PM
GPT-5 seems like a pretty significant step towards PhD level. But a PhD-level researcher knows the literature, i.e., names of researchers and contents of key papers, much better. Or maybe it's only because we are working in a very niche field?
Today we got immediate desk rejection .... almost 8 weeks after submission! I think respectful journals could do better than this.
June 26, 2025 at 10:43 AM
Today we got immediate desk rejection .... almost 8 weeks after submission! I think respectful journals could do better than this.
Reposted by Gogl lab
I’m thrilled to share that I have secured a permanent position within Section 20 of the CNRS. I will do my utmost to advance our understanding of the intricate interactome of transcription factors, an area of research I am deeply passionate about. 🎆
Congratulations to Boglarka for obtaining a CNRS permanent position! 🎉🥂 She will start a new line of research in the Gogl lab focusing on the quantitative interactomics and biophysics of protein-DNA interactions and their consequences on transcription regulation and chromatin organization.
June 12, 2025 at 8:49 AM
I’m thrilled to share that I have secured a permanent position within Section 20 of the CNRS. I will do my utmost to advance our understanding of the intricate interactome of transcription factors, an area of research I am deeply passionate about. 🎆
Congratulations to Boglarka for obtaining a CNRS permanent position! 🎉🥂 She will start a new line of research in the Gogl lab focusing on the quantitative interactomics and biophysics of protein-DNA interactions and their consequences on transcription regulation and chromatin organization.
June 12, 2025 at 7:44 AM
Congratulations to Boglarka for obtaining a CNRS permanent position! 🎉🥂 She will start a new line of research in the Gogl lab focusing on the quantitative interactomics and biophysics of protein-DNA interactions and their consequences on transcription regulation and chromatin organization.
Reposted by Gogl lab
We have a preprint for you
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
June 8, 2025 at 11:22 AM
We have a preprint for you
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
EHD2 forms rings on caveolae necks, in contrast to most EHDs forming helices. We determined its structure on membranes and show that N-term acts as a spacer
By Elena, Vasya @vasiliimikirtumov.bsky.social, Jeff &Oli Daumke www.biorxiv.org/content/10.1...
Every time our team needs to order something important, the university’s response is basically...
May 29, 2025 at 9:51 AM
Every time our team needs to order something important, the university’s response is basically...
Our brand new iD5 multi mode plate reader arrived from Molecular Devices! I cannot wait to see some data measured on it!
May 27, 2025 at 1:42 PM
Our brand new iD5 multi mode plate reader arrived from Molecular Devices! I cannot wait to see some data measured on it!
Reposted by Gogl lab
We are recruiting a junior group leader in computational structural biology.
Spread the news!
www.nature.com/naturecareer...
Spread the news!
www.nature.com/naturecareer...
Junior Group Leader Position in Computational Structural Biology - Marseille (Arrondissement), Bouches-du-Rhône (FR) job with AFMB Laboratory (amU/CNRS/INSERM/INRAe) | 12839733
Junior Group Leader position with a focus on applying artificial intelligence (AI) to the field of integrative structural biology.
www.nature.com
May 26, 2025 at 9:05 AM
We are recruiting a junior group leader in computational structural biology.
Spread the news!
www.nature.com/naturecareer...
Spread the news!
www.nature.com/naturecareer...
Reposted by Gogl lab
Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology
Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.
www.nature.com
May 2, 2025 at 10:31 AM
Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Gogl lab
Short interview
hupo.org/Humans-of-HUPO
hupo.org/Humans-of-HUPO
Human Proteome Organization (HUPO) - Humans of HUPO
hupo.org
April 20, 2025 at 1:12 PM
Short interview
hupo.org/Humans-of-HUPO
hupo.org/Humans-of-HUPO
HUGE NEWS FOR THE TEAM - The most amazing Boglarka Zambo just got ranked at #6 in the CNRS N°20 concours. Seems like nothing is stopping her from getting a permanent position this year!
March 28, 2025 at 1:43 PM
HUGE NEWS FOR THE TEAM - The most amazing Boglarka Zambo just got ranked at #6 in the CNRS N°20 concours. Seems like nothing is stopping her from getting a permanent position this year!