Varjosalo_Lab
@varjosal.bsky.social
Unveiling the secrets of life through proteomics @helsinkiuni, @HiLIFE_helsinki, @BIOTECH_UH, Proteomics, Genomics, Systems biology 🇫🇮🇨🇳🇧🇩🇭🇷🇮🇳🇮🇹🇹🇷
Reposted by Varjosalo_Lab
New paper out in J Proteome Res! 🧬
We automated plasma proteomics with Mag-Net enrichment on Biomek i5—achieving deep coverage at just a few dollars per sample.
🔗 pubs.acs.org/doi/10.1021/acs.jproteome.5c00420
@hilife-helsinki.bsky.social @resynbio.bsky.social @evosep.bsky.social
We automated plasma proteomics with Mag-Net enrichment on Biomek i5—achieving deep coverage at just a few dollars per sample.
🔗 pubs.acs.org/doi/10.1021/acs.jproteome.5c00420
@hilife-helsinki.bsky.social @resynbio.bsky.social @evosep.bsky.social
Automated Mag-Net Enrichment Unlocks Deep and Cost-Effective LC–MS Plasma Proteomics
Plasma is an ideal material for proteomics due to its diverse protein content reflecting physiological and pathological states and its compatibility with minimally invasive sampling. Deep proteomic pr...
pubs.acs.org
December 22, 2025 at 11:54 AM
New paper out in J Proteome Res! 🧬
We automated plasma proteomics with Mag-Net enrichment on Biomek i5—achieving deep coverage at just a few dollars per sample.
🔗 pubs.acs.org/doi/10.1021/acs.jproteome.5c00420
@hilife-helsinki.bsky.social @resynbio.bsky.social @evosep.bsky.social
We automated plasma proteomics with Mag-Net enrichment on Biomek i5—achieving deep coverage at just a few dollars per sample.
🔗 pubs.acs.org/doi/10.1021/acs.jproteome.5c00420
@hilife-helsinki.bsky.social @resynbio.bsky.social @evosep.bsky.social
Reposted by Varjosalo_Lab
PubMed wrapped: categorizing the top 5 high-level topics of papers published in 2025. LLM-based classification of 1,783,299 documents in total 1/3
December 29, 2025 at 9:30 PM
PubMed wrapped: categorizing the top 5 high-level topics of papers published in 2025. LLM-based classification of 1,783,299 documents in total 1/3
Reposted by Varjosalo_Lab
📢Publication Alert🌶️! Congratulations HiLIFE Helsinki for selecting #Mag_Net from #TeamReSynBio for your automated HT platform for deep proteomics profiling of plasma: pubs.acs.org/doi/10.1021/...
Automated Mag-Net Enrichment Unlocks Deep and Cost-Effective LC–MS Plasma Proteomics
Plasma is an ideal material for proteomics due to its diverse protein content reflecting physiological and pathological states and its compatibility with minimally invasive sampling. Deep proteomic pr...
pubs.acs.org
December 22, 2025 at 9:41 AM
📢Publication Alert🌶️! Congratulations HiLIFE Helsinki for selecting #Mag_Net from #TeamReSynBio for your automated HT platform for deep proteomics profiling of plasma: pubs.acs.org/doi/10.1021/...
Reposted by Varjosalo_Lab
🎉Congratulations to the team from the @helsinki.fi!
In their recent study, the authors report preliminary data showing that the P2 and P2-iST Plasma kits delivered the highest plasma proteome coverage compared with other enrichment approaches.
Read the publication: pubs.acs.org/doi/10.1021/...
In their recent study, the authors report preliminary data showing that the P2 and P2-iST Plasma kits delivered the highest plasma proteome coverage compared with other enrichment approaches.
Read the publication: pubs.acs.org/doi/10.1021/...
December 22, 2025 at 3:09 PM
🎉Congratulations to the team from the @helsinki.fi!
In their recent study, the authors report preliminary data showing that the P2 and P2-iST Plasma kits delivered the highest plasma proteome coverage compared with other enrichment approaches.
Read the publication: pubs.acs.org/doi/10.1021/...
In their recent study, the authors report preliminary data showing that the P2 and P2-iST Plasma kits delivered the highest plasma proteome coverage compared with other enrichment approaches.
Read the publication: pubs.acs.org/doi/10.1021/...
New paper out in J Proteome Res! 🧬
We automated plasma proteomics with Mag-Net enrichment on Biomek i5—achieving deep coverage at just a few dollars per sample.
🔗 pubs.acs.org/doi/10.1021/acs.jproteome.5c00420
@hilife-helsinki.bsky.social @resynbio.bsky.social @evosep.bsky.social
We automated plasma proteomics with Mag-Net enrichment on Biomek i5—achieving deep coverage at just a few dollars per sample.
🔗 pubs.acs.org/doi/10.1021/acs.jproteome.5c00420
@hilife-helsinki.bsky.social @resynbio.bsky.social @evosep.bsky.social
Automated Mag-Net Enrichment Unlocks Deep and Cost-Effective LC–MS Plasma Proteomics
Plasma is an ideal material for proteomics due to its diverse protein content reflecting physiological and pathological states and its compatibility with minimally invasive sampling. Deep proteomic pr...
pubs.acs.org
December 22, 2025 at 11:54 AM
New paper out in J Proteome Res! 🧬
We automated plasma proteomics with Mag-Net enrichment on Biomek i5—achieving deep coverage at just a few dollars per sample.
🔗 pubs.acs.org/doi/10.1021/acs.jproteome.5c00420
@hilife-helsinki.bsky.social @resynbio.bsky.social @evosep.bsky.social
We automated plasma proteomics with Mag-Net enrichment on Biomek i5—achieving deep coverage at just a few dollars per sample.
🔗 pubs.acs.org/doi/10.1021/acs.jproteome.5c00420
@hilife-helsinki.bsky.social @resynbio.bsky.social @evosep.bsky.social
🧬 New paper in Nature Communications!
We found that POLE2,part of DNA polymerase ε,moonlights as a receptor for NPF motifs, binding 70+ proteins across replication, transcription & repair.
The interactome is more interconnected than thought.
@teamgogl.bsky.social 🇫🇮🇫🇷🇭🇺🇬🇧
www.nature.com/articles/s41...
We found that POLE2,part of DNA polymerase ε,moonlights as a receptor for NPF motifs, binding 70+ proteins across replication, transcription & repair.
The interactome is more interconnected than thought.
@teamgogl.bsky.social 🇫🇮🇫🇷🇭🇺🇬🇧
www.nature.com/articles/s41...
December 15, 2025 at 11:58 AM
🧬 New paper in Nature Communications!
We found that POLE2,part of DNA polymerase ε,moonlights as a receptor for NPF motifs, binding 70+ proteins across replication, transcription & repair.
The interactome is more interconnected than thought.
@teamgogl.bsky.social 🇫🇮🇫🇷🇭🇺🇬🇧
www.nature.com/articles/s41...
We found that POLE2,part of DNA polymerase ε,moonlights as a receptor for NPF motifs, binding 70+ proteins across replication, transcription & repair.
The interactome is more interconnected than thought.
@teamgogl.bsky.social 🇫🇮🇫🇷🇭🇺🇬🇧
www.nature.com/articles/s41...
Reposted by Varjosalo_Lab
Astral users, if you're getting sequence interruptions in Xcalibur/Chromeleon, it's time to update your software:
- LC–MS sequences may be interrupted due to an MS
response timeout
- full resolution of this defect has now been achieved with AST 2.0 SP1 QF
thermo.flexnetoperations.com/control/thmo...
- LC–MS sequences may be interrupted due to an MS
response timeout
- full resolution of this defect has now been achieved with AST 2.0 SP1 QF
thermo.flexnetoperations.com/control/thmo...
December 4, 2025 at 11:44 AM
Astral users, if you're getting sequence interruptions in Xcalibur/Chromeleon, it's time to update your software:
- LC–MS sequences may be interrupted due to an MS
response timeout
- full resolution of this defect has now been achieved with AST 2.0 SP1 QF
thermo.flexnetoperations.com/control/thmo...
- LC–MS sequences may be interrupted due to an MS
response timeout
- full resolution of this defect has now been achieved with AST 2.0 SP1 QF
thermo.flexnetoperations.com/control/thmo...
Reposted by Varjosalo_Lab
This is our loading buffer on our Exploris 480 /U3000 system today. Coming to Nature Methods ASAP: The Proteomics S.P.I.D.E.R. Method (Suitability Protocol Integrating Dead Eight-legged Reference)
December 2, 2025 at 10:18 PM
This is our loading buffer on our Exploris 480 /U3000 system today. Coming to Nature Methods ASAP: The Proteomics S.P.I.D.E.R. Method (Suitability Protocol Integrating Dead Eight-legged Reference)
Reposted by Varjosalo_Lab
I just published: ERC-Plus: jackpot science or missed chance to fix academia?
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.
medium.com/p/erc-plus-j...
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.
medium.com/p/erc-plus-j...
ERC-Plus: jackpot science or missed chance to fix academia?
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re…
medium.com
December 3, 2025 at 11:42 AM
I just published: ERC-Plus: jackpot science or missed chance to fix academia?
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.
medium.com/p/erc-plus-j...
My reflections on ERC-Plus, Europe’s newest ultra-competitive research grant and what it tells us about the academic culture we’re building.
medium.com/p/erc-plus-j...
Reposted by Varjosalo_Lab
Artificial intelligence promises rapid and polite feedback on papers — but we must first review the reviewer. This stand first says it all…
A timely World View Colin in our pages by Giorgio Gilestro
🧪 #academicSky
@nature.com
www.nature.com/articles/d41...
A timely World View Colin in our pages by Giorgio Gilestro
🧪 #academicSky
@nature.com
www.nature.com/articles/d41...
AI reviewers are here — we are not ready
Artificial intelligence promises rapid and polite feedback on papers — but we must first review the reviewer.
www.nature.com
December 3, 2025 at 2:09 PM
Artificial intelligence promises rapid and polite feedback on papers — but we must first review the reviewer. This stand first says it all…
A timely World View Colin in our pages by Giorgio Gilestro
🧪 #academicSky
@nature.com
www.nature.com/articles/d41...
A timely World View Colin in our pages by Giorgio Gilestro
🧪 #academicSky
@nature.com
www.nature.com/articles/d41...
Reposted by Varjosalo_Lab
Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...
Predictomes, a classifier-curated database of AlphaFold-modeled protein-protein interactions
Schmid and Walter train a classifier that discerns functionally relevant structure
predictions in proteome-wide protein-protein interaction (PPI) screens using AlphaFold-Multimer,
and they use this co...
www.cell.com
February 26, 2025 at 6:14 PM
Very excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...
Reposted by Varjosalo_Lab
Exited to share our latest work! Out now in @natcomms.nature.com
Koina aims to transform how #proteomics uses machine learning. You no longer need to be a tech wizard to use ML and now can easily run #ML models. Integrated with FragPipe, Skyline and EncyclopeDIA!
www.nature.com/articles/s41...
Koina aims to transform how #proteomics uses machine learning. You no longer need to be a tech wizard to use ML and now can easily run #ML models. Integrated with FragPipe, Skyline and EncyclopeDIA!
www.nature.com/articles/s41...
Koina: Democratizing machine learning for proteomics research - Nature Communications
Koina is an open-source, online platform that simplifies access to machine learning models in proteomics, enabling easier integration into analysis tools and helping researchers adopt and reuse ML mod...
www.nature.com
November 11, 2025 at 8:06 PM
Exited to share our latest work! Out now in @natcomms.nature.com
Koina aims to transform how #proteomics uses machine learning. You no longer need to be a tech wizard to use ML and now can easily run #ML models. Integrated with FragPipe, Skyline and EncyclopeDIA!
www.nature.com/articles/s41...
Koina aims to transform how #proteomics uses machine learning. You no longer need to be a tech wizard to use ML and now can easily run #ML models. Integrated with FragPipe, Skyline and EncyclopeDIA!
www.nature.com/articles/s41...
Reposted by Varjosalo_Lab
A new era for plasma proteomics is on the horizon. 🌅
Get ready for next-generation performance, precision, and simplicity — brought to you by PreOmics® and Biognosys.
✨ www.preomics.com/products/p2-...
#plasmaprep #proteomics #iST #sampleprep #P2-iST
Get ready for next-generation performance, precision, and simplicity — brought to you by PreOmics® and Biognosys.
✨ www.preomics.com/products/p2-...
#plasmaprep #proteomics #iST #sampleprep #P2-iST
November 10, 2025 at 1:35 PM
A new era for plasma proteomics is on the horizon. 🌅
Get ready for next-generation performance, precision, and simplicity — brought to you by PreOmics® and Biognosys.
✨ www.preomics.com/products/p2-...
#plasmaprep #proteomics #iST #sampleprep #P2-iST
Get ready for next-generation performance, precision, and simplicity — brought to you by PreOmics® and Biognosys.
✨ www.preomics.com/products/p2-...
#plasmaprep #proteomics #iST #sampleprep #P2-iST
Reposted by Varjosalo_Lab
I try the newest version of DIA-NN, version 2.3 and its new Infini search approach on some Lumos and tismTOF HT datasets. If you're new to DIA-NN this might be a good video to watch. youtu.be/MIMnDw0loCk
We try the new DIA-NN 2.3 (November 2025)
YouTube video by Brett Phinney
youtu.be
November 3, 2025 at 8:01 PM
I try the newest version of DIA-NN, version 2.3 and its new Infini search approach on some Lumos and tismTOF HT datasets. If you're new to DIA-NN this might be a good video to watch. youtu.be/MIMnDw0loCk
Reposted by Varjosalo_Lab
Science HR in 2026: Smarter, Flexible, and Affordable Job Posting for Scientists and Employers
#science #jobs #recruiting
www.scientific.today/news/1275/sc...
#science #jobs #recruiting
www.scientific.today/news/1275/sc...
Science HR in 2026: Smarter, Flexible, and Affordable Job Posting for Scientists and Employers
www.scientific.today
October 18, 2025 at 5:36 PM
Science HR in 2026: Smarter, Flexible, and Affordable Job Posting for Scientists and Employers
#science #jobs #recruiting
www.scientific.today/news/1275/sc...
#science #jobs #recruiting
www.scientific.today/news/1275/sc...
Reposted by Varjosalo_Lab
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Varjosalo_Lab
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
October 6, 2025 at 9:34 AM
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
Reposted by Varjosalo_Lab
September 27, 2025 at 12:54 AM
Reposted by Varjosalo_Lab
Final countdown! Only 3 days to go until the YPIC Webinar #19: Transition from Academia to Start-Up.
#YPIC #Proteomics #StartUpScience #ScienceCareers #AcademicToIndustry
#YPIC #Proteomics #StartUpScience #ScienceCareers #AcademicToIndustry
September 15, 2025 at 7:12 AM
Final countdown! Only 3 days to go until the YPIC Webinar #19: Transition from Academia to Start-Up.
#YPIC #Proteomics #StartUpScience #ScienceCareers #AcademicToIndustry
#YPIC #Proteomics #StartUpScience #ScienceCareers #AcademicToIndustry
New review w/ Lotta J. Happonen (MCP): “State-of-the-Art and Future Directions in Structural Proteomics.” Integrating XL-MS/HDX-MS/LiP-MS with cryo-EM, NMR, X-ray, SAXS/SANS, native & top-down MS + AI.
Full text: www.mcponline.org/article/S153...
Full text: www.mcponline.org/article/S153...
State-of-the-Art and Future Directions in Structural Proteomics
Structural proteomics has undergone a profound transformation, driven by the convergence
of advanced experimental methodologies and computational innovations. Cutting-edge
mass spectrometry (MS)-based...
www.mcponline.org
September 5, 2025 at 6:09 AM
New review w/ Lotta J. Happonen (MCP): “State-of-the-Art and Future Directions in Structural Proteomics.” Integrating XL-MS/HDX-MS/LiP-MS with cryo-EM, NMR, X-ray, SAXS/SANS, native & top-down MS + AI.
Full text: www.mcponline.org/article/S153...
Full text: www.mcponline.org/article/S153...
Thrilled to share: Helsinki Proteomics Center is installing 3 Thermo Scientific Orbitrap Astral/Astral Zoom mass spectrometers. First Astral Zoom arrived in early Aug—among the first worldwide. Rollout by end of summer 2025. Read more: lnkd.in/d76vpMf6 #proteomics #massspectrometry
August 26, 2025 at 11:41 AM
Thrilled to share: Helsinki Proteomics Center is installing 3 Thermo Scientific Orbitrap Astral/Astral Zoom mass spectrometers. First Astral Zoom arrived in early Aug—among the first worldwide. Rollout by end of summer 2025. Read more: lnkd.in/d76vpMf6 #proteomics #massspectrometry
Reposted by Varjosalo_Lab
Reposted by Varjosalo_Lab
🐧📉 Emperor penguin decline worse than predicted
A new study finds a 22% drop in emperor penguins (2020–2023) in part of Antarctica – far steeper than climate models expected.
This highlights urgent risks from sea ice loss
🔗 www.nature.com/articles/s43...
#SciComm #ClimateChange #Penguins 🧪
A new study finds a 22% drop in emperor penguins (2020–2023) in part of Antarctica – far steeper than climate models expected.
This highlights urgent risks from sea ice loss
🔗 www.nature.com/articles/s43...
#SciComm #ClimateChange #Penguins 🧪
Regional emperor penguin population declines exceed modelled projections - Communications Earth & Environment
The number of emperor penguins in the Bellingshausen and Weddell Sea declined by 22% over the period 2009–2023, a reduction of 1.6% per year, exceeding predictions from population models based on high...
www.nature.com
June 16, 2025 at 4:33 AM
🐧📉 Emperor penguin decline worse than predicted
A new study finds a 22% drop in emperor penguins (2020–2023) in part of Antarctica – far steeper than climate models expected.
This highlights urgent risks from sea ice loss
🔗 www.nature.com/articles/s43...
#SciComm #ClimateChange #Penguins 🧪
A new study finds a 22% drop in emperor penguins (2020–2023) in part of Antarctica – far steeper than climate models expected.
This highlights urgent risks from sea ice loss
🔗 www.nature.com/articles/s43...
#SciComm #ClimateChange #Penguins 🧪
Reposted by Varjosalo_Lab
Luke Brzozowski of @uhn.ca showed how 20+ core facilities are driving hospital-based innovation at #CTLS2025, from genomics to theranostics.
💡 Techna team
🧪 Biobanks & imaging
🏥 Research meets care
#CTLSBrno #CoreFacilities #TranslationalResearch #Stratocore @ctlslifescience.bsky.social
💡 Techna team
🧪 Biobanks & imaging
🏥 Research meets care
#CTLSBrno #CoreFacilities #TranslationalResearch #Stratocore @ctlslifescience.bsky.social
June 10, 2025 at 1:59 PM
Luke Brzozowski of @uhn.ca showed how 20+ core facilities are driving hospital-based innovation at #CTLS2025, from genomics to theranostics.
💡 Techna team
🧪 Biobanks & imaging
🏥 Research meets care
#CTLSBrno #CoreFacilities #TranslationalResearch #Stratocore @ctlslifescience.bsky.social
💡 Techna team
🧪 Biobanks & imaging
🏥 Research meets care
#CTLSBrno #CoreFacilities #TranslationalResearch #Stratocore @ctlslifescience.bsky.social
Back from ASMS 2025 — what a ride!
Tech 💥 Science 🧬 Pirates 🏴☠️ Crabs 🦀 and great conversations with old and new friends.
Grateful for the laughs, the inspiration, and the community.
Already missing Baltimore a bit.
See you next year at ASMS in San Diego! 🌞🌊
#ASMS2025 #massspec #blueskyscience
Tech 💥 Science 🧬 Pirates 🏴☠️ Crabs 🦀 and great conversations with old and new friends.
Grateful for the laughs, the inspiration, and the community.
Already missing Baltimore a bit.
See you next year at ASMS in San Diego! 🌞🌊
#ASMS2025 #massspec #blueskyscience
June 8, 2025 at 9:11 AM
Back from ASMS 2025 — what a ride!
Tech 💥 Science 🧬 Pirates 🏴☠️ Crabs 🦀 and great conversations with old and new friends.
Grateful for the laughs, the inspiration, and the community.
Already missing Baltimore a bit.
See you next year at ASMS in San Diego! 🌞🌊
#ASMS2025 #massspec #blueskyscience
Tech 💥 Science 🧬 Pirates 🏴☠️ Crabs 🦀 and great conversations with old and new friends.
Grateful for the laughs, the inspiration, and the community.
Already missing Baltimore a bit.
See you next year at ASMS in San Diego! 🌞🌊
#ASMS2025 #massspec #blueskyscience