Stefan Mundlos
@stemundi.bsky.social
Reposted by Stefan Mundlos
So happy to see the illustration of our work featured on the cover of @natgenet.nature.com 😍
It represents digits desintegrating into viral like particles. Thank you so much @annaamonaco.bsky.social for making this design!
It represents digits desintegrating into viral like particles. Thank you so much @annaamonaco.bsky.social for making this design!
💫The July issue of @natgenet.nature.com is out!
Featuring:
✅retrotransposons in limb malformation and cancer
✅single-cell Micro-C
✅long-term effects of chemotherapy on normal blood cells
✅blood regulatory variation map in South Africans
And more!
⬇️
www.nature.com/ng/volumes/5...
Featuring:
✅retrotransposons in limb malformation and cancer
✅single-cell Micro-C
✅long-term effects of chemotherapy on normal blood cells
✅blood regulatory variation map in South Africans
And more!
⬇️
www.nature.com/ng/volumes/5...
July 24, 2025 at 9:43 PM
So happy to see the illustration of our work featured on the cover of @natgenet.nature.com 😍
It represents digits desintegrating into viral like particles. Thank you so much @annaamonaco.bsky.social for making this design!
It represents digits desintegrating into viral like particles. Thank you so much @annaamonaco.bsky.social for making this design!
Reposted by Stefan Mundlos
So happy to see this paper out in @natecoevo.nature.com. Huge congrats to the whole team, and especially to @fany-real.bsky.social, @dariloops.bsky.social, @stemundi.bsky.social, Magdalena Schindler & Christian Feregrino. Ever wondered how bats develop wings from their hands? 🦇 Enjoy the read ;) 👇
Thrilled to see our revised preprint now published in Nature Ecology & Evolution!
If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers!
www.nature.com/articles/s41...
If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers!
www.nature.com/articles/s41...
July 23, 2025 at 10:24 AM
So happy to see this paper out in @natecoevo.nature.com. Huge congrats to the whole team, and especially to @fany-real.bsky.social, @dariloops.bsky.social, @stemundi.bsky.social, Magdalena Schindler & Christian Feregrino. Ever wondered how bats develop wings from their hands? 🦇 Enjoy the read ;) 👇
Our comparative single-cell study on limb development in bats vs. mice reveals insights how evolution can produce massive changes by just changing the expression of a few TFs 😱
www.nature.com/articles/s41...
www.nature.com/articles/s41...
July 24, 2025 at 9:29 AM
Our comparative single-cell study on limb development in bats vs. mice reveals insights how evolution can produce massive changes by just changing the expression of a few TFs 😱
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our really exciting bat work got published. This was a fantastic effort by @fany-real.bsky.social, @dariloops.bsky.social, Magdalena Schindler and Christian Feregrino. Many thanks to all our collaborators! who made this possible!!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution
Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...
www.nature.com
July 24, 2025 at 9:21 AM
Our really exciting bat work got published. This was a fantastic effort by @fany-real.bsky.social, @dariloops.bsky.social, Magdalena Schindler and Christian Feregrino. Many thanks to all our collaborators! who made this possible!!!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our first paper in Naturre Ecology & Evolution - it won't be the last. Essential insights in bat wing development and how evolution achieves such drastic morphological changes:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution
Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...
www.nature.com
July 24, 2025 at 9:14 AM
Our first paper in Naturre Ecology & Evolution - it won't be the last. Essential insights in bat wing development and how evolution achieves such drastic morphological changes:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our first bat story is out! What turns a limb into a wing? Evolution's most impressive adaptation. The massive difference is achieved by small changes and the re-purposing of existing pathways - the principle of parsimony! Meis2 gene, normally expressed in proximal limb gets expressed distally.
July 24, 2025 at 9:13 AM
Our first bat story is out! What turns a limb into a wing? Evolution's most impressive adaptation. The massive difference is achieved by small changes and the re-purposing of existing pathways - the principle of parsimony! Meis2 gene, normally expressed in proximal limb gets expressed distally.
50-70% of cases for WGS remain undiagnosed. Searching for an explanation? Read this article by Glaser et al. Activation of endogenous retroviruses can induce cell death in the embry. You can detect virus-like particles in these cell in EM! www.nature.com/ng/volumes/5...
Nature Genetics - An endogenous retrovirus causes limb malformation
Activation of a long terminal repeat retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles that cause limb malformation in...
www.nature.com
July 24, 2025 at 9:00 AM
50-70% of cases for WGS remain undiagnosed. Searching for an explanation? Read this article by Glaser et al. Activation of endogenous retroviruses can induce cell death in the embry. You can detect virus-like particles in these cell in EM! www.nature.com/ng/volumes/5...
Our new story in Nature Genetics: endogenous retroviruses can produce viral-like particles in the embryo resulting in apoptosis and congenital malformation. If this would happen in human, it wouldn't leave a trace. No WGS or other analysis would identify this. www.nature.com/articles/s41...
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 24, 2025 at 8:56 AM
Our new story in Nature Genetics: endogenous retroviruses can produce viral-like particles in the embryo resulting in apoptosis and congenital malformation. If this would happen in human, it wouldn't leave a trace. No WGS or other analysis would identify this. www.nature.com/articles/s41...
Nature Genetics' new issue is out: Our project is on the cover: An endogenous retrovirus causes limb malformation. Juliane's great scientific work and Anna's cover design!
July 24, 2025 at 8:48 AM
Nature Genetics' new issue is out: Our project is on the cover: An endogenous retrovirus causes limb malformation. Juliane's great scientific work and Anna's cover design!
Reposted by Stefan Mundlos
Pretty surreal to see my artwork on the cover of Nature Genetics! Big congrats to @julianeg.bsky.social, @stemundi.bsky.social and the others, and thank you Juliane for letting me help bring your research to life visually.
www.nature.com/ng/volumes/5...
www.nature.com/ng/volumes/5...
July 23, 2025 at 8:06 AM
Pretty surreal to see my artwork on the cover of Nature Genetics! Big congrats to @julianeg.bsky.social, @stemundi.bsky.social and the others, and thank you Juliane for letting me help bring your research to life visually.
www.nature.com/ng/volumes/5...
www.nature.com/ng/volumes/5...
Genome comparisons identify gene flow events between three species of right whales and the bowhead whale. Evidence of historical trans-equatorial migration during ancient glacial cycles. Beautiful work by BaiWei Lo in the lab together with Paolo Franchini: Genome Biology and Evolution, in press.
May 15, 2025 at 7:40 AM
Genome comparisons identify gene flow events between three species of right whales and the bowhead whale. Evidence of historical trans-equatorial migration during ancient glacial cycles. Beautiful work by BaiWei Lo in the lab together with Paolo Franchini: Genome Biology and Evolution, in press.
Reposted by Stefan Mundlos
Nuage Therapeutics, co-founded by our group leader Denes Hnisz was highlighted in recent Nature Spotlight article: www.nature.com/articles/d42...
Find out more about work in the Hnisz lab: www.molgen.mpg.de/3857230/tran...
@irbbarcelona.org @xsalvatella1.bsky.social
Find out more about work in the Hnisz lab: www.molgen.mpg.de/3857230/tran...
@irbbarcelona.org @xsalvatella1.bsky.social
May 14, 2025 at 10:12 AM
Nuage Therapeutics, co-founded by our group leader Denes Hnisz was highlighted in recent Nature Spotlight article: www.nature.com/articles/d42...
Find out more about work in the Hnisz lab: www.molgen.mpg.de/3857230/tran...
@irbbarcelona.org @xsalvatella1.bsky.social
Find out more about work in the Hnisz lab: www.molgen.mpg.de/3857230/tran...
@irbbarcelona.org @xsalvatella1.bsky.social
A genetic study on Korean divers renowned for their remarkable diving abilities. They identified SNPs, one associated significantly with RBC count. Hematological variation is believed to provide additional oxygen capacity during diving. COOL!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Genetic and training adaptations in the Haenyeo divers of Jeju, Korea
Aguilar-Gómez et al. find evidence of evolutionary adaptation with potential relevance
to breath-hold diving in the Haenyeo divers of Korea. Genetic variants under selection
in this population may hel...
www.cell.com
May 13, 2025 at 3:48 PM
A genetic study on Korean divers renowned for their remarkable diving abilities. They identified SNPs, one associated significantly with RBC count. Hematological variation is believed to provide additional oxygen capacity during diving. COOL!
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Stefan Mundlos
The Robson lab's second paper! A truly fun collaboration with an unexpected and important finding - progenitors reconfigure 3D genomes organisation to commission loci for future cell fates. A heroic amount of work from a rockstar team.
🚨 Preprint 🚨
Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens!
doi.org/10.1101/2025...
Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens!
doi.org/10.1101/2025...
Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates
Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...
www.biorxiv.org
May 8, 2025 at 10:47 AM
The Robson lab's second paper! A truly fun collaboration with an unexpected and important finding - progenitors reconfigure 3D genomes organisation to commission loci for future cell fates. A heroic amount of work from a rockstar team.
May 9, 2025 at 12:41 PM
Reposted by Stefan Mundlos
Thanks also to the @stemundi.bsky.social lab where this work started and the Robson lab where it was finished! Last, my amazing supervisor @drmrobson.bsky.social who devised the inducible DamID mouse and spearheaded the project!
May 8, 2025 at 9:43 AM
Thanks also to the @stemundi.bsky.social lab where this work started and the Robson lab where it was finished! Last, my amazing supervisor @drmrobson.bsky.social who devised the inducible DamID mouse and spearheaded the project!
Fantastic work - groundbreaking, important!
🚨 Preprint 🚨
Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens!
doi.org/10.1101/2025...
Ever wondered how cells prepare their genomes to enable new cell-fates? In this team up with the Kind lab, we show that genes are repositioned in the nucleus to get ready for future activation and tissue formation. Read 🧵👇 to find out how and when this happens!
doi.org/10.1101/2025...
Reconfiguration of genome-lamina interactions marks the commissioning of limb cell-fates
Diverse forms of heterochromatin block inappropriate transcription and safeguard differentiation and cell identity. Yet, how and when heterochromatin is reconfigured to facilitate changes in cell-fate...
www.biorxiv.org
May 9, 2025 at 10:20 AM
Fantastic work - groundbreaking, important!
This is an important paper: genome-lamina interactions are selectively released in early multipotent progenitors preceding gene expression, suggesting it primes regulatory domains for future potential activation. Fantastic collboration of Robson/Kind/Mundlos labs.
May 9, 2025 at 10:17 AM
This is an important paper: genome-lamina interactions are selectively released in early multipotent progenitors preceding gene expression, suggesting it primes regulatory domains for future potential activation. Fantastic collboration of Robson/Kind/Mundlos labs.
Our new study on whale genomics by BaiWei Lo together with Paolo Franchini. Evidence of historical trans-equatorial migration impacted by glacial cycles and connectivity of bowhead whale populations between the North Pacific right whale, the Southern right whale and the North Atlantic right whale.
May 9, 2025 at 10:02 AM
Our new study on whale genomics by BaiWei Lo together with Paolo Franchini. Evidence of historical trans-equatorial migration impacted by glacial cycles and connectivity of bowhead whale populations between the North Pacific right whale, the Southern right whale and the North Atlantic right whale.
Reposted by Stefan Mundlos
Beautiful work 🤩
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound
of TE-derived sequences repurposed for organismal function. ...
www.pnas.org
May 7, 2025 at 1:39 PM
Beautiful work 🤩
Reposted by Stefan Mundlos
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
Chromatin loops are an ancestral hallmark of the animal regulatory genome - Nature
The physical organization of the genome in non-bilaterian animals and their closest unicellular relatives is characterized; comparative analysis shows chromatin looping is a conserved feature of ...
www.nature.com
May 7, 2025 at 3:23 PM
I’m very excited to share our work on the early evolution of animal regulatory genome architecture - the main project of my postdoc, carried out across two wonderful and inspirational labs of @arnausebe.bsky.social and @mamartirenom.bsky.social. www.nature.com/articles/s41...
Reposted by Stefan Mundlos
Really proud of Michaela Bartusel, who initiated this work while being a PhD in our lab. Michaela never gave up and, together with the great guidance of my friend and former colleague Eliezer Calo, made some very interesting findings regarding the genetic basis of orofacial clefting.
Non-syndromic orofacial clefts (OFCs) are common birth defects with unclear molecular causes. @ajhgnews.bsky.social latest article studies an OFC-associated risk locus & implicates tRNA splicing defects that cause ribosome stalling & neural crest cell dysfunction: www.cell.com/ajhg/abstrac... #ASHG
May 3, 2025 at 4:36 PM
Really proud of Michaela Bartusel, who initiated this work while being a PhD in our lab. Michaela never gave up and, together with the great guidance of my friend and former colleague Eliezer Calo, made some very interesting findings regarding the genetic basis of orofacial clefting.
Reposted by Stefan Mundlos
Just published the new edition of “Principles of Development’ from now called “Wolpert’s Principles of Development’ to honour his memory and the origin of this textbooks that aims at distilling the, sometimes elusive, principles underlying animal and plant development shorturl.at/LrOxn
May 4, 2025 at 4:31 PM
Just published the new edition of “Principles of Development’ from now called “Wolpert’s Principles of Development’ to honour his memory and the origin of this textbooks that aims at distilling the, sometimes elusive, principles underlying animal and plant development shorturl.at/LrOxn
Cassandra Extavour today at MPIMG.
May 7, 2025 at 9:21 AM
Cassandra Extavour today at MPIMG.
Nature is amazing! Efficient waste disposal as documented by my nest camera. Its all in the DNA, or?
May 6, 2025 at 8:36 AM
Nature is amazing! Efficient waste disposal as documented by my nest camera. Its all in the DNA, or?