Our comparative single-cell study on limb development in bats vs. mice reveals insights how evolution can produce massive changes by just changing the expression of a few TFs 😱
www.nature.com/articles/s41...

Our first bat story is out! What turns a limb into a wing? Evolution's most impressive adaptation. The massive difference is achieved by small changes and the re-purposing of existing pathways - the principle of parsimony! Meis2 gene, normally expressed in proximal limb gets expressed distally.

Nature Genetics' new issue is out: Our project is on the cover: An endogenous retrovirus causes limb malformation. Juliane's great scientific work and Anna's cover design!

Genome comparisons identify gene flow events between three species of right whales and the bowhead whale. Evidence of historical trans-equatorial migration during ancient glacial cycles. Beautiful work by BaiWei Lo in the lab together with Paolo Franchini: Genome Biology and Evolution, in press.

This is an important paper: genome-lamina interactions are selectively released in early multipotent progenitors preceding gene expression, suggesting it primes regulatory domains for future potential activation. Fantastic collboration of Robson/Kind/Mundlos labs.

Our new study on whale genomics by BaiWei Lo together with Paolo Franchini. Evidence of historical trans-equatorial migration impacted by glacial cycles and connectivity of bowhead whale populations between the North Pacific right whale, the Southern right whale and the North Atlantic right whale.

Cassandra Extavour today at MPIMG.

Nature is amazing! Efficient waste disposal as documented by my nest camera. Its all in the DNA, or?

Our BAT paper is accepted in Nature Ecology & Evolution! Single cell, gene regulation, TADs and key TFs that shape the bat wing. Genomics goes Evodevo 😍