Stephane Vassilopoulos
@stefvass.bsky.social
Cell biologist @INSERM @Sorbonne_Univ_, clathrin, dynamin, neuromuscular diseases, electron microscopy, metal replicas #CLEM
🔬🇪🇺 🇬🇷 🇨🇵
🔬🇪🇺 🇬🇷 🇨🇵
Pinned
One of my favorite images: a platinum replica electron microscopy shot of an unroofed cancer cell migrating along collagen fibers (blue). It beautifully captures the clathrin-coated pits (red, ~100 nm) and the intricate network of branched actin filaments (orange) 🔬
Reposted by Stephane Vassilopoulos
Want to hear a mid-career PI pontificate about science, career and cooking? Today's your lucky day thanks to The Microscopists podcast! Thanks Peter @yorkbioimaging.bsky.social for having me 🎙️🎧
themicroscopists.bitesizebio.com/episodes/chr...
themicroscopists.bitesizebio.com/episodes/chr...
The Microscopists | Christophe Leterrier (CNRS & Aix-Marseille Université)
This time on The Microscopists, we're joined by Christophe Leterrier, team leader at NeuroCyto in Marseille and director of a Nikon Center of Excellence for super-resolution microscopy.Christophe r...
themicroscopists.bitesizebio.com
October 3, 2025 at 12:40 PM
Want to hear a mid-career PI pontificate about science, career and cooking? Today's your lucky day thanks to The Microscopists podcast! Thanks Peter @yorkbioimaging.bsky.social for having me 🎙️🎧
themicroscopists.bitesizebio.com/episodes/chr...
themicroscopists.bitesizebio.com/episodes/chr...
Reposted by Stephane Vassilopoulos
New NeuroCyto preprint about to drop! @wiesner-t.bsky.social 😎⏳
September 16, 2025 at 4:48 PM
New NeuroCyto preprint about to drop! @wiesner-t.bsky.social 😎⏳
Reposted by Stephane Vassilopoulos
www.sciencedirect.com/science/arti...
check out the recent dispatch on endolysosomes and melano-biology interplay in @currentbiology.bsky.social by @delevoyecedric.bsky.social & @laurasalavessa.bsky.social from @membramics-lab.bsky.social
check out the recent dispatch on endolysosomes and melano-biology interplay in @currentbiology.bsky.social by @delevoyecedric.bsky.social & @laurasalavessa.bsky.social from @membramics-lab.bsky.social
September 8, 2025 at 3:48 PM
www.sciencedirect.com/science/arti...
check out the recent dispatch on endolysosomes and melano-biology interplay in @currentbiology.bsky.social by @delevoyecedric.bsky.social & @laurasalavessa.bsky.social from @membramics-lab.bsky.social
check out the recent dispatch on endolysosomes and melano-biology interplay in @currentbiology.bsky.social by @delevoyecedric.bsky.social & @laurasalavessa.bsky.social from @membramics-lab.bsky.social
Reposted by Stephane Vassilopoulos
If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system
Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...
www.biorxiv.org
September 3, 2025 at 11:51 AM
If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Stephane Vassilopoulos
Happy to contribute to this new work from @micoxscopy.bsky.social et al, helping apply SSQUASH to analyse the shape of spectrin rings along axons. Data analysis is the next frontier in SMLM, and I'm always up for chatting, sharing data and see how we can push things further!
August 13, 2025 at 10:38 AM
Happy to contribute to this new work from @micoxscopy.bsky.social et al, helping apply SSQUASH to analyse the shape of spectrin rings along axons. Data analysis is the next frontier in SMLM, and I'm always up for chatting, sharing data and see how we can push things further!
Reposted by Stephane Vassilopoulos
Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).
Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).
Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
July 7, 2025 at 2:05 PM
Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).
Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).
Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
Reposted by Stephane Vassilopoulos
How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 24, 2025 at 7:22 PM
How do cells switch on the actin assembly at endocytic sites? How can this on-switch evolve? Check out our new preprint!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Stephane Vassilopoulos
I'm grateful for the Research Council of Finland for granting me the Academy Research fellowship! After getting over the shock I will soon move back to Finland to start as a group leader at the Institute of Biotechnology @helsinki.fi. Looking for a PhD student soon! www.aka.fi/en/about-us/...
RCF winter call results: funding decisions in biosciences, health and environmental research
The Research Council of Finland’s Scientific Council for Biosciences, Health and the Environment has granted funding for 38 Academy Research Fellowships, 12 Clinical Researchers and 76 Academy P...
www.aka.fi
June 22, 2025 at 9:18 AM
I'm grateful for the Research Council of Finland for granting me the Academy Research fellowship! After getting over the shock I will soon move back to Finland to start as a group leader at the Institute of Biotechnology @helsinki.fi. Looking for a PhD student soon! www.aka.fi/en/about-us/...
💥 Very cool science session at the @academiesciences.bsky.social with @christlet.bsky.social for the "Grandes avancées Françaises en biologie"
🎖prize to @florianwerner.bsky.social and @moparthisk.bsky.social
Check out the live stream here
m.youtube.com/watch?v=PIWI...
🎖prize to @florianwerner.bsky.social and @moparthisk.bsky.social
Check out the live stream here
m.youtube.com/watch?v=PIWI...
June 17, 2025 at 2:05 PM
💥 Very cool science session at the @academiesciences.bsky.social with @christlet.bsky.social for the "Grandes avancées Françaises en biologie"
🎖prize to @florianwerner.bsky.social and @moparthisk.bsky.social
Check out the live stream here
m.youtube.com/watch?v=PIWI...
🎖prize to @florianwerner.bsky.social and @moparthisk.bsky.social
Check out the live stream here
m.youtube.com/watch?v=PIWI...
Reposted by Stephane Vassilopoulos
Honored to be on stage this morning @academiesciences.bsky.social for the work done with @florianwerner.bsky.social and @moparthisk.bsky.social. Also celebrating almost ten years of collaboration and friendship with @stefvass.bsky.social, merging microscopies to discover new biology 🤝
June 17, 2025 at 9:46 AM
Honored to be on stage this morning @academiesciences.bsky.social for the work done with @florianwerner.bsky.social and @moparthisk.bsky.social. Also celebrating almost ten years of collaboration and friendship with @stefvass.bsky.social, merging microscopies to discover new biology 🤝
Reposted by Stephane Vassilopoulos
Fierté de DU @inp-marseille.bsky.social : voir les travaux de Florian Werner et Satish Moparthi avec @christlet.bsky.social @stefvass.bsky.social aux 20 ans des grandes avancées françaises en biologie @academiesciences.bsky.social
Bravo à eux !
@cnrsbiologie.bsky.social @univ-amu.fr @cnrs.fr
Bravo à eux !
@cnrsbiologie.bsky.social @univ-amu.fr @cnrs.fr
June 17, 2025 at 8:47 AM
Fierté de DU @inp-marseille.bsky.social : voir les travaux de Florian Werner et Satish Moparthi avec @christlet.bsky.social @stefvass.bsky.social aux 20 ans des grandes avancées françaises en biologie @academiesciences.bsky.social
Bravo à eux !
@cnrsbiologie.bsky.social @univ-amu.fr @cnrs.fr
Bravo à eux !
@cnrsbiologie.bsky.social @univ-amu.fr @cnrs.fr
Reposted by Stephane Vassilopoulos
🎉 It's such a pleasure to congratulate Nicolas Jullien, full-stack ingénieur, CRISPR wizard in the NeuroCyto team, software developer extraordinaire and more, who was awarded the @cnrs.fr crystal medal! Thank you @nico-juulien.bsky.social 🙏https://www.insb.cnrs.fr/fr/personne/nicolas-jullien/
Nicolas Jullien
www.insb.cnrs.fr
June 16, 2025 at 1:08 PM
🎉 It's such a pleasure to congratulate Nicolas Jullien, full-stack ingénieur, CRISPR wizard in the NeuroCyto team, software developer extraordinaire and more, who was awarded the @cnrs.fr crystal medal! Thank you @nico-juulien.bsky.social 🙏https://www.insb.cnrs.fr/fr/personne/nicolas-jullien/
Reposted by Stephane Vassilopoulos
#Communiqué 🗞️ Des scientifiques ont réalisé une avancée majeure dans le traitement d’une maladie musculaire génétique grave pour laquelle il n'existe actuellement aucune thérapie, la myopathie centronucléaire liée à la mutation du gène BIN1.
👉 www.cnrs.fr/fr/presse/un...
👉 www.cnrs.fr/fr/presse/un...
June 12, 2025 at 3:55 PM
#Communiqué 🗞️ Des scientifiques ont réalisé une avancée majeure dans le traitement d’une maladie musculaire génétique grave pour laquelle il n'existe actuellement aucune thérapie, la myopathie centronucléaire liée à la mutation du gène BIN1.
👉 www.cnrs.fr/fr/presse/un...
👉 www.cnrs.fr/fr/presse/un...
Reposted by Stephane Vassilopoulos
Acknowledgments slide done! Time to rehearse for @academiesciences.bsky.social
June 5, 2025 at 3:27 PM
Acknowledgments slide done! Time to rehearse for @academiesciences.bsky.social
Reposted by Stephane Vassilopoulos
This is a summary of our recent @jcellsci.bsky.social paper.
If you've ever wondered why ATG9A has many and varied roles, we think it's because it is trafficked by a subset of a large, diverse family of vesicles - intracellular nanovesicles.
doi.org/10.1242/jcs....
If you've ever wondered why ATG9A has many and varied roles, we think it's because it is trafficked by a subset of a large, diverse family of vesicles - intracellular nanovesicles.
doi.org/10.1242/jcs....
ATG9A vesicles are a subtype of intracellular nanovesicle
Highlighted Article: Presentation of the first intracellular nanovesicle (INV) proteome, showing that a subset of INVs are ATG9A vesicles. This places ATG9A vesicles in a broader superfamily of traffi...
doi.org
June 5, 2025 at 7:41 AM
This is a summary of our recent @jcellsci.bsky.social paper.
If you've ever wondered why ATG9A has many and varied roles, we think it's because it is trafficked by a subset of a large, diverse family of vesicles - intracellular nanovesicles.
doi.org/10.1242/jcs....
If you've ever wondered why ATG9A has many and varied roles, we think it's because it is trafficked by a subset of a large, diverse family of vesicles - intracellular nanovesicles.
doi.org/10.1242/jcs....
Reposted by Stephane Vassilopoulos
This will be at the Académie des Sciences on June 17th, for the 20th anniversary of the “Grandes Avancées Françaises en Biologie” prize. More info here: www.academie-sciences.fr/en/node/2699
May 23, 2025 at 2:42 PM
This will be at the Académie des Sciences on June 17th, for the 20th anniversary of the “Grandes Avancées Françaises en Biologie” prize. More info here: www.academie-sciences.fr/en/node/2699
💥🔬💥
Super happy to announce that together with @stefvass.bsky.social , we will have the honor to join 1st authors Florian Wernert and @moparthisk.bsky.social to present our recent work (www.science.org/doi/10.1126/...) to the French Academy of Sciences @academiesciences.bsky.social!
The actin-spectrin submembrane scaffold restricts endocytosis along proximal axons
Clathrin-mediated endocytosis has characteristic features in neuronal dendrites and presynapses, but how membrane proteins are internalized along the axon shaft remains unclear. We focused on clathrin...
www.science.org
May 23, 2025 at 4:03 PM
💥🔬💥
Reposted by Stephane Vassilopoulos
Great talks these two last days, including Marc Bitoun (Institut de Myologie, Paris) as keynote speaker who showed impressive data on allele-specific silencing therapy for centronuclear myopathy due to dyn2 mutations.
May 7, 2025 at 4:43 PM
Great talks these two last days, including Marc Bitoun (Institut de Myologie, Paris) as keynote speaker who showed impressive data on allele-specific silencing therapy for centronuclear myopathy due to dyn2 mutations.
Reposted by Stephane Vassilopoulos
Congrats @wiesner-t.bsky.social who gave a great talk at the Exo-Endo Meeting yesterday, showing how the acitn-spectrin scaffold regulates exocytosis along the axon shaft!
The 27th Club Exo-Endo meeting has started at Fort-Mahon.
exoendo.org/evenement/27...
Nice place, nice talks and congratulation to young researchers who made great talks!!
exoendo.org/evenement/27...
Nice place, nice talks and congratulation to young researchers who made great talks!!
May 6, 2025 at 1:36 PM
Congrats @wiesner-t.bsky.social who gave a great talk at the Exo-Endo Meeting yesterday, showing how the acitn-spectrin scaffold regulates exocytosis along the axon shaft!
Reposted by Stephane Vassilopoulos
Interesting new #NatureNeuro paper: Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes. #Myoblue tinyurl.com/ysvwdejm
Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes - Nature Neuroscience
Sznajder et al. identified a molecular link between autism and myotonic dystrophy, showing that a tandem repeat mutation in a single gene can disrupt splicing of multiple autism-related genes during b...
tinyurl.com
April 21, 2025 at 3:09 PM
Interesting new #NatureNeuro paper: Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes. #Myoblue tinyurl.com/ysvwdejm
Reposted by Stephane Vassilopoulos
Congrats to my fantastic coauthors on this work with a surprising conclusion. www.biorxiv.org/content/10.1...
Force-insensitive myosin-I enhances endocytosis robustness through actin network-scale collective ratcheting
Force production by Type-I myosins influences endocytic progression in many cell types. Since different myosin-I isoforms exhibit distinct force-dependent kinetic properties, it is important to invest...
www.biorxiv.org
April 9, 2025 at 7:09 PM
Congrats to my fantastic coauthors on this work with a surprising conclusion. www.biorxiv.org/content/10.1...
Reposted by Stephane Vassilopoulos
We have a new review out! In this Microscopy & Microanalysis piece, Louisa Mezache and I survey some of the latest commercially available microscope technologies: Nikon NSPARC, Re-scan Gaia, CSR Biotech MI-SIM, refinements to STED, SMLM from Bruker and Abbelight… Check it out with free access:
Advancing Super-Resolution Microscopy: Recent Innovations in Commercial Instruments
Abstract. Super-resolution microscopy techniques have accelerated scientific progress, enabling researchers to explore cellular structures and dynamics wit
academic.oup.com
April 9, 2025 at 3:47 PM
We have a new review out! In this Microscopy & Microanalysis piece, Louisa Mezache and I survey some of the latest commercially available microscope technologies: Nikon NSPARC, Re-scan Gaia, CSR Biotech MI-SIM, refinements to STED, SMLM from Bruker and Abbelight… Check it out with free access:
Reposted by Stephane Vassilopoulos
Very happy to present the latest preprint of the lab. This was work done predominantly by a Master student, Leonardo Tadini, assisted by Lilia Younsi, Isabel Holguera, Felix Simon, and Max Courgeon: www.biorxiv.org/content/10.1...
Gene expression cartography of a developing neuronal structure
The brain is a complex structure comprising thousands to billions of neurons that belong to thousands to millions of different neuronal types. These neurons often come from different progenitor domain...
www.biorxiv.org
April 3, 2025 at 1:52 PM
Very happy to present the latest preprint of the lab. This was work done predominantly by a Master student, Leonardo Tadini, assisted by Lilia Younsi, Isabel Holguera, Felix Simon, and Max Courgeon: www.biorxiv.org/content/10.1...
Reposted by Stephane Vassilopoulos
James and Selena's paper is out in @jcb.org !
We present a structural model of the TACC3-ch-TOG interaction. Using Affimers that can inhibit this interaction, we uncovered a new role for TACC3-ch-TOG in maintaining the pericentriolar material during mitosis. 🧪 1/n
doi.org/10.1083/jcb....
We present a structural model of the TACC3-ch-TOG interaction. Using Affimers that can inhibit this interaction, we uncovered a new role for TACC3-ch-TOG in maintaining the pericentriolar material during mitosis. 🧪 1/n
doi.org/10.1083/jcb....
Structural characterization and inhibition of the interaction between ch-TOG and TACC3 | Journal of Cell Biology | Rockefeller University Press
Shelford, Burgess, and colleagues present a structural model of the interaction between TACC3 and ch-TOG. They discover Affimers that can inhibit this inte
doi.org
March 20, 2025 at 11:57 AM
James and Selena's paper is out in @jcb.org !
We present a structural model of the TACC3-ch-TOG interaction. Using Affimers that can inhibit this interaction, we uncovered a new role for TACC3-ch-TOG in maintaining the pericentriolar material during mitosis. 🧪 1/n
doi.org/10.1083/jcb....
We present a structural model of the TACC3-ch-TOG interaction. Using Affimers that can inhibit this interaction, we uncovered a new role for TACC3-ch-TOG in maintaining the pericentriolar material during mitosis. 🧪 1/n
doi.org/10.1083/jcb....
Reposted by Stephane Vassilopoulos
More white coats, less white robes! @eddpasquier.bsky.social #standupforscience #standupforscience2025
March 7, 2025 at 11:33 AM
More white coats, less white robes! @eddpasquier.bsky.social #standupforscience #standupforscience2025