Sergi Roig Puiggros
@sroig.bsky.social
Developmental Neurobiology
Postdoc - University of Geneva
Postdoc - University of Geneva
Pinned
Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience
Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...
www.nature.com
I'm very excited to finally see this one out in @natneuro.nature.com ! It has been an incredible journey alongside extremely talented people! Thanks to everyone involved and enjoy the reading! 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Relating to our recently published paper in @natneuro.nature.com! 🔥🚨
Find here a research briefing that we wrote w/ @djabaudon.bsky.social trying to reach a broader neuroscience audience! Enjoy the reading!
www.nature.com/articles/s41...
Find here a research briefing that we wrote w/ @djabaudon.bsky.social trying to reach a broader neuroscience audience! Enjoy the reading!
www.nature.com/articles/s41...
www.nature.com
January 12, 2026 at 8:53 AM
Relating to our recently published paper in @natneuro.nature.com! 🔥🚨
Find here a research briefing that we wrote w/ @djabaudon.bsky.social trying to reach a broader neuroscience audience! Enjoy the reading!
www.nature.com/articles/s41...
Find here a research briefing that we wrote w/ @djabaudon.bsky.social trying to reach a broader neuroscience audience! Enjoy the reading!
www.nature.com/articles/s41...
Reposted by Sergi Roig Puiggros
Delighted to have contributed to this thorough and collaborative piece of work with amazing colleagues and friends! 🧠🚀
I'm very excited to finally see this one out in @natneuro.nature.com ! It has been an incredible journey alongside extremely talented people! Thanks to everyone involved and enjoy the reading! 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience
Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...
www.nature.com
January 7, 2026 at 9:00 PM
Delighted to have contributed to this thorough and collaborative piece of work with amazing colleagues and friends! 🧠🚀
Thanks Ioana ♥️🫶🏼
January 7, 2026 at 5:13 PM
Thanks Ioana ♥️🫶🏼
Thanks for your involvement since day 1! It wouldn't have been possible without you and all the others!
January 7, 2026 at 2:29 PM
Thanks for your involvement since day 1! It wouldn't have been possible without you and all the others!
Thank you Fernando!
January 7, 2026 at 2:28 PM
Thank you Fernando!
Thank you Cedric! 🥳
January 7, 2026 at 12:38 PM
Thank you Cedric! 🥳
Mil gracias! Me alegro que lo hayas disfrutado! ❤️
January 7, 2026 at 12:35 PM
Mil gracias! Me alegro que lo hayas disfrutado! ❤️
Finally, we have collaborated with Le Figaro to make the findings of this work more accessible, although in french: connect.lefigaro.fr/login?client...
Enjoy the reading! 6/n
Enjoy the reading! 6/n
Le Figaro.fr - Connexion compte Figaro
Page de connexion à votre compte Figaro
connect.lefigaro.fr
January 7, 2026 at 12:26 PM
Finally, we have collaborated with Le Figaro to make the findings of this work more accessible, although in french: connect.lefigaro.fr/login?client...
Enjoy the reading! 6/n
Enjoy the reading! 6/n
This work also expands our understanding on the pathology behind these malformations, and particularly relating to epilepsy. 5/n
January 7, 2026 at 12:26 PM
This work also expands our understanding on the pathology behind these malformations, and particularly relating to epilepsy. 5/n
We show that heterotopic neurons acquire proper molecular identities, integrate developing and functional circuits, triggering behavioral responses after receiving sensory stimuli. Overall supporting Karten's "circuit equivalence" hypothesis. 4/n
January 7, 2026 at 12:26 PM
We show that heterotopic neurons acquire proper molecular identities, integrate developing and functional circuits, triggering behavioral responses after receiving sensory stimuli. Overall supporting Karten's "circuit equivalence" hypothesis. 4/n
Also, to everyone making this possible through their different expertise, allowing to build a complete view on how gray matter heterotopias integrate cortical circuits and function. @jbmanent.bsky.social @maelleguyoton.bsky.social @elboustanilab.bsky.social and many many others 3/n
January 7, 2026 at 12:26 PM
Also, to everyone making this possible through their different expertise, allowing to build a complete view on how gray matter heterotopias integrate cortical circuits and function. @jbmanent.bsky.social @maelleguyoton.bsky.social @elboustanilab.bsky.social and many many others 3/n
A special thanks to @djabaudon.bsky.social, who has allowed me to explore, dig and question several avenues without putting limits and pushing my creativity and curiosity. 2/n
January 7, 2026 at 12:26 PM
A special thanks to @djabaudon.bsky.social, who has allowed me to explore, dig and question several avenues without putting limits and pushing my creativity and curiosity. 2/n
I'm very excited to finally see this one out in @natneuro.nature.com ! It has been an incredible journey alongside extremely talented people! Thanks to everyone involved and enjoy the reading! 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience
Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...
www.nature.com
January 7, 2026 at 12:26 PM
I'm very excited to finally see this one out in @natneuro.nature.com ! It has been an incredible journey alongside extremely talented people! Thanks to everyone involved and enjoy the reading! 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sergi Roig Puiggros
Great @natneuro.nature.com study by @sroig.bsky.social @djabaudon.bsky.social @jbmanent.bsky.social & colleagues,
showing “equivalent circuits can emerge in different spatial configurations, allowing diverse brain architectures to converge on similar functional outcomes” 🧪🧠🧬
showing “equivalent circuits can emerge in different spatial configurations, allowing diverse brain architectures to converge on similar functional outcomes” 🧪🧠🧬
Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience
Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...
www.nature.com
January 1, 2026 at 6:18 PM
Great @natneuro.nature.com study by @sroig.bsky.social @djabaudon.bsky.social @jbmanent.bsky.social & colleagues,
showing “equivalent circuits can emerge in different spatial configurations, allowing diverse brain architectures to converge on similar functional outcomes” 🧪🧠🧬
showing “equivalent circuits can emerge in different spatial configurations, allowing diverse brain architectures to converge on similar functional outcomes” 🧪🧠🧬
Reposted by Sergi Roig Puiggros
Very happy to have contributed to this wonderful/tentacular work alongside so many amazing colleagues and friends!
It opens up new ways of understanding grey matter heterotopia associated with altered cortical function and #epilepsy in humans.
🧠🧪🔥
www.nature.com/articles/s41...
It opens up new ways of understanding grey matter heterotopia associated with altered cortical function and #epilepsy in humans.
🧠🧪🔥
www.nature.com/articles/s41...
Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience
Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...
www.nature.com
January 1, 2026 at 4:52 PM
Very happy to have contributed to this wonderful/tentacular work alongside so many amazing colleagues and friends!
It opens up new ways of understanding grey matter heterotopia associated with altered cortical function and #epilepsy in humans.
🧠🧪🔥
www.nature.com/articles/s41...
It opens up new ways of understanding grey matter heterotopia associated with altered cortical function and #epilepsy in humans.
🧠🧪🔥
www.nature.com/articles/s41...
Reposted by Sergi Roig Puiggros
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Cell-extrinsic controls over neocortical neuron fate and diversity
Cell-extrinsic cues are key for neocortical cell identity and diversity.
www.science.org
September 19, 2025 at 6:04 AM
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Very happy to have contributed to this great story 🧠🚀. It focuses on environment-dependent neuronal identity acquisition in the cortex! Big congrats to Natalia Baumann, Ilaria Morassut and Sabine Fièvre for pushing this w/ @djabaudon.bsky.social. Congrats to all!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Cell-extrinsic controls over neocortical neuron fate and diversity
Cell-extrinsic cues are key for neocortical cell identity and diversity.
www.science.org
September 18, 2025 at 11:30 AM
Very happy to have contributed to this great story 🧠🚀. It focuses on environment-dependent neuronal identity acquisition in the cortex! Big congrats to Natalia Baumann, Ilaria Morassut and Sabine Fièvre for pushing this w/ @djabaudon.bsky.social. Congrats to all!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Sergi Roig Puiggros
Super lab looking for postdoc ... do not miss it! 👇🏼
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
www.upf.edu
September 1, 2025 at 2:13 PM
Super lab looking for postdoc ... do not miss it! 👇🏼
Reposted by Sergi Roig Puiggros
How bats developed their wings? 🦇
Turns out they reutilize existing gene programs 🔧
Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs
www.nature.com/articles/s41...
Turns out they reutilize existing gene programs 🔧
Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs
www.nature.com/articles/s41...
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution
Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...
www.nature.com
July 17, 2025 at 1:47 PM
How bats developed their wings? 🦇
Turns out they reutilize existing gene programs 🔧
Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs
www.nature.com/articles/s41...
Turns out they reutilize existing gene programs 🔧
Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs
www.nature.com/articles/s41...
Reposted by Sergi Roig Puiggros
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the
late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α
partners with ERRγ and Mef2c to ...
www.cell.com
July 16, 2025 at 7:59 AM
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
Reposted by Sergi Roig Puiggros
Thrilled to co-chair Symposium S08: Developmental Origins of Astrocyte Diversity tomorrow at #GLIA2025! Join us for cutting-edge insights into how astrocytes are born , diversify, and shape brain function. Wed, July 9 | 🕙 10:00–12:00 With @loulierk.bsky.social , Maryam Faiz & @sloanlab.bsky.social
July 8, 2025 at 9:25 PM
Thrilled to co-chair Symposium S08: Developmental Origins of Astrocyte Diversity tomorrow at #GLIA2025! Join us for cutting-edge insights into how astrocytes are born , diversify, and shape brain function. Wed, July 9 | 🕙 10:00–12:00 With @loulierk.bsky.social , Maryam Faiz & @sloanlab.bsky.social
Reposted by Sergi Roig Puiggros
✨ Astrocyte diversity starts at the source!
🧬 We uncover how dual radial glia lineages generate distinct astrocyte subtypes in the neocortex — revealed by MERFISH, scRNA-seq & clonal tracing.
📍#GLIA2025 | Poster T10-010A
🧠 w/
@alanzhoujf.bsky.social
in Marseille
Come talk glia with us!
🧬 We uncover how dual radial glia lineages generate distinct astrocyte subtypes in the neocortex — revealed by MERFISH, scRNA-seq & clonal tracing.
📍#GLIA2025 | Poster T10-010A
🧠 w/
@alanzhoujf.bsky.social
in Marseille
Come talk glia with us!
July 8, 2025 at 9:35 AM
✨ Astrocyte diversity starts at the source!
🧬 We uncover how dual radial glia lineages generate distinct astrocyte subtypes in the neocortex — revealed by MERFISH, scRNA-seq & clonal tracing.
📍#GLIA2025 | Poster T10-010A
🧠 w/
@alanzhoujf.bsky.social
in Marseille
Come talk glia with us!
🧬 We uncover how dual radial glia lineages generate distinct astrocyte subtypes in the neocortex — revealed by MERFISH, scRNA-seq & clonal tracing.
📍#GLIA2025 | Poster T10-010A
🧠 w/
@alanzhoujf.bsky.social
in Marseille
Come talk glia with us!
Reposted by Sergi Roig Puiggros
Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
www.nature.com/articles/s41...
1/n
Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience
Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...
www.nature.com
July 8, 2025 at 12:04 PM
Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
www.nature.com/articles/s41...
1/n