Sergi Roig Puiggros
@sroig.bsky.social
Developmental Neurobiology
Postdoc - University of Geneva
Postdoc - University of Geneva
Reposted by Sergi Roig Puiggros
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Cell-extrinsic controls over neocortical neuron fate and diversity
Cell-extrinsic cues are key for neocortical cell identity and diversity.
www.science.org
September 19, 2025 at 6:04 AM
Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...
Very happy to have contributed to this great story 🧠🚀. It focuses on environment-dependent neuronal identity acquisition in the cortex! Big congrats to Natalia Baumann, Ilaria Morassut and Sabine Fièvre for pushing this w/ @djabaudon.bsky.social. Congrats to all!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Cell-extrinsic controls over neocortical neuron fate and diversity
Cell-extrinsic cues are key for neocortical cell identity and diversity.
www.science.org
September 18, 2025 at 11:30 AM
Very happy to have contributed to this great story 🧠🚀. It focuses on environment-dependent neuronal identity acquisition in the cortex! Big congrats to Natalia Baumann, Ilaria Morassut and Sabine Fièvre for pushing this w/ @djabaudon.bsky.social. Congrats to all!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Sergi Roig Puiggros
Super lab looking for postdoc ... do not miss it! 👇🏼
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
www.upf.edu
September 1, 2025 at 2:13 PM
Super lab looking for postdoc ... do not miss it! 👇🏼
Reposted by Sergi Roig Puiggros
How bats developed their wings? 🦇
Turns out they reutilize existing gene programs 🔧
Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs
www.nature.com/articles/s41...
Turns out they reutilize existing gene programs 🔧
Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs
www.nature.com/articles/s41...
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution
Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...
www.nature.com
July 17, 2025 at 1:47 PM
How bats developed their wings? 🦇
Turns out they reutilize existing gene programs 🔧
Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs
www.nature.com/articles/s41...
Turns out they reutilize existing gene programs 🔧
Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs
www.nature.com/articles/s41...
Reposted by Sergi Roig Puiggros
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the
late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α
partners with ERRγ and Mef2c to ...
www.cell.com
July 16, 2025 at 7:59 AM
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social
@wellcometrust.bsky.social
Reposted by Sergi Roig Puiggros
Thrilled to co-chair Symposium S08: Developmental Origins of Astrocyte Diversity tomorrow at #GLIA2025! Join us for cutting-edge insights into how astrocytes are born , diversify, and shape brain function. Wed, July 9 | 🕙 10:00–12:00 With @loulierk.bsky.social , Maryam Faiz & @sloanlab.bsky.social
July 8, 2025 at 9:25 PM
Thrilled to co-chair Symposium S08: Developmental Origins of Astrocyte Diversity tomorrow at #GLIA2025! Join us for cutting-edge insights into how astrocytes are born , diversify, and shape brain function. Wed, July 9 | 🕙 10:00–12:00 With @loulierk.bsky.social , Maryam Faiz & @sloanlab.bsky.social
Reposted by Sergi Roig Puiggros
✨ Astrocyte diversity starts at the source!
🧬 We uncover how dual radial glia lineages generate distinct astrocyte subtypes in the neocortex — revealed by MERFISH, scRNA-seq & clonal tracing.
📍#GLIA2025 | Poster T10-010A
🧠 w/
@alanzhoujf.bsky.social
in Marseille
Come talk glia with us!
🧬 We uncover how dual radial glia lineages generate distinct astrocyte subtypes in the neocortex — revealed by MERFISH, scRNA-seq & clonal tracing.
📍#GLIA2025 | Poster T10-010A
🧠 w/
@alanzhoujf.bsky.social
in Marseille
Come talk glia with us!
July 8, 2025 at 9:35 AM
✨ Astrocyte diversity starts at the source!
🧬 We uncover how dual radial glia lineages generate distinct astrocyte subtypes in the neocortex — revealed by MERFISH, scRNA-seq & clonal tracing.
📍#GLIA2025 | Poster T10-010A
🧠 w/
@alanzhoujf.bsky.social
in Marseille
Come talk glia with us!
🧬 We uncover how dual radial glia lineages generate distinct astrocyte subtypes in the neocortex — revealed by MERFISH, scRNA-seq & clonal tracing.
📍#GLIA2025 | Poster T10-010A
🧠 w/
@alanzhoujf.bsky.social
in Marseille
Come talk glia with us!
Reposted by Sergi Roig Puiggros
Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
www.nature.com/articles/s41...
1/n
Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience
Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...
www.nature.com
July 8, 2025 at 12:04 PM
Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n
www.nature.com/articles/s41...
1/n
Reposted by Sergi Roig Puiggros
We're hiring! Our lab is looking for a postdoc to investigate the #evodevo of #cephalopod brains. Did you recently graduate, and do you want to join our EU #WEAVE project with the Simakov and @simon-sprecher.bsky.social labs? Find the application form👇Thanks for RT 🐙🦑
www.kuleuven.be/personeel/jo...
www.kuleuven.be/personeel/jo...
Postdoctoral researcher in evolutionary developmental neurobiology
Come join our EU cephalopod consortium to discover how octopuses and other coleoids developed their large nervous system. Postdoc position available in the Seuntjens Lab in Leuven, Belgium.
www.kuleuven.be
May 15, 2025 at 10:11 AM
We're hiring! Our lab is looking for a postdoc to investigate the #evodevo of #cephalopod brains. Did you recently graduate, and do you want to join our EU #WEAVE project with the Simakov and @simon-sprecher.bsky.social labs? Find the application form👇Thanks for RT 🐙🦑
www.kuleuven.be/personeel/jo...
www.kuleuven.be/personeel/jo...
Very grateful to have been able to present our work at the @corticodevelopment.bsky.social meeting in Naxos! Thanks putting together such a great line of speakers in this amazing location! 🧠☀️🍕
May 28, 2025 at 12:21 PM
Very grateful to have been able to present our work at the @corticodevelopment.bsky.social meeting in Naxos! Thanks putting together such a great line of speakers in this amazing location! 🧠☀️🍕
Reposted by Sergi Roig Puiggros
Still openings, check it out!
🧠Job Opening!🧠
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
May 28, 2025 at 5:02 AM
Still openings, check it out!
Reposted by Sergi Roig Puiggros
🎉 Excited to share that our paper on FCDII is out today! 🙌🏻 Huge thanks to @sbaulac.bsky.social and @sara baldassari for bringing me on board and introducing me to the complexity of somatic mutations. Hope our work helps advance understanding of the disease mechanisms.
Single-cell genotyping and transcriptomic analysis reveals cell-type specific and non-autonomous effects of mTOR pathway mutations in mosaic focal cortical dysplasia type II (FCDII) 🧠🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia - Nature Neuroscience
In this work, the authors performed a single-cell genotyping and transcriptomics analysis, revealing cell-type-specific and nonautonomous effects of mTOR pathway mutations in mosaic focal cortical dys...
www.nature.com
April 30, 2025 at 7:47 PM
🎉 Excited to share that our paper on FCDII is out today! 🙌🏻 Huge thanks to @sbaulac.bsky.social and @sara baldassari for bringing me on board and introducing me to the complexity of somatic mutations. Hope our work helps advance understanding of the disease mechanisms.
Reposted by Sergi Roig Puiggros
Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social.
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
May 7, 2025 at 3:32 PM
Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social.
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
www.nature.com/articles/s41...
This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu
Reposted by Sergi Roig Puiggros
🚨 We're hiring! A Research Project Manager position is open in our lab at the Institute of Neuroscience (CSIC-UMH, Alicante)! Join us in exploring how spontaneous activity shapes sensory circuits 🧠✨ @glb-lab.bsky.social #Neuroscience #Jobs #ResearchManager
📅 Deadline: May 25
📅 Deadline: May 25
May 6, 2025 at 9:15 AM
🚨 We're hiring! A Research Project Manager position is open in our lab at the Institute of Neuroscience (CSIC-UMH, Alicante)! Join us in exploring how spontaneous activity shapes sensory circuits 🧠✨ @glb-lab.bsky.social #Neuroscience #Jobs #ResearchManager
📅 Deadline: May 25
📅 Deadline: May 25
Reposted by Sergi Roig Puiggros
Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...
May 5, 2025 at 4:52 PM
Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...
Reposted by Sergi Roig Puiggros
Find out more about this exciting initiative from Biology Open in this editorial and the accompanying preprint www.biorxiv.org/content/10.1...
March 25, 2025 at 11:48 AM
Find out more about this exciting initiative from Biology Open in this editorial and the accompanying preprint www.biorxiv.org/content/10.1...
Reposted by Sergi Roig Puiggros
Peer review completed within 7 days!
Paying peer reviewers!
Yes, it's possible.
Fast & Fair peer review by @biologyopen.bsky.social
More innovation from @biologists.bsky.social
Details here: www.biorxiv.org/content/10.1...
Paying peer reviewers!
Yes, it's possible.
Fast & Fair peer review by @biologyopen.bsky.social
More innovation from @biologists.bsky.social
Details here: www.biorxiv.org/content/10.1...
March 25, 2025 at 12:05 PM
Peer review completed within 7 days!
Paying peer reviewers!
Yes, it's possible.
Fast & Fair peer review by @biologyopen.bsky.social
More innovation from @biologists.bsky.social
Details here: www.biorxiv.org/content/10.1...
Paying peer reviewers!
Yes, it's possible.
Fast & Fair peer review by @biologyopen.bsky.social
More innovation from @biologists.bsky.social
Details here: www.biorxiv.org/content/10.1...
Reposted by Sergi Roig Puiggros
📣 Postdoc opportunity !
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏
March 10, 2025 at 8:10 AM
📣 Postdoc opportunity !
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏
Our lab is hiring a funded postdoc to explore the development of fear circuits using slice electrophysiology. If you have expertise in this area and are interested about cutting-edge neuroscience, reach out ! 🤗
klinglerlab.org
Please share with your network 🙏
Reposted by Sergi Roig Puiggros
Super proud of this massive work led by Mar Anibal from the lab. Early rescaling of barrel maps is possible and thanks to a transcriptional switch in thalamic neurons! Check it out!
@neuroalc.bsky.social
@neuroalc.bsky.social
Using a mouse model born without its principal whiskers, researchers found that the brain reshapes its sensory regions before birth. The area for upper lip whiskers expands, compensating for the missing input.
📷 @naturecomms.bsky.social
@csic.es @umh.es @erc.europa.eu @fmiscience.bsky.social
📷 @naturecomms.bsky.social
@csic.es @umh.es @erc.europa.eu @fmiscience.bsky.social
March 6, 2025 at 1:17 PM
Super proud of this massive work led by Mar Anibal from the lab. Early rescaling of barrel maps is possible and thanks to a transcriptional switch in thalamic neurons! Check it out!
@neuroalc.bsky.social
@neuroalc.bsky.social
Reposted by Sergi Roig Puiggros
🌌 The journey into astrocyte diversity doesn’t stop here! Stay tuned for new insights into how their molecular and functional diversity originates during brain development. 🚀 A new story is coming soon—check out our bioRxiv preprint here: www.biorxiv.org/content/10.1...
Dual lineage origins of neocortical astrocytes
Astrocytes represent one of the most abundant cell types in the central nervous system, and play an essential role in nearly all aspects of brain functions[1][1]. Recent studies have challenged the no...
www.biorxiv.org
February 24, 2025 at 4:06 PM
🌌 The journey into astrocyte diversity doesn’t stop here! Stay tuned for new insights into how their molecular and functional diversity originates during brain development. 🚀 A new story is coming soon—check out our bioRxiv preprint here: www.biorxiv.org/content/10.1...
Reposted by Sergi Roig Puiggros
🚀 Think all white matter (WM) astrocytes are the same? Think again! 🌟 Our latest research reveals striking regional differences that challenge existing views on astrocyte diversity and function. 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter - Nature Neuroscience
White matter (WM) astrocytes differ significantly from gray matter astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity, which is absent in cerebellar WM, suggestin...
www.nature.com
February 24, 2025 at 4:06 PM
🚀 Think all white matter (WM) astrocytes are the same? Think again! 🌟 Our latest research reveals striking regional differences that challenge existing views on astrocyte diversity and function. 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sergi Roig Puiggros
White matter (WM) #astrocytes differ significantly from grey matter (GM) astrocytes, with WM
astrocytes in the forebrain exhibiting unique proliferation capacity 🧪🧠
www.nature.com/articles/s41...
astrocytes in the forebrain exhibiting unique proliferation capacity 🧪🧠
www.nature.com/articles/s41...
Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter - Nature Neuroscience
White matter (WM) astrocytes differ significantly from gray matter astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity, which is absent in cerebellar WM, suggestin...
www.nature.com
February 24, 2025 at 8:14 PM
White matter (WM) #astrocytes differ significantly from grey matter (GM) astrocytes, with WM
astrocytes in the forebrain exhibiting unique proliferation capacity 🧪🧠
www.nature.com/articles/s41...
astrocytes in the forebrain exhibiting unique proliferation capacity 🧪🧠
www.nature.com/articles/s41...
Reposted by Sergi Roig Puiggros
Delighted to have this out as a preprint! Thanks to all authors, especially @estherkli.bsky.social and @djabaudon.bsky.social for leading the work. If you are interested in how conserved genes played a part in evolving human brains, give it a read!
✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 20, 2025 at 9:43 AM
Delighted to have this out as a preprint! Thanks to all authors, especially @estherkli.bsky.social and @djabaudon.bsky.social for leading the work. If you are interested in how conserved genes played a part in evolving human brains, give it a read!
Reposted by Sergi Roig Puiggros
✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 20, 2025 at 8:11 AM
✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sergi Roig Puiggros
🧠Job Opening!🧠
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
February 2, 2025 at 9:27 AM
🧠Job Opening!🧠
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!
We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.
Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!