Soldati Lab
@soldatilab.bsky.social
Studying phagocytosis and cell-autonomous defences against mycobacteria
Reposted by Soldati Lab
🚨 New preprint!
Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria
Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬
Check it out: doi.org/10.64898/202...
Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria
Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬
Check it out: doi.org/10.64898/202...
February 12, 2026 at 10:30 AM
🚨 New preprint!
Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria
Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬
Check it out: doi.org/10.64898/202...
Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria
Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬
Check it out: doi.org/10.64898/202...
🎉 Big news! Last Saturday, Thierry was awarded the Egon Naef Foundation Prize for in vitro research 🏆 A wonderful recognition of his innovative work throughout his career developing alternatives to animal testing 👏
www.unige.ch/sciences/chi...
@sciencesunige.bsky.social
www.unige.ch/sciences/chi...
@sciencesunige.bsky.social
February 4, 2026 at 5:19 PM
🎉 Big news! Last Saturday, Thierry was awarded the Egon Naef Foundation Prize for in vitro research 🏆 A wonderful recognition of his innovative work throughout his career developing alternatives to animal testing 👏
www.unige.ch/sciences/chi...
@sciencesunige.bsky.social
www.unige.ch/sciences/chi...
@sciencesunige.bsky.social
🚨 Preprint alert 🚨
In this study, we reveal how a calcium-sensing protein coordinates membrane damage sensing with repair pathways in response to damage from intracellular mycobacteria
Huge congrats to @guallar-garrido.bsky.social for leading this project! 🤩👏
www.biorxiv.org/content/10.6...
In this study, we reveal how a calcium-sensing protein coordinates membrane damage sensing with repair pathways in response to damage from intracellular mycobacteria
Huge congrats to @guallar-garrido.bsky.social for leading this project! 🤩👏
www.biorxiv.org/content/10.6...
February 2, 2026 at 4:50 PM
🚨 Preprint alert 🚨
In this study, we reveal how a calcium-sensing protein coordinates membrane damage sensing with repair pathways in response to damage from intracellular mycobacteria
Huge congrats to @guallar-garrido.bsky.social for leading this project! 🤩👏
www.biorxiv.org/content/10.6...
In this study, we reveal how a calcium-sensing protein coordinates membrane damage sensing with repair pathways in response to damage from intracellular mycobacteria
Huge congrats to @guallar-garrido.bsky.social for leading this project! 🤩👏
www.biorxiv.org/content/10.6...
Reposted by Soldati Lab
🚨 Want to know how we demonstrated the importance of sterol-rich membrane microdomains for M. marinum infection?
Check out our latest paper published in Science Advances 👇
www.science.org/doi/10.1126/...
✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨
Check out our latest paper published in Science Advances 👇
www.science.org/doi/10.1126/...
✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨
Membrane microdomains are crucial for Mycobacterium marinum EsxA-dependent membrane damage, escape to the cytosol, and infection
Sterol-rich microdomain accumulation at the MCV is crucial for Mm-induced damage and infection in D. discoideum and BV-2 cells.
www.science.org
January 4, 2026 at 10:54 AM
🚨 Want to know how we demonstrated the importance of sterol-rich membrane microdomains for M. marinum infection?
Check out our latest paper published in Science Advances 👇
www.science.org/doi/10.1126/...
✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨
Check out our latest paper published in Science Advances 👇
www.science.org/doi/10.1126/...
✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨
New paper out! 🚨
We uncover how Mycobacterium marinum (red) exploits host sterol-rich membrane microdomains (green) to damage and escape from its phagosome
Huge shoutout to @angieprrt.bsky.social and Cristina Bosmani for their very elegant work! 👏
www.science.org/doi/10.1126/...
We uncover how Mycobacterium marinum (red) exploits host sterol-rich membrane microdomains (green) to damage and escape from its phagosome
Huge shoutout to @angieprrt.bsky.social and Cristina Bosmani for their very elegant work! 👏
www.science.org/doi/10.1126/...
January 2, 2026 at 1:03 PM
New paper out! 🚨
We uncover how Mycobacterium marinum (red) exploits host sterol-rich membrane microdomains (green) to damage and escape from its phagosome
Huge shoutout to @angieprrt.bsky.social and Cristina Bosmani for their very elegant work! 👏
www.science.org/doi/10.1126/...
We uncover how Mycobacterium marinum (red) exploits host sterol-rich membrane microdomains (green) to damage and escape from its phagosome
Huge shoutout to @angieprrt.bsky.social and Cristina Bosmani for their very elegant work! 👏
www.science.org/doi/10.1126/...
🏆 It's a double win for the Soldati Lab! Last Friday, our former PhD students @angieprrt.bsky.social and Jahn Nitschke each received an award for their doctoral work: the Laemmli Prize for Angélique and Best Thesis in Life Sciences for Jahn. So proud of both for these well-deserved honors! 🤩
December 8, 2025 at 12:26 PM
🏆 It's a double win for the Soldati Lab! Last Friday, our former PhD students @angieprrt.bsky.social and Jahn Nitschke each received an award for their doctoral work: the Laemmli Prize for Angélique and Best Thesis in Life Sciences for Jahn. So proud of both for these well-deserved honors! 🤩
🚨 Preprint alert 🚨
Don’t miss our latest story on how mycobacterial surface shedding shapes the host response !
Don’t miss our latest story on how mycobacterial surface shedding shapes the host response !
Why would Mycobacterium shed its surface right after entering a host cell? Host phagocytes rapidly strip its outer layer, releasing components that alert neighbors and trigger defense responses
Our preprint is out, curious to hear your take! 👀
www.biorxiv.org/content/10.1...
Our preprint is out, curious to hear your take! 👀
www.biorxiv.org/content/10.1...
November 20, 2025 at 2:47 PM
🚨 Preprint alert 🚨
Don’t miss our latest story on how mycobacterial surface shedding shapes the host response !
Don’t miss our latest story on how mycobacterial surface shedding shapes the host response !
A long journey with a fantastic conclusion! Congrats 🍾🧑🎓
One month ago, I defended my PhD thesis 🎓, the end of a long, intense journey filled with challenges, growth, and resilience. 💪
October 9, 2025 at 3:24 PM
A long journey with a fantastic conclusion! Congrats 🍾🧑🎓
🇻🇳 What a great week at the BPHCI Conference in Vietnam! @j-toinon.bsky.social and @angieprrt.bsky.social enjoyed sharing their results on M. marinum–Dicty interactions. A small crowd, but packed with brilliant science and great vibes! 🥂
October 8, 2025 at 9:51 AM
🇻🇳 What a great week at the BPHCI Conference in Vietnam! @j-toinon.bsky.social and @angieprrt.bsky.social enjoyed sharing their results on M. marinum–Dicty interactions. A small crowd, but packed with brilliant science and great vibes! 🥂
Reposted by Soldati Lab
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance | PNAS
Tuberculosis remains the deadliest infectious disease caused by a single pathogen,
highlighting the urgent need for novel therapies. A deeper under...
www.pnas.org
September 23, 2025 at 3:32 AM
Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org!
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance.
Huge congrats to Wendy & colleagues!
shorturl.at/WbFQC
Reposted by Soldati Lab
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
Nitrate-responsive Mycobacterial Intracytoplasmic Membranes dampen Inflammation during Mycobacterium tuberculosis Infection https://www.biorxiv.org/content/10.1101/2025.09.17.676823v1
September 18, 2025 at 4:58 PM
🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫
Thread coming soon!
Thread coming soon!
Reposted by Soldati Lab
Be our new colleague! 🎉
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.
👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch
Please feel free to share this opportunity with your network.
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.
👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch
Please feel free to share this opportunity with your network.
September 15, 2025 at 2:33 PM
Be our new colleague! 🎉
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.
👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch
Please feel free to share this opportunity with your network.
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.
👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch
Please feel free to share this opportunity with your network.
Reposted by Soldati Lab
Watch @maxgg.bsky.social, Group Leader at the Crick, as he explains what happens to cells that are infected with tuberculosis and how his lab is studying our bodies’ response to this infection.
www.youtube.com/watch?v=VWCt...
www.youtube.com/watch?v=VWCt...
Researching the World’s Deadliest Infectious Disease – with Maximiliano Gutierrez
YouTube video by Francis Crick Institute
www.youtube.com
September 10, 2025 at 3:32 PM
Watch @maxgg.bsky.social, Group Leader at the Crick, as he explains what happens to cells that are infected with tuberculosis and how his lab is studying our bodies’ response to this infection.
www.youtube.com/watch?v=VWCt...
www.youtube.com/watch?v=VWCt...
Long live Dicty! ✨
So grateful for the chance to attend this wonderful meeting one last time. Always a joy to reconnect with old colleagues and friends
So grateful for the chance to attend this wonderful meeting one last time. Always a joy to reconnect with old colleagues and friends
August 19, 2025 at 7:23 AM
Long live Dicty! ✨
So grateful for the chance to attend this wonderful meeting one last time. Always a joy to reconnect with old colleagues and friends
So grateful for the chance to attend this wonderful meeting one last time. Always a joy to reconnect with old colleagues and friends
Reposted by Soldati Lab
How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi!
www.cell.com/current-biol...
www.cell.com/current-biol...
Mosaic evolution of clathrin-mediated endocytosis in fungi
Picco et al. take an evolutionary approach to study clathrin-mediated endocytosis
in a fungal clade and discover that the process is evolving in a mosaic fashion. The
early phase of endocytosis has sh...
www.cell.com
July 10, 2025 at 3:31 PM
How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi!
www.cell.com/current-biol...
www.cell.com/current-biol...
Last week was a fantastic opportunity for @lucasceseti.bsky.social to share his work on Xanthomonas and Dicty at #ETOX25 🦠
The Basque Country was the place to hear great science on toxins🤩
The Basque Country was the place to hear great science on toxins🤩
July 8, 2025 at 2:56 PM
Last week was a fantastic opportunity for @lucasceseti.bsky.social to share his work on Xanthomonas and Dicty at #ETOX25 🦠
The Basque Country was the place to hear great science on toxins🤩
The Basque Country was the place to hear great science on toxins🤩
Reposted by Soldati Lab
Come and Join our Dpt in Beautiful #Geneva !
We are looking for a #Microscopy & #Image #Analysis expert to help all of us at the Dpt.
We are looking for a #Microscopy & #Image #Analysis expert to help all of us at the Dpt.
Hello microscopy and imaging experts and enthusiasts!
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).
Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
We are looking for a staff scientist to join us here in Geneva to work on microscopy and image analysis projects! See the link for the job announcement (in French and in English).
Please apply and/or repost!
jobs.unige.ch/www/wd_porta...
July 8, 2025 at 4:24 AM
Come and Join our Dpt in Beautiful #Geneva !
We are looking for a #Microscopy & #Image #Analysis expert to help all of us at the Dpt.
We are looking for a #Microscopy & #Image #Analysis expert to help all of us at the Dpt.
Check our latest methods chapter on how to use Dictyostelium–Mycobacterium marinum as a high-throughput screening platform for anti-infective compounds 👇
www.frontiersin.org/journals/mic...
@nabilhanna3.bsky.social
www.frontiersin.org/journals/mic...
@nabilhanna3.bsky.social
Frontiers | Dictyosteliumdiscoideum–Mycobacterium marinum infection model: a powerful high-throughput screening platform for anti-infective compounds
Tuberculosis is among the world’s deadliest diseases, causing approximately 2 million deaths annually. The urgent need for new antitubercular drugs has been ...
www.frontiersin.org
July 4, 2025 at 11:26 AM
Check our latest methods chapter on how to use Dictyostelium–Mycobacterium marinum as a high-throughput screening platform for anti-infective compounds 👇
www.frontiersin.org/journals/mic...
@nabilhanna3.bsky.social
www.frontiersin.org/journals/mic...
@nabilhanna3.bsky.social
Last week’s ESCRT meeting was full of great science and engaging discussions! 🤩
Such a great place to share our work on ESCRT during Mycobacterium marinum infection 🦠
Such a great place to share our work on ESCRT during Mycobacterium marinum infection 🦠
July 1, 2025 at 1:10 PM
Last week’s ESCRT meeting was full of great science and engaging discussions! 🤩
Such a great place to share our work on ESCRT during Mycobacterium marinum infection 🦠
Such a great place to share our work on ESCRT during Mycobacterium marinum infection 🦠
Reposted by Soldati Lab
💥 Very excited to share this review in Nature Reviews Microbiology.
Contributing to this review with Val, Digby and Amy was an enlightening experience! Hope people in the community find it useful- we managed to cite around 200 papers...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Contributing to this review with Val, Digby and Amy was an enlightening experience! Hope people in the community find it useful- we managed to cite around 200 papers...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mycobacterium tuberculosis biology, pathogenicity and interaction with the host
Nature Reviews Microbiology - In this Review, Warner, Barczak, Gutierrez and Mizrahi explore essential aspects of Mycobacterium tuberculosis physiology and biology, present recent advances related...
www.nature.com
July 1, 2025 at 6:49 AM
💥 Very excited to share this review in Nature Reviews Microbiology.
Contributing to this review with Val, Digby and Amy was an enlightening experience! Hope people in the community find it useful- we managed to cite around 200 papers...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Contributing to this review with Val, Digby and Amy was an enlightening experience! Hope people in the community find it useful- we managed to cite around 200 papers...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Soldati Lab
Jinich et al. present an important new resource for the Mtb community!
The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB) is an interactive web resource summarizing 150+ published screens.
#MicroSky #Mycobacterium #tuberculosis
onlinelibrary.wiley.com/doi/10.1111/...
The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB) is an interactive web resource summarizing 150+ published screens.
#MicroSky #Mycobacterium #tuberculosis
onlinelibrary.wiley.com/doi/10.1111/...
The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB): A Large‐Scale Guide to Genetic Conditional Essentiality
Mtb transposon sequencing database is a unified resource for exploring conditional gene essentiality in Mycobacterium tuberculosis. By standardizing over 150 transposon sequencing screens, it enables...
onlinelibrary.wiley.com
June 24, 2025 at 11:27 AM
Jinich et al. present an important new resource for the Mtb community!
The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB) is an interactive web resource summarizing 150+ published screens.
#MicroSky #Mycobacterium #tuberculosis
onlinelibrary.wiley.com/doi/10.1111/...
The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB) is an interactive web resource summarizing 150+ published screens.
#MicroSky #Mycobacterium #tuberculosis
onlinelibrary.wiley.com/doi/10.1111/...
🚨 Great story released by @gm-charriere.bsky.social and co.!
They identified and characterised a natural interaction between amoebae and Vibrio, pointing to Paramoeba as a potential reservoir of oyster pathogens 🦪
Congrats! 🥂
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
They identified and characterised a natural interaction between amoebae and Vibrio, pointing to Paramoeba as a potential reservoir of oyster pathogens 🦪
Congrats! 🥂
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
Paramoeba atlantica as a Natural Intracellular Niche for Vibrios in Marine Ecosystems
Various vibrios can colonise a large vacuole called VCV (Vibrio-containing-vacuole) within Paramoeba atlantica. The VCVs acidify and the vibrios multiply and remain alive inside the VCVs for hours. T....
enviromicro-journals.onlinelibrary.wiley.com
June 19, 2025 at 8:19 AM
🚨 Great story released by @gm-charriere.bsky.social and co.!
They identified and characterised a natural interaction between amoebae and Vibrio, pointing to Paramoeba as a potential reservoir of oyster pathogens 🦪
Congrats! 🥂
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
They identified and characterised a natural interaction between amoebae and Vibrio, pointing to Paramoeba as a potential reservoir of oyster pathogens 🦪
Congrats! 🥂
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
🥳🙌
🤩 Last week I successfully defended my PhD!
It was such a special day, made even better by having friends, family, and colleagues there with me. Thanks for all the support and kind words!
Huge thanks to my jury members for the thoughtful feedback and conversations.
@soldatilab.bsky.social
It was such a special day, made even better by having friends, family, and colleagues there with me. Thanks for all the support and kind words!
Huge thanks to my jury members for the thoughtful feedback and conversations.
@soldatilab.bsky.social
June 17, 2025 at 2:01 PM
🥳🙌
What better way to wrap up the Soldati tour than with a fantastic talk from @mel-foulon.bsky.social? 🎤
She enjoyed “shedding” her enthusiasm for Myco lipids with such a brilliant crowd of passionate scientists at #EMBOcellBioHostPath! 🧫✨
She enjoyed “shedding” her enthusiasm for Myco lipids with such a brilliant crowd of passionate scientists at #EMBOcellBioHostPath! 🧫✨
May 29, 2025 at 5:30 PM
What better way to wrap up the Soldati tour than with a fantastic talk from @mel-foulon.bsky.social? 🎤
She enjoyed “shedding” her enthusiasm for Myco lipids with such a brilliant crowd of passionate scientists at #EMBOcellBioHostPath! 🧫✨
She enjoyed “shedding” her enthusiasm for Myco lipids with such a brilliant crowd of passionate scientists at #EMBOcellBioHostPath! 🧫✨
Yesterday, @nabilhanna3.bsky.social had the fantastic opportunity to present one of his projects during another vibrant and successful poster session at #EMBOcellBioHostPath! 👏
Stay tuned for @mel-foulon.bsky.social ‘s talk
Stay tuned for @mel-foulon.bsky.social ‘s talk
May 29, 2025 at 5:44 AM
Yesterday, @nabilhanna3.bsky.social had the fantastic opportunity to present one of his projects during another vibrant and successful poster session at #EMBOcellBioHostPath! 👏
Stay tuned for @mel-foulon.bsky.social ‘s talk
Stay tuned for @mel-foulon.bsky.social ‘s talk