Sofia Ahola
@sofiaahola.bsky.social
Assistant Professor at Uni Birmingham, 🇬🇧 working on mitochondrial diseases, stress signalling, metabolism and ferroptosis.
Hobby science artist 🎨
http://www.sofiaahola.com
PhD 🇫🇮 @helsinkiuni | Postdoc 🇩🇪 @mpiage @cecad
Hobby science artist 🎨
http://www.sofiaahola.com
PhD 🇫🇮 @helsinkiuni | Postdoc 🇩🇪 @mpiage @cecad
Pinned
Sofia Ahola
@sofiaahola.bsky.social
· Nov 21
On the cover #MolecularCell. In this issue Acharya and Demetriades show how #mTORC1 🎈activation mediates its own release from the #lysosomes 🪐🌎. It was my pleasure to bring to life the grand idea from Aishwarya and Costas!
Really interesting results!
Makes you wonder if this could link the role of mitochondria in ageing as well via mtDNA release and cGAS.
Makes you wonder if this could link the role of mitochondria in ageing as well via mtDNA release and cGAS.
Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years?
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
A 30-year long mystery unraveled @ScienceMagazine today!
Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation
www.science.org/doi/10.1126/...
October 9, 2025 at 7:19 PM
Really interesting results!
Makes you wonder if this could link the role of mitochondria in ageing as well via mtDNA release and cGAS.
Makes you wonder if this could link the role of mitochondria in ageing as well via mtDNA release and cGAS.
Lovely news for the summer! My latest artwork was just published on the cover of @cp-cellmetabolism.bsky.social. Incredible science from @daveyboyhod.bsky.social lab! They discovered how pancreatic alpha cells regulate beta cell function via enriched GLP-1 receptor nanodomains.
August 6, 2025 at 1:42 PM
Lovely news for the summer! My latest artwork was just published on the cover of @cp-cellmetabolism.bsky.social. Incredible science from @daveyboyhod.bsky.social lab! They discovered how pancreatic alpha cells regulate beta cell function via enriched GLP-1 receptor nanodomains.
Highland Wink of Arthur's Seat (BIMDG Meeting in Edinburgh) to the Finnish Seaside Juhannus!
From whispering winds of the city below, to the shimmering shores of the Finnish midsummer night, where the sun refuses to set! ⛰️🔥😄
Happy Midsummer everyone!
From whispering winds of the city below, to the shimmering shores of the Finnish midsummer night, where the sun refuses to set! ⛰️🔥😄
Happy Midsummer everyone!
June 26, 2025 at 7:10 PM
Highland Wink of Arthur's Seat (BIMDG Meeting in Edinburgh) to the Finnish Seaside Juhannus!
From whispering winds of the city below, to the shimmering shores of the Finnish midsummer night, where the sun refuses to set! ⛰️🔥😄
Happy Midsummer everyone!
From whispering winds of the city below, to the shimmering shores of the Finnish midsummer night, where the sun refuses to set! ⛰️🔥😄
Happy Midsummer everyone!
This time science inspired collage workshop that @jonwolfmueller.bsky.social conceptualized for the students @unibirmingham.bsky.social
June 10, 2025 at 7:23 PM
This time science inspired collage workshop that @jonwolfmueller.bsky.social conceptualized for the students @unibirmingham.bsky.social
First time as a lecturer in Mitochondrial Summer School! It’s been a while since I got to enjoy the talks as a student. Had fantastic time meeting friends, making new ones and discussing everything mitochondria. Thank you @unioulu.bsky.social and FibroHealth for the lovely time at Rokua, Finland!
June 2, 2025 at 11:25 AM
First time as a lecturer in Mitochondrial Summer School! It’s been a while since I got to enjoy the talks as a student. Had fantastic time meeting friends, making new ones and discussing everything mitochondria. Thank you @unioulu.bsky.social and FibroHealth for the lovely time at Rokua, Finland!
Reposted by Sofia Ahola
Muscle needs to make serine from glucose to protect the fibers from mitochondrial disease. Read our story, a tour de force of Anastasiia Marmyleva and Christopher Jackson @SWAN @STEMM Helsinki University www.cell.com/cell-reports...
De novo serine biosynthesis is protective in mitochondrial disease
Jackson et al. show that serine becomes an essential amino acid in mitochondrial muscle
disease, delaying disease progression. Blocking local biosynthesis of serine challenges
cellular phospholipid ho...
www.cell.com
May 16, 2025 at 3:00 PM
Muscle needs to make serine from glucose to protect the fibers from mitochondrial disease. Read our story, a tour de force of Anastasiia Marmyleva and Christopher Jackson @SWAN @STEMM Helsinki University www.cell.com/cell-reports...
Reposted by Sofia Ahola
I had the chance to host an art workshop for our postgraduate students at MSS @unibirmingham.bsky.social with @jonwolfmueller.bsky.social
It was a great opportunity to combine science and art and enjoy some time together. 🎨 🧪 🧫 🧠
Thanks to everyone who joined — it was an inspiring and fun evening!
It was a great opportunity to combine science and art and enjoy some time together. 🎨 🧪 🧫 🧠
Thanks to everyone who joined — it was an inspiring and fun evening!
April 28, 2025 at 1:01 PM
I had the chance to host an art workshop for our postgraduate students at MSS @unibirmingham.bsky.social with @jonwolfmueller.bsky.social
It was a great opportunity to combine science and art and enjoy some time together. 🎨 🧪 🧫 🧠
Thanks to everyone who joined — it was an inspiring and fun evening!
It was a great opportunity to combine science and art and enjoy some time together. 🎨 🧪 🧫 🧠
Thanks to everyone who joined — it was an inspiring and fun evening!
Reposted by Sofia Ahola
Reposted by Sofia Ahola
Clinically translatable mitochondrial #GeneTherapy in muscle using tandem mtZFN architecture.
By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social
🗞️ doi.org/10.1038/s443...
Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...
By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social
🗞️ doi.org/10.1038/s443...
Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...
April 11, 2025 at 2:36 PM
Clinically translatable mitochondrial #GeneTherapy in muscle using tandem mtZFN architecture.
By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social
🗞️ doi.org/10.1038/s443...
Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...
By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social
🗞️ doi.org/10.1038/s443...
Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...
Reposted by Sofia Ahola
Huge congrats to Pavel Nash on publishing his PhD work! 🎉 We showcase a safer mtDNA gene therapy using a novel mtZFN architecture compatible with a single AAV. Thanks to the entire team! @mrc-mbu.bsky.social
@mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA
www.embopress.org/doi/full/10....
@mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA
www.embopress.org/doi/full/10....
Clinically translatable mitochondrial gene therapy in muscle using tandem mtZFN architecture | EMBO Molecular Medicine
imageimageEfficient mitochondrial gene therapy is achieved with a novel tandem zinc finger nuclease (mtZFN) architecture delivered via adeno-associated viral (AAV) vectors, significantly reducing mutation loads in muscle tissue and rescuing ...
www.embopress.org
April 9, 2025 at 7:10 PM
Huge congrats to Pavel Nash on publishing his PhD work! 🎉 We showcase a safer mtDNA gene therapy using a novel mtZFN architecture compatible with a single AAV. Thanks to the entire team! @mrc-mbu.bsky.social
@mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA
www.embopress.org/doi/full/10....
@mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA
www.embopress.org/doi/full/10....
Reposted by Sofia Ahola
Application deadline approaching fast! If you are a PhD student or a postdoc register for this summer school in the happiest country in the world. Amazing program, amazing people, amazing place! ssl.eventilla.com/mitochondria...
Mitochondria Summer School
ssl.eventilla.com
April 9, 2025 at 6:51 AM
Application deadline approaching fast! If you are a PhD student or a postdoc register for this summer school in the happiest country in the world. Amazing program, amazing people, amazing place! ssl.eventilla.com/mitochondria...
What a lovely paper from @dplamartin.bsky.social and his team! Mechanistic insight to mtDNA turnover at the lysosomes. 📬
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
www.science.org
April 5, 2025 at 7:16 AM
What a lovely paper from @dplamartin.bsky.social and his team! Mechanistic insight to mtDNA turnover at the lysosomes. 📬
Reposted by Sofia Ahola
📌UK Funding Opportunities After Brexit: Experiences and Practical Guidance
🎙️Sofia Ahola, Vitória Baptista, Selin Tüzüner
🗓️13.3. 7:00 PM CET
🔗https://us06web.zoom.us/webinar/register/WN_6EmZmK8kSSaueDtQWhLz9A
➡ Network: network.febs.org/posts/febs-j...
#YoungFEBS #onlinetalk #funding #career
🎙️Sofia Ahola, Vitória Baptista, Selin Tüzüner
🗓️13.3. 7:00 PM CET
🔗https://us06web.zoom.us/webinar/register/WN_6EmZmK8kSSaueDtQWhLz9A
➡ Network: network.febs.org/posts/febs-j...
#YoungFEBS #onlinetalk #funding #career
March 10, 2025 at 7:36 PM
📌UK Funding Opportunities After Brexit: Experiences and Practical Guidance
🎙️Sofia Ahola, Vitória Baptista, Selin Tüzüner
🗓️13.3. 7:00 PM CET
🔗https://us06web.zoom.us/webinar/register/WN_6EmZmK8kSSaueDtQWhLz9A
➡ Network: network.febs.org/posts/febs-j...
#YoungFEBS #onlinetalk #funding #career
🎙️Sofia Ahola, Vitória Baptista, Selin Tüzüner
🗓️13.3. 7:00 PM CET
🔗https://us06web.zoom.us/webinar/register/WN_6EmZmK8kSSaueDtQWhLz9A
➡ Network: network.febs.org/posts/febs-j...
#YoungFEBS #onlinetalk #funding #career
Reposted by Sofia Ahola
🌍Euromit 2026 is coming to Angers!🌍
✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨
📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬
✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨
📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬
February 3, 2025 at 8:46 AM
🌍Euromit 2026 is coming to Angers!🌍
✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨
📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬
✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨
📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬
Reposted by Sofia Ahola
Today is #RareDiseaseDay
Did you know there's still no cure for #mitochondrialdisease?
@lilyfoundation.bsky.social are fighting to change this. We've invested over £3 million in research since 2007
Please help us to raise awareness of mito
Find out more
www.thelilyfoundation.org.uk
Did you know there's still no cure for #mitochondrialdisease?
@lilyfoundation.bsky.social are fighting to change this. We've invested over £3 million in research since 2007
Please help us to raise awareness of mito
Find out more
www.thelilyfoundation.org.uk
February 28, 2025 at 9:49 AM
Today is #RareDiseaseDay
Did you know there's still no cure for #mitochondrialdisease?
@lilyfoundation.bsky.social are fighting to change this. We've invested over £3 million in research since 2007
Please help us to raise awareness of mito
Find out more
www.thelilyfoundation.org.uk
Did you know there's still no cure for #mitochondrialdisease?
@lilyfoundation.bsky.social are fighting to change this. We've invested over £3 million in research since 2007
Please help us to raise awareness of mito
Find out more
www.thelilyfoundation.org.uk
Reposted by Sofia Ahola
Ahead of #RareDiseaseDay, please join us to educate and increase awareness about rare mitochondrial diseases
Getting mito in the public eye helps drive research, boost donations and improve clinical care for those affected
Please share to advance rare
www.thelilyfoundation.org.uk/affected-by-...
Getting mito in the public eye helps drive research, boost donations and improve clinical care for those affected
Please share to advance rare
www.thelilyfoundation.org.uk/affected-by-...
February 26, 2025 at 2:21 PM
Ahead of #RareDiseaseDay, please join us to educate and increase awareness about rare mitochondrial diseases
Getting mito in the public eye helps drive research, boost donations and improve clinical care for those affected
Please share to advance rare
www.thelilyfoundation.org.uk/affected-by-...
Getting mito in the public eye helps drive research, boost donations and improve clinical care for those affected
Please share to advance rare
www.thelilyfoundation.org.uk/affected-by-...
Nature, Science, Sauna, Mitochondria. Great line up of speakers! 😀
💚 Mitochondria Summer School in Finland May2025! 💚
www.oulu.fi/en/events/mi...
💚 Mitochondria Summer School in Finland May2025! 💚
www.oulu.fi/en/events/mi...
Mitochondria Summer School in Rokua
Join us for an immersive week at the Mitochondria Summer School 2025, where leading experts and researchers will explore cutting-edge topics in mitochondrial biology!
www.oulu.fi
February 21, 2025 at 2:41 PM
Nature, Science, Sauna, Mitochondria. Great line up of speakers! 😀
💚 Mitochondria Summer School in Finland May2025! 💚
www.oulu.fi/en/events/mi...
💚 Mitochondria Summer School in Finland May2025! 💚
www.oulu.fi/en/events/mi...
Astonishing paper that makes you question if you truly understand #mitochondrial dynamics 😅 The complexity of Parkin, Oma1, Opa1, Mfn1 in coordinating mitochondrial fitness. The story of Megamitochondria with MegaDNA and an overwhelming amount of mouse crosses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1 - Nature
We find that, in mice, although the individual loss of Parkin or OMA1 does not affect mitochondrial integrity, their combined loss results in small body size, low locomotor activity, premature death, ...
www.nature.com
February 20, 2025 at 9:46 AM
Astonishing paper that makes you question if you truly understand #mitochondrial dynamics 😅 The complexity of Parkin, Oma1, Opa1, Mfn1 in coordinating mitochondrial fitness. The story of Megamitochondria with MegaDNA and an overwhelming amount of mouse crosses
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Supporting #bcfcwomen to victory! 💙 @unibirmingham.bsky.social is the official partner of the Blues now
February 17, 2025 at 11:48 AM
Supporting #bcfcwomen to victory! 💙 @unibirmingham.bsky.social is the official partner of the Blues now
Such a great pleasure to host @dplamartin.bsky.social at UoB! A day full of cool science about #mitochondria, #endosomes and #mtDNA! Thank you for the visit!
Lovely visit to @unibirmingham.bsky.social . Thanks to my host @sofiaahola.bsky.social and to the best campus tour guide possible @jonwolfmueller.bsky.social. See you soon!
February 14, 2025 at 11:40 AM
Such a great pleasure to host @dplamartin.bsky.social at UoB! A day full of cool science about #mitochondria, #endosomes and #mtDNA! Thank you for the visit!
Great scientist and a person! Can highly recommend! 👏🏻👏🏻👏🏻
Very happy to share that my research group has launched at the German Diabetes Center (DDZ) in Düsseldorf!
We're looking for a PhD student to study the effects of inter-tissue communication on energy balance and metabolic health. Interested? Get in touch!
ddz.de/en/job/docto...
We're looking for a PhD student to study the effects of inter-tissue communication on energy balance and metabolic health. Interested? Get in touch!
ddz.de/en/job/docto...
Doctoral Student (PhD/Dr. rer. nat., m/f/div., E13 TV-L 65%) - Deutsches Diabetes-Zentrum (DDZ)
A job-opening of the German Diabetes-Center (DDZ). (24681)
ddz.de
February 13, 2025 at 2:30 PM
Great scientist and a person! Can highly recommend! 👏🏻👏🏻👏🏻
Happy International Day of Women and Girls in Science 🔬🧬🧪
There are two of us behing this door 👩🏼🔬👩🏻🔬 @mashauob.bsky.social and many more @unibirmingham.bsky.social
#WomeninSTEM #WomenInScience
There are two of us behing this door 👩🏼🔬👩🏻🔬 @mashauob.bsky.social and many more @unibirmingham.bsky.social
#WomeninSTEM #WomenInScience
February 11, 2025 at 11:31 AM
Happy International Day of Women and Girls in Science 🔬🧬🧪
There are two of us behing this door 👩🏼🔬👩🏻🔬 @mashauob.bsky.social and many more @unibirmingham.bsky.social
#WomeninSTEM #WomenInScience
There are two of us behing this door 👩🏼🔬👩🏻🔬 @mashauob.bsky.social and many more @unibirmingham.bsky.social
#WomeninSTEM #WomenInScience
Reposted by Sofia Ahola
Such a pleasure to show around our guest @martazaninello.bsky.social at the beautiful #Edgbaston campus...
We did both, the "known" selfie-spots, and some secret ones...
@unibirmingham.bsky.social
@sofiaahola.bsky.social
We did both, the "known" selfie-spots, and some secret ones...
@unibirmingham.bsky.social
@sofiaahola.bsky.social
February 6, 2025 at 6:18 PM
Such a pleasure to show around our guest @martazaninello.bsky.social at the beautiful #Edgbaston campus...
We did both, the "known" selfie-spots, and some secret ones...
@unibirmingham.bsky.social
@sofiaahola.bsky.social
We did both, the "known" selfie-spots, and some secret ones...
@unibirmingham.bsky.social
@sofiaahola.bsky.social
Always good to talk more about #mitochondria! It was my great pleasure to have @martazaninello.bsky.social to visit us in @unibirmingham.bsky.social and give a seminar on RNA-binding proteins, axons and mitochondria!
💚 Even Old Joe was #GreenForMito and #mitoaware 💚
💚 Even Old Joe was #GreenForMito and #mitoaware 💚
February 6, 2025 at 12:47 PM
Always good to talk more about #mitochondria! It was my great pleasure to have @martazaninello.bsky.social to visit us in @unibirmingham.bsky.social and give a seminar on RNA-binding proteins, axons and mitochondria!
💚 Even Old Joe was #GreenForMito and #mitoaware 💚
💚 Even Old Joe was #GreenForMito and #mitoaware 💚