Stefan Pöhlmann
@snpoehlm.bsky.social
Viruses & Proteases, Head of Infection Biology Unit, Deutsches Primatenzentrum, @primatenzentrum.bsky.social, Decoding viral entry, Tracking SARS-CoV-2 variants, https://linktr.ee/snpoehlm, Views are my own
Pinned
Stefan Pöhlmann
@snpoehlm.bsky.social
· Oct 28
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
The emerging SARS-coronavirus 2 (SARS-CoV-2) threatens public health. Hoffmann and
coworkers show that SARS-CoV-2 infection depends on the host cell factors ACE2 and
TMPRSS2 and can be blocked by a cl...
www.cell.com
Our starting point
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor: Cell www.cell.com/cell/fulltex...
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor: Cell www.cell.com/cell/fulltex...
Reposted by Stefan Pöhlmann
BA.3.2 reaches for thee first time HK
February 4, 2026 at 2:15 PM
BA.3.2 reaches for thee first time HK
44 new sequences from Scotland.
BA.3.2* frequency has plateaued at a high level.
For Jan 19–25, frequency is 50%, but sample numbers are low.
BA.3.2* frequency has plateaued at a high level.
For Jan 19–25, frequency is 50%, but sample numbers are low.
February 3, 2026 at 2:08 PM
44 new sequences from Scotland.
BA.3.2* frequency has plateaued at a high level.
For Jan 19–25, frequency is 50%, but sample numbers are low.
BA.3.2* frequency has plateaued at a high level.
For Jan 19–25, frequency is 50%, but sample numbers are low.
First BA.3.2* detected in New Zealand 🇳🇿 on Dec 5, 2025.
No appreciable expansion observed since then; counts remain low with no growth signal.
No appreciable expansion observed since then; counts remain low with no growth signal.
February 3, 2026 at 11:08 AM
First BA.3.2* detected in New Zealand 🇳🇿 on Dec 5, 2025.
No appreciable expansion observed since then; counts remain low with no growth signal.
No appreciable expansion observed since then; counts remain low with no growth signal.
10 new sequences from New South Wales 🇦🇺.
BA.3.2* frequency continues to decline, but sample numbers remain very low - no firm conclusions yet.
If the trend persists, we’ll need to see whether the variant co-circulates (as observed in South Africa) or fades out entirely.
BA.3.2* frequency continues to decline, but sample numbers remain very low - no firm conclusions yet.
If the trend persists, we’ll need to see whether the variant co-circulates (as observed in South Africa) or fades out entirely.
February 3, 2026 at 10:56 AM
10 new sequences from New South Wales 🇦🇺.
BA.3.2* frequency continues to decline, but sample numbers remain very low - no firm conclusions yet.
If the trend persists, we’ll need to see whether the variant co-circulates (as observed in South Africa) or fades out entirely.
BA.3.2* frequency continues to decline, but sample numbers remain very low - no firm conclusions yet.
If the trend persists, we’ll need to see whether the variant co-circulates (as observed in South Africa) or fades out entirely.
BA.3.2 might mark a step towards endemic coronaviruses rather than the next dominant variant.
BA.3.2 is behaving differently than any of the other variants we've seen.
I've been wondering for some time if this is our first example of co-circulation, where only part of the population is susceptable to infection. It is starting to look stabilized in Germany, does not look like a sweep.
I've been wondering for some time if this is our first example of co-circulation, where only part of the population is susceptable to infection. It is starting to look stabilized in Germany, does not look like a sweep.
February 1, 2026 at 11:04 PM
BA.3.2 might mark a step towards endemic coronaviruses rather than the next dominant variant.
A perspective article in EID on the health threats posed by Influenza D and canine coronavirus, highlighting zoonotic risk and the importance of surveillance at the animal-human interface. #OneHealth #PublicHealth
wwwnc.cdc.gov/eid/article/32…
wwwnc.cdc.gov/eid/article/32…
https://wwwnc.cdc.gov/eid/article/32…
February 1, 2026 at 12:55 PM
A perspective article in EID on the health threats posed by Influenza D and canine coronavirus, highlighting zoonotic risk and the importance of surveillance at the animal-human interface. #OneHealth #PublicHealth
wwwnc.cdc.gov/eid/article/32…
wwwnc.cdc.gov/eid/article/32…
Independent AI agents running on single PCs were given a shared platform to talk to each other. They used it to generate websites, contents - and even their own religion?!
So relieved that ChatGPT tells me this is not concerning….
So relieved that ChatGPT tells me this is not concerning….
February 1, 2026 at 11:12 AM
Independent AI agents running on single PCs were given a shared platform to talk to each other. They used it to generate websites, contents - and even their own religion?!
So relieved that ChatGPT tells me this is not concerning….
So relieved that ChatGPT tells me this is not concerning….
Rejecting Decades of Science, Vaccine Panel Chair Says Polio and Other Shots Should Be Optional www.nytimes.com/2026/01/23/h...
Rejecting Decades of Science, Vaccine Panel Chair Says Polio and Other Shots Should Be Optional
www.nytimes.com
January 31, 2026 at 11:16 PM
Rejecting Decades of Science, Vaccine Panel Chair Says Polio and Other Shots Should Be Optional www.nytimes.com/2026/01/23/h...
Long COVID is here to stay—even in children - The Lancet Infectious Diseases www.thelancet.com/journals/lan...
Long COVID is here to stay—even in children
Post-acute sequelae of SARS-CoV-2 infection (PASC, also known as long COVID) are complex,
multisystem, long-lasting complications of SARS-CoV-2 infection that profoundly impact
the daily life of those...
www.thelancet.com
January 31, 2026 at 4:12 PM
Long COVID is here to stay—even in children - The Lancet Infectious Diseases www.thelancet.com/journals/lan...
Reposted by Stefan Pöhlmann
First evidence in Europe of highly pathogenic avian influenza virus H5N1 infection in a dairy cow. Antibodies against H5N1 detected in a cow with mastitis and respiratory signs on a Dutch dairy farm at the end of December. A cat on that farm had died from H5N1. www.tweedekamer.nl/downloads/do...
January 23, 2026 at 9:26 PM
First evidence in Europe of highly pathogenic avian influenza virus H5N1 infection in a dairy cow. Antibodies against H5N1 detected in a cow with mastitis and respiratory signs on a Dutch dairy farm at the end of December. A cat on that farm had died from H5N1. www.tweedekamer.nl/downloads/do...
Also seeing a decrease in BA.3.2* frequency in Denmark 🇩🇰 for the week Jan 5–11. Whether this represents a true trend reversal remains to be seen. For the following week, BA.3.2* frequency is currently ~50%, but based on only 4 samples.
January 29, 2026 at 11:36 AM
Also seeing a decrease in BA.3.2* frequency in Denmark 🇩🇰 for the week Jan 5–11. Whether this represents a true trend reversal remains to be seen. For the following week, BA.3.2* frequency is currently ~50%, but based on only 4 samples.
Surprising: Marked drop in BA.3.2* frequency in Western Australia, for the second time in a row. Sample numbers are extremely low, so conclusions are shaky — but this may indicate a trend reversal.
January 29, 2026 at 11:35 AM
Surprising: Marked drop in BA.3.2* frequency in Western Australia, for the second time in a row. Sample numbers are extremely low, so conclusions are shaky — but this may indicate a trend reversal.
Reposted by Stefan Pöhlmann
So far there has only been one US patient reported with BA.3.2.
Meanwhile, these are the wastewater detections to date.
Want to know what's really going on? Check the wastewater; we don't miss shit.
Meanwhile, these are the wastewater detections to date.
Want to know what's really going on? Check the wastewater; we don't miss shit.
January 28, 2026 at 6:01 PM
So far there has only been one US patient reported with BA.3.2.
Meanwhile, these are the wastewater detections to date.
Want to know what's really going on? Check the wastewater; we don't miss shit.
Meanwhile, these are the wastewater detections to date.
Want to know what's really going on? Check the wastewater; we don't miss shit.
25 new sequences from Ireland 🇮🇪, ~75% are BA.3.2
Almost 60% Jan 5-11 but very low sample numbers
Almost 60% Jan 5-11 but very low sample numbers
January 27, 2026 at 5:19 PM
25 new sequences from Ireland 🇮🇪, ~75% are BA.3.2
Almost 60% Jan 5-11 but very low sample numbers
Almost 60% Jan 5-11 but very low sample numbers
14 sequences from Western Australia; 1 BA.3.2*.
No BA.3.2* detected from Jan 5-11, despite ~50% frequencies in December.
Unexpected - yes. Meaningful - likey not at this point, given the very low overall sample numbers.
No BA.3.2* detected from Jan 5-11, despite ~50% frequencies in December.
Unexpected - yes. Meaningful - likey not at this point, given the very low overall sample numbers.
January 27, 2026 at 3:41 PM
14 sequences from Western Australia; 1 BA.3.2*.
No BA.3.2* detected from Jan 5-11, despite ~50% frequencies in December.
Unexpected - yes. Meaningful - likey not at this point, given the very low overall sample numbers.
No BA.3.2* detected from Jan 5-11, despite ~50% frequencies in December.
Unexpected - yes. Meaningful - likey not at this point, given the very low overall sample numbers.
60 new sequences from Germany 🇩🇪, 40% are BA3.2*. Update for December 1-21, 2025:
January 26, 2026 at 11:17 PM
60 new sequences from Germany 🇩🇪, 40% are BA3.2*. Update for December 1-21, 2025:
60 new sequences from Germany 🇩🇪, 40% are BA3.2*. Update for December 1-21, 2025:
January 26, 2026 at 6:26 PM
60 new sequences from Germany 🇩🇪, 40% are BA3.2*. Update for December 1-21, 2025:
48 new sequences from Scotland, roughly 30% are BA.3.2.
January 26, 2026 at 2:53 PM
48 new sequences from Scotland, roughly 30% are BA.3.2.
BA.3.2* has been detected in Northern Ireland. Roughly 35% of new sequences submitted to GISAID are BA.3.2*.
January 26, 2026 at 2:52 PM
BA.3.2* has been detected in Northern Ireland. Roughly 35% of new sequences submitted to GISAID are BA.3.2*.
24 new sequences from England, roughly 30% are BA.3.2*
3 out of 41 new sequences from England are BA.3.2*. 2 x RE.1.1 and 1 x RE.2.2
January 26, 2026 at 2:52 PM
24 new sequences from England, roughly 30% are BA.3.2*
Roughly 10% of new sequences from Wales 🏴(n = 50) are BA.3.2*
January 26, 2026 at 2:51 PM
Roughly 10% of new sequences from Wales 🏴(n = 50) are BA.3.2*
94 new sequences from Luxembourg 🇱🇺, 6 are BA.3.2*
January 25, 2026 at 11:51 PM
94 new sequences from Luxembourg 🇱🇺, 6 are BA.3.2*
15 new sequences from Ireland 🇮🇪 submitted over the weekend, 6 are BA.3.2*
Roughly 25 % (3 of 13) of SARS-CoV-2 sequences from Ireland submitted to GISAID today are BA.3.2.2.
🎃
🎃
January 25, 2026 at 11:50 PM
15 new sequences from Ireland 🇮🇪 submitted over the weekend, 6 are BA.3.2*
Bird flu antibodies found in cow in the Netherlands, a first outside of U.S. | Science | AAAS www.science.org/content/arti...
Bird flu antibodies found in cow in the Netherlands, a first outside of U.S.
Dead cat led to discovery, but officials stress no further spread of H5N1 has been detected
www.science.org
January 24, 2026 at 8:35 AM
Bird flu antibodies found in cow in the Netherlands, a first outside of U.S. | Science | AAAS www.science.org/content/arti...
BA.3.2 has been detected in South Korea 🇰🇷. EPI_ISL_20333204, RE.1.1
January 23, 2026 at 9:28 AM
BA.3.2 has been detected in South Korea 🇰🇷. EPI_ISL_20333204, RE.1.1