Sarah Gallois-Montbrun
@sarahgalloism.bsky.social
Group leader, CR INSERM, Institut Cochin, Paris. Molecular virologist with a focus on HIV, SARS-CoV-2 and RNA research.
Reposted by Sarah Gallois-Montbrun
Thanks to all the team Marjory Palaric, Margaux Versapuech, @delphinej.bsky.social, @corentinaube.bsky.social , @sarahgalloism.bsky.social
and collaborators Jacques Dutrieux, Jean-Christophe Paillart, the proteom'ic plateform
@institutcochin.bsky.social
@inserm.fr
@cnrs.fr
@upcite.bsky.social
and collaborators Jacques Dutrieux, Jean-Christophe Paillart, the proteom'ic plateform
@institutcochin.bsky.social
@inserm.fr
@cnrs.fr
@upcite.bsky.social
November 4, 2025 at 10:05 AM
Thanks to all the team Marjory Palaric, Margaux Versapuech, @delphinej.bsky.social, @corentinaube.bsky.social , @sarahgalloism.bsky.social
and collaborators Jacques Dutrieux, Jean-Christophe Paillart, the proteom'ic plateform
@institutcochin.bsky.social
@inserm.fr
@cnrs.fr
@upcite.bsky.social
and collaborators Jacques Dutrieux, Jean-Christophe Paillart, the proteom'ic plateform
@institutcochin.bsky.social
@inserm.fr
@cnrs.fr
@upcite.bsky.social
Reposted by Sarah Gallois-Montbrun
Excited to share our new publication about how GABARAP #autophagy proteins regulate #HIV genomic RNA packaging.
Link to the article ⬇️
doi.org/10.1038/s443...
Thank you to @anrs-mie.bsky.social, @sidaction.bsky.social @frm-officiel.bsky.social for supporting our work.
@institutcochin.bsky.social
Link to the article ⬇️
doi.org/10.1038/s443...
Thank you to @anrs-mie.bsky.social, @sidaction.bsky.social @frm-officiel.bsky.social for supporting our work.
@institutcochin.bsky.social
November 4, 2025 at 10:05 AM
Excited to share our new publication about how GABARAP #autophagy proteins regulate #HIV genomic RNA packaging.
Link to the article ⬇️
doi.org/10.1038/s443...
Thank you to @anrs-mie.bsky.social, @sidaction.bsky.social @frm-officiel.bsky.social for supporting our work.
@institutcochin.bsky.social
Link to the article ⬇️
doi.org/10.1038/s443...
Thank you to @anrs-mie.bsky.social, @sidaction.bsky.social @frm-officiel.bsky.social for supporting our work.
@institutcochin.bsky.social
Reposted by Sarah Gallois-Montbrun
Clarisse Berlioz-Torrent @cberlioztorrent.bsky.social @institutcochin.bsky.social @upcite.bsky.social and co-workers @unistra.fr report that GABARAP #autophagy proteins regulate the packaging of #HIV-1 genomic RNA into infectious #virions. #virology
-> www.embopress.org/doi/full/10....
-> www.embopress.org/doi/full/10....
November 1, 2025 at 9:14 AM
Clarisse Berlioz-Torrent @cberlioztorrent.bsky.social @institutcochin.bsky.social @upcite.bsky.social and co-workers @unistra.fr report that GABARAP #autophagy proteins regulate the packaging of #HIV-1 genomic RNA into infectious #virions. #virology
-> www.embopress.org/doi/full/10....
-> www.embopress.org/doi/full/10....
Reposted by Sarah Gallois-Montbrun
I am so proud of @jezcarlton.bsky.social . What a magnificent inaugural lecture, many congratulations Professor Carlton!
July 16, 2025 at 10:14 PM
I am so proud of @jezcarlton.bsky.social . What a magnificent inaugural lecture, many congratulations Professor Carlton!
Reposted by Sarah Gallois-Montbrun
transiently associates with them, and induces their retrograde transport via dynein and the microtubule network toward a perinuclear region near the microtubule-organizing center (MTOC), where the vRNPs remain sequestered.
October 7, 2025 at 6:26 PM
transiently associates with them, and induces their retrograde transport via dynein and the microtubule network toward a perinuclear region near the microtubule-organizing center (MTOC), where the vRNPs remain sequestered.
Reposted by Sarah Gallois-Montbrun
Contrary to previous assumptions, we show in this study that the human restriction factor MX1 most potently inhibits human influenza A viruses during the late stages of replication. MX1 appears to sense trafficking viral ribonucleoproteins (vRNPs) en route to the plasma membrane,
October 7, 2025 at 6:26 PM
Contrary to previous assumptions, we show in this study that the human restriction factor MX1 most potently inhibits human influenza A viruses during the late stages of replication. MX1 appears to sense trafficking viral ribonucleoproteins (vRNPs) en route to the plasma membrane,
Reposted by Sarah Gallois-Montbrun
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS
Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza
A virus (IAV) transcription/replication process. Herein,...
www.pnas.org
October 7, 2025 at 6:26 PM
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Reposted by Sarah Gallois-Montbrun
Pleased to announce launching Institut Cochin Foundation, on Sept. 18 at 6 p.m., upon registration, either in the Rosalind Franklin room, 22 rue Méchain, Paris or via video conference: presentation of @institutcochin.bsky.social, meet researchers and call for donations-thanks for your support!
September 6, 2025 at 6:46 AM
Pleased to announce launching Institut Cochin Foundation, on Sept. 18 at 6 p.m., upon registration, either in the Rosalind Franklin room, 22 rue Méchain, Paris or via video conference: presentation of @institutcochin.bsky.social, meet researchers and call for donations-thanks for your support!
Reposted by Sarah Gallois-Montbrun
🎊🎉🎊🎉🎊🎉🎊🎉🎊🎉
Pleased to announce the start of the Institut Cochin Foundation !
On September 18th at 6 p.m., upon registration come or connect to learn about the fantastic research done at the Institut Cochin @institutcochin.bsky.social , meet the people that do it and call for donations!
Pleased to announce the start of the Institut Cochin Foundation !
On September 18th at 6 p.m., upon registration come or connect to learn about the fantastic research done at the Institut Cochin @institutcochin.bsky.social , meet the people that do it and call for donations!
September 11, 2025 at 6:32 PM
🎊🎉🎊🎉🎊🎉🎊🎉🎊🎉
Pleased to announce the start of the Institut Cochin Foundation !
On September 18th at 6 p.m., upon registration come or connect to learn about the fantastic research done at the Institut Cochin @institutcochin.bsky.social , meet the people that do it and call for donations!
Pleased to announce the start of the Institut Cochin Foundation !
On September 18th at 6 p.m., upon registration come or connect to learn about the fantastic research done at the Institut Cochin @institutcochin.bsky.social , meet the people that do it and call for donations!
🦠🦠🦠New paper out in JBC! Argonaute 1 contributes to HIV-1 transcriptional silencing. doi.org/10.1016/j.jb...
Collaboration between the Host-Virus Interaction & Rétrovirus, infection & latency teams @institutcochin.bsky.social @inserm.fr @cnrs.fr @upcite.bsky.social ⬇️
Collaboration between the Host-Virus Interaction & Rétrovirus, infection & latency teams @institutcochin.bsky.social @inserm.fr @cnrs.fr @upcite.bsky.social ⬇️
August 28, 2025 at 2:50 PM
🦠🦠🦠New paper out in JBC! Argonaute 1 contributes to HIV-1 transcriptional silencing. doi.org/10.1016/j.jb...
Collaboration between the Host-Virus Interaction & Rétrovirus, infection & latency teams @institutcochin.bsky.social @inserm.fr @cnrs.fr @upcite.bsky.social ⬇️
Collaboration between the Host-Virus Interaction & Rétrovirus, infection & latency teams @institutcochin.bsky.social @inserm.fr @cnrs.fr @upcite.bsky.social ⬇️
Reposted by Sarah Gallois-Montbrun
🔴 EXCLUSIF. L'appel des trois grands instituts de recherche français : "Trump ne cible pas la science par hasard" ⬇️
✍️ @stephaniebenz.bsky.social, @ericchol.bsky.social et Thomas Mahler
✍️ @stephaniebenz.bsky.social, @ericchol.bsky.social et Thomas Mahler
EXCLUSIF. L'appel des trois grands instituts de recherche français : "Trump ne cible pas la science par hasard"
Trois de nos plus grands scientifiques, Yasmine Belkaid, Bana Jabri et Alain Puisieux, prennent la parole pour appeler à des réponses courageuses des pouvoirs publics face aux attaques contre la recherche, aux Etats-Unis, mais aussi de ce côté de l’Atlantique.
l.lexpress.fr
April 8, 2025 at 4:06 PM
🔴 EXCLUSIF. L'appel des trois grands instituts de recherche français : "Trump ne cible pas la science par hasard" ⬇️
✍️ @stephaniebenz.bsky.social, @ericchol.bsky.social et Thomas Mahler
✍️ @stephaniebenz.bsky.social, @ericchol.bsky.social et Thomas Mahler
Reposted by Sarah Gallois-Montbrun
Proud of this work, led by the amazing Jeannette Tenthorey (now Assistant Professor at UCSF), demonstrating the adaptive power of single indel mutations in host-virus arms races, but a little sad that this is the coda to her amazing postdoc in the Malik & Emerman labs.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations
Tenthorey et al. compare the effects of missense and indel mutations on the acquisition
of functional novelty by the rapidly evolving antiviral protein TRIM5α. They find
that single indel mutations al...
www.cell.com
March 27, 2025 at 9:36 PM
Proud of this work, led by the amazing Jeannette Tenthorey (now Assistant Professor at UCSF), demonstrating the adaptive power of single indel mutations in host-virus arms races, but a little sad that this is the coda to her amazing postdoc in the Malik & Emerman labs.
www.cell.com/cell-genomic...
www.cell.com/cell-genomic...
Reposted by Sarah Gallois-Montbrun
👩⚕️👨⚕️ VIH-1 : le génome du virus produit plus d’antigènes qu’on ne le pensait.
Cette découverte élargit les cibles potentielles des vaccins contre le VIH et pourrait ouvrir la voie à de nouvelles stratégies thérapeutiques.
▶ www.insb.cnrs.fr/fr/cnrsinfo/...
Cette découverte élargit les cibles potentielles des vaccins contre le VIH et pourrait ouvrir la voie à de nouvelles stratégies thérapeutiques.
▶ www.insb.cnrs.fr/fr/cnrsinfo/...
March 21, 2025 at 8:23 AM
👩⚕️👨⚕️ VIH-1 : le génome du virus produit plus d’antigènes qu’on ne le pensait.
Cette découverte élargit les cibles potentielles des vaccins contre le VIH et pourrait ouvrir la voie à de nouvelles stratégies thérapeutiques.
▶ www.insb.cnrs.fr/fr/cnrsinfo/...
Cette découverte élargit les cibles potentielles des vaccins contre le VIH et pourrait ouvrir la voie à de nouvelles stratégies thérapeutiques.
▶ www.insb.cnrs.fr/fr/cnrsinfo/...
Reposted by Sarah Gallois-Montbrun
#VeilleESR #ESR
#StandUpForScience publie un manifeste déjà signé par 3000 personnes, qui articule ce qui se passe aux Etats-Unis, et ce que nous pouvons faire ici. La tribune devrait être ouverte à la signature de toutes et tous sous peu.
Hauts les cœurs !
www.liberation.fr/idees-et-deb...
#StandUpForScience publie un manifeste déjà signé par 3000 personnes, qui articule ce qui se passe aux Etats-Unis, et ce que nous pouvons faire ici. La tribune devrait être ouverte à la signature de toutes et tous sous peu.
Hauts les cœurs !
www.liberation.fr/idees-et-deb...
«Stand Up for Science» et après ?
La journée du 7 mars a donné lieu à une mobilisation inédite pour témoigner de la solidarité avec les universitaires américains, mais elle ne peut consister à accueillir une poignée de «stars».
www.liberation.fr
March 20, 2025 at 9:44 AM
#VeilleESR #ESR
#StandUpForScience publie un manifeste déjà signé par 3000 personnes, qui articule ce qui se passe aux Etats-Unis, et ce que nous pouvons faire ici. La tribune devrait être ouverte à la signature de toutes et tous sous peu.
Hauts les cœurs !
www.liberation.fr/idees-et-deb...
#StandUpForScience publie un manifeste déjà signé par 3000 personnes, qui articule ce qui se passe aux Etats-Unis, et ce que nous pouvons faire ici. La tribune devrait être ouverte à la signature de toutes et tous sous peu.
Hauts les cœurs !
www.liberation.fr/idees-et-deb...
Reposted by Sarah Gallois-Montbrun
La science est un bien commun !
Stand up for Science!
Stand up for Science!
March 8, 2025 at 9:55 AM
La science est un bien commun !
Stand up for Science!
Stand up for Science!
Reposted by Sarah Gallois-Montbrun
Encore bravo pour cette mobilisation. Le combat pour les libertés académiques continue.
March 7, 2025 at 3:31 PM
Encore bravo pour cette mobilisation. Le combat pour les libertés académiques continue.
Reposted by Sarah Gallois-Montbrun
@sufs-paris-rp.bsky.social #StandUpForScience felt really good to walk the streets of Paris for a couple of hours in support of science. We were thousands!
March 7, 2025 at 5:39 PM
@sufs-paris-rp.bsky.social #StandUpForScience felt really good to walk the streets of Paris for a couple of hours in support of science. We were thousands!
Reposted by Sarah Gallois-Montbrun
March 7, 2025 at 4:48 PM
Reposted by Sarah Gallois-Montbrun
PUBLIC RESEARCH!! ✊🧪 @standupforscifr.bsky.social @sufs-paris-rp.bsky.social @standupforscience.bsky.social
March 7, 2025 at 2:21 PM
PUBLIC RESEARCH!! ✊🧪 @standupforscifr.bsky.social @sufs-paris-rp.bsky.social @standupforscience.bsky.social
Reposted by Sarah Gallois-Montbrun
#Communiqué 🗞️ Le CNRS exprime sa solidarité avec les scientifiques exerçant aux États-Unis, où la liberté académique est aujourd'hui mise à l’épreuve.
👉 www.cnrs.fr/fr/presse/le...
👉 www.cnrs.fr/fr/presse/le...
March 6, 2025 at 2:51 PM
#Communiqué 🗞️ Le CNRS exprime sa solidarité avec les scientifiques exerçant aux États-Unis, où la liberté académique est aujourd'hui mise à l’épreuve.
👉 www.cnrs.fr/fr/presse/le...
👉 www.cnrs.fr/fr/presse/le...
Reposted by Sarah Gallois-Montbrun
L’Inserm est solidaire du mouvement Stand Up For Science
presse.inserm.fr/cest-dans-la...
#StandUpForScience2025
presse.inserm.fr/cest-dans-la...
#StandUpForScience2025
March 7, 2025 at 5:42 AM
Reposted by Sarah Gallois-Montbrun
I am very pleased to share with you this fantastic work done in in collaboration with Arnaud Moris’steam. It has been a very pleasant collaboration and a fantastic project done at the #I2BC. #microproteine #riboseq #HIV www.nature.com/articles/s41...
Unveiling conserved HIV-1 open reading frames encoding T cell antigens using ribosome profiling - Nature Communications
Here, using ribosomal profiling, the authors characterize the translatome of HIV-1 revealing tens of alternative open reading frames (ARF) that encode conserved viral antigens and show that ARF-derive...
www.nature.com
February 18, 2025 at 11:19 AM
I am very pleased to share with you this fantastic work done in in collaboration with Arnaud Moris’steam. It has been a very pleasant collaboration and a fantastic project done at the #I2BC. #microproteine #riboseq #HIV www.nature.com/articles/s41...
Reposted by Sarah Gallois-Montbrun
Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
www.science.org
February 7, 2025 at 10:22 AM
Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin?
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient!
#chromatin #3Dgenome #generegulation
www.science.org/doi/10.1126/...
👇
🧪Excited to host a webinar on RNA-binding proteins and their pivotal role in viral pathogenesis and immune defense 🦠
🗓️Friday, Feb 14th at 11:00 AM (Paris Time)
Great speakers: Alfredo Castello, Yara Bouery and Sébastien Pfeffer.
Register here: sondage.app.u-paris.fr/954299 or using the QR code
🗓️Friday, Feb 14th at 11:00 AM (Paris Time)
Great speakers: Alfredo Castello, Yara Bouery and Sébastien Pfeffer.
Register here: sondage.app.u-paris.fr/954299 or using the QR code
February 7, 2025 at 6:15 PM
🧪Excited to host a webinar on RNA-binding proteins and their pivotal role in viral pathogenesis and immune defense 🦠
🗓️Friday, Feb 14th at 11:00 AM (Paris Time)
Great speakers: Alfredo Castello, Yara Bouery and Sébastien Pfeffer.
Register here: sondage.app.u-paris.fr/954299 or using the QR code
🗓️Friday, Feb 14th at 11:00 AM (Paris Time)
Great speakers: Alfredo Castello, Yara Bouery and Sébastien Pfeffer.
Register here: sondage.app.u-paris.fr/954299 or using the QR code