rwsobol
@rwsobol.bsky.social
Dean’s Professor of Cancer Biology @ Brown University, Legorreta Cancer Center. My lab studies Poly(ADP-ribose)-dependent protein complexes and their role in DNA repair and the cellular response to environmental genotoxins and chemotherapy.
Reposted by rwsobol
September 29, 2025 at 5:53 PM
Fantastic review from my former colleague Ming Tan: Exploiting metabolic vulnerabilities to improve cancer therapeutics: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...
Exploiting metabolic vulnerabilities to improve cancer therapeutics
Over the past decade, our understanding of cancer metabolism has advanced significantly,
revealing a complex and dynamic landscape of metabolic reprogramming that facilitates
tumor progression and pro...
www.cell.com
September 3, 2025 at 8:24 PM
Fantastic review from my former colleague Ming Tan: Exploiting metabolic vulnerabilities to improve cancer therapeutics: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...
August 21, 2025 at 12:49 PM
Check out this article from USA TODAY:
Olympics organizers willing to treat Trump like a toddler to protect 2028 LA Games | Opinion
www.usatoday.com/story/sports...
Olympics organizers willing to treat Trump like a toddler to protect 2028 LA Games | Opinion
www.usatoday.com/story/sports...
Olympics organizers willing to treat Trump like a toddler to protect 2028 LA Games | Opinion
President Donald Trump is leading an Olympics task force to handle security issues that are already being handled for the 2028 Games in Los Angeles.
www.usatoday.com
August 6, 2025 at 12:37 AM
Check out this article from USA TODAY:
Olympics organizers willing to treat Trump like a toddler to protect 2028 LA Games | Opinion
www.usatoday.com/story/sports...
Olympics organizers willing to treat Trump like a toddler to protect 2028 LA Games | Opinion
www.usatoday.com/story/sports...
Reposted by rwsobol
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. A proteomics approach is developed using these domains to map ADP-ribosyl-ubiquitylation sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Serine ADPr on histones and PARP1 is a cellular target of ester-linked ubiquitylation - Nature Chemical Biology
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. Using these domains, Kolvenbach and Palumbieri et al. developed a proteomics approach to map ADP-ribosy...
www.nature.com
July 10, 2025 at 4:56 PM
RNF114 is an E3 ligase that can recognize ADP-ribose (ADPr) and ubiquitin with separate domains. A proteomics approach is developed using these domains to map ADP-ribosyl-ubiquitylation sites
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by rwsobol
A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications
Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...
www.nature.com
July 10, 2025 at 6:11 AM
A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Reposted by rwsobol
🔔 GP2’s 10th data release is live on the cohort dashboard!
It includes a new family file and data discovery report with pairwise kinship estimates, capturing both inferred and reported relationships.
🧪 Learn more: gp2.org/the-components-of-gp2s-10th-data-release/
It includes a new family file and data discovery report with pairwise kinship estimates, capturing both inferred and reported relationships.
🧪 Learn more: gp2.org/the-components-of-gp2s-10th-data-release/
July 9, 2025 at 2:12 PM
🔔 GP2’s 10th data release is live on the cohort dashboard!
It includes a new family file and data discovery report with pairwise kinship estimates, capturing both inferred and reported relationships.
🧪 Learn more: gp2.org/the-components-of-gp2s-10th-data-release/
It includes a new family file and data discovery report with pairwise kinship estimates, capturing both inferred and reported relationships.
🧪 Learn more: gp2.org/the-components-of-gp2s-10th-data-release/
Congratulations to Mark Hedglin, PhD: the 2025 Samuel H. Wilson Award for Studies on DNA Repair Winner @emgsus.bsky.social emgs-us.org/news/news.as...
2025 Samuel H. Wilson Award for Studies on DNA Repair Winner - Environmental Mutagenesis and Genomics Society
Mark Hedglin, PhD Assistant Professor of Chemistry, The Pennsylvania State UniversityPenn State Huck Institute of the Life Sciences, Center for Structural Biology Penn State Huck Institute of the Life Sciences, Molecular, Cellular, and Integrative Biosciences (MCIBS)
emgs-us.org
July 7, 2025 at 1:54 PM
Congratulations to Mark Hedglin, PhD: the 2025 Samuel H. Wilson Award for Studies on DNA Repair Winner @emgsus.bsky.social emgs-us.org/news/news.as...
Thrilled to share how proteomic analysis led to the discovery of "TRIP12’s role in the governance of DNA polymerase β involvement in DNA damage response and repair" url: academic.oup.com/nar/article/... @ianywonglab.bsky.social @weldeiry.bsky.social @emgsus.bsky.social
TRIP12’s role in the governance of DNA polymerase β involvement in DNA damage response and repair
Abstract. The multitude of DNA lesion types, and the nuclear dynamic context in which they occur, presents a challenge for genome integrity maintenance as
academic.oup.com
July 6, 2025 at 12:46 PM
Thrilled to share how proteomic analysis led to the discovery of "TRIP12’s role in the governance of DNA polymerase β involvement in DNA damage response and repair" url: academic.oup.com/nar/article/... @ianywonglab.bsky.social @weldeiry.bsky.social @emgsus.bsky.social
Reposted by rwsobol
👇we must resist
July 3, 2025 at 10:52 PM
👇we must resist
Judge rules some NIH grant cuts illegal, saying he's never seen such discrimination in 40 years
apnews.com/article/nih-...
apnews.com/article/nih-...
Judge rules some NIH grant cuts illegal, saying he's never seen such discrimination in 40 years
A federal judge says it was illegal for the Trump administration to cancel several hundred research grants issued by the National Institutes of Health.
apnews.com
June 16, 2025 at 10:27 PM
Judge rules some NIH grant cuts illegal, saying he's never seen such discrimination in 40 years
apnews.com/article/nih-...
apnews.com/article/nih-...
NIH scientists publish declaration criticizing Trump's deep cuts in public health research
apnews.com/article/nih-...
apnews.com/article/nih-...
NIH scientists publish declaration criticizing Trump's deep cuts in public health research
Scores of National Institutes of Health researchers and staffers have come forward to send their Trump-appointed leader a letter challenging policies they say undermine the NIH mission.
apnews.com
June 9, 2025 at 1:51 PM
NIH scientists publish declaration criticizing Trump's deep cuts in public health research
apnews.com/article/nih-...
apnews.com/article/nih-...
Check out our latest: DNA polymerase beta expression in head and neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint: www.sciencedirect.com/science/arti... @weldeiry.bsky.social @emgsus.bsky.social
DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint
Head and Neck Squamous Cell Carcinoma (HNSCC) imposes a significant health burden, necessitating innovative therapeutic strategies to enhance treatmen…
www.sciencedirect.com
June 4, 2025 at 1:08 PM
Check out our latest: DNA polymerase beta expression in head and neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint: www.sciencedirect.com/science/arti... @weldeiry.bsky.social @emgsus.bsky.social
Reposted by rwsobol
All of us are in grave danger this year before of this inept fascist takeover
June 3, 2025 at 6:43 PM
All of us are in grave danger this year before of this inept fascist takeover
Reposted by rwsobol
Remember folks, the budget cuts for NSF and NIH *can still be stopped*. That is a luxury not granted to our agency science colleagues who have or could still lose their jobs from the top down. So - Fight! Speak up! Pay attention!
May 31, 2025 at 12:22 AM
Remember folks, the budget cuts for NSF and NIH *can still be stopped*. That is a luxury not granted to our agency science colleagues who have or could still lose their jobs from the top down. So - Fight! Speak up! Pay attention!
Science in War, Science in Peace: The Origins of the NSF daily.jstor.org/science-in-w...
Science in War, Science in Peace: The Origins of the NSF - JSTOR Daily
The 1950 establishment of a federal agency devoted to space, physics, and more belied a cross-party consensus that such disciplines were vital to national interest.
daily.jstor.org
May 30, 2025 at 1:49 PM
Science in War, Science in Peace: The Origins of the NSF daily.jstor.org/science-in-w...
Reposted by rwsobol
NSF Physics was cut by 85%, basically wiping out most of its capacity for supporting research.
NSF Astronomy was cut by 53%
Undergrad education was cut by 71% and research on learning by 79%
Graduate education was cut by 100% to ZERO.
#GiftLink ⚛️🔭
www.nytimes.com/interactive/...
NSF Astronomy was cut by 53%
Undergrad education was cut by 71% and research on learning by 79%
Graduate education was cut by 100% to ZERO.
#GiftLink ⚛️🔭
www.nytimes.com/interactive/...
Trump Has Cut Science Funding to Its Lowest Level in Decades (Gift Article)
The lag in funding extends far beyond D.E.I. initiatives, affecting almost every area of science: chemistry, computing, engineering, materials and more.
www.nytimes.com
May 22, 2025 at 3:34 PM
NSF Physics was cut by 85%, basically wiping out most of its capacity for supporting research.
NSF Astronomy was cut by 53%
Undergrad education was cut by 71% and research on learning by 79%
Graduate education was cut by 100% to ZERO.
#GiftLink ⚛️🔭
www.nytimes.com/interactive/...
NSF Astronomy was cut by 53%
Undergrad education was cut by 71% and research on learning by 79%
Graduate education was cut by 100% to ZERO.
#GiftLink ⚛️🔭
www.nytimes.com/interactive/...
Interested in proteins that bind to poly(ADP-ribose)? Check out our recent study here at the Legorreta Cancer Center at Brown University on WWE domains and binding to poly(ADP-ribose) in cells: www.sciencedirect.com/science/arti... @brownuresearch.bsky.social @weldeiry.bsky.social
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage
Protein poly-ADP-ribosylation (PARylation) is a post-translational modification formed by transferring successive units of ADP-ribose to target protei…
www.sciencedirect.com
May 22, 2025 at 3:12 PM
Interested in proteins that bind to poly(ADP-ribose)? Check out our recent study here at the Legorreta Cancer Center at Brown University on WWE domains and binding to poly(ADP-ribose) in cells: www.sciencedirect.com/science/arti... @brownuresearch.bsky.social @weldeiry.bsky.social
Reposted by rwsobol
Innovation takes time
US scientists who received renewals from the NIH over the past four decades produced more novel research than those who didn’t
https://go.nature.com/44oKEwV
US scientists who received renewals from the NIH over the past four decades produced more novel research than those who didn’t
https://go.nature.com/44oKEwV
Renewal of NIH grants linked to more innovative results, study finds
Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research.
go.nature.com
May 8, 2025 at 3:59 PM
Innovation takes time
US scientists who received renewals from the NIH over the past four decades produced more novel research than those who didn’t
https://go.nature.com/44oKEwV
US scientists who received renewals from the NIH over the past four decades produced more novel research than those who didn’t
https://go.nature.com/44oKEwV
Reposted by rwsobol
A US judge to govt lawyers defending the NIH's grant terminations:
"I understand the administration is against DEI. Respectfully, I just don't know what you mean. This isn't a teasing question. There has to be some working definition.
This is research to advance healthcare for all our citizens."
"I understand the administration is against DEI. Respectfully, I just don't know what you mean. This isn't a teasing question. There has to be some working definition.
This is research to advance healthcare for all our citizens."
May 8, 2025 at 4:27 PM
A US judge to govt lawyers defending the NIH's grant terminations:
"I understand the administration is against DEI. Respectfully, I just don't know what you mean. This isn't a teasing question. There has to be some working definition.
This is research to advance healthcare for all our citizens."
"I understand the administration is against DEI. Respectfully, I just don't know what you mean. This isn't a teasing question. There has to be some working definition.
This is research to advance healthcare for all our citizens."
Reposted by rwsobol
Due to great enthusiasm, we are extending the early bird registration deadline, at a reduced rate, until 25 May. After this date, the rate will increase by 1500NOK (approx. 135USD). We look forward to seeing you in Trondheim! www.endodnadamage.com
April 28, 2025 at 2:00 PM
Due to great enthusiasm, we are extending the early bird registration deadline, at a reduced rate, until 25 May. After this date, the rate will increase by 1500NOK (approx. 135USD). We look forward to seeing you in Trondheim! www.endodnadamage.com
Reposted by rwsobol
Apply Now for the 2025 Samuel H. Wilson Award for Studies on DNA Repair - emgs-us.org/general/cust... @emgsus.bsky.social @weldeiry.bsky.social @ianywonglab.bsky.social
Sam Wilson Award Application Form - Environmental Mutagenesis and Genomics Society
11/28/2023July 2023 EMM Editor's Choice Article
emgs-us.org
February 13, 2025 at 8:32 PM
Apply Now for the 2025 Samuel H. Wilson Award for Studies on DNA Repair - emgs-us.org/general/cust... @emgsus.bsky.social @weldeiry.bsky.social @ianywonglab.bsky.social
Legorreta Cancer Center Newsletter | Spring 2025 createsend.com/t/r-01DBD817...
Cancer Center Newsletter | Spring 2025
createsend.com
March 24, 2025 at 3:12 PM
Legorreta Cancer Center Newsletter | Spring 2025 createsend.com/t/r-01DBD817...