Ryan Leenay
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rtleenay.bsky.social
Ryan Leenay
@rtleenay.bsky.social
Head of Gene Editing at Lilly.

“We cannot predict the future, but we can invent it” -Dennis Gabor

Likes and retweets are not endorsements.
Duck duck grey duck
(IYKYK)
In 5 or less words, start a fight not about religion or politics:

You’re wrong about Uptown’s borders
In 5 or less words, start a fight not about religion or politics:

Raisins complement a potato salad.😏
January 19, 2025 at 12:20 AM
Reposted by Ryan Leenay
In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
January 17, 2025 at 6:43 PM
Reposted by Ryan Leenay
In an apparently unprecedented move, Eli Lilly is partnering with the fabled venture capital firm Andreessen Horowitz on a new fund backed with $500 million of the drug giant’s money. www.statnews.com/2025/01/10/e...
Spurred by AI’s possibilities, Eli Lilly and Andreessen Horowitz partner on $500M venture fund
Eli Lilly is partnering with the fabled venture capital firm Andreessen Horowitz on a new fund backed with $500 million of the drug giant’s money.
www.statnews.com
January 10, 2025 at 1:07 PM
Some of the best advice I got early in my career was that the best scientists “never really turned their brain off”.

This is a perfect description of that. It wasn’t a call to action on working stupid hours, it’s pushing into the creative problem solving needed for complex science.
Research involves day science and night science, requiring you to become good at both. Day science proceeds in logical steps and specializes in hypothesis testing, but to generate new ideas we pop out to the creative night science world, where leaps among ideas are made possible.
December 29, 2024 at 12:38 PM
Reposted by Ryan Leenay
After nearly three decades, a Minnesota summer camp for kids with HIV/AIDS is closing and up for sale... because retroviral drugs are so effective that there aren't enough campers.

Science works, y'all.

www.startribune.com/closure-of-n...
Closure of northern Minnesota camp is ‘the greatest story.’ Here’s why.
Willow River, Minn., camp One Heartland is for sale after serving kids there for nearly three decades.
www.startribune.com
December 27, 2024 at 9:46 PM
Reposted by Ryan Leenay
The American Journal of Human Genetics' latest article reports that nearly one-third of NICU neonates initially not considered appropriate for rapid genetic testing have a genetic disease, highlighting the promise of broad implementation of genome sequencing-based newborn screening.
#ASHG #Genetics
Genome-based newborn screening for severe childhood genetic diseases has high positive predictive value and sensitivity in a NICU pilot trial
Among NICU neonates not considered appropriate for genetic testing, a clinical trial found 30% to have genetic diseases by genome sequencing, 3.6% positives and 27% positive predictive value (PPV) by newborn screening, and 4.2% positives and 100% PPV by genome sequencing-based newborn screening. Genetic diseases are unexpectedly common in NICUs.
www.cell.com
December 12, 2024 at 7:29 PM
Reposted by Ryan Leenay
New starter pack for all people interested in Gene Editing & Gene Therapy 🧬✂️ including Tools & Delivery|CRISPR-Cas|Zinc finger nucleases|Viral vectors|Non-viral delivery methods

go.bsky.app/8R4dVez
November 20, 2024 at 9:12 PM
Great thread by Harmit. Industry success (individual and company) also extremely luck dependent… what matters is your *return* on said luck. Graphic and concept from “Great by Choice”.
December 9, 2024 at 11:54 AM
Beautiful paper by Jacob Corn’s lab on the influence of DNA repair on editing outcomes:

www.nature.com/articles/s41...

Although not included, would really be curious to understand the magnitude of the effect in non-cycling cells.
www.nature.com
December 1, 2024 at 5:51 PM
November 30, 2023 at 9:44 PM