Ross Chapman
@rosschapmanlab.bsky.social
DNA damage & repair biologist | Cancer Research UK Senior Fellow | PI at the MRC Weatherall Institute in Oxford | Science, papers, lab news & some personal views & opinions
When the work of your colleagues really blows your mind 🤯🔥. Congratulations @jojdavies.bsky.social, team and collaborators! 🥂
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 6, 2025 at 6:33 AM
When the work of your colleagues really blows your mind 🤯🔥. Congratulations @jojdavies.bsky.social, team and collaborators! 🥂
Thanks Shan Zha for hosting my Social DNA’ing on Thursday. Was a honour to celebrate the 5th anniversary of this epic series. If you didn’t catch it, pls check out the recorded webinar to find out what we’ve been up to with research support from @cruk-ci.bsky.social! fast.wistia.com/embed/channe...
Actual Social DNAing Webinar
Social DNAing Weekly Webinar Serial hosted by Columbia University College for Physicians and Surgerons. The channel host the webinar from preivious week with permission from the speaker.
fast.wistia.com
June 21, 2025 at 8:33 AM
Thanks Shan Zha for hosting my Social DNA’ing on Thursday. Was a honour to celebrate the 5th anniversary of this epic series. If you didn’t catch it, pls check out the recorded webinar to find out what we’ve been up to with research support from @cruk-ci.bsky.social! fast.wistia.com/embed/channe...
Congrats Kelly! 🥂
Congratulations to @kellythd-nguyen.bsky.social, Group Leader in the LMB’s Structural Studies Division, who has been awarded the 2025 Research Prize from @thelisterinstitute.bsky.social .
Read more here: www2.mrc-lmb.cam.ac.uk/kelly-nguyen...
#LMBNews
Read more here: www2.mrc-lmb.cam.ac.uk/kelly-nguyen...
#LMBNews
June 19, 2025 at 1:51 PM
Congrats Kelly! 🥂
Reposted by Ross Chapman
Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...
Ku limits RNA-induced innate immunity to allow Alu-expansion in primates - Nature
Nature - Ku limits RNA-induced innate immunity to allow Alu-expansion in primates
www.nature.com
May 16, 2025 at 11:11 PM
Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...
Reposted by Ross Chapman
A new treatment significantly improves survival rates for women with aggressive, inherited breast cancer involving BRCA1 or BRCA2 gene mutations.
Giving them the targeted drug olaparib before surgery greatly reduced the chances of the cancer coming back.
🧪🧬💊 #medsky
www.bbc.com/news/article...
Giving them the targeted drug olaparib before surgery greatly reduced the chances of the cancer coming back.
🧪🧬💊 #medsky
www.bbc.com/news/article...
Breast cancer gene families given hope by drug trial
Treating patients with a drug before surgery greatly reduced the chances of the cancer coming back, a small trial found.
www.bbc.com
May 14, 2025 at 6:21 AM
A new treatment significantly improves survival rates for women with aggressive, inherited breast cancer involving BRCA1 or BRCA2 gene mutations.
Giving them the targeted drug olaparib before surgery greatly reduced the chances of the cancer coming back.
🧪🧬💊 #medsky
www.bbc.com/news/article...
Giving them the targeted drug olaparib before surgery greatly reduced the chances of the cancer coming back.
🧪🧬💊 #medsky
www.bbc.com/news/article...
Reposted by Ross Chapman
Don’t miss the 2025 César Milstein Lecture, by David Pellman from the Dana-Farber Cancer Institute and Harvard University.
Join us at 10am (BST) on Thu 24th April to learn about “Mechanisms driving the rapid evolution of genomes”
More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
#LMBSeminar
Join us at 10am (BST) on Thu 24th April to learn about “Mechanisms driving the rapid evolution of genomes”
More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
#LMBSeminar
April 3, 2025 at 9:28 AM
Don’t miss the 2025 César Milstein Lecture, by David Pellman from the Dana-Farber Cancer Institute and Harvard University.
Join us at 10am (BST) on Thu 24th April to learn about “Mechanisms driving the rapid evolution of genomes”
More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
#LMBSeminar
Join us at 10am (BST) on Thu 24th April to learn about “Mechanisms driving the rapid evolution of genomes”
More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
#LMBSeminar
Reposted by Ross Chapman
Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info
March 12, 2025 at 2:51 PM
Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info
Reposted by Ross Chapman
Register and submit your abstract now: The ageing genome: from mechanisms to disease www.embl.org/about/info/c...
The ageing genome: from mechanisms to disease
www.embl.org
March 2, 2025 at 5:55 PM
Register and submit your abstract now: The ageing genome: from mechanisms to disease www.embl.org/about/info/c...
Reposted by Ross Chapman
BRCA1 turned 30 🎉
To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers.
Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...
To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers.
Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...
Thirty Years of BRCA1: Mechanistic Insights and Their Impact on Mutation Carriers
Abstract. Thirty years ago, the cloning of the first breast cancer susceptibility gene, BRCA1, marked a milestone in our understanding of hereditary breast and ovarian cancers. This discovery initiate...
aacrjournals.org
March 3, 2025 at 9:26 AM
BRCA1 turned 30 🎉
To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers.
Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...
To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers.
Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...
Reposted by Ross Chapman
We show transcriptomic buffering of tumour suppressor loss via syn. lethal genes is not anecdotal but a cancer hallmark. Buffering also seen in BRCAness, predicts penetrant syn leth effects and outcome. @icr.ac.uk @cancerresearchuk.org @breastcancernow.bsky.social www.nature.com/articles/s41...
The transcriptomic architecture of common cancers reflects synthetic lethal interactions - Nature Genetics
Tumor cells upregulate compensatory buffering genes following tumor suppressor loss. These genes may represent new synthetic lethal partners that could be harnessed therapeutically.
www.nature.com
March 3, 2025 at 11:16 AM
We show transcriptomic buffering of tumour suppressor loss via syn. lethal genes is not anecdotal but a cancer hallmark. Buffering also seen in BRCAness, predicts penetrant syn leth effects and outcome. @icr.ac.uk @cancerresearchuk.org @breastcancernow.bsky.social www.nature.com/articles/s41...
Reposted by Ross Chapman
Really cool work, demonstrating TRF2-RAP1 mediated inhibition of the NHEJ machinery at chromosome ends!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Chromosome end protection by RAP1-mediated inhibition of DNA-PK
During classical non-homologous end joining (cNHEJ), DNA-dependent protein kinase (DNA-PK) encapsulates free DNA ends, forming a recruitment platform for downstream end-joining factors including Ligas...
www.biorxiv.org
January 2, 2025 at 5:29 PM
Really cool work, demonstrating TRF2-RAP1 mediated inhibition of the NHEJ machinery at chromosome ends!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Few better ways to end the year with the team than over a few pints (& mini Guinness’s) in the @StarPubOxford
December 19, 2024 at 9:36 AM
Few better ways to end the year with the team than over a few pints (& mini Guinness’s) in the @StarPubOxford
In our first skeet, check out a very cool postdoc opportunity, in the very cool @susanagodinho.bsky.social lab 👇
We have a very cool (I know I am biased😁) project for a computational biologist (postdoc) interested in cancer evolution in collaboration with Nicky McGranahan’s lab! Perfect opportunity to expand your computational skills too!
👉 www.godinholab.com
RT please 🙏🙏🙏👍👍
👉 www.godinholab.com
RT please 🙏🙏🙏👍👍
Godinho Lab
www.godinholab.com
December 12, 2024 at 7:29 AM
In our first skeet, check out a very cool postdoc opportunity, in the very cool @susanagodinho.bsky.social lab 👇